Preparation and evaluation of self-nanoemulsified drug delivery systems (SNEDDSs) of matrine based on drug-phospholipid complex technique

International Journal of Pharmaceutics

Volumn 386, Issue 1-2, 2010, Pages 282-290

  Ruan, Jinghua ^a,b   Liu, Jie ^a   Zhu, Di ^a   Gong, Tao ^a   Yang, Fumei ^b   Hao, Xiaojiang ^b   Zhang, Zhirong ^a  

^a SICHUAN UNIVERSITY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Bioavailability of matrine; Enhanced oral bioavailability; SNEDDSs

Indexed keywords

CREMOPHOR; DIETHYLENE GLYCOL MONOETHYL ETHER; MATRINE; PHOSPHOLIPID;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DILUTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; DRUG STRUCTURE; HALF LIFE TIME; INFRARED SPECTROSCOPY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PH; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; SELF NANOEMULSIFIED DRUG DELIVERY SYSTEM; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ALKALOIDS; ANIMALS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; EMULSIONS; ETHYLENE GLYCOLS; GLYCEROL; HYDROGEN-ION CONCENTRATION; INJECTIONS, INTRAVENOUS; MALE; NANOSTRUCTURES; NANOTECHNOLOGY; PARTICLE SIZE; PHOSPHOLIPIDS; QUINOLIZINES; RATS; RATS, WISTAR; SOLUBILITY; SPECTROPHOTOMETRY, INFRARED; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 74149090979     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.11.026     Document Type: Article

References (26)

1. Carini R., Comoglio A., Albano E., and Poli G. Lipid peroxidation and irreversible damage in the rat hepatocyte model: protection by the silybin-phospholipid complex IdB 1016. Biochem. Pharmacol. 43 (1992) 2111-2115
2. Chui C.H., Lau F.Y., Tang J.C., Kan K.L., Cheng G.Y., Wong R.S., et al. Activities of fresh juice of Scutellaria barbata and warmed water extract of Radix Sophorae Tonkinensis on anti-proliferation and apoptosis of human cancer cell lines. Int. J. Mol. Med. 16 (2005) 337-341
3. Cilek A., Celebi N., Tirnaksiz F., and Tay A. A lecithin-based microemulsion of rh-insulin with aprotinin for oral administration: investigation of hypoglycemic effects in non-diabetic and STZ-induced diabetic rats. Int. J. Pharm. 298 (2005) 176-185
4. Comoglio A., Tomasi A., Malandrino S., Poli G., and Albani E. Scavenging effect of silipide, a newsilybin-phospholipid complex, on ethanol-derived free radicals. Biochem. Pharmacol. 50 (1995) 1313-1316
5. Constantinides P.P. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm. Res. 12 (1995) 1561-1572
6. Cui F.D., Shi K., Zhang L.Q., Tao A.J., and Kawashima Y. Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: Preparation, in vitro characterization and in vivo evaluation. J. Controlled Release 114 (2006) 242-250
7. Galasso V., Asaro F., Berti F., Pergolese B., Kovač B., and Pichierri F. On the molecular and electronic structure of matrine-type alkaloids. Chem Phys. 330 (2006) 457-468
8. Ho H.O., Hsiao C.C., and Sheu M.T. Preparation of microemulsions using polyglycerol fatty acid esters as surfactant for the delivery of protein drugs. J. Pharm. Sci. 85 (1996) 138-143
9. Hu M.J., Zeng H., Wu Y.L., Zhang Y.P., Zhang S., Qiao M.M., et al. Synergistic effects of matrine and 5-fluorouracil on tumor growth of the implanted gastric cancer in nude mice. Chin. J. Dig. Dis. 6 (2005) 68-71
10. Lai J.P., He X.W., Jiang Y., and Chen F. Preparative separation and determination of matrine from the Chinese medicinal plant Sophora flavescens Ait. by molecularly imprinted solid-phase extraction. Anal. Bioanal. Chem. 375 (2003) 264-269
11. Liu J., Shen H.M., and Ong C.N. Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG(2) cells. Cancer Lett. 153 (2000) 85-93
12. Maiti K., Mukherjee K., Gantait A., Saha B.P., and Mukherjee P.K. Curcumin-phospholipid complex: preparation, therapeutic evaluation and pharmacokinetic study in rats. Int. J. Pharm. 330 (2007) 155-163
13. Nazzal S., Smalyukh I.I., Lavrentovich O.D., and Khan M.A. Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: mechanism and progress of emulsion formation. Int. J. Pharm. 235 (2002) 247-265
14. Porter C.J.H., Pouton, Colin W., Cuine, Jean F., and Charman William N. Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv. Drug Deliv. Rev. 60 (2008) 73-691
15. Sarciaux J.M., Acar L., and Sado P.A. Using microemulsion formulations for oral drug delivery of therapeutic peptides. Int. J. Pharm. 120 (1995) 127-136
16. Shah R.B., Zidan A.S., Funck T., Tawakkul M.A., Nguyenpho A., and Khan M.A. Quality by design: characterization of self-nano-emulsified drug delivery systems (SNEDDs) using ultrasonic resonator technology. Int. J. Pharm. 341 (2007) 189-194
17. Swenson E.C., and Curatolo W.J. Intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanisms and potential toxicity. Adv. Drug Deliv. Rev. 8 (1992) 39-92
18. Venkata Ramana Rao S., and Shao J. Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs. Int. J. Pharm. 362 (2008) 2-9
19. Wang S.J., Wang G.J., Li X.T., Sun J.G., Ma R.L., and Sheng L.S. Simultaneous determination of oxymatrine and its active metabolite matrine in dog plasma by liquid chromatography-mass spectrometry and its application to pharmacokinetic studies. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 817 (2005) 319-325
20. Wu X.N., Yamashit F., Hashid M., Chen X.G., and Hu Z.D. Determination of matrine in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. Talanta 59 (2003) 965-971
21. Wu X.L., Hang T.J., Shen J.P., and Zhang Y.D. Determination and pharmacokinetic study of oxymatrine and its metabolite matrine in human plasma by liquid chromatography tandem mass spectrometry. J. Pharm. Biomed. Anal. 41 (2006) 918-924
22. Xue R., Shang B.W., and Di T.Y. HPLC analysis of determination of matrine by different column. Ningxia Med. J. 28 (2006) 518-519
23. Zhang M.J., and Huang J. Recent research progress of antitumor mechanism of Matrine. China J. Chin. Mater. Med. 29 (2004) 115-118
24. Zhang L.P., Jiang J.K., Tam J.W., Zhang Y., Liu X.S., Xu X.R., et al. Effects of matrine on proliferation and differentiation in K2562 cells. Leuk. Res. 25 (2001) 793-800
25. Zhang L., Liu W.T., Zhang R.W., Wang Z.W., Shen Z.D., Chen X.H., et al. Pharmacokinetic study of matrine, oxymatrine and oxysophocarpine in rat plasma after oral administration of Sophora flavescens Ait. extract by liquid chromatography tandem mass spectrometry. J. Pharm. Biomed. Anal. 47 (2008) 892-898
26. Zhu J.P., Xin S.M., and Ma Z.Q. The bioavailability study of matrine by intragastric administration. Chin. Tradi. Pat. Med. 28 (1998) 2-3