Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation

Neuropsychopharmacology

Volumn 40, Issue 3, 2015, Pages 525-536

  Delpech, Jean Christophe ^a,b   Madore, Charlotte ^a,b   Joffre, Corinne ^a,b   Aubert, Agnès ^a,b   Kang, Jing Xuan ^c   Nadjar, Agnès ^a,b   Layé, Sophie ^a,b  

^a NutriNeuro Bordeaux University   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CYCLOOXYGENASE 2; DNA; DOCOSAPENTAENOIC ACID; ICOSAPENTAENOIC ACID; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PHOSPHOLIPID; PROSTAGLANDIN E SYNTHASE 1; TUMOR NECROSIS FACTOR ALPHA; ACYL COENZYME A DESATURASE; AUTACOID; CAENORHABDITIS ELEGANS PROTEIN; CYTOKINE; FAT-1 PROTEIN, C ELEGANS;

ADULT; AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BODY WEIGHT; CELL ISOLATION; COGNITION; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA EXTRACTION; FATIGUE; FATTY ACID ANALYSIS; FLOW CYTOMETRY; FOOD INTAKE; GENOTYPE; HIPPOCAMPUS; ILLNESS BEHAVIOR; INNATE IMMUNITY; LIPID COMPOSITION; MICROGLIA; MOTIVATION; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SPATIAL MEMORY; Y-MAZE TEST; ANIMAL; BRAIN; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; IMMUNOLOGY; INFLAMMATION; MALE; MAZE TEST; MEMORY DISORDERS; METABOLISM; TRANSGENIC MOUSE;

ANIMALS; BRAIN; CAENORHABDITIS ELEGANS PROTEINS; CYTOKINES; FATTY ACID DESATURASES; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; HIPPOCAMPUS; ILLNESS BEHAVIOR; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MICROGLIA; PHENOTYPE; SPATIAL MEMORY;

EID: 84922072976     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2014.196     Document Type: Article

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