Propofol (Diprivan®) and Intralipid® exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking

Anesthesia and Analgesia

Volumn 120, Issue 2, 2015, Pages 329-340

  Lou, Phing How ^a   Lucchinetti, Eliana ^a   Zhang, Liyan ^a   Affolter, Andreas ^b   Gandhi, Manoj ^a   Zhakupova, Assem ^c   Hersberger, Martin ^b   Hornemann, Thorsten ^c   Clanachan, Alexander S ^a   Zaugg, Michael ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; FRUCTOSE; GLUCOSE TRANSPORTER 4; GLYCEROPHOSPHOLIPID; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INTRALIPID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYGLYCEROL; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; PROPOFOL; PROTEIN; PROTEIN KINASE B; PROTEIN KINASE C BETA; PROTEIN KINASE C THETA; PROTEIN S6K1; SERINE; SPHINGOLIPID; SPHINGOSINE; STRESS ACTIVATED PROTEIN KINASE; TYROSINE; UNCLASSIFIED DRUG; CITRATE SYNTHASE; EMULSION; GLUCOSE; GLYCOGEN; INTRAVENOUS ANESTHETIC AGENT; LIPID EMULSION; SLC2A4 PROTEIN, RAT; SOYBEAN OIL; SOYBEAN OIL, PHOSPHOLIPID EMULSION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; GLUCOSE TRANSPORT; GLYCOGEN METABOLISM; GLYCOLYSIS; HEART; IMMUNOBLOTTING; INSULIN RESISTANCE; MALE; MASS SPECTROMETRY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RAT; SARCOLEMMA; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DRUG EFFECTS; EMULSION; METABOLISM; SPRAGUE DAWLEY RAT; TOXICITY;

ANESTHETICS, INTRAVENOUS; ANIMALS; CITRATE (SI)-SYNTHASE; DIABETES MELLITUS, TYPE 2; EMULSIONS; FAT EMULSIONS, INTRAVENOUS; FRUCTOSE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; GLYCOGEN; GLYCOLYSIS; HEART; INSULIN RESISTANCE; MALE; PHOSPHOLIPIDS; PROPOFOL; RATS; RATS, SPRAGUE-DAWLEY; SOYBEAN OIL;

EID: 84922069675     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0000000000000558     Document Type: Article

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