Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms β2 and θ

Diabetologia

Volumn 43, Issue 4, 2000, Pages 443-449

  Strack, V ^a   Hennige, A M ^a   Krutzfeldt J ^a   Bossenmaier, B ^b   Klein, H H ^c   Kellerer, M ^a   Lammers, R ^a   Haring H U ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

^c UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Insulin receptor inhibition; Protein kinase C; Serine phosphorylation; Tyrosine kinase activity

Indexed keywords

ALANINE; INHIBITOR PROTEIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR KINASE; PHORBOL ESTER; PHOSPHATASE; PROTEIN KINASE C; PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SERINE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INSULIN BINDING; INSULIN RESISTANCE; PHOSPHORYLATION; PRIORITY JOURNAL;

EID: 0005726439     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051327     Document Type: Article

References (39)

1. Kasuga M, Fujita-Yamaguchi Y, Blithe D, Kahn CR (1983) Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc Natl Acad Sci USA 80: 2137-2141
2. White MF, Kahn CR (1994) The insulin signaling system. J Biol Chem 269: 1-4
3. Kaburagi Y, Momomura K, Yamamoto-Honda R et al. (1993) Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor. J Biol Chem 268: 16610-16622
4. Pillay TS, Whittaker J, Lammers R, Ullrich A, Siddle K (1991) Multisite serine phosphorylation of the insulin and IGF-I receptors in transfected cells. FEBS Lett 288: 206-211
5. Takayama S, White MF, Lauris V, Kahn CR (1984) Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells. Proc Natl Acad Sci USA 81: 7797-7801
6. Bollag GE, Roth RA, Beaudoin J, Mochly-Rosen D, Koshland DE (1986) Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein kinase activity. Proc Natl Acad Sci USA 83: 5822-5824
7. Häring HU, Kasuga M, White MF, Crettaz M, Kahn CR (1984) Phosphorylation and dephosphorylation of the insulin receptor: evidence against an intrinsic phosphatase activity. Biochemistry 23: 3298-3306
8. White MF (1998) The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol Cell Biochem 182: 3-11
9. Shepherd PR, Withers DJ, Siddle K (1998) Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 333: 471-490
10. Holman GD, Kasuga M (1997) From receptor to transporter: insulin signalling to glucose transport. Diabetologia 40: 991-1003
11. Seedorf K, Juhl L, Hansen L, Nielsen L, Mosthaf L (1996) Insulin-induced activation of MAP kinase involves Grb-2, SHPTP2, PI-3 kinase and PLCγ. Exp Clin Endocrinol Diabetes 104: 138-139
12. Cohen P, Alessi DR, Cross DA (1997) PDK1, one of the missing links in insulin signal transduction? FEBS Lett 410: 3-10
13. Alessi DR, Cohen P (1998) Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev 8: 55-62
14. Takayama S, White MF, Kahn CR (1988) Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. J Biol Chem 263: 3440-3447
15. Dunaif A, Xia J, Book CB, Schenker E, Tang Z (1995) Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome. J Clin Invest 96: 801-810
16. Liu F, Roth RA (1994) Identification of serines-1035/1037 in the kinase domain of the insulin receptor as protein kinase C alpha mediated phosphorylation sites FEBS Lett 352: 389-392
17. Lewis RE, Wu PG, MacDonald RG, Czech MP (1990) Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase. J Biol Chem 265: 947-954
18. Tavare JM, Zhang B, Ellis L, Roth RA (1991) Insulin-stimulated serine and threonine phosphorylation of the human insulin receptor. J Biol Chem 266: 21804-21809
19. AI Hasani H, Eisermann B, Tennagels N et al. (1997) Identification of Ser-1275 and Ser-1309 as autophosphorylation sites of the insulin receptor. FEBS Lett 400: 65-70
20. Danielsen AG, Liu F, Hosomi Y, Shii K, Roth RA (1995) Activation of protein kinase C alpha inhibits signaling by members of the insulin receptor family. J Biol Chem 270: 21600-21605
21. Strack V, Stoyanov B, Bossenmaier B, Mosthaf L, Kellerer M, Häring HU (1997) Impact of mutations at different serine residues on the tyrosine kinase activity of the insulin receptor. Biochem Biophys Res Commun 239: 235-239
22. Bossenmaier B, Mosthaf L, Mischak H, Ullrich A, Häring HU (1997) Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor. Diabetologia 40: 863-866
23. Kellerer M, Mushack J, Seffer E, Mischak H, Ullrich SA, Häring HU (1998) Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells). Diabetologia 41: 833-838
24. Kunkel TA, Roberts J, Zankour R (1985) Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci USA 82: 488-492
25. Gorman CM, Gies D, McGray G, Huang M (1989) The human cytomegalovirus major immediate early promotor can be trans-activated by adenovirus early proteins. Virology 171: 377-385
26. Ullrich A, Bell JR, Chen EY et al. (1985) Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313: 756-761
27. Chen C, Okayama H (1987) High-effeciency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7: 2745-2752
28. Klein HH, Kowalewski B, Drenckhan M, Fehm HL (1997) Insulin stimulation of human adipocytes activates the kinase of only a fraction of the insulin receptors. Am J Physiol 272: E576-E583
29. Klein HH, Müller R, Vestergaard H, Pedersen O (1999) Implications of compound heterozygous insulin receptor mutations in congenital muscle fibre type disproportion myopathy for the receptor kinase activation. Diabetologia 42: 245-249
30. Kaburagi Y, Yamamoto-Honda R, Tobe K et al. (1995) The role of the NPXY motif in the insulin receptor in tyrosine phosphorylation of insulin receptor substrate-1 and She. Endocrinology 136: 3437-3443
31. Lammers R, Moller NP, Ullrich A (1997) The transmembrane protein tyrosine phosphatase alpha dephosphorylates the insulin receptor in intact cells. FEBS Lett 404: 37-40
32. Kharitonenkov A, Schnekenburger J, Chen ZJ et al. (1995) Adapter function of protein-tyrosine phosphatase ID in insulin receptor/insulin receptor substrate-1 interaction. J Biol Chem 270: 29189-29193
33. Kharitonenkov A, Chen ZJ, Sures I, Wang HY, Schilling J, Ullrich A (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386: 181-186
34. Uchida T, Matozaki T, Noguchi T et al. (1994) Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains. J Biol Chem 269: 12220-12228
35. Hashimoto N, Feener EP, Zhang WR, Goldstein BJ (1992) Insulin receptor protein-tyrosine phosphatases. Leukocyte common antigen-related phosphatase rapidly deactivates the insulin receptor kinase by preferential dephosphorylation of the receptor regulatory domain. J Biol Chem 267: 13811-13814
36. De Fea K, Roth RA (1997) Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase. J Biol Chem 272: 31400-31406
37. Eldar-Finkelman H, Krebs EG (1997) Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action. Proc Natl Acad Sci USA 94: 9660-9664
38. Lam K, Carpenter CL, Ruderman NB, Friel JC, Kelly KL (1994) The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin. J Biol Chem 269: 20648-20652
39. De Fea K, Roth RA (1997) Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612. Biochemistry 36: 12939-12947