Metabolic profiling of hearts exposed to sevoflurane and propofol reveals distinct regulation of fatty acid and glucose oxidation: CD36 and pyruvate dehydrogenase as key regulators in anesthetic-induced fuel shift

Anesthesiology

Volumn 113, Issue 3, 2010, Pages 541-551

  Wang, Lianguo ^a   Ko, Kerry W S ^b   Lucchinetti, Eliana ^b   Zhang, Liyan ^c   Troxler, Heinz ^e   Hersberger, Martin ^f   Omar, Mohamed A ^b   De Chaves, Elena I Posse ^b   Lopaschuk, Gary D ^d   Clanachan, Alexander S ^d   Zaugg, Michael ^d,f  

^a Departments of Anesthesiology and Pain Medicine   (United States)

^b Department of Anesthesiology and Pain Medicine ^*

^c Cardiovascular Research Group   (Australia)

^d UNIVERSITY OF ALBERTA   (Canada)

^e UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^f MAZANKOWSKI ALBERTA HEART INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ACYL COENZYME A; ACYLCARNITINE; ADENOSINE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; CD36 ANTIGEN; CERAMIDE; COENZYME A; GLUCOSE TRANSPORTER 4; GUANOSINE TRIPHOSPHATE; INTRALIPID; MALONYL COENZYME A; NICOTINAMIDE ADENINE DINUCLEOTIDE; NUCLEOTIDE; PROPIONYL COENZYME A; PROPOFOL; PYRUVATE DEHYDROGENASE; SEVOFLURANE; SUCCINYL COENZYME A; CD36 PROTEIN, RAT; ETHER DERIVATIVE; FATTY ACID; GLUCOSE; INTRAVENOUS ANESTHETIC AGENT; PYRUVATE DEHYDROGENASE COMPLEX;

ANIMAL TISSUE; ARTICLE; CAVEOLA; CONTROLLED STUDY; ENERGY METABOLISM; FATTY ACID OXIDATION; GLUCOSE OXIDATION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART MUSCLE CONTRACTILITY; LIPID RAFT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; RAT; ANIMAL; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; HEART; IN VITRO STUDY; MALE; METABOLISM; METABOLOME; OXIDATION REDUCTION REACTION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANESTHETICS, INTRAVENOUS; ANIMALS; ANTIGENS, CD36; ENERGY METABOLISM; FATTY ACIDS; GLUCOSE; HEART; MALE; METABOLOME; METHYL ETHERS; MYOCARDIUM; OXIDATION-REDUCTION; PROPOFOL; PYRUVATE DEHYDROGENASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77956988316     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3181e2c1a1     Document Type: Article

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