Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat

American Journal of Physiology - Endocrinology and Metabolism

Volumn 306, Issue 6, 2014, Pages

  Warren, Blair E ^a   Lou, Phing How ^a   Lucchinetti, Eliana ^a   Zhang, Liyan ^a   Clanachan, Alexander S ^a   Affolter, Andreas ^b   Hersberger, Martin ^b   Zaugg, Michael ^a   Lemieux, Hélène ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

Aconitase; Fatty acid oxidation; Insulin resistance; Mitochondrial dysfunction; Sirtuin 3; Skeletal muscle; Type 2 diabetes

Indexed keywords

ACETYLCARNITINE; ACONITATE HYDRATASE; ACYLCARNITINE; ASCORBIC ACID; FRUCTOSE; GLUTAMIC ACID; GLUTATHIONE PEROXIDASE; PALMITOYL COENZYME A; PALMITOYLCARNITINE; PYRUVATE DEHYDROGENASE; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINIC ACID; THIOREDOXIN REDUCTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY RESOURCE; ENZYME ACTIVITY; EXTENSOR DIGITORUM LONGUS MUSCLE; FATTY ACID OXIDATION; GLYCOLYSIS; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; MALE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MUSCLE METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; SOLEUS MUSCLE;

ACONITASE; FATTY ACID OXIDATION; INSULIN RESISTANCE; MITOCHONDRIAL DYSFUNCTION; SIRTUIN-3; SKELETAL MUSCLE; TYPE 2 DIABETES;

ACONITATE HYDRATASE; ANIMALS; CARNITINE; DIABETES MELLITUS, TYPE 2; DIETARY CARBOHYDRATES; DISEASE PROGRESSION; ENERGY METABOLISM; FATTY ACIDS; FRUCTOSE; GLUTAMIC ACID; GLYCOLYSIS; INSULIN RESISTANCE; MALE; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OXIDATIVE PHOSPHORYLATION; PREDIABETIC STATE; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84900533115     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00511.2013     Document Type: Article

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