Cytosolic double-stranded DNA induces nonnecroptotic programmed cell death in trophoblasts via IFI16

Journal of Infectious Diseases

Volumn 210, Issue 9, 2014, Pages 1476-1486

  Chu, Xiao ^a   Chen, Wei ^a   Li, Ning ^a   Hu, Xiao Zhu ^a   Du, Chong Tao ^a   Yu, Shui Xing ^a   Zhou, Min ^a   Zhang, Xiao Jing ^a   Jiang, Gui Mei ^a   Han, Wen Yu ^a   Deng, Xu Ming ^a   Yang, Yong Jun ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Double stranded DNA; IFI16; L. monocytogenes; Pregnancy; Trophoblasts

Indexed keywords

CASPASE; CHEMOKINE; CYTOSOLIC DOUBLE STRANDED DNA; DOUBLE STRANDED DNA; GENOMIC DNA; IFI16 PROTEIN; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN KINASE 3; UNCLASSIFIED DRUG; BACTERIAL DNA; DNA; IFI16 PROTEIN, HUMAN; NUCLEAR PROTEIN; PHOSPHOPROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BLOOD PLACENTA BARRIER; CONTROLLED STUDY; CYTOSOL; FEMALE; HOST CELL; HUMAN; HUMAN CELL; LISTERIA MONOCYTOGENES; MALE; MOLECULAR RECOGNITION; MOUSE; NECROPTOSIS; NONHUMAN; NONNECROPTOTIC PROGRAMMED CELL DEATH; PATHOGEN ASSOCIATED MOLECULAR PATTERN RECOGNITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TROPHOBLAST; ANIMAL; C57BL MOUSE; CELL DEATH; CELL LINE; DRUG EFFECTS; LISTERIOSIS; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; PREGNANCY;

ANIMALS; CASPASES; CELL DEATH; CELL LINE; DNA; DNA, BACTERIAL; FEMALE; HUMANS; LISTERIA MONOCYTOGENES; LISTERIOSIS; MALE; MICE, INBRED C57BL; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PREGNANCY; TROPHOBLASTS;

EID: 84922021728     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu272     Document Type: Article

References (49)

1. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371:75-84.
2. Robbins JR, Bakardjiev AI. Pathogens and the placental fortress. Curr Opin Microbiol 2012; 15:36-43.
3. Robbins JR, Skrzypczynska KM, Zeldovich VB, Kapidzic M, Bakardjiev AI. Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes. PLoS Pathog 2010; 6:e1000732.
4. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001; 2:675-80.
5. Gordon S. Pattern recognition receptors: doubling up for the innate immune response. Cell 2002; 111:927-30.
6. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124:783-801.
7. Meylan E, Tschopp J, Karin M. Intracellular pattern recognition receptors in the host response. Nature 2006; 442:39-44.
8. Cardenas I, Mulla MJ, Myrtolli K, et al. Nod1 activation by bacterial iEDAP induces maternal-fetal inflammation and preterm labor. J Immunol 2011; 187:980-6.
9. Abrahams VM. The role of the Nod-like receptor family in trophoblast innate immune responses. J Reprod Immunol 2011; 88:112-7.
10. Koga K, Mor G. Toll-like receptors at the maternal-fetal interface in normal pregnancy and pregnancy disorders. Am J Reprod Immunol 2010; 63:587-600.
11. Abrahams VM, Aldo PB, Murphy SP, et al. TLR6 modulates first trimester trophoblast responses to peptidoglycan. J Immunol 2008; 180:6035-43.
12. Kavathas PB, Boeras CM, Mulla MJ, Abrahams VM. Nod1, but not the ASC inflammasome, contributes to induction of IL-1beta secretion in human trophoblasts after sensing of Chlamydia trachomatis. Mucosal Immunol 2013; 6:235-43.
13. Ashida H, Mimuro H, Ogawa M, et al. Cell death and infection: a double-edged sword for host and pathogen survival. J Cell Biol 2011; 195:931-42.
14. Zhang DW, Shao J, Lin J, et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009; 325:332-6.
15. Roca FJ, Ramakrishnan L. TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Cell 2013; 153:521-34.
16. Gunther C, Martini E, Wittkopf N, et al. Caspase-8 regulates TNF-alpha- induced epithelial necroptosis and terminal ileitis. Nature 2011; 477:335-9.
17. Jouan-Lanhouet S, Arshad MI, Piquet-Pellorce C, et al. TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. Cell Death Differ 2012; 19:2003-14.
18. Kaiser WJ, Sridharan H, Huang C, et al. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem 2013; 288:31268-79.
19. Zou J, Kawai T, Tsuchida T, et al. Poly IC triggers a cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis. Immunity 2013; 38:717-28.
20. Kim SJ, Li J. Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia. Cell Death Dis 2013; 4:e716.
21. He S, Liang Y, Shao F, Wang X. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A 2011; 108:20054-9.
22. Robinson N, McComb S, Mulligan R, Dudani R, Krishnan L, Sad S. Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium. Nat Immunol 2012; 13:954-62.
23. Deng Q, Yu X, Xiao L, et al. Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway. Cell Death Dis 2013; 4:e804.
24. Rosenbaum DM, Degterev A, David J, et al. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res 2010; 88:1569-76.
25. Harberts E, Fishelevich R, Liu J, Atamas SP, Gaspari AA. MyD88 mediates the decision to die by apoptosis or necroptosis after UV irradiation. Innate Immun 2013. [Epub ahead of print].
26. Upton JW, Kaiser WJ, Mocarski ES. DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe 2012; 11:290-7.
27. Handke W, Krause E, Brune W. Live or let die: manipulation of cellular suicide programs by murine cytomegalovirus. Med Microbiol Immunol 2012; 201:475-86.
28. Peri P, Nuutila K, Vuorinen T, Saukko P, Hukkanen V. Cathepsins are involved in virus-induced cell death in ICP4 and Us3 deletion mutant herpes simplex virus type 1-infected monocytic cells. J Gen Virol 2011; 92:173-80.
29. Cho YS, Challa S, Moquin D, et al. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009; 137:1112-23.
30. Hornung V, Ablasser A, Charrel-Dennis M, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009; 458:514-8.
31. Moujalled DM, Cook WD, Okamoto T, et al. TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1. Cell Death Dis 2013; 4:e465.
32. Upton JW, Kaiser WJ, Mocarski ES. Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe 2010; 7:302-13.
33. Moriwaki K, Chan FK. RIP3: a molecular switch for necrosis and inflammation. Genes Dev 2013; 27:1640-9.
34. Kaczmarek A, Vandenabeele P, Krysko DV. Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity 2013; 38:209-23.
35. Kovalenko A, Kim JC, Kang TB, et al. Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J Exp Med 2009; 206:2161-77.
36. Welz PS, Wullaert A, Vlantis K, et al. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 2011; 477:330-4.
37. Degterev A, Huang Z, Boyce M, et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005; 1:112-9.
38. Mareninova OA, Sung KF, Hong P, et al. Cell death in pancreatitis: caspases protect from necrotizing pancreatitis. J Biol Chem 2006; 281:3370-81.
39. Lotze MT, Zeh HJ, Rubartelli A, et al. The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity. Immunol Rev 2007; 220:60-81.
40. Rubartelli A, Lotze MT. Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox. Trends Immunol 2007; 28:429-36.
41. Chung EY, Kim SJ, Ma XJ. Regulation of cytokine production during phagocytosis of apoptotic cells. Cell Res 2006; 16:154-61.
42. Rock KL, Kono H. The inflammatory response to cell death. Annu Rev Pathol 2008; 3:99-126.
43. Ravichandran KS. Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums. J Exp Med 2010; 207:1807-17.
44. Griffith TS, Ferguson TA. Cell death in the maintenance and abrogation of tolerance: the five Ws of dying cells. Immunity 2011; 35:456-66.
45. Unterholzner L, Keating SE, Baran M, et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 2010; 11:997-1004.
46. Satoh T, Kambe N, Matsue H. NLRP3 activation induces ASC-dependent programmed necrotic cell death, which leads to neutrophilic inflammation. Cell Death Dis 2013; 4:e644.
47. Sagulenko V, Thygesen SJ, Sester DP, et al. AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death Differ 2013; 20:1149-60.
48. Gugliesi F, De Andrea M, Mondini M, et al. The proapoptotic activity of the interferon-inducible gene IFI16 provides new insights into its etiopathogenetic role in autoimmunity. J Autoimmun 2010; 35: 114-23.
49. Fujiuchi N, Aglipay JA, Ohtsuka T, et al. Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. J Biol Chem 2004; 279:20339-44.