Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway

Cell Death and Disease

Volumn 4, Issue 9, 2013, Pages

  Deng, Q ^a,b   Yu, X ^a,b   Xiao, L ^a,b   Hu, Z ^a,b   Luo, X ^a,b   Tao, Y ^a,b   Yang, L ^a,b   Liu, X ^a,b   Chen, H ^d   Ding, Z ^c   Feng, T ^c   Tang, Y ^a,b   Weng, X ^a,b   Gao, J ^a,b   Yi, W ^a,b   Bode, A M ^d   Dong, Z ^d   Liu, J ^c   Cao, Y ^a,b  

^a Central South University   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c KUNMING INSTITUTE OF BOTANY   (China)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cancer cell death; Energy depletion; Neoalbaconol; PDK1; PI3 K Akt

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; FUNGAL EXTRACT; GLUCOSE; NEOALBACONOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL;

ALBATRELLUS CONFLUENS; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ATTENUATION; AUTOPHAGY; CANCER CELL; CANCER INHIBITION; CELL ENERGY; CELL METABOLISM; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENERGY; FLOW CYTOMETRY; FORCE; FUNGUS; GLUCOSE INTAKE; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NASOPHARYNX CARCINOMA; NECROPTOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENERGY METABOLISM; GLUCOSE; HEXOKINASE; MICE; MICE, NUDE; MODELS, BIOLOGICAL; NASOPHARYNGEAL NEOPLASMS; NECROSIS; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SESQUITERPENES; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TREATMENT OUTCOME;

EID: 84884997814     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.324     Document Type: Article

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