A comparison of type 2 diabetes risk allele load between African Americans and European Americans

Human Genetics

Volumn 133, Issue 12, 2014, Pages 1487-1495

  Keaton, Jacob M ^a   Cooke Bailey, Jessica N ^a   Palmer, Nicholette D ^a   Freedman, Barry I ^a   Langefeld, Carl D ^a   Ng, Maggie C Y ^a   Bowden, Donald W ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMTS9 PROTEIN; ANK1 PROTEIN; BCL11A PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; FTO PROTEIN; PRC1 PROTEIN; PROTEIN; PSMD6 PROTEIN; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG; ZFAND6 PROTEIN;

ADULT; AFRICAN AMERICAN; AGE; ALLELE; ARTICLE; BODY MASS; CLINICAL PROTOCOL; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ETHNIC DIFFERENCE; EUROPEAN AMERICAN; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; POPULATION GENETICS; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; CAUCASIAN; CHRONIC KIDNEY FAILURE; ETHNOLOGY; GENETICS; RISK;

ADULT; AFRICAN AMERICANS; AGED; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK;

EID: 84921937752     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-014-1486-5     Document Type: Article

References (48)

1. Bento JL, Palmer ND, Zhong M et al (2008) Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. Genomics 92:226–234. doi:10.1016/j.ygeno.2008.06.004
2. Buetow KH, Edmonson M, MacDonald R et al (2001) High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Natl Acad Sci 98:581–584. doi:10.1073/pnas.021506298
3. Centers for Disease Control and Prevention (2012) Diabetes Report Card 2012. Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta
4. Cheng C-Y, Reich D, Haiman CA et al (2012) African ancestry and its correlation to type 2 diabetes in African Americans: a genetic admixture analysis in three US population cohorts. PLoS One 7:e32840. doi:10.1371/journal.pone.0032840
5. Cho YS, Chen C-H, Hu C et al (2012) Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet 44:67–72. doi:10.1038/ng.1019
6. Cooke JN, Bostrom MA, Hicks PJ et al (2012a) Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans. Nephrol Dial Transplant 27:1505–1511. doi:10.1093/ndt/gfr522
7. Cooke JN, Ng MCY, Palmer ND et al (2012b) Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans. Diabetes Care 35:287–292. doi:10.2337/dc11-0957
8. Cui B, Zhu X, Xu M et al (2011) A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese. PLoS One 6:e22353. doi:10.1371/journal.pone.0022353
9. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF et al (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331–1336. doi:10.1126/science.1142358
10. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium et al (2014) Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet 46:234–244. doi:10.1038/ng.2897
11. Freedman BI, Yu H, Anderson PJ et al (2000) Genetic analysis of nitric oxide and endothelin in end-stage renal disease. Nephrol Dial Transplant 15:1794–1800
12. Haiman CA, Fesinmeyer MD, Spencer KL et al (2012) Consistent directions of effect for established type 2 diabetes risk variants across populations: the population architecture using Genomics and Epidemiology (PAGE) Consortium. Diabetes 61:1642–1647. doi:10.2337/db11-1296
13. Harris MI, Flegal KM, Cowie CC et al (1998) Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in US adults. The Third National Health and Nutrition Examination Survey, 1988–1994. Diabetes Care 21:518–524
14. Hivert M-F, Jablonski KA, Perreault L et al (2011) Updated genetic score based on 34 confirmed type 2 diabetes loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program. Diabetes 60:1340–1348. doi:10.2337/db10-1119
15. Huang J, Ellinghaus D, Franke A et al (2012) 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data. Eur J Hum Genet 20:801–805. doi:10.1038/ejhg.2012.3
16. Imamura M, Maeda S, Yamauchi T et al (2012) A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Hum Mol Genet 21:3042–3049. doi:10.1093/hmg/dds113
17. Johnson AD, Handsaker RE, Pulit SL et al (2008) SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics 24:2938–2939. doi:10.1093/bioinformatics/btn564
18. Kooner JS, Saleheen D, Sim X et al (2011) Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet 43:984–989. doi:10.1038/ng.921
19. Lewis JP, Palmer ND, Hicks PJ et al (2008) Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes 57:2220–2225. doi:10.2337/db07-1319
20. Lyssenko V, Jonsson A, Almgren P et al (2008) Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 359:2220–2232. doi:10.1056/NEJMoa0801869
21. Maskarinec G, Grandinetti A, Matsuura G et al (2009) Diabetes prevalence and body mass index differ by ethnicity: the multiethnic cohort. Ethn Dis 19:49–55
22. McDonough CW, Palmer ND, Hicks PJ et al (2011) A genome wide association study for diabetic nephropathy genes in African Americans. Kidney Int 79:563–572. doi:10.1038/ki.2010.467
23. Meigs JB, Shrader P, Sullivan LM et al (2008) Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med 359:2208–2219. doi:10.1056/NEJMoa0804742
24. Morris AP, Voight BF, Teslovich TM et al (2012) Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 44:981–990. doi:10.1038/ng.2383
25. Ng MCY, Shriner D, Chen BH et al (2014) Meta-analysis of genome-wide association studies in african americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet 10:e1004517. doi:10.1371/journal.pgen.1004517
26. Ng MCY, Saxena R, Li J et al (2013) Transferability and fine mapping of type 2 diabetes loci in African Americans: the candidate gene association resource plus study. Diabetes 62:965–976. doi:10.2337/db12-0266
27. Palmer ND, McDonough CW, Hicks PJ et al (2012) A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 7:e29202. doi:10.1371/journal.pone.0029202
28. Parra EJ, Below JE, Krithika S et al (2011) Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas. Diabetologia 54:2038–2046. doi:10.1007/s00125-011-2172-y
29. Perry JRB, Voight BF, Yengo L et al (2012) Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet 8:e1002741. doi:10.1371/journal.pgen.1002741
30. Qi L, Hu FB, Hu G (2008) Genes, environment, and interactions in prevention of type 2 diabetes: a focus on physical activity and lifestyle changes. Curr Mol Med 8:519–532
31. Qi L, Cornelis MC, Kraft P et al (2010) Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet 19:2706–2715. doi:10.1093/hmg/ddq156
32. Rung J, Cauchi S, Albrechtsen A et al (2009) Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet 41:1110–1115. doi:10.1038/ng.443
33. Sale MM, Freedman BI, Langefeld CD et al (2004) A genome-wide scan for type 2 diabetes in African-American families reveals evidence for a locus on chromosome 6q. Diabetes 53:830–837
34. Shu XO, Long J, Cai Q et al (2010) Identification of new genetic risk variants for type 2 diabetes. PLoS Genet 6:e1001127. doi:10.1371/journal.pgen.1001127
35. Sim X, Ong RT-H, Suo C et al (2011) Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. PLoS Genet 7:e1001363. doi:10.1371/journal.pgen.1001363
36. Steinthorsdottir V, Thorleifsson G, Reynisdottir I et al (2007) A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39:770–775. doi:10.1038/ng2043
37. Takeuchi F, Serizawa M, Yamamoto K et al (2009) Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 58:1690–1699. doi:10.2337/db08-1494
38. Tang H, Peng J, Wang P, Risch NJ (2005) Estimation of individual admixture: analytical and study design considerations. Genet Epidemiol 28:289–301. doi:10.1002/gepi.20064
39. Timpson NJ, Lindgren CM, Weedon MN et al (2009) Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes 58:505–510. doi:10.2337/db08-0906
40. Tsai F-J, Yang C-F, Chen C-C et al (2010) A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet 6:e1000847. doi:10.1371/journal.pgen.1000847
41. Unoki H, Takahashi A, Kawaguchi T et al (2008) SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 40:1098–1102. doi:10.1038/ng.208
42. Voight BF, Scott LJ, Steinthorsdottir V et al (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42:579–589. doi:10.1038/ng.609
43. Waters KM, Stram DO, Hassanein MT et al (2010) Consistent association of type 2 diabetes risk variants found in Europeans in diverse racial and ethnic groups. PLoS Genet. doi:10.1371/journal.pgen.1001078
44. Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661–678. doi:10.1038/nature05911
45. Yamauchi T, Hara K, Maeda S et al (2010) A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet 42:864–868. doi:10.1038/ng.660
46. Yu H, Bowden DW, Spray BJ et al (1998) Identification of human plasma kallikrein gene polymorphisms and evaluation of their role in end-stage renal disease. Hypertension 31:906–911
47. Zeggini E, Weedon MN, Lindgren CM et al (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336–1341. doi:10.1126/science.1142364
48. Zeggini E, Scott LJ, Saxena R et al (2008) Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638–645. doi:10.1038/ng.120