Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans

Diabetes Care

Volumn 35, Issue 2, 2012, Pages 287-292

  Cooke, Jessica N ^a   Hester, Jessica M ^a   Ng, Maggie C Y ^a   Freedman, Barry I ^a   Palmer, Nicholette D ^a   Langefeld, Carl D ^a   An, S Sandy ^a   Bowden, Donald W ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMTS9 GENE; ADULT; AFRICAN AMERICAN; AGED; ALLELE; ARTICLE; CDKAL1 GENE; CONTROLLED STUDY; EUROPEAN AMERICAN; FEMALE; GENE FREQUENCY; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; JAZF1 GENE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; SINGLE NUCLEOTIDE POLYMORPHISM; TCF7L2 GENE; WFS1 GENE;

ADAM PROTEINS; ADULT; AFRICAN AMERICANS; AGED; ALLELES; CYCLIN-DEPENDENT KINASE 5; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NEOPLASM PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN;

EID: 84859068424     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc11-0957     Document Type: Article

References (24)

1. Centers for Disease Control and Prevention. National Diabetes Fact Sheet: National Estimates and General Information on Diabetes and Prediabetes in the United States, 011. Atlanta, GA, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2011
2. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research; Saxena R, Voight BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007;316:1331-1336
3. Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007;316:1341-1345 (Pubitemid 46871655)
4. Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007;445:881-885
5. Zeggini E, Scott LJ, Saxena R, et al.; Wellcome Trust Case Control Consortium. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008;40: 638-645 (Pubitemid 351601209)
6. Zeggini E, Weedon MN, Lindgren CM, et al.; Wellcome Trust Case Control Consortium (WTCCC). Replication of genomewide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007;316:1336-1341 (Pubitemid 46871654)
7. Lewis JP, Palmer ND, Hicks PJ, et al. Association analysis inAfrican Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes 2008; 57:2220-2225
8. Palmer ND, Hester JM, An SS, et al. Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant. Diabetes 2011; 60:662-668
9. Sale MM, Smith SG, Mychaleckyj JC, et al. Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy. Diabetes 2007; 56:2638-2642 (Pubitemid 47523273)
10. Cornelis MC, Qi L, Zhang C, et al. Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. Ann Intern Med 2009;150:541-550
11. Hivert MF, Jablonski KA, Perreault L, et al. An updated genetic score based on 34 confirmed type 2 diabetes loci is associated with diabetes incidence and regression to normoglycemia in the Diabetes Prevention Program. Diabetes 2011;60:1340-1348
12. Lango H, Palmer CN, Morris AD, et al.; UK Type 2Diabetes Genetics Consortium. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 2008;57:3129-3135
13. Meigs JB, Shrader P, Sullivan LM, et al. Genotype score inaddition to common risk factors for prediction of type 2 diabetes. N Engl J Med 2008;359:2208-2219
14. Rong R, Hanson RL, Ortiz D, et al. Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes 2009;58: 478-488
15. van Hoek M, Dehghan A, Witteman JC, et al. Predicting type 2diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes 2008;57:3122-3128
16. Waters KM, Stram DO, Hassanein MT, et al. Consistent association of type 2 diabetes risk variants found in Europeans in diverse racial and ethnic groups. PLoS Genet 2010;6:e1001078
17. Weedon MN, McCarthy MI, Hitman G, et al. Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med 2006;3:e374
18. McDonough CW, Palmer ND, Hicks PJ, et al. A genome-wide association study for diabetic nephropathy genes in African Americans. Kidney Int 2011;79:563-572
19. Keene KL, Mychaleckyj JC, Leak TS, et al. Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease. Hum Genet 2008;124:147-154
20. Tang H, Peng J, Wang P, Risch NJ. Estimation ofindividual admixture: analytical and study design considerations. Genet Epidemiol 2005;28:289-301 (Pubitemid 40559542)
21. Moore AF, Jablonski KA, McAteer JB, et al.; Diabetes Prevention Program Research Group. Extension of type 2diabetes genome-wide association scan results in the diabetes prevention program. Diabetes 2008;57:2503-2510
22. Helgason A, Pálsson S, Thorleifsson G, et al. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 2007;39:218-225 (Pubitemid 46184353)
23. Lyssenko V, Jonsson A, Almgren P, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 2008;359:2220-2232
24. Genovese G, Friedman DJ, Ross MD, et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 2010;329:841-845