Consistent directions of effect for established type 2 diabetes risk variants across populations: The Population Architecture using Genomics and Epidemiology (PAGE) Consortium

Diabetes

Volumn 61, Issue 6, 2012, Pages 1642-1647

  Haiman, Christopher A ^a   Fesinmeyer, Megan D ^b   Spencer, Kylee L ^c   Bůžková, Petra ^d   Voruganti, V Saroja ^e   Wan, Peggy ^a   Haessler, Jeff ^b   Franceschini, Nora ^f   Monroe, Kristine R ^a   Howard, Barbara V ^g   Jackson, Rebecca D ^h   Florez, Jose C ^i,j,k   Kolonel, Laurence N ^l   Buyske, Steven ^m   Goodloe, Robert J ^c   Liu, Simin ⁿ   Manson, JoAnn E ^i,o   Meigs, James B ^i,j   Waters, Kevin ^a   Mukamal, Kenneth J ^p   Pendergrass, Sarah A ^c   Shrader, Peter ^j   Wilkens, Lynne R ^l   Hindorff, Lucia A ^q   Ambite, Jose Luis ^r   North, Kari E ^f   Peters, Ulrike ^b   Crawford, Dana C ^c   Le Marchand, Loic ^l   Pankow, James S ^s   more..

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^f The University of North Carolina at Chapel Hill   (United States)

^g GEORGETOWN UNIVERSITY   (United States)

^h OHIO STATE UNIVERSITY   (United States)

ⁱ HARVARD MEDICAL SCHOOL   (United States)

^j MASSACHUSETTS GENERAL HOSPITAL   (United States)

^k BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^l UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^m RUTGERS UNIVERSITY   (United States)

ⁿ UNIVERSITY OF CALIFORNIA   (United States)

^o BRIGHAM AND WOMEN S HOSPITAL   (United States)

^p BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^q NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^r UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^s UNIVERSITY OF MINNESOTA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AFRICAN AMERICAN; ALLELE; AMERICAN INDIAN; ARTICLE; ASIAN; CONTROLLED STUDY; ETHNIC GROUP; EUROPEAN AMERICAN; FEMALE; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC EPIDEMIOLOGY; GENETIC HETEROGENEITY; GENETIC RISK; GENETIC VARIABILITY; GENOME ANALYSIS; HUMAN; INDIGENOUS PEOPLE; MAJOR CLINICAL STUDY; MALE; NATIVE HAWAIIAN; NON INSULIN DEPENDENT DIABETES MELLITUS; POPULATION RESEARCH; PRIORITY JOURNAL; RACE; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; METAGENOMICS; MIDDLE AGED; POPULATION GROUPS; RISK; RISK FACTORS;

EID: 84861839407     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1296     Document Type: Article

References (44)

1. Altshuler D, Hirschhorn JN, Klannemark M, et al. The common PPAR-gamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000;26:76-80
2. Gloyn AL, Weedon MN, Owen KR, et al. Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 2003;52:568-572 (Pubitemid 36173218)
3. Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006;38:320-323
4. Gudmundsson J, Sulem P, Steinthorsdottir V, et al. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet 2007;39:977-983 (Pubitemid 47185170)
5. Rung J, Cauchi S, Albrechtsen A, et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet 2009;41:1110-1115
6. Saxena R, Voight BF, Lyssenko V, et al.; Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007;316:1331-1336
7. Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007;316:1341-1345 (Pubitemid 46871655)
8. Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007;445:881-885
9. Steinthorsdottir V, Thorleifsson G, Reynisdottir I, et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 2007;39:770-775 (Pubitemid 46848592)
10. Tsai FJ, Yang CF, Chen CC, et al. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet 2010;6:e1000847
11. Unoki H, Takahashi A, Kawaguchi T, et al. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 2008;40:1098-1102
12. Voight BF, Scott LJ, Steinthorsdottir V, et al.; MAGIC investigators; GIANT Consortium. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010;42:579-589
13. Yasuda K, Miyake K, Horikawa Y, et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 2008;40:1092-1097
14. Zeggini E, Scott LJ, Saxena R, et al.; Wellcome Trust Case Control Consortium. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008;40:638-645 (Pubitemid 351601209)
15. Zeggini E, Weedon MN, Lindgren CM, et al.; Wellcome Trust Case Control Consortium (WTCCC). Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007;316:1336-1341 (Pubitemid 46871654)
16. Chauhan G, Spurgeon CJ, Tabassum R, et al. Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. Diabetes 2010;59: 2068-2074
17. Han X, Luo Y, Ren Q, et al. Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. BMC Med Genet 2010;11:81
18. Lehman DM, Hunt KJ, Leach RJ, et al. Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans. Diabetes 2007;56:389-393
19. Lewis JP, Palmer ND, Hicks PJ, et al. Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes 2008;57: 2220-2225
20. Rong R, Hanson RL, Ortiz D, et al. Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes 2009;58:478-488
21. Tabara Y, Osawa H, Kawamoto R, et al. Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening. Diabetes 2009;58:493-498
22. Takeuchi F, Serizawa M, Yamamoto K, et al. Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 2009;58:1690-1699
23. Tan JT, Ng DP, Nurbaya S, et al. Polymorphisms identified through genome- wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore. J Clin Endocrinol Metab 2010;95:390-397
24. Yan Y, North KE, Ballantyne CM, et al. Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study. Diabetes 2009;58:285-289
25. Matise TC, Ambite JL, Buyske S, et al.; PAGE Study. The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. Am J Epidemiol 2011;174:849-859
26. The ARIC investigators. The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. Am J Epidemiol 1989;129:687-702
27. Fried LP, Borhani NO, Enright P, et al. The Cardiovascular Health Study: design and rationale. Ann Epidemiol 1991;1:263-276
28. Lee ET, Welty TK, Fabsitz R, et al. The Strong Heart Study. A study of cardiovascular disease in American Indians: design and methods. Am J Epidemiol 1990;132:1141-1155
29. North KE, Howard BV, Welty TK, et al. Genetic and environmental contributions to cardiovascular disease risk in American Indians: the strong heart family study. Am J Epidemiol 2003;157:303-314 (Pubitemid 36193933)
30. Chang MH, Lindegren ML, Butler MA, et al.; CDC/NCI NHANES III Genomics Working Group. Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. Am J Epidemiol 2009;169:54-66
31. Centers for Disease Control and Prevention. Plan and Operation of the Third National Health and Nutrition Examination Survey, 1988-94. Bethesda, MD, 2004
32. Centers for Disease Control and Prevention (CDC) NCfHSN. U.S. Department of Health and Human Services, Hyattsville, MD, 2002
33. Steinberg KK, Sanderlin KC, Ou CY, Hannon WH, McQuillan GM, Sampson EJ. DNA banking in epidemiologic studies. Epidemiol Rev 1997;19:156-162 (Pubitemid 27485608)
34. Kolonel LN, Henderson BE, Hankin JH, et al. A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics. Am J Epidemiol 2000; 151:346-357 (Pubitemid 30463612)
35. The Women's Health Initiative Study Group. Design of the Women's Health Initiative clinical trial and observational study. Control Clin Trials 1998;19: 61-109
36. Anderson GL, Manson J, Wallace R, et al. Implementation of the Women's Health Initiative study design. Ann Epidemiol 2003;13(Suppl): S5-S17 (Pubitemid 37324175)
37. Waters KM, Stram DO, Hassanein MT, et al. Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups. PLoS Genet 2010;6:6
38. Kosoy R, Nassir R, Tian C, et al. Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America. Hum Mutat 2009;30:69-78
39. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006;38:904-909 (Pubitemid 44141658)
40. Gauderman WJ. Sample size requirements for association studies of gene-gene interaction. Am J Epidemiol 2002;155:478-484 (Pubitemid 34174160)
41. Wang H, Haiman CA, Kolonel LN, et al. Self-reported ethnicity, genetic structure and the impact of population stratification in a multiethnic study. Hum Genet 2010;128:165-177
42. Dickson SP, Wang K, Krantz I, Hakonarson H, Goldstein DB. Rare variants create synthetic genome-wide associations. PLoS Biol 2010;8:e1000294
43. Palmer ND, Hester JM, An SS, et al. Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant. Diabetes 2011;60:662-668
44. Gaulton KJ, Nammo T, Pasquali L, et al. A map of open chromatin in human pancreatic islets. Nat Genet 2010;42:255-259