Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways

International Journal of Oncology

Volumn 46, Issue 3, 2015, Pages 1007-1017

  Meng, Guanmin ^a   Wang, Wei ^a   Chai, Kequn ^a   Yang, Suwen ^b   Li, Fangqiong ^a   Jiang, Kai ^a  

^a Tongde Hospital of Zhejiang Province   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Akt; Apoptosis; Hydroxycamptothecin; Mitogen activated protein kinases; Protein phosphatase 2A; Triptolide

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 9; CYTOCHROME C; FIRTECAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 14; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; TRIPTOLIDE; ANTINEOPLASTIC AGENT; CALCINEURIN; CAMPTOTHECIN; DITERPENE; EPOXIDE; IRINOTECAN; MITOGEN ACTIVATED PROTEIN KINASE P38; PHENANTHRENE DERIVATIVE;

A549 CELL LINE; ADENOCARCINOMA CELL LINE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; MITOCHONDRION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ADENOCARCINOMA; ANALOGS AND DERIVATIVES; DRUG EFFECTS; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ADENOCARCINOMA; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CALCINEURIN; CAMPTOTHECIN; CELL LINE, TUMOR; DITERPENES; DRUG SYNERGISM; EPOXY COMPOUNDS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LUNG NEOPLASMS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENANTHRENES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84921900610     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2015.2814     Document Type: Article

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