Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 306, Issue 11, 2014, Pages

  Mujumdar, Nameeta ^a   Banerjee, Sulagna ^a   Chen, Zhiyu ^a   Sangwan, Veena ^a   Chugh, Rohit ^a   Dudeja, Vikas ^a   Yamamoto, Masato ^a,b   Vickers, Selwyn M ^a,b   Saluja, Ashok K ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Apoptosis; Autophagy; Endoplasmic reticulum stress; Glucose regulated protein 78; Pancreatic cancer; Triptolide

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; INOSITOL; PHOSPHOTRANSFERASE; TRIPTOLIDE; X BOX BINDING PROTEIN 1;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL VIABILITY ASSAY; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; PANCREAS CANCER; PANCREATIC CANCER CELL LINE; PRIORITY JOURNAL; UNFOLDED PROTEIN RESPONSE;

APOPTOSIS; AUTOPHAGY; ENDOPLASMIC RETICULUM STRESS; GLUCOSE-REGULATED PROTEIN 78; PANCREATIC CANCER; TRIPTOLIDE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CHRONIC DISEASE; DITERPENES; DNA-BINDING PROTEINS; DOWN-REGULATION; ENDOPLASMIC RETICULUM; EPOXY COMPOUNDS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HEAT-SHOCK PROTEINS; MEMBRANE PROTEINS; PANCREATIC NEOPLASMS; PHENANTHRENES; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 84901703822     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00466.2013     Document Type: Article

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