Microcystin-LR induces cytoskeleton system reorganization through hyperphosphorylation of tau and HSP27 via PP2A inhibition and subsequent activation of the p38 MAPK signaling pathway in neuroendocrine (PC12) cells

Toxicology

Volumn 290, Issue 2-3, 2011, Pages 218-229

  Meng, Guanmin ^a   Sun, Yu ^a   Fu, Wenyu ^a   Guo, Zonglou ^b   Xu, Lihong ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Cytoskeletal rearrangement; HSP27; Microcystin LR; P38 mitogen activated protein kinase; PP2A; Tau

Indexed keywords

ACTIN; HEAT SHOCK PROTEIN 27; MICROCYSTIN LR; MITOGEN ACTIVATED PROTEIN KINASE 14; PHOSPHOPROTEIN PHOSPHATASE 2A; TAU PROTEIN;

ACETYLATION; ACTIN FILAMENT; ARTICLE; BIOTRANSFORMATION; CELLULAR PARAMETERS; CONTROLLED STUDY; CYTOSKELETON; CYTOSKELETON SYSTEM REORGANIZATION; CYTOSOL; GENE REARRANGEMENT; HYPERPHOSPHORYLATION; INHIBITION KINETICS; MICROTUBULE; MORPHOLOGY; NERVE CELL; NEUROSECRETORY CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TYROSINATION;

CYANOBACTERIA;

EID: 84858616802     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2011.09.085     Document Type: Article

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