-
1
-
-
0035990608
-
Cellular pharmacology studies of shikonin derivatives
-
DOI 10.1002/ptr.1100
-
X. Chen, L. Yang, J.J. Oppenheim, and M.Z. Howard Cellular pharmacology studies of shikonin derivatives Phytother. Res. 16 2002 199 209 (Pubitemid 34534943)
-
(2002)
Phytotherapy Research
, vol.16
, Issue.3
, pp. 199-209
-
-
Chen, X.1
Yang, L.2
Oppenheim, J.J.3
Zack Howard, O.M.4
-
2
-
-
0035032366
-
Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription
-
DOI 10.1089/108705701750160282
-
K. Subbaramaiah, P. Bulic, Y. Lin, A.J. Dannenberg, and D.S. Pasco Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription J. Biomol. Screening 6 2001 101 110 (Pubitemid 32373801)
-
(2001)
Journal of Biomolecular Screening
, vol.6
, Issue.2
, pp. 101-110
-
-
Subbaramaiah, K.1
Bulic, P.2
Lin, Y.3
Dannenberg, A.J.4
Pasco, D.S.5
-
3
-
-
79960800563
-
Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic Goto-Kakizaki rats
-
A.I. Oberg, K. Yassin, R.I. Csikasz, N. Dehvari, I.G. Shabalina, D.S. Hutchinson, M. Wilcke, C.G. Ostenson, and T. Bengtsson Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic Goto-Kakizaki rats PLoS One 6 2011 e22510
-
(2011)
PLoS One
, vol.6
, pp. 22510
-
-
Oberg, A.I.1
Yassin, K.2
Csikasz, R.I.3
Dehvari, N.4
Shabalina, I.G.5
Hutchinson, D.S.6
Wilcke, M.7
Ostenson, C.G.8
Bengtsson, T.9
-
4
-
-
79953795868
-
Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition
-
L. Lu, A. Qin, H. Huang, P. Zhou, C. Zhang, N. Liu, S. Li, G. Wen, W. Dong, X. Wang, Q.P. Dou, and J. Liu Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition Eur. J. Pharmacol. 658 2011 242 247
-
(2011)
Eur. J. Pharmacol.
, vol.658
, pp. 242-247
-
-
Lu, L.1
Qin, A.2
Huang, H.3
Zhou, P.4
Zhang, C.5
Liu, N.6
Li, S.7
Wen, G.8
Dong, W.9
Wang, X.10
Dou, Q.P.11
Liu, J.12
-
5
-
-
0019429897
-
Antitumor activity of shikonin, alkannin and their derivatives. II. X-ray analysis of cyclo-alkannin leucoacetate, tautomerism of alkannin and cyclo-alkannin and antitumor activity of alkannin deriviatives
-
U. Sankawa, H. Otsuka, Y. Kataoka, Y. Iitaka, A. Hoshi, and K. Kuretani Antitumor activity of shikonin, alkannin and their derivatives. II. X-ray analysis of cyclo-alkannin leucoacetate, tautomerism of alkannin and cyclo-alkannin and antitumor activity of alkannin derivatives Chem. Pharm. Bull. (Tokyo) 29 1981 116 122 (Pubitemid 11131684)
-
(1981)
Chemical and Pharmaceutical Bulletin
, vol.29
, Issue.1
, pp. 116-122
-
-
Sankawa, U.1
Otsuka, H.2
Kataoka, Y.3
-
6
-
-
0032796797
-
Shikonin, an ingredient of Lithospermum erythrorhizon induced apoptosis in HL60 human premyelocytic leukemia cell line
-
DOI 10.1055/s-1999-14010
-
Y. Yoon, Y.O. Kim, N.Y. Lim, W.K. Jeon, and H.J. Sung Shikonin, an ingredient of Lithospermum erythrorhizon induced apoptosis in HL60 human premyelocytic leukemia cell line Planta Med. 65 1999 532 535 (Pubitemid 29399955)
-
(1999)
Planta Medica
, vol.65
, Issue.6
, pp. 532-535
-
-
Yoon, Y.1
Kim, Y.-O.2
Lim, N.-Y.3
Jeon, W.-K.4
Sung, H.J.5
-
7
-
-
4744374011
-
Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells
-
P.C. Hsu, Y.T. Huang, M.L. Tsai, Y.J. Wang, J.K. Lin, and M.H. Pan Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells J. Agric. Food Chem. 52 2004 6330 6337
-
(2004)
J. Agric. Food Chem.
, vol.52
, pp. 6330-6337
-
-
Hsu, P.C.1
Huang, Y.T.2
Tsai, M.L.3
Wang, Y.J.4
Lin, J.K.5
Pan, M.H.6
-
8
-
-
77952397814
-
Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells
-
I.C. Chang, Y.J. Huang, T.I. Chiang, C.W. Yeh, and L.S. Hsu Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells Biol. Pharm. Bull. 33 2010 816 824
-
(2010)
Biol. Pharm. Bull.
, vol.33
, pp. 816-824
-
-
Chang, I.C.1
Huang, Y.J.2
Chiang, T.I.3
Yeh, C.W.4
Hsu, L.S.5
-
9
-
-
0642335056
-
Shikonin modulates cell proliferation by inhibiting epidermal growth factor receptor signaling in human epidermoid carcinoma cells
-
DOI 10.1016/S0304-3835(03)00239-8, PII S0304383503002398
-
F. Singh, D. Gao, M.G. Lebwohl, and H. Wei Shikonin modulates cell proliferation by inhibiting epidermal growth factor receptor signaling in human epidermoid carcinoma cells Cancer Lett. 200 2003 115 121 (Pubitemid 38366091)
-
(2003)
Cancer Letters
, vol.200
, Issue.2
, pp. 115-121
-
-
Singh, F.1
Gao, D.2
Lebwohl, M.G.3
Wei, H.4
-
10
-
-
81855218666
-
Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma
-
K. Gong, and W. Li Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: a potential new treatment for hepatocellular carcinoma Free Radical Biol. Med. 51 2011 2259 2271
-
(2011)
Free Radical Biol. Med.
, vol.51
, pp. 2259-2271
-
-
Gong, K.1
Li, W.2
-
11
-
-
84867400770
-
Novel multiple apoptotic mechanism of shikonin in human glioma cells
-
C.H. Chen, M.L. Lin, P.L. Ong, and J.T. Yang Novel multiple apoptotic mechanism of shikonin in human glioma cells Ann. Surg. Oncol. 19 2012 3097 3106
-
(2012)
Ann. Surg. Oncol.
, vol.19
, pp. 3097-3106
-
-
Chen, C.H.1
Lin, M.L.2
Ong, P.L.3
Yang, J.T.4
-
12
-
-
34250748014
-
Shikonin circumvents cancer drug resistance by induction of a necroptotic death
-
DOI 10.1158/1535-7163.MCT-06-0511
-
W. Han, L. Li, S. Qiu, Q. Lu, Q. Pan, Y. Gu, J. Luo, and X. Hu Shikonin circumvents cancer drug resistance by induction of a necroptotic death Mol. Cancer Ther. 6 2007 1641 1649 (Pubitemid 46954031)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.5
, pp. 1641-1649
-
-
Han, W.1
Li, L.2
Qiu, S.3
Lu, Q.4
Pan, Q.5
Gu, Y.6
Luo, J.7
Hu, X.8
-
13
-
-
84859647259
-
Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES
-
H.M. Chen, P.H. Wang, K. Aravindaram, Y.H. Chen, H.H. Yu, W.C. Yang, and N.S. Yang Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES J. Biomed. Sci. 19 2012 42
-
(2012)
J. Biomed. Sci.
, vol.19
, pp. 42
-
-
Chen, H.M.1
Wang, P.H.2
Aravindaram, K.3
Chen, Y.H.4
Yu, H.H.5
Yang, W.C.6
Yang, N.S.7
-
14
-
-
79953756477
-
Shikonin inhibits tumor invasion via down-regulation of NF-kappaB-mediated MMP-9 expression in human ACC-M cells
-
R. Min, Z. Zun, Y. Min, D. Wenhu, Y. Wenjun, and Z. Chenping Shikonin inhibits tumor invasion via down-regulation of NF-kappaB-mediated MMP-9 expression in human ACC-M cells Oral Dis. 17 2011 362 369
-
(2011)
Oral Dis.
, vol.17
, pp. 362-369
-
-
Min, R.1
Zun, Z.2
Min, Y.3
Wenhu, D.4
Wenjun, Y.5
Chenping, Z.6
-
15
-
-
79955045995
-
(-)-Epigallocatechin-3-gallate induces apoptosis in gastric cancer cell lines by down-regulating survivin expression
-
C. Onoda, K. Kuribayashi, S. Nirasawa, N. Tsuji, M. Tanaka, D. Kobayashi, and N. Watanabe (-)-Epigallocatechin-3-gallate induces apoptosis in gastric cancer cell lines by down-regulating survivin expression Int. J. Oncol. 38 2011 1403 1408
-
(2011)
Int. J. Oncol.
, vol.38
, pp. 1403-1408
-
-
Onoda, C.1
Kuribayashi, K.2
Nirasawa, S.3
Tsuji, N.4
Tanaka, M.5
Kobayashi, D.6
Watanabe, N.7
-
16
-
-
84862830137
-
Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo
-
C.J. Li, C.Y. Chu, L.H. Huang, M.H. Wang, L.F. Sheu, J.I. Yeh, and H.Y. Hsu Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo Cancer Lett. 319 2012 203 213
-
(2012)
Cancer Lett.
, vol.319
, pp. 203-213
-
-
Li, C.J.1
Chu, C.Y.2
Huang, L.H.3
Wang, M.H.4
Sheu, L.F.5
Yeh, J.I.6
Hsu, H.Y.7
-
17
-
-
0032610936
-
Apoptosis. Molecules and mechanisms
-
M. Konopleva, S. Zhao, Z. Xie, H. Segall, A. Younes, D.F. Claxton, Z. Estrov, S.M. Kornblau, and M. Andreeff Apoptosis. Molecules and mechanisms Adv. Exp. Med. Biol. 457 1999 217 236
-
(1999)
Adv. Exp. Med. Biol.
, vol.457
, pp. 217-236
-
-
Konopleva, M.1
Zhao, S.2
Xie, Z.3
Segall, H.4
Younes, A.5
Claxton, D.F.6
Estrov, Z.7
Kornblau, S.M.8
Andreeff, M.9
-
18
-
-
67349269527
-
Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis
-
W. Han, J. Xie, L. Li, Z. Liu, and X. Hu Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis Apoptosis 14 2009 674 686
-
(2009)
Apoptosis
, vol.14
, pp. 674-686
-
-
Han, W.1
Xie, J.2
Li, L.3
Liu, Z.4
Hu, X.5
-
19
-
-
1642545128
-
P53-Mediated Cell Cycle Arrest and Apoptosis Induced by Shikonin via a Caspase-9-Dependent Mechanism in Human Malignant Melanoma A375-S2 Cells
-
DOI 10.1254/jphs.94.166
-
Z. Wu, L. Wu, L. Li, S. Tashiro, S. Onodera, and T. Ikejima P53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells J. Pharmacol. Sci. 94 2004 166 176 (Pubitemid 38405131)
-
(2004)
Journal of Pharmacological Sciences
, vol.94
, Issue.2
, pp. 166-176
-
-
Wu, Z.1
Wu, L.2
Li, L.3
Tashiro, S.-I.4
Onodera, S.5
Ikejima, T.6
-
20
-
-
3042636192
-
Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis
-
DOI 10.1080/1028602032000169622
-
Z. Wu, L.J. Wu, L.H. Li, S. Tashiro, S. Onodera, and T. Ikejima Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis J. Asian Nat. Prod. Res. 6 2004 155 166 (Pubitemid 38833171)
-
(2004)
Journal of Asian Natural Products Research
, vol.6
, Issue.3
, pp. 155-166
-
-
Wu, Z.1
Wu, L.-J.2
Li, L.-H.3
Tashiro, S.-I.4
Onodera, S.5
Ikejima, T.6
-
21
-
-
43749092334
-
Intracellular redox status and oxidative stress: Implications for cell proliferation, apoptosis, and carcinogenesis
-
J.M. Mates, J.A. Segura, F.J. Alonso, and J. Marquez Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis Arch. Toxicol. 82 2008 273 299
-
(2008)
Arch. Toxicol.
, vol.82
, pp. 273-299
-
-
Mates, J.M.1
Segura, J.A.2
Alonso, F.J.3
Marquez, J.4
-
22
-
-
1242306739
-
Involvement of reactive oxygen species, but not mitochondrial permeability transition in the apoptotic induction of human SK-Hep-1 hepatoma cells by shikonin
-
C.H. Chen, C.L. Chern, C.C. Lin, F.J. Lu, M.K. Shih, P.Y. Hsieh, and T.Z. Liu Involvement of reactive oxygen species, but not mitochondrial permeability transition in the apoptotic induction of human SK-Hep-1 hepatoma cells by shikonin Planta Med. 69 2003 1119 1124
-
(2003)
Planta Med.
, vol.69
, pp. 1119-1124
-
-
Chen, C.H.1
Chern, C.L.2
Lin, C.C.3
Lu, F.J.4
Shih, M.K.5
Hsieh, P.Y.6
Liu, T.Z.7
-
23
-
-
49149088537
-
Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells
-
X. Mao, C.R. Yu, W.H. Li, and W.X. Li Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells Cell Res. 18 2008 879 888
-
(2008)
Cell Res.
, vol.18
, pp. 879-888
-
-
Mao, X.1
Yu, C.R.2
Li, W.H.3
Li, W.X.4
-
24
-
-
25444480003
-
Programmed cell death via mitochondria: Different modes of dying
-
DOI 10.1007/s10541-005-0105-4
-
M. Bras, B. Queenan, and S.A. Susin Programmed cell death via mitochondria: different modes of dying Biochemistry (Mosc) 70 2005 231 239 (Pubitemid 40512332)
-
(2005)
Biochemistry (Moscow)
, vol.70
, Issue.2
, pp. 231-239
-
-
Bras, M.1
Queenan, B.2
Susin, S.A.3
-
25
-
-
78650243853
-
Shikonin inhibits the proliferation and induces the apoptosis of human HepG2 cells
-
N. Yingkun, Z. Lvsong, and Y. Huimin Shikonin inhibits the proliferation and induces the apoptosis of human HepG2 cells Can. J. Physiol. Pharmacol. 88 2010 1138 1146
-
(2010)
Can. J. Physiol. Pharmacol.
, vol.88
, pp. 1138-1146
-
-
Yingkun, N.1
Lvsong, Z.2
Huimin, Y.3
-
26
-
-
34248597065
-
Differential regulation and properties of MAPKs
-
DOI 10.1038/sj.onc.1210392, PII 1210392
-
M. Raman, W. Chen, and M.H. Cobb Differential regulation and properties of MAPKs Oncogene 26 2007 3100 3112 (Pubitemid 46763006)
-
(2007)
Oncogene
, vol.26
, Issue.22
, pp. 3100-3112
-
-
Raman, M.1
Chen, W.2
Cobb, M.H.3
-
27
-
-
17844402016
-
Phosphorylated extracellular signal-regulated kinase up-regulated p53 expression in shikonin-induced HeLa cell apoptosis
-
Z. Wu, L.J. Wu, S. Tashiro, S. Onodera, and T. Ikejima Phosphorylated extracellular signal-regulated kinase up-regulated p53 expression in shikonin-induced HeLa cell apoptosis Chin. Med. J. (Engl.) 118 2005 671 677 (Pubitemid 40585030)
-
(2005)
Chinese Medical Journal
, vol.118
, Issue.8
, pp. 671-677
-
-
Wu, Z.1
Wu, L.-J.2
Tashiro, S.3
Onodera, S.4
Ikejima, T.5
-
28
-
-
0036086005
-
Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathway
-
DOI 10.1006/bbrc.2002.6714
-
R. Kamei, Y. Kitagawa, M. Kadokura, F. Hattori, O. Hazeki, Y. Ebina, T. Nishihara, and S. Oikawa Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathway Biochem. Biophys. Res. Commun. 292 2002 642 651 (Pubitemid 34681108)
-
(2002)
Biochemical and Biophysical Research Communications
, vol.292
, Issue.3
, pp. 642-651
-
-
Kamei, R.1
Kitagawa, Y.2
Kadokura, M.3
Hattori, F.4
Hazeki, O.5
Ebina, Y.6
Nishihara, T.7
Oikawa, S.8
-
29
-
-
33747590757
-
A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases
-
DOI 10.1124/mol.106.025809
-
K. Nigorikawa, K. Yoshikawa, T. Sasaki, E. Iida, M. Tsukamoto, H. Murakami, T. Maehama, K. Hazeki, and O. Hazeki A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases Mol. Pharmacol. 70 3 2006 1143 1149 (Pubitemid 44268471)
-
(2006)
Molecular Pharmacology
, vol.70
, Issue.3
, pp. 1143-1149
-
-
Nigorikawa, K.1
Yoshikawa, K.2
Sasaki, T.3
Iida, E.4
Tsukamoto, M.5
Murakami, H.6
Maehama, T.7
Hazeki, K.8
Hazeki, O.9
-
30
-
-
42249102086
-
Identification of RIP1 kinase as a specific cellular target of necrostatins
-
DOI 10.1038/nchembio.83, PII NCHEMBIO83
-
A. Degterev, J. Hitomi, M. Germscheid, I.L. Ch'en, O. Korkina, X. Teng, D. Abbott, G.D. Cuny, C. Yuan, G. Wagner, S.M. Hedrick, S.A. Gerber, A. Lugovskoy, and J. Yuan Identification of RIP1 kinase as a specific cellular target of necrostatins Nat. Chem. Biol. 4 2008 313 321 (Pubitemid 351550892)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.5
, pp. 313-321
-
-
Degterev, A.1
Hitomi, J.2
Germscheid, M.3
Ch'en, I.L.4
Korkina, O.5
Teng, X.6
Abbott, D.7
Cuny, G.D.8
Yuan, C.9
Wagner, G.10
Hedrick, S.M.11
Gerber, S.A.12
Lugovskoy, A.13
Yuan, J.14
-
31
-
-
33644840693
-
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
-
A. Degterev, Z. Huang, M. Boyce, Y. Li, P. Jagtap, N. Mizushima, G.D. Cuny, T.J. Mitchison, M.A. Moskowitz, and J. Yuan Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury Nat. Chem. Biol. 1 2005 112 119
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 112-119
-
-
Degterev, A.1
Huang, Z.2
Boyce, M.3
Li, Y.4
Jagtap, P.5
Mizushima, N.6
Cuny, G.D.7
Mitchison, T.J.8
Moskowitz, M.A.9
Yuan, J.10
-
32
-
-
84862490700
-
Nec-1 enhances shikonin-induced apoptosis in leukemia cells by inhibition of RIP-1 and ERK1/2
-
W. Han, J. Xie, Y. Fang, Z. Wang, and H. Pan Nec-1 enhances shikonin-induced apoptosis in leukemia cells by inhibition of RIP-1 and ERK1/2 Int. J. Mol. Sci. 13 2012 7212 7225
-
(2012)
Int. J. Mol. Sci.
, vol.13
, pp. 7212-7225
-
-
Han, W.1
Xie, J.2
Fang, Y.3
Wang, Z.4
Pan, H.5
-
33
-
-
84873269420
-
Shikonin induces programmed necrosis-like cell death through the formation of receptor interacting protein 1 and 3 complex
-
S. Park, H. Shin, and Y. Cho Shikonin induces programmed necrosis-like cell death through the formation of receptor interacting protein 1 and 3 complex Food Chem. Toxicol. 55 2013 36 41
-
(2013)
Food Chem. Toxicol.
, vol.55
, pp. 36-41
-
-
Park, S.1
Shin, H.2
Cho, Y.3
-
34
-
-
60149110680
-
Attenuation of cadmium-induced necrotic cell death by necrostatin-1: Potential necrostatin-1 acting sites
-
T.S. Hsu, P.M. Yang, J.S. Tsai, and L.Y. Lin Attenuation of cadmium-induced necrotic cell death by necrostatin-1: potential necrostatin-1 acting sites Toxicol. Appl. Pharmacol. 235 2009 153 162
-
(2009)
Toxicol. Appl. Pharmacol.
, vol.235
, pp. 153-162
-
-
Hsu, T.S.1
Yang, P.M.2
Tsai, J.S.3
Lin, L.Y.4
|