Involvement of NADPH oxidase in oxidized LDL-induced upregulation of heat shock factor-1 and plasminogen activator inhibitor-1 in vascular endothelial cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 297, Issue 1, 2009, Pages

  Zhao, Ruozhi ^a   Ma, Xiuli ^a   Xie, Xueping ^a   Shen, Garry X ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Oxidized low density lipoprotein; Reduced nicotinamide adenine dinucleotide phosphatase

Indexed keywords

BUTYLCRESOL; COPPER; DRUG VEHICLE; HEAT SHOCK TRANSCRIPTION FACTOR 1; HYDROGEN PEROXIDE; IRON; LINSIDOMINE; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; ENDOTHELIUM CELL; ENZYME REGULATION; EXTRACELLULAR MATRIX; FIBRINOLYSIS; GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERCHOLESTEROLEMIA; INFLAMMATION; OXIDATIVE STRESS; PAI 1 GENE; PRIORITY JOURNAL; PROMOTER REGION; THROMBOGENESIS; TRANSCRIPTION REGULATION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANTIOXIDANTS; CELLS, CULTURED; DNA-BINDING PROTEINS; ENDOTHELIAL CELLS; ENZYME INHIBITORS; HUMANS; HYDROGEN PEROXIDE; LIPOPROTEINS, LDL; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 67650065293     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.91023.2008     Document Type: Article

References (37)

1. Brodsky SV, Malinowski K, Golightly M, Jesty J, Goligorsky MS. Plasminogen activator inhibitor-1 promotes formation of endothelial microparticles with procoagulant potential. Circulation 106: 2372-2378, 2002.
2. Christians ES, Zhou Q, Renard J, Benjamin IJ. Heat shock proteins in mammalian development. Semin Cell Dev Biol 14: 283-290, 2003.
3. Diamond MP, ELHammady E, Wang R, Kruger M, Saed G. Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroflasts from normal peritoneum and adhesions. Am J Obstet Gynecol 190: 926-934, 2004.
4. Guy RA, Maguire GF, Crandall I, Connelly PW, Kain KC. Characterization of peroxynitrite-oxidized low density lipoprotein binding to human CD36. Atherosclerosis 155: 1619-1628, 2001.
5. Hermans PW, Hazelzet JA. Plasminogen activator inhibitor type 1 gene polymorphism and sepsis. Clin Infect Dis 41, Suppl 7: S453-S458, 2005.
6. Honjo T, Otsui K, Shiraki R, Kawashima S, Sawamura T, Yokoyama M, Inoue N. Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells. Endothelium 15: 137-141, 2008.
7. Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation 111: 3481-3488, 2005.
8. Ludwig S, Dharmalingam S, Erickson-Nesmith S, Ren S, Zhu F, Ma GM, Zhao R, Fenton JW 2nd, Ofosu FA, Velthuis HT, van Mierlo G, Shen GX. Impact of simvastatin on hemostatic and fibrinolytic regulators in Type 2 diabetes mellitus. Diabetes Res Clin Pract 70: 110-118, 2005.
9. Ma GM, Halayko AJ, Stelmack GL, Zhu F, Zhao R, Hillier CT, Shen GX. Effects of oxidized and glycated low-density lipoproteins on transcription and secretion of plasminogen activator inhibitor-1 in vascular endothelial cells. Cardiovasc Pathol 15: 3-10, 2006.
10. Maggi E, Finardi G, Poli M, Bollati P, Filipponi M, Stefano PL, Paolini G, Grossi A, Clot P, Albano E. Specificity of autoantibodies against oxidized LDL as an additional marker for atherosclerotic risk. Coron Artery Dis 4: 1119-1122, 1993.
11. Meigs JB. Prevention of coronary heart disease in diabetes. Curr Treat Options Cardiovasc Med 7: 259-271, 2005.
12. Metzler B, Abia R, Ahmad M, Wernig F, Pachinger O, Hu Y, Xu Q. Activation of heat shock transcription factor 1 in atherosclerosis. Am J Pathol 162: 1669-1676, 2003.
13. Modlinger P, Chabrashvili T, Gill PS, Mendonca M, Harrison DG, Griendling KK, Li M, Raggio J, Wellstein A, Chen Y, Welch WJ, Wilcox CS. RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response. Hypertension 47: 238-244, 2006.
14. Morano KA, Thiele DJ. Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals. Gene Expr 7: 271-282, 1999.
15. O'Callaghan-Sunol C, Sherman MY. Heat shock transcription factor (HSF1) plays a critical role in cell migration via maintaining MAP kinase signaling. Cell Cycle 5: 1431-1437, 2006.
16. Oszajca K, Bieniasz M, Brown G, Swiatkowska M, Bartkowiak J, Szemraj J. Effect of oxidative stress on the expression of t-PA, u-PA, u-PAR, and PAI-1 in endothelial cells. Biochem Cell Biol 86: 477-486, 2008.
17. Pedruzzi E, Guichard C, Ollivier V, Driss F, Fay M, Prunet C, Marie JC, Pouzet C, Samadi M, Elbim C, O'dowd Y, Bens M, Vandewalle A, Gougerot-Pocidalo MA, Lizard G, Ogier-Denis E. NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells. Mol Cell Biol 24: 10703-10717, 2004.
18. Ren S, Lee H, Hu L, Lu L, Shen GX. Impact of diabetes-associated lipoproteins on generation of fibrinolytic regulators from vascular endothelial cells. J Clin Endocrinol Metab 87: 286-291, 2002.
19. Ren S, Man RY, Angel A, Shen GX. Oxidative modification enhances lipoprotein(a)-induced overproduction of plasminogen activator inhibitor-1 in cultured vascular endothelial cells. Atherosclerosis 128: 1-10, 1997.
20. Ren S, Shatadal S, Shen GX. Protein kinase C-β mediates lipoprotein-induced generation of PAI-1 from vascular endothelial cells. Am J Physiol Endocrinol Metab 278: E656-E662, 2000.
21. Ren S, Shen GX. Impact of antioxidants and HDL on glycated LDL-induced generation of fibrinolytic regulator in vascular endothelial cells. Arterioscler Thromb Vasc Biol 20: 1688-1693, 2000.
22. Rücker M, Schafer T, Scheuer C, Harder Y, Vollmar B, Menger MD. Local heat shock priming promotes recanalization of thromboembolized microvasculature by upregulation of plasminogen activators. Arterioscler Thromb Vasc Biol 26: 1632-1639, 2006.
23. Sangle G, Zhao R, Shen GX. Transmembrane signaling pathway mediates oxidized low-density lipoprotein-induced expression of expression of plasminogen activator inhibitor-1 in vascular endothelial cells. Am J Physiol Endocrinol Metab 295: E1243-E1254, 2008.
24. Shen GX. Vascular cell-derived fibrinolytic regulators and atherothrombotic vascular disorders. Int J Mol Med 1: 399-408, 1998.
25. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum Beyond cholesterol JL. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 320: 915-924, 1989.
26. Stielow C, Catar RA, Muller G, Wingler K, Scheurer P, Schmidt HH, Morawietz H. Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells. Biochem Biophys Res Commun 344: 200-205, 2006.
27. Sumimoto H. Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. FEBS J 275: 3249-3277, 2008.
28. Tremoli E, Camera M, Maderna P, Sironi L, Prati L, Colli S, Piovella F, Bernini F, Corsini A, Mussoni L. Increased synthesis of plasminogen activator inhibitor-1 by cultured human endothelial cells exposed to native and modified LDLs. An LDL receptor-independent phenomenon. Arterioscler Thromb 13: 338-346, 1993.
29. Tsimikas S, Bergmark C, Beyer RW, Patel R, Pattison J, Miller E, Juliano J, Witztum JL. Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes. J Am Coll Cardiol 41: 360-370, 2003.
30. Uchiyama T, Atsuta H, Utsugi T, Oguri M, Hasegawa A, Nakamura T, Nakai A, Nakata M, Maruyama I, Tomura H, Okajima F, Tomono S, Kawazu S, Nagai R, Kurabayashi M. HSF1 and constitutively active HSF1 improve vascular endothelial function (heat shock proteins improve vascular endothelial function). Atherosclerosis 190: 321-329, 2007.
31. Watson AD, Navab M, Hama SY, Sevanian A, Prescott SM, Stafforini DM, McIntyre TM, Du BN, Fogelman AM, Berliner JA. Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein. J Clin Invest 95: 774-782, 1995.
32. Wiman B, Andersson T, Hallqvist J, Reuterwall C, Ahlbom A, deFaire U. Plasma levels of tissue plasminogen activator/plasminogen activator inhibitor-1 complex and von Willebrand factor are significant risk markers for recurrent myocardial infarction in the Stockholm Heart Epidemiology Program (SHEEP) study. Arterioscler Thromb Vasc Biol 20: 2019-2023, 2000.
33. Zhao R, Ma X, Shen GX. Transcriptional regulation of plasminogen activator inhibitor-1 in vascular endothelial cells induced by oxidized very low density lipoproteins. Mol Cell Biochem 317: 197-204, 2008.
34. Zhao R, Shen GX. Functional modulation of antioxidant enzymes in vascular endothelial cells by glycated LDL. Atherosclerosis 179: 277-284, 2005.
35. Zhao R, Shen GX. Involvement of heat shock factor-1 in glycated low density lipoprotein-induced upregulation of plasminogen activator inhibitor-1 in vascular endothelial cells. Diabetes 56: 1436-1444, 2007.
36. Zhu W, Roma P, Pellegatta F, Catapano AL. Oxidized-LDL induces the expression of heat shock protein 70 in human endothelial cells. Biochem Biophys Res Commun 200: 389-394, 1994.
37. Zou J, Salminen WF, Roberts SM, Voellmy R. Correlation between glutathione oxidation and trimerization of heat shock factor 1, an early step in stress induction of the Hsp response. Cell Stress Chaperones 3: 130-141, 1998.