Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity

Biochemical and Biophysical Research Communications

Volumn 457, Issue 2, 2015, Pages 194-199

  Takasugi, Nobumasa ^a,b,c   Sasaki, Tomoki ^a   Shinohara, Mitsuru ^a   Iwatsubo, Takeshi ^a,b   Tomita, Taisuke ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Alzheimer disease; Amyloid; Ceramide; Secretase

Indexed keywords

(DEXTRO ERYTHRO 2 N MYRISTOYLAMINO) 1 PHENYL 1 PROPANOL; 2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL; AMYLOID BETA PROTEIN[1-42]; CERAMIDE DERIVATIVE; GAMMA SECRETASE; GLUCOSYLCERAMIDE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ALPHA-ETHYLBENZYL ALCOHOL; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); BENZYL ALCOHOL DERIVATIVE; CERAMIDE; MORPHOLINE DERIVATIVE; PEPTIDE FRAGMENT; SECRETASE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PRIORITY JOURNAL; PROTEIN SECRETION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; GENETICS; HAMSTER; METABOLISM; MOUSE; MUTATION;

AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOPTOSIS; BENZYL ALCOHOLS; CERAMIDES; CHO CELLS; CRICETINAE; CRICETULUS; HEK293 CELLS; HUMANS; MICE; MORPHOLINES; MUTATION; PEPTIDE FRAGMENTS; UP-REGULATION;

EID: 84921779973     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.12.087     Document Type: Article

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