Mechanistic studies of in vitro cytotoxicity of poly(amidoamine) dendrimers in mammalian cells

Toxicology and Applied Pharmacology

Volumn 248, Issue 3, 2010, Pages 259-268

  Mukherjee, Sourav Prasanna ^a   Lyng, Fiona M ^a   Garcia, Amaya ^a   Davoren, Maria ^a   Byrne, Hugh J ^a  

^a DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

Apoptosis; Cytotoxicity; DNA damage; EC50; Increased lysosomal activity; PAMAM dendrimers; Reactive oxygen species

Indexed keywords

DENDRIMER; NANOPARTICLE; POLYAMIDOAMINE; REACTIVE OXYGEN METABOLITE; BIOMATERIAL; CYTOTOXIN; PAMAM STARBURST;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA STRAND BREAKAGE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MAMMAL CELL; MITOCHONDRION; NICK END LABELING; OXIDATIVE STRESS; COMPARATIVE STUDY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; KERATINOCYTE; METABOLISM; PHYSIOLOGY; TOXICITY; TRANSFORMED CELL LINE; TUMOR CELL LINE;

APOPTOSIS; BIOCOMPATIBLE MATERIALS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CYTOTOXINS; DENDRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KERATINOCYTES; REACTIVE OXYGEN SPECIES;

MAMMALIA;

EID: 77955982005     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.08.016     Document Type: Article

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