Nα-tosyl-L-phenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed human B cell lines with transcriptional down-regulation of anti-apoptotic HS1-associated protein X-1

Journal of Biological Chemistry

Volumn 284, Issue 41, 2009, Pages 27827-27837

  Jitkaew, Siriporn ^a,b,c   Trebinska, Alicja ^d   Grzybowska, Ewa ^d   Carlsson, Göran ^a   Nordström, Anders ^a   Lehtiö, Janne ^a   Fröjmark, Anne Sophie ^e   Dahl, Niklas ^e   Fadeel, Bengt ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b MAHIDOL UNIVERSITY   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

^d INSTITUTE OF ONCOLOGY   (Poland)

^e UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-APOPTOTIC FACTOR; ANTI-APOPTOTIC PROTEIN; APOPTOSIS; APOPTOTIC; APOPTOTIC PROTEINS; B CELLS; CASPASES; CHLOROMETHYL; DONOR CELLS; DOWN-REGULATION; EPSTEIN-BARR VIRUS; INDUCED APOPTOSIS; L-PHENYLALANINE; MULTIPLE EFFECT; N-ACETYLCYSTEINE; PHARMACOLOGICAL INHIBITORS; QUANTITATIVE PCR; SIGNAL TRANSDUCTION PATHWAYS; SIGNALING EVENTS; TRANSCRIPTIONAL LEVELS;

AMINO ACIDS; CELL CULTURE; CELL MEMBRANES; KETONES; SIGNAL TRANSDUCTION; SULFUR COMPOUNDS; TRANSCRIPTION; TRANSCRIPTION FACTORS;

CELL DEATH;

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ACETYLCYSTEINE; CASPASE; CELLULAR INHIBITOR OF APOPTOSIS PROTEIN 1; CELLULAR INHIBITOR OF APOPTOSIS PROTEIN 2; HS1 ASSOCIATED PROTEIN X 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN BCL 2; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MEMBRANE DEPOLARIZATION; MITOCHONDRION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; TRANSCRIPTION REGULATION;

ACETYLCYSTEINE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIOXIDANTS; APOPTOSIS; B-LYMPHOCYTES; CASPASES; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; COUMARINS; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FLUORESCENT DYES; HERPESVIRUS 4, HUMAN; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; JURKAT CELLS; MITOCHONDRIA; NF-KAPPA B; OLIGOPEPTIDES; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN SYNTHESIS INHIBITORS; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TRANSCRIPTION, GENETIC; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

HUMAN HERPESVIRUS 4;

EID: 70350435090     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.027912     Document Type: Article

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