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Volumn 818, Issue , 2014, Pages 127-153

MDA-7/IL-24: Multifunctional cancer killing cytokine

Author keywords

Apoptosis; Autophagy; Bystander antitumor activity; Cancer; Cancer terminator virus; Cytokine; IL 24; MDA 7

Indexed keywords

ADENOVIRUS VECTOR; ARSENIC TRIOXIDE; BEVACIZUMAB; CISPLATIN; ERLOTINIB; GEFITINIB; INGN 241; INTERLEUKIN 24; ONCOLYTIC ADENOVIRUS; TEMOZOLOMIDE; UNCLASSIFIED DRUG; INTERLEUKIN DERIVATIVE; INTERLEUKIN-24; TUMOR SUPPRESSOR PROTEIN;

EID: 84921689308     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-1-4471-6458-6_6     Document Type: Article
Times cited : (113)

References (106)
  • 2
    • 84862908037 scopus 로고    scopus 로고
    • Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells
    • Azab B, Dash R, Das SK, Bhutia SK, Shen XN, Quinn BA, Sarkar S, Wang XY, Hedvat M, Dmitriev IP et al (2012) Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells. J Cell Physiol 227:2145-2153
    • (2012) J Cell Physiol , vol.227 , pp. 2145-2153
    • Azab, B.1    Dash, R.2    Das, S.K.3    Bhutia, S.K.4    Shen, X.N.5    Quinn, B.A.6    Sarkar, S.7    Wang, X.Y.8    Hedvat, M.9    Dmitriev, I.P.10
  • 5
    • 84884853347 scopus 로고    scopus 로고
    • Targeting breast cancer initiating/stem cells with melanoma differentiation associated gene- 7/interleukin-24 (mda-7/IL-24)
    • (in press)
    • Bhutia SK, Das SK, Azab B, Menezes ME, Dent P, Wang XY, Sarkar D, Fisher PB (2013) Targeting breast cancer initiating/stem cells with melanoma differentiation associated gene- 7/interleukin-24 (mda-7/IL-24). Int J Cancer (in press)
    • (2013) Int J Cancer
    • Bhutia, S.K.1    Das, S.K.2    Azab, B.3    Menezes, M.E.4    Dent, P.5    Wang, X.Y.6    Sarkar, D.7    Fisher, P.B.8
  • 6
    • 77951761420 scopus 로고    scopus 로고
    • Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24
    • Bhutia SK, Dash R, Das SK, Azab B, Su ZZ, Lee SG, Grant S, Yacoub A, Dent P, Curiel DT et al (2010) Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation- associated gene 7/interleukin-24. Cancer Res 70:3667-3676
    • (2010) Cancer Res , vol.70 , pp. 3667-3676
    • Bhutia, S.K.1    Dash, R.2    Das, S.K.3    Azab, B.4    Su, Z.Z.5    Lee, S.G.6    Grant, S.7    Yacoub, A.8    Dent, P.9    Curiel, D.T.10
  • 8
    • 0034948738 scopus 로고    scopus 로고
    • The autophagosomal-lysosomal compartment in programmed cell death
    • Bursch W (2001) The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ 8:569-581
    • (2001) Cell Death Differ , vol.8 , pp. 569-581
    • Bursch, W.1
  • 10
    • 33645851045 scopus 로고    scopus 로고
    • Mda-7 gene transfer sensitizes breast carcinoma cells to chemotherapy, biologic therapies and radiotherapy: Correlation with expression of bcl-2 family members
    • Chada S, Mhashilkar AM, Liu Y, Nishikawa T, Bocangel D, Zheng M, Vorburger SA, Pataer A, Swisher SG, Ramesh R et al (2006) mda-7 gene transfer sensitizes breast carcinoma cells to chemotherapy, biologic therapies and radiotherapy: correlation with expression of bcl-2 family members. Cancer Gene Ther 13:490-502
    • (2006) Cancer Gene Ther , vol.13 , pp. 490-502
    • Chada, S.1    Mhashilkar, A.M.2    Liu, Y.3    Nishikawa, T.4    Bocangel, D.5    Zheng, M.6    Vorburger, S.A.7    Pataer, A.8    Swisher, S.G.9    Ramesh, R.10
  • 11
    • 19944379432 scopus 로고    scopus 로고
    • Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: A phase i study
    • Cunningham CC, Chada S, Merritt JA, Tong A, Senzer N, Zhang Y, Mhashilkar A, Parker K, Vukelja S, Richards D et al (2005) Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study. Mol Ther 11:149-159
    • (2005) Mol Ther , vol.11 , pp. 149-159
    • Cunningham, C.C.1    Chada, S.2    Merritt, J.A.3    Tong, A.4    Senzer, N.5    Zhang, Y.6    Mhashilkar, A.7    Parker, K.8    Vukelja, S.9    Richards, D.10
  • 12
    • 84880623053 scopus 로고    scopus 로고
    • Applications of viruses for cancer therapy
    • Curiel DT, Fisher PB (eds) (2012) Applications of viruses for cancer therapy. Adv Cancer Res 115: 1-334
    • (2012) Adv Cancer Res , vol.115 , pp. 1-334
    • Curiel, D.T.1    Fisher, P.B.2
  • 13
  • 15
    • 79955508961 scopus 로고    scopus 로고
    • Developing an effective gene therapy for prostate cancer: New technologies with potential to translate from the laboratory into the clinic
    • Dash R, Azab B, Shen XN, Sokhi UK, Sarkar S, Su ZZ, Wang XY, Claudio PP, Dent P, Dmitriev IP et al (2011) Developing an effective gene therapy for prostate cancer: new technologies with potential to translate from the laboratory into the clinic. Discov Med 11:46-56
    • (2011) Discov Med , vol.11 , pp. 46-56
    • Dash, R.1    Azab, B.2    Shen, X.N.3    Sokhi, U.K.4    Sarkar, S.5    Su, Z.Z.6    Wang, X.Y.7    Claudio, P.P.8    Dent, P.9    Dmitriev, I.P.10
  • 19
    • 34250822281 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy
    • Dice JF (2007) Chaperone-mediated autophagy. Autophagy 3:295-299
    • (2007) Autophagy , vol.3 , pp. 295-299
    • Dice, J.F.1
  • 20
    • 0035478639 scopus 로고    scopus 로고
    • Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types
    • Dumoutier L, Leemans C, Lejeune D, Kotenko SV, Renauld JC (2001) Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. J Immunol 167:3545-3549
    • (2001) J Immunol , vol.167 , pp. 3545-3549
    • Dumoutier, L.1    Leemans, C.2    Lejeune, D.3    Kotenko, S.V.4    Renauld, J.C.5
  • 21
    • 54349120011 scopus 로고    scopus 로고
    • Ad-MDA-7; INGN 241: A review of preclinical and clinical experience
    • Eager R, Harle L, Nemunaitis J (2008) Ad-MDA-7; INGN 241: a review of preclinical and clinical experience. Expert Opin Biol Ther 8:1633-1643
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 1633-1643
    • Eager, R.1    Harle, L.2    Nemunaitis, J.3
  • 22
    • 33845664085 scopus 로고    scopus 로고
    • Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy
    • Emdad L, Lebedeva IV, Su ZZ, Gupta P, Sarkar D, Settleman J, Fisher PB (2007) Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy. J Cell Physiol 210:549-559
    • (2007) J Cell Physiol , vol.210 , pp. 549-559
    • Emdad, L.1    Lebedeva, I.V.2    Su, Z.Z.3    Gupta, P.4    Sarkar, D.5    Settleman, J.6    Fisher, P.B.7
  • 23
    • 33751285479 scopus 로고    scopus 로고
    • The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth
    • Fels DR, Koumenis C (2006) The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth. Cancer Biol Ther 5:723-728
    • (2006) Cancer Biol Ther , vol.5 , pp. 723-728
    • Fels, D.R.1    Koumenis, C.2
  • 24
    • 28544435618 scopus 로고    scopus 로고
    • Is mda-7/IL-24 a "magic bullet" for cancer?
    • Fisher PB (2005) Is mda-7/IL-24 a "magic bullet" for cancer? Cancer Res 65:10128-10138
    • (2005) Cancer Res , vol.65 , pp. 10128-10138
    • Fisher, P.B.1
  • 26
    • 0021848970 scopus 로고
    • Effects of combined treatment with interferon and mezerein on melanogenesis and growth in human melanoma cells
    • Fisher PB, Prignoli DR, Hermo H Jr, Weinstein IB, Pestka S (1985) Effects of combined treatment with interferon and mezerein on melanogenesis and growth in human melanoma cells. J Interferon Res 5:11-22
    • (1985) J Interferon Res , vol.5 , pp. 11-22
    • Fisher, P.B.1    Prignoli, D.R.2    Hermo Jr., H.3    Weinstein, I.B.4    Pestka, S.5
  • 27
    • 0001914547 scopus 로고
    • Enhancement of viral transformation and expression of the transformed phenotype by tumor promoters
    • In: Slaga TJ (ed) CRC Press, Inc., Boca Raton
    • Fisher PB (1984) Enhancement of viral transformation and expression of the transformed phenotype by tumor promoters. In: Slaga TJ (ed) Tumor promotion and cocarcinogenesis in vitro, mechanisms of tumor promotion. CRC Press, Inc., Boca Raton, pp 57-123
    • (1984) Tumor Promotion and Cocarcinogenesis in Vitro, Mechanisms of Tumor Promotion , pp. 57-123
    • Fisher, P.B.1
  • 28
    • 34547949167 scopus 로고    scopus 로고
    • Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation
    • Fritsch RM, Schneider G, Saur D, Scheibel M, Schmid RM (2007) Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation. J Biol Chem 282:22551-22562
    • (2007) J Biol Chem , vol.282 , pp. 22551-22562
    • Fritsch, R.M.1    Schneider, G.2    Saur, D.3    Scheibel, M.4    Schmid, R.M.5
  • 29
    • 45549098748 scopus 로고    scopus 로고
    • Secretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24
    • Gao P, Sun X, Chen X, Wang Y, Foster BA, Subjeck J, Fisher PB, Wang XY (2008) Secretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24. Cancer Res 68:3890-3898
    • (2008) Cancer Res , vol.68 , pp. 3890-3898
    • Gao, P.1    Sun, X.2    Chen, X.3    Wang, Y.4    Foster, B.A.5    Subjeck, J.6    Fisher, P.B.7    Wang, X.Y.8
  • 31
    • 42949106089 scopus 로고    scopus 로고
    • Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva
    • Gupta P, Emdad L, Lebedeva IV, Sarkar D, Dent P, Curiel DT, Settleman J, Fisher PB (2008) Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva. J Cell Physiol 215:827-836
    • (2008) J Cell Physiol , vol.215 , pp. 827-836
    • Gupta, P.1    Emdad, L.2    Lebedeva, I.V.3    Sarkar, D.4    Dent, P.5    Curiel, D.T.6    Settleman, J.7    Fisher, P.B.8
  • 35
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646-674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 36
    • 77949889459 scopus 로고    scopus 로고
    • IL-24 transgenic mice: In vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis
    • He M, Liang P (2010) IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis. J Immunol 184:1793-1798
    • (2010) J Immunol , vol.184 , pp. 1793-1798
    • He, M.1    Liang, P.2
  • 37
  • 38
    • 0035950553 scopus 로고    scopus 로고
    • Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties
    • Huang EY, Madireddi MT, Gopalkrishnan RV, Leszczyniecka M, Su Z, Lebedeva IV, Kang D, Jiang H, Lin JJ, Alexandre D et al (2001) Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties. Oncogene 20:7051-7063
    • (2001) Oncogene , vol.20 , pp. 7051-7063
    • Huang, E.Y.1    Madireddi, M.T.2    Gopalkrishnan, R.V.3    Leszczyniecka, M.4    Su, Z.5    Lebedeva, I.V.6    Kang, D.7    Jiang, H.8    Lin, J.J.9    Alexandre, D.10
  • 39
    • 84879671369 scopus 로고    scopus 로고
    • MDA-7/IL-24 suppresses tumor adhesion and invasive potential in hepatocellular carcinoma cell lines
    • (in press)
    • Huo W, Li ZM, Zhu XM, Bao YM, An LJ (2013) MDA-7/IL-24 suppresses tumor adhesion and invasive potential in hepatocellular carcinoma cell lines. Oncol Rep (in press)
    • (2013) Oncol Rep
    • Huo, W.1    Li, Z.M.2    Zhu, X.M.3    Bao, Y.M.4    An, L.J.5
  • 40
    • 33846325144 scopus 로고    scopus 로고
    • Mda-7 in combination with bevacizumab treatment produces a synergistic and complete inhibitory effect on lung tumor xenograft
    • Inoue S, Hartman A, Branch CD, Bucana CD, Bekele BN, Stephens LC, Chada S, Ramesh R (2007) mda-7 In combination with bevacizumab treatment produces a synergistic and complete inhibitory effect on lung tumor xenograft. Mol Ther 15:287-294
    • (2007) Mol Ther , vol.15 , pp. 287-294
    • Inoue, S.1    Hartman, A.2    Branch, C.D.3    Bucana, C.D.4    Bekele, B.N.5    Stephens, L.C.6    Chada, S.7    Ramesh, R.8
  • 41
    • 25144475372 scopus 로고    scopus 로고
    • Inhibition of Src kinase activity by Ad-mda-7 suppresses vascular endothelial growth factor expression in prostate carcinoma cells
    • Inoue S, Branch CD, Gallick GE, Chada S, Ramesh R (2005) Inhibition of Src kinase activity by Ad-mda-7 suppresses vascular endothelial growth factor expression in prostate carcinoma cells. Mol Ther 12:707-715
    • (2005) Mol Ther , vol.12 , pp. 707-715
    • Inoue, S.1    Branch, C.D.2    Gallick, G.E.3    Chada, S.4    Ramesh, R.5
  • 42
    • 84855802717 scopus 로고    scopus 로고
    • IL-2 regulates the expression of the tumor suppressor IL-24 in melanoma cells
    • Jen EY, Poindexter NJ, Farnsworth ES, Grimm EA (2012) IL-2 regulates the expression of the tumor suppressor IL-24 in melanoma cells. Melanoma Res 22:19-29
    • (2012) Melanoma Res , vol.22 , pp. 19-29
    • Jen, E.Y.1    Poindexter, N.J.2    Farnsworth, E.S.3    Grimm, E.A.4
  • 43
    • 0029558740 scopus 로고
    • Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression
    • Jiang H, Lin JJ, Su ZZ, Goldstein NI, Fisher PB (1995) Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene 11:2477-2486
    • (1995) Oncogene , vol.11 , pp. 2477-2486
    • Jiang, H.1    Lin, J.J.2    Su, Z.Z.3    Goldstein, N.I.4    Fisher, P.B.5
  • 45
    • 37449013636 scopus 로고    scopus 로고
    • The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy
    • Kragstrup TW, Otkjaer K, Holm C, Jorgensen A, Hokland M, Iversen L, Deleuran B (2008) The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy. Cytokine 41:16-23
    • (2008) Cytokine , vol.41 , pp. 16-23
    • Kragstrup, T.W.1    Otkjaer, K.2    Holm, C.3    Jorgensen, A.4    Hokland, M.5    Iversen, L.6    Deleuran, B.7
  • 46
    • 38449096542 scopus 로고    scopus 로고
    • Mda-7/IL-24, novel anticancer cytokine: Focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase i clinical experience
    • Lebedeva IV, Emdad L, Su ZZ, Gupta P, Sauane M, Sarkar D, Staudt MR, Liu SJ, Taher MM, Xiao R et al (2007) mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience. Int J Oncol 31:985-1007
    • (2007) Int J Oncol , vol.31 , pp. 985-1007
    • Lebedeva, I.V.1    Emdad, L.2    Su, Z.Z.3    Gupta, P.4    Sauane, M.5    Sarkar, D.6    Staudt, M.R.7    Liu, S.J.8    Taher, M.M.9    Xiao, R.10
  • 48
    • 85047695547 scopus 로고    scopus 로고
    • The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells
    • Lebedeva IV, Su ZZ, Chang Y, Kitada S, Reed JC, Fisher PB (2002) The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells. Oncogene 21:708-718
    • (2002) Oncogene , vol.21 , pp. 708-718
    • Lebedeva, I.V.1    Su, Z.Z.2    Chang, Y.3    Kitada, S.4    Reed, J.C.5    Fisher, P.B.6
  • 49
    • 0346365376 scopus 로고    scopus 로고
    • Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species
    • Lebedeva IV, Su ZZ, Sarkar D, Kitada S, Dent P, Waxman S, Reed JC, Fisher PB (2003) Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species. Cancer Res 63:8138-8144
    • (2003) Cancer Res , vol.63 , pp. 8138-8144
    • Lebedeva, I.V.1    Su, Z.Z.2    Sarkar, D.3    Kitada, S.4    Dent, P.5    Waxman, S.6    Reed, J.C.7    Fisher, P.B.8
  • 51
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132:27-42
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 52
    • 73249135127 scopus 로고    scopus 로고
    • IL-24 protects against Salmonella typhimurium infection by stimulating early neutrophil Th1 cytokine production, which in turn activates CD8+ T cells
    • Ma Y, Chen H, Wang Q, Luo F, Yan J, Zhang XL (2009) IL-24 protects against Salmonella typhimurium infection by stimulating early neutrophil Th1 cytokine production, which in turn activates CD8+ T cells. Eur J Immunol 39:3357-3368
    • (2009) Eur J Immunol , vol.39 , pp. 3357-3368
    • Ma, Y.1    Chen, H.2    Wang, Q.3    Luo, F.4    Yan, J.5    Zhang, X.L.6
  • 53
    • 80053386669 scopus 로고    scopus 로고
    • Interleukin 24 as a novel potential cytokine immunotherapy for the treatment of Mycobacterium tuberculosis infection
    • Ma Y, Chen HD, Wang Y, Wang Q, Li Y, Zhao Y, Zhang XL (2011) Interleukin 24 as a novel potential cytokine immunotherapy for the treatment of Mycobacterium tuberculosis infection. Microbes Infect Instit Pasteur 13:1099-1110
    • (2011) Microbes Infect Instit Pasteur , vol.13 , pp. 1099-1110
    • Ma, Y.1    Chen, H.D.2    Wang, Y.3    Wang, Q.4    Li, Y.5    Zhao, Y.6    Zhang, X.L.7
  • 54
    • 0033842787 scopus 로고    scopus 로고
    • AP-1 and C/EBP transcription factors contribute to mda-7 gene promoter activity during human melanoma differentiation
    • Madireddi MT, Dent P, Fisher PB (2000) AP-1 and C/EBP transcription factors contribute to mda-7 gene promoter activity during human melanoma differentiation. J Cell Physiol 185:36-46
    • (2000) J Cell Physiol , vol.185 , pp. 36-46
    • Madireddi, M.T.1    Dent, P.2    Fisher, P.B.3
  • 55
    • 0034594998 scopus 로고    scopus 로고
    • Regulation of mda-7 gene expression during human melanoma differentiation
    • Madireddi MT, Dent P, Fisher PB (2000) Regulation of mda-7 gene expression during human melanoma differentiation. Oncogene 19:1362-1368
    • (2000) Oncogene , vol.19 , pp. 1362-1368
    • Madireddi, M.T.1    Dent, P.2    Fisher, P.B.3
  • 56
    • 0034475080 scopus 로고    scopus 로고
    • Mda-7, a novel melanoma differentiation associated gene with promise for cancer gene therapy
    • Madireddi MT, Su ZZ, Young CS, Goldstein NI, Fisher PB (2000) Mda-7, a novel melanoma differentiation associated gene with promise for cancer gene therapy. Adv Exp Med Biol 465:239-261
    • (2000) Adv Exp Med Biol , vol.465 , pp. 239-261
    • Madireddi, M.T.1    Su, Z.Z.2    Young, C.S.3    Goldstein, N.I.4    Fisher, P.B.5
  • 58
    • 3843083029 scopus 로고    scopus 로고
    • Combination therapy of Ad-mda7 and trastuzumab increases cell death in Her-2/neu-overexpressing breast cancer cells
    • McKenzie T, Liu Y, Fanale M, Swisher SG, Chada S, Hunt KK (2004) Combination therapy of Ad-mda7 and trastuzumab increases cell death in Her-2/neu-overexpressing breast cancer cells. Surgery 136:437-442
    • (2004) Surgery , vol.136 , pp. 437-442
    • McKenzie, T.1    Liu, Y.2    Fanale, M.3    Swisher, S.G.4    Chada, S.5    Hunt, K.K.6
  • 59
    • 3042856164 scopus 로고    scopus 로고
    • Adenovirus-mediated mda-7 (IL24) gene therapy suppresses angiogenesis and sensitizes NSCLC xenograft tumors to radiation
    • Nishikawa T, Ramesh R, Munshi A, Chada S, Meyn RE (2004) Adenovirus-mediated mda-7 (IL24) gene therapy suppresses angiogenesis and sensitizes NSCLC xenograft tumors to radiation. Mol Ther 9:818-828
    • (2004) Mol Ther , vol.9 , pp. 818-828
    • Nishikawa, T.1    Ramesh, R.2    Munshi, A.3    Chada, S.4    Meyn, R.E.5
  • 65
    • 2942593991 scopus 로고    scopus 로고
    • ROS stress in cancer cells and therapeutic implications
    • Pelicano H, Carney D, Huang P (2004) ROS stress in cancer cells and therapeutic implications. Drug Resist Updat 7:97-110
    • (2004) Drug Resist Updat , vol.7 , pp. 97-110
    • Pelicano, H.1    Carney, D.2    Huang, P.3
  • 66
    • 2342623458 scopus 로고    scopus 로고
    • Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells
    • Ramesh R, Ito I, Gopalan B, Saito Y, Mhashilkar AM, Chada S (2004) Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells. Mol Ther 9:510-518
    • (2004) Mol Ther , vol.9 , pp. 510-518
    • Ramesh, R.1    Ito, I.2    Gopalan, B.3    Saito, Y.4    Mhashilkar, A.M.5    Chada, S.6
  • 68
    • 44349125754 scopus 로고    scopus 로고
    • PERK and PKR: Old kinases learn new tricks
    • Raven JF, Koromilas AE (2008) PERK and PKR: old kinases learn new tricks. Cell Cycle 7:1146-1150
    • (2008) Cell Cycle , vol.7 , pp. 1146-1150
    • Raven, J.F.1    Koromilas, A.E.2
  • 69
    • 0034502591 scopus 로고    scopus 로고
    • Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro
    • Saeki T, Mhashilkar A, Chada S, Branch C, Roth JA, Ramesh R (2000) Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro. Gene Ther 7:2051-2057
    • (2000) Gene Ther , vol.7 , pp. 2051-2057
    • Saeki, T.1    Mhashilkar, A.2    Chada, S.3    Branch, C.4    Roth, J.A.5    Ramesh, R.6
  • 74
    • 0037162507 scopus 로고    scopus 로고
    • Mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK
    • Sarkar D, Su ZZ, Lebedeva IV, Sauane M, Gopalkrishnan RV, Valerie K, Dent P, Fisher PB (2002) mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc Natl Acad Sci U S A 99:10054-10059
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10054-10059
    • Sarkar, D.1    Su, Z.Z.2    Lebedeva, I.V.3    Sauane, M.4    Gopalkrishnan, R.V.5    Valerie, K.6    Dent, P.7    Fisher, P.B.8
  • 76
    • 25444519500 scopus 로고    scopus 로고
    • Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice
    • Sarkar D, Su ZZ, Vozhilla N, Park ES, Gupta P, Fisher PB (2005) Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice. Proc Natl Acad Sci U S A 102:14034-14039
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 14034-14039
    • Sarkar, D.1    Su, Z.Z.2    Vozhilla, N.3    Park, E.S.4    Gupta, P.5    Fisher, P.B.6
  • 83
    • 2342557922 scopus 로고    scopus 로고
    • Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways
    • Sauane M, Lebedeva IV, Su ZZ, Choo HT, Randolph A, Valerie K, Dent P, Gopalkrishnan RV, Fisher PB (2004) Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways. Cancer Res 64:2988-2993
    • (2004) Cancer Res , vol.64 , pp. 2988-2993
    • Sauane, M.1    Lebedeva, I.V.2    Su, Z.Z.3    Choo, H.T.4    Randolph, A.5    Valerie, K.6    Dent, P.7    Gopalkrishnan, R.V.8    Fisher, P.B.9
  • 86
    • 36949004138 scopus 로고    scopus 로고
    • Melanoma differentiation-associated gene-7/interleukin 24 inhibits invasion and migration of human cervical cancer cells in vitro
    • Shi H, Wei LL, Yuan CF, Yang JX, Yi FP, Ma YP, Song FZ (2007) Melanoma differentiation-associated gene-7/interleukin 24 inhibits invasion and migration of human cervical cancer cells in vitro. Saudi Med J 28:1671-1675
    • (2007) Saudi Med J , vol.28 , pp. 1671-1675
    • Shi, H.1    Wei, L.L.2    Yuan, C.F.3    Yang, J.X.4    Yi, F.P.5    Ma, Y.P.6    Song, F.Z.7
  • 87
    • 0344258425 scopus 로고    scopus 로고
    • Cutaneous rat wounds express c49a, a novel gene with homology to the human melanoma differentiation associated gene, mda-7
    • Soo C, Shaw WW, Freymiller E, Longaker MT, Bertolami CN, Chiu R, Tieu A, Ting K (1999) Cutaneous rat wounds express c49a, a novel gene with homology to the human melanoma differentiation associated gene, mda-7. J Cell Biochem 74:1-10
    • (1999) J Cell Biochem , vol.74 , pp. 1-10
    • Soo, C.1    Shaw, W.W.2    Freymiller, E.3    Longaker, M.T.4    Bertolami, C.N.5    Chiu, R.6    Tieu, A.7    Ting, K.8
  • 88
    • 76249090337 scopus 로고    scopus 로고
    • Macroautophagy and its role in nutrient homeostasis
    • Stipanuk MH (2009) Macroautophagy and its role in nutrient homeostasis. Nutr Rev 67:677-689
    • (2009) Nutr Rev , vol.67 , pp. 677-689
    • Stipanuk, M.H.1
  • 89
    • 27844459421 scopus 로고    scopus 로고
    • Unique aspects of mda-7/IL-24 antitumor bystander activity: Establishing a role for secretion of MDA-7/IL-24 protein by normal cells
    • Su Z, Emdad L, Sauane M, Lebedeva IV, Sarkar D, Gupta P, James CD, Randolph A, Valerie K, Walter MR et al (2005) Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells. Oncogene 24:7552-7566
    • (2005) Oncogene , vol.24 , pp. 7552-7566
    • Su, Z.1    Emdad, L.2    Sauane, M.3    Lebedeva, I.V.4    Sarkar, D.5    Gupta, P.6    James, C.D.7    Randolph, A.8    Valerie, K.9    Walter, M.R.10
  • 91
    • 33646127801 scopus 로고    scopus 로고
    • Ionizing radiation enhances therapeutic activity of mda-7/IL-24: Overcoming radiation- and mda-7/IL-24-resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl-xL or bcl-2
    • Su ZZ, Lebedeva IV, Sarkar D, Emdad L, Gupta P, Kitada S, Dent P, Reed JC, Fisher PB (2006) Ionizing radiation enhances therapeutic activity of mda-7/IL-24: overcoming radiation- and mda-7/IL-24-resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl-xL or bcl-2. Oncogene 25:2339-2348
    • (2006) Oncogene , vol.25 , pp. 2339-2348
    • Su, Z.Z.1    Lebedeva, I.V.2    Sarkar, D.3    Emdad, L.4    Gupta, P.5    Kitada, S.6    Dent, P.7    Reed, J.C.8    Fisher, P.B.9
  • 92
    • 0032564357 scopus 로고    scopus 로고
    • The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice
    • Su ZZ, Madireddi MT, Lin JJ, Young CS, Kitada S, Reed JC, Goldstein NI, Fisher PB (1998) The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. Proc Natl Acad Sci U S A 95:14400-14405
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 14400-14405
    • Su, Z.Z.1    Madireddi, M.T.2    Lin, J.J.3    Young, C.S.4    Kitada, S.5    Reed, J.C.6    Goldstein, N.I.7    Fisher, P.B.8
  • 93
    • 19944384118 scopus 로고    scopus 로고
    • Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): Biologic outcome in advanced cancer patients
    • Tong AW, Nemunaitis J, Su D, Zhang Y, Cunningham C, Senzer N, Netto G, Rich D, Mhashilkar A, Parker K et al (2005) Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients. Mol Ther 11:160-172
    • (2005) Mol Ther , vol.11 , pp. 160-172
    • Tong, A.W.1    Nemunaitis, J.2    Su, D.3    Zhang, Y.4    Cunningham, C.5    Senzer, N.6    Netto, G.7    Rich, D.8    Mhashilkar, A.9    Parker, K.10
  • 94
    • 77956896379 scopus 로고    scopus 로고
    • Ad.mda-7 (IL-24) selectively induces apoptosis in hepatocellular carcinoma cell lines, suppresses metastasis, and enhances the effect of doxorubicin on xenograft tumors
    • Wang CJ, Zhang H, Chen K, Zheng JW, Xiao CW, Ji WW, Yu Y, Hu HY, Li Y, Xue XB (2010) Ad.mda-7 (IL-24) selectively induces apoptosis in hepatocellular carcinoma cell lines, suppresses metastasis, and enhances the effect of doxorubicin on xenograft tumors. Oncol Res 18:561-574
    • (2010) Oncol Res , vol.18 , pp. 561-574
    • Wang, C.J.1    Zhang, H.2    Chen, K.3    Zheng, J.W.4    Xiao, C.W.5    Ji, W.W.6    Yu, Y.7    Hu, H.Y.8    Li, Y.9    Xue, X.B.10
  • 95
    • 0036510539 scopus 로고    scopus 로고
    • Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2
    • Wang M, Tan Z, Zhang R, Kotenko SV, Liang P (2002) Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. J Biol Chem 277:7341-7347
    • (2002) J Biol Chem , vol.277 , pp. 7341-7347
    • Wang, M.1    Tan, Z.2    Zhang, R.3    Kotenko, S.V.4    Liang, P.5
  • 96
    • 79960401862 scopus 로고    scopus 로고
    • Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
    • Wei H, Wei S, Gan B, Peng X, Zou W, Guan JL (2011) Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev 25:1510-1527
    • (2011) Genes Dev , vol.25 , pp. 1510-1527
    • Wei, H.1    Wei, S.2    Gan, B.3    Peng, X.4    Zou, W.5    Guan, J.L.6
  • 97
    • 84855439046 scopus 로고    scopus 로고
    • Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation
    • Wu SY, Lan SH, Cheng DE, Chen WK, Shen CH, Lee YR, Zuchini R, Liu HS (2011) Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation. Neoplasia 13:1171-1182
    • (2011) Neoplasia , vol.13 , pp. 1171-1182
    • Wu, S.Y.1    Lan, S.H.2    Cheng, D.E.3    Chen, W.K.4    Shen, C.H.5    Lee, Y.R.6    Zuchini, R.7    Liu, H.S.8
  • 98
    • 65249112667 scopus 로고    scopus 로고
    • Enhancement of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying MDA-7/IL-24
    • Wu YM, Zhang KJ, Yue XT, Wang YQ, Yang Y, Li GC, Li N, Wang YG (2009) Enhancement of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying MDA-7/IL-24. Acta Pharmacol Sin 30:467-477
    • (2009) Acta Pharmacol Sin , vol.30 , pp. 467-477
    • Wu, Y.M.1    Zhang, K.J.2    Yue, X.T.3    Wang, Y.Q.4    Yang, Y.5    Li, G.C.6    Li, N.7    Wang, Y.G.8
  • 100
    • 76249095217 scopus 로고    scopus 로고
    • PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells
    • Yacoub A, Hamed HA, Allegood J, Mitchell C, Spiegel S, Lesniak MS, Ogretmen B, Dash R, Sarkar D, Broaddus WC et al (2010) PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells. Cancer Res 70:1120-1129
    • (2010) Cancer Res , vol.70 , pp. 1120-1129
    • Yacoub, A.1    Hamed, H.A.2    Allegood, J.3    Mitchell, C.4    Spiegel, S.5    Lesniak, M.S.6    Ogretmen, B.7    Dash, R.8    Sarkar, D.9    Broaddus, W.C.10
  • 101
    • 74549205375 scopus 로고    scopus 로고
    • Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24- induced killing in ovarian carcinoma cells
    • Yacoub A, Liu R, Park MA, Hamed HA, Dash R, Schramm DN, Sarkar D, Dimitriev IP, Bell JK, Grant S et al (2010) Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24- induced killing in ovarian carcinoma cells. Mol Pharmacol 77:298-310
    • (2010) Mol Pharmacol , vol.77 , pp. 298-310
    • Yacoub, A.1    Liu, R.2    Park, M.A.3    Hamed, H.A.4    Dash, R.5    Schramm, D.N.6    Sarkar, D.7    Dimitriev, I.P.8    Bell, J.K.9    Grant, S.10
  • 102
    • 1642417725 scopus 로고    scopus 로고
    • MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity
    • Yacoub A, Mitchell C, Brannon J, Rosenberg E, Qiao L, McKinstry R, Linehan WM, Su ZS, Sarkar D, Lebedeva IV et al (2003) MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity. Mol Cancer Ther 2:623-632
    • (2003) Mol Cancer Ther , vol.2 , pp. 623-632
    • Yacoub, A.1    Mitchell, C.2    Brannon, J.3    Rosenberg, E.4    Qiao, L.5    McKinstry, R.6    Linehan, W.M.7    Su, Z.S.8    Sarkar, D.9    Lebedeva, I.V.10
  • 106
    • 57749115016 scopus 로고    scopus 로고
    • Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells
    • Zheng M, Bocangel D, Ramesh R, Ekmekcioglu S, Poindexter N, Grimm EA, Chada S (2008) Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells. Mol Cancer Ther 7:3842-3851
    • (2008) Mol Cancer Ther , vol.7 , pp. 3842-3851
    • Zheng, M.1    Bocangel, D.2    Ramesh, R.3    Ekmekcioglu, S.4    Poindexter, N.5    Grimm, E.A.6    Chada, S.7


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