Mda-7, a novel melanoma differentiation associated gene with promise for cancer gene therapy

Advances in Experimental Medicine and Biology

Volumn 465, Issue , 2000, Pages 239-261

  Madireddi, M T ^a   Su, Z Z ^a   Young, C S H ^a   Goldstein, N I ^a   Fisher, P B ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; MDA 7; MEZEREIN; UNCLASSIFIED DRUG;

ADENOVIRUS; APOPTOSIS; CANCER; DRUG MECHANISM; GENE THERAPY; HUMAN; HYBRIDIZATION; MELANOMA CELL; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVIEW; VIRUS GENE; VIRUS RECOMBINANT;

ADENOVIRUSES, HUMAN; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL DIFFERENTIATION; FORECASTING; GENE THERAPY; GENES, TUMOR SUPPRESSOR; GENETIC VECTORS; GROWTH SUBSTANCES; HUMANS; INTERLEUKINS; MELANOMA; MOLECULAR SEQUENCE DATA;

ADENOVIRIDAE;

EID: 0034475080     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (90)

1. The bcl-2 protein family: Arbiters of cell survival
2. p53 gene therapy in a rat model of hepatocellular carcinoma: Intra-arterial delivery of a recombinant adenovirus
3. Inhibition of Bax channel-forming activity by Bcl-2
4. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
5. Molecular themes in oncogenesis
6. Targeting of an inducible toxic phenotype in animal cells
7. Role of cyclin-dependent kinases and their inhibitors in cellular differentiation and development
8. Systemic gene therapy with p53 inhibits breast cancer: Recent advances and therapeutic implications
9. Tumor progression and the nature of cancer
10. Transfer of genes to humans: Early lessons and obstacles to success
11. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
12. Engineering tissue-specific expression of a recombinant adenovirus: Selective transgene transcription in the pancreas using the amylase gene
13. Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma
14. Lifestyle factors and human lung cancer: An overview of recent advances
15. WAF1, a potential mediator of p53 tumor suppression
16. Enhancement of viral transformation and expression of the transformed phenotype by tumor promoters
17. Effects of combined treatment with interferon and mezerein on melanogenesis and growth in human melanoma cells
18. Cleavage of CDK inhibitor p21(Cip1/Waf1) by caspases is an early event during DNA damage-induced apoptosis
19. Clinical application for gene therapy in prostate cancer
20. Mitochondria and apoptosis
21. Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis
22. In vitro differentiation and antigenic changes in human melanoma cell lines
23. Modulation of the antigenic phenotype of human melanoma cells by differentiation-inducing and growth-suppressing agents
24. DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease
25. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
26. Cell cycle control of cancer
27. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
28. Human melanoma: Development and progression
29. Differentiation induction subtraction hybridization (DISH): An approach for defining the spectrum of genes differentially expressed during induction of irreversible growth arrest and terminal differentiation in human melanoma cells
30. Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death
31. Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene
32. Bcl-2 phosphorylation required for anti-apoptosis function
33. Use of a sensitive and efficient subtraction hybridization protocol for the identification of genes differentially regulated during the induction of differentiation in human melanoma cells
34. Gene expression changes associated with reversible growth suppression and the induction of terminal differentiation in human melanoma cells
35. Regulation of c-fos, c-jun and jun-B expression in human melanoma cells induced to terminally differentiate
36. A molecular definition of terminal differentiation in human melanoma cells
37. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression
38. The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells
39. Cell cycle gene expression and E2F transcription factor complexes in human melanoma cells induced to terminally differentiate
40. The melanoma differentiation associated gene mda-7 suppresses cancer cell growth
41. Tumor cell rejection through terminal cell differentiation
42. Role of the transcription factor AP1 in melanoma differentiation
43. Growth dominance and the metastatic cancer cell: Cellular and molecular aspects
44. Current perspectives on the molecular pathogenesis of virus-induced cancers in human immunodeficiency virus infection and acquired immunodeficiency syndrome
45. Variant sublines of early-stage human melanomas selected for tumorigenicity in nude mice express a multicytokine-resistant phenotype
46. Gene therapy strategies for tumor antiangiogenesis
47. Antioncogenes and human cancer
48. The proto-oncogene Bcl-2 and its role in regulating apoptosis
49. The tumor suppressor genes
50. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic cascade
51. L has activity independent of cytochrome c release
52. Characterization of a novel melanoma differentiation associated gene, mda-9, that is down-regulated during terminal cell differentiation
53. Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene
54. Cytokines, growth factors and the loss of negative growth controls in the progression of human cutaneous malignant melanoma
55. Mitochondrial permeability transition is the central coordinating event of apoptosis
56. SV40-transformed human melanocyte sensitivity to growth inhibition by the phorbol ester 12-0-tetradecanoylphorbol-13-acetate
57. Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors
58. Properties and functions of interleukin-10
59. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
60. Identification of a germ-cell-specific transcriptional repressor in the promoter of Tctex-1
61. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
62. p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells
63. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance
64. Bcl-2 family proteins: Regulators of apoptosis and chemoresistance in hematologic malignancies
65. Differentiation therapy of cancer: Basic science and clinical applications
66. p16INK4A adenovirus-mediated gene therapy for human head and neck squamous cell cancer
67. Prostate attenuated replication competent adenovirus (ARCA) CN706: A selective cytotoxic for prostate-specific antigen-positive prostate cancer cells
68. Gene therapy for cancer
69. Gene therapy for cancer: What have we done and where are we going?
70. Gene therapy for non-small cell lung cancer: A preliminary report of a phase I trial of adenoviral p53 gene replacement
71. Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex
72. Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid cells
73. Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death
74. Bcl-2 family proteins as ion-channels
75. Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSV-TK) gene to thoracic neoplasms: An effective in vitro drug sensitization system
76. Regulation of the cell cycle by CDK inhibitors. Results and problems
77. Viral vectors in gene therapy
78. Subtraction hybridization identifies a transformation progression-associated gene PEG-3 with sequence homology to a growth arrest and DNA damage inducible gene
79. Antisense inhibition of the PTI-1 oncogene reverses cancer phenotypes
80. The cancer growth suppressor gene mda-7 selectively induces apoptosis in human cancer cells and inhibits tumor growth in nude mice
81. Melanoma differentiation associated gene-7 (Mda-7): A ubiquitous cancer growth suppressor gene
82. Gene therapy for pancreatic cancer
83. The multistep nature of cancer
84. Life, death, and the pursuit of apoptosis
85. Apoptosis: Unmasking the executioner
86. Enhanced tumor suppressor gene therapy via replication-deficient adenovirus vectors expressing an N-terminal truncated retinoblastoma protein
87. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
88. Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype
89. Apaf-1, a human protein homologous to C. elegans Ced-4, participates in cytochrome c-dependent activation of caspase-3