The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24

Journal of Immunology

Volumn 168, Issue 12, 2002, Pages 6041-6046

  Caudell, Eva G ^a   Mumm, John B ^a   Poindexter, Nancy ^a   Ekmekcioglu, Suhendan ^a   Mhashilkar, Abner M ^a   Yang, Xiaohong Helena ^a   Retter, Mark W ^a   Hill, Paul ^a   Chada, Sunil ^a   Grimm, Elizabeth A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD56 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GENE PRODUCT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 24; INTERLEUKIN 6; MELANOMA ASSOCIATED GENE 7; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE LOCATION; GENE LOCUS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; LEUKOCYTE; MELANOMA; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

EID: 0037097637     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.12.6041     Document Type: Article

References (27)

1. Biological properties of interleukin-10
2. Differential increase of Fas ligand expression on metastatic and thin or thick primary melanoma cells compared with interleukin-10
3. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
4. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI
5. Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)
6. Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)
7. Interleukin-20: Discovery, receptor identification, and role in epidermal function
8. Human interleukin-10-related T cell-derived inducible factor: Molecular cloning and functional characterization as an hepatocyte-stimulating factor
9. Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri
10. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression
11. Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties
12. The melanoma differentiation associated gene mda-7 suppresses cancer cell growth
13. The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice
14. Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro
15. Melanoma differentiation associated gene-7 (mda-7): A novel anti-tumor gene for cancer gene therapy
16. Mda-7, a novel melanoma differentiation associated gene with promise for cancer gene therapy
17. Regulation of mda-7 gene expression during human melanoma differentiation
18. Cutting edge: FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells
19. Cutaneous rat wounds express C49a, a novel gene with homology to the human melanoma differentiation associated gene, mda-7
20. Identification of a novel ligand-receptor pair constitutively activated by ras oncogenes
21. Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas
22. Interleukin 24 (MDA/MOB-5) signals through two heterodimeric receptors, IL-22RI/IL-20R2 and IL-20RI/IL-20R2
23. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
24. STAT activation by IL-19, IL-20, and mda-7 through IL-20 receptor complexes of two types
25. Interteukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R
26. Marked cell-type-specific differences in glycosylation of human interleukin-6
27. O- and N-glycosylation lead to different molecular mass forms of human monocyte interleukin-6