Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): Biologic outcome in advanced cancer patients

Molecular Therapy

Volumn 11, Issue 1, 2005, Pages 160-172

  Tong, Alex W ^a,b   Nemunaitis, John ^b   Su, Dan ^a   Zhang, Yuan ^a   Cunningham, Casey ^b   Senzer, Neil ^a,b   Netto, George ^a   Rich, Dawn ^b   Mhashilkar, Abner ^c   Parker, Karen ^c   Coffee, Keith ^c   Ramesh, Rajagopal ^d   Ekmekcioglu, Suhendan ^d   Grimm, Elizabeth A ^d   van Wart Hood, Jill ^c   Merritt, James ^c   Chada, Sunil ^c,d  

^a BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^b Developmental Therapeutics Committee and Co Chair of the Genitourinary Committee   (United States)

^c Introgen Therapeutics Inc   (United States)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BETA CATENIN; CD31 ANTIGEN; CYTOKINE; GENE PRODUCT; INGN 241; INTERLEUKIN 10; INTERLEUKIN 24; INTERLEUKIN 6; MELANOMA DIFFERENTIATION ASSOCIATED PROTEIN 7; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADRENAL CORTEX CARCINOMA; ADVANCED CANCER; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL CARCINOMA; CYTOKINE PRODUCTION; DNA DETERMINATION; DOSE RESPONSE; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE TARGETING; GENE TRANSFER; HUMAN; IMMUNE RESPONSE; LIVER CELL CARCINOMA; MELANOMA; PHASE 1 CLINICAL TRIAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; T LYMPHOCYTE; TRANSGENE; TREATMENT OUTCOME; TUMOR SUPPRESSOR GENE;

ADENOVIRIDAE; APOPTOSIS; BETA CATENIN; BIOLOGICAL MARKERS; CYTOSKELETAL PROTEINS; GENE EXPRESSION REGULATION; GENE THERAPY; GENES, TUMOR SUPPRESSOR; GENETIC VECTORS; HUMANS; IMMUNITY, ACTIVE; INJECTIONS; INTERLEUKINS; MELANOMA; NEOPLASM STAGING; NEOPLASMS; TRANS-ACTIVATORS; TRANSGENES; TREATMENT OUTCOME; VIRUS REPLICATION;

EID: 19944384118     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.09.021     Document Type: Article

References (40)

1. H. Jiang Z.Z. Su J.J. Lin M.I. Goldstein C.S. Young P.B. Fisher The melanoma differentiation associated gene mda-7 suppresses cancer cell growth Proc. Natl. Acad. Sci. USA 93 1996 9160-9165
2. A.M. Mhashilkar et al. Melanoma differentiation associated gene-7 (mda-7): A novel anti-tumor gene for cancer gene therapy Mol. Med. 7 2001 271-282
3. I.V. Lebedeva Z.Z. Su Y. Chang S. Kitada J.C. Reed P.B. Fisher The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells Oncogene 21 2002 708-718
4. T. Saeki A. Mhashilkar S. Chada C. Branch J.A. Roth R. Ramesh Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro Gene Ther. 7 2000 2051-2057
5. T. Saeki et al. Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo Oncogene 21 2002 4558-4566
6. D. Sarkar Z.Z. Su I.V. Lebedeva M. Sauane R.V. Gopalkrishnan K. Lalerie Mda-7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK Proc. Natl. Acad. Sci. USA 99 2002 10054-10059
7. M. Sauane et al. Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways J. Cell. Physiol. 196 2003 334-345
8. X.X. Cao et al. Adenoviral transfer of mda-7 leads to BAX up-regulation and apoptosis in mesothelioma cells, and is abrogated by over-expression of BCL-XL Mol. Med. 8 2002 869-876
9. E.G. Caudell et al. The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24 J. Immunol. 168 2002 6041-6046
10. Z.Z. Su et al. Melanoma differentiation associated gene-7, mda-7-IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner Oncogene 22 2003 1164-1180
11. A.M. Mhashilkar et al. MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells Mol. Ther. 8 2003 207-219
12. R. Ramesh I. Ito Y. Saito A. Mhashilkar C.D. Branch S. Chada Overexpression of the melanoma differentiation associated-7 (mda-7)/interleukin-24 (IL-24) gene impairs lung cancer cell migration by modulating matrix metalloproteinase-2 (MMP-2) and E-cadherin expression Mol. Ther. 9 2004 510-518
13. R. Ramesh et al. Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor Cancer Res. 63 2003 5105-5113
14. C.C. Cunningham et al. Clinical and local biological effects of an intratumoral injection of mda-7 (INGN 241) in patients with advanced carcinoma: A Phase I study Mol. Ther. 2004
15. S. Ekmekcioglu et al. Negative association of melanoma differentiation-associated gene (mda-7) and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells Mol. Cancer Ther. 2 2003 9-17
16. E.Y. Huang et al. Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties Oncogene 20 2001 7051-7063
17. Z.Z. Su et al. The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice Proc. Natl. Acad. Sci. USA 95 1998 14400-14405
18. A. Yacoub et al. Mda-7 (IL-24) inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling Cancer Biol. Ther. 2 2003 347-353
19. J. Nemunaitis et al. Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small cell lung cancer J. Clin. Oncol. 18 2000 609-622
20. H. Kubo et al. Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer Hum. Gene Ther. 14 2003 227-241
21. S. Ekmekcioglu et al. Inducible nitric oxide synthase (iNOS) and nitrotyrosine (nt) in human metastatic melanoma tumors correlate with poor survival Clin. Cancer Res. 6 2000 4768
22. S.V. Kotenko The family of IL-10-related cytokines and their receptors: related, but to what extent? Cytokine Growth Factor Rev. 13 2002 223-240
23. J. Nemunaitis et al. Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients Cancer Gene Ther. 10 2003 341-352
24. J.A. St George Gene therapy progress and prospects: Adenoviral vectors Gene Ther. 10 2003 1135-1141
25. S. Kawabe T. Nishikawa A. Munshi J.A. Roth S. Chada R.E. Meyn Adenovirus-mediated mda-7 gene expression radiosensitizes non-small cell lung cancer cells via TP53-independent mechanisms Mol. Ther. 6 2002 637-644
26. J. Nemunaitis Live viruses in cancer treatment Oncology 16 2002 483-492
27. K.A. Sieger et al. The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells Mol. Ther. 9 2004 355-367
28. J. Nemunaitis et al. Prognostic value of K-ras mutations, ras oncoprotein and c-erbB-2 oncoprotein expression in adenocarcinoma of the lung Am. J. Clin. Oncol. 21 1998 155-160
29. J. Nemunaitis et al. Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: Safety, feasibility, and biological activity Gene Ther. 8 2001 746-759
30. Y.A. Zhang J. Nemunaitis K.J. Scanlon A.W. Tong Anti-tumorigenic effect of a K-ras ribozyme against human lung cancer cell line heterotransplants in nude mice Gene Ther. 7 2000 2041-2050
31. A.W. Tong et al. Cellular immune profile of patients with advanced cancer before and after taxane treatment Am. J. Clin. Oncol. 23 2000 463-472
32. T. McKenzie Y. Liu M. Fanale S.G. Swisher S. Chada K.K. Hunt Combination therapy of Ad-mda7 and trastuzumab increases cell death in her-2/neu-overexpressing breast cancer cells Surgery 136 2004 437-442
33. S. Chada et al. MDA-7/IL-24 is a unique cytokine in the IL-10 family Int. Immunopharmacol. 4 2004 649-667
34. P.B. Fisher et al. mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene Cancer Biol. Ther. 2 2003 24-38
35. A. Pataeret al. mda-7 induces apoptosis via upregulation of the double-stranded RNA dependent kinase PKR Cancer Res. 62 2002 2239-2243
36. S. Chada A. Mhashilkar R. Ramesh Cytokine- and chemokine-based gene therapy for cancer Curr. Opin. Mol. Ther. 5 2003 463-474
37. T. Nishikawa R. Ramesh S. Chada R.E. Meyn Suppression of tumor growth and angiogenesis by adenovirus-mediated mda-7/IL-24 gene transfer in combination with ionizing radiation Mol. Ther. 9 2004 818-828
38. T. Nishikawa et al. Adenoviral-mediated mda-7 expression suppresses DNA repair capacity and radiosensitizes non-small cell lung cancer cells Oncogene 23 2004 7125-7131
39. R. Ramesh et al. Local and systemic inhibition of lung tumor growth after liposome-mediated mda-7/IL-24 gene delivery DNA Cell Biol. 2004 (in press)
40. S. Chada et al. Bystander activity of Ad-mda7: Human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism Mol. Ther. 2004 (in press)