-
1
-
-
0003056776
-
The lysosome in retrospect
-
Dingle JT, Fell HB, eds. Amsterdam: North- Holland Pub. Co.
-
de Duve C. The lysosome in retrospect. In: Dingle JT, Fell HB, eds. Lysosomes in Biology and Pathology. Amsterdam: North- Holland Pub. Co.; 1969:3-40.
-
(1969)
Lysosomes in Biology and Pathology
, pp. 3-40
-
-
De Duve, C.1
-
2
-
-
0026668042
-
Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction
-
Takeshige K, Baba M, Tsuboi S, Noda T, Ohsumi Y. Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. J Cell Biol. 1992;119:301-311.
-
(1992)
J Cell Biol
, vol.119
, pp. 301-311
-
-
Takeshige, K.1
Baba, M.2
Tsuboi, S.3
Noda, T.4
Ohsumi, Y.5
-
3
-
-
0027424777
-
Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae
-
Tsukada M, Ohsumi Y. Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett. 1993;333:169-174.
-
(1993)
FEBS Lett
, vol.333
, pp. 169-174
-
-
Tsukada, M.1
Ohsumi, Y.2
-
4
-
-
0027936092
-
Isolation of autophagocytosis mutants of Saccharomyces cerevisiae
-
Thumm M, Egner R, Koch B, et al. Isolation of autophagocytosis mutants of Saccharomyces cerevisiae. FEBS Lett. 1994;349:275-280.
-
(1994)
FEBS Lett
, vol.349
, pp. 275-280
-
-
Thumm, M.1
Egner, R.2
Koch, B.3
-
5
-
-
0001488499
-
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
-
Liang XH, Kleeman LK, Jiang HH, et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol. 1998;72:8586-8596.
-
(1998)
J Virol
, vol.72
, pp. 8586-8596
-
-
Liang, X.H.1
Kleeman, L.K.2
Jiang, H.H.3
-
6
-
-
0032545292
-
A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy
-
Mizushima N, Sugita H, Yoshimori T, Ohsumi Y. A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. J Biol Chem. 1998;273:33889-33892.
-
(1998)
J Biol Chem
, vol.273
, pp. 33889-33892
-
-
Mizushima, N.1
Sugita, H.2
Yoshimori, T.3
Ohsumi, Y.4
-
7
-
-
58049192897
-
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
-
Sun Q, FanW, Chen K, Ding X, Chen S, Zhong Q. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA. 2008;105:19211-19216.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19211-19216
-
-
Sun, Q.1
FanW Chen, K.2
Ding, X.3
Chen, S.4
Zhong, Q.5
-
8
-
-
59249089394
-
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
-
Itakura E, Kishi C, Inoue K, Mizushima N. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell. 2008;19:5360-5372.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 5360-5372
-
-
Itakura, E.1
Kishi, C.2
Inoue, K.3
Mizushima, N.4
-
9
-
-
43149090064
-
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
-
Hara T, Takamura A, Kishi C, et al. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol. 2008;181:497-510.
-
(2008)
J Cell Biol
, vol.181
, pp. 497-510
-
-
Hara, T.1
Takamura, A.2
Kishi, C.3
-
10
-
-
65249119430
-
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
-
Hosokawa N, Hara T, Kaizuka T, et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell. 2009;20:1981-1991.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1981-1991
-
-
Hosokawa, N.1
Hara, T.2
Kaizuka, T.3
-
11
-
-
66449083078
-
ULK1·ATG13·FIP200 Complexmediates mTOR signaling and is essential for autophagy
-
Ganley IG, Lam du H, Wang J, Ding X, Chen S, Jiang X. ULK1·ATG13·FIP200 Complexmediates mTOR signaling and is essential for autophagy. J Biol Chem. 2009;284:12297-12305.
-
(2009)
J Biol Chem
, vol.284
, pp. 12297-12305
-
-
Ganley, I.G.1
Lam Du, H.2
Wang, J.3
Ding, X.4
Chen, S.5
Jiang, X.6
-
12
-
-
34250864795
-
Protein turnover via autophagy: Implications for metabolism
-
DOI 10.1146/annurev.nutr.27.061406.093749
-
Mizushima N, Klionsky DJ. Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr. 2007;27:19-40. (Pubitemid 351373346)
-
(2007)
Annual Review of Nutrition
, vol.27
, pp. 19-40
-
-
Mizushima, N.1
Klionsky, D.J.2
-
14
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature. 2008;451:1069-1075.
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
15
-
-
48949098967
-
New insights into the mechanisms of macroautophagy in mammalian cells
-
Eskelinen EL. New insights into the mechanisms of macroautophagy in mammalian cells. Int Rev Cell Mol Biol. 2008;266:207-247.
-
(2008)
Int Rev Cell Mol Biol
, vol.266
, pp. 207-247
-
-
Eskelinen, E.L.1
-
16
-
-
33749055522
-
Autophagy: A cell repair mechanism that retards ageing and age-associated diseases and can be intensified pharmacologically
-
Bergamini E. Autophagy: a cell repair mechanism that retards ageing and age-associated diseases and can be intensified pharmacologically. Mol Aspects Med. 2006;27:403-410.
-
(2006)
Mol Aspects Med
, vol.27
, pp. 403-410
-
-
Bergamini, E.1
-
17
-
-
38549101188
-
Quality control of mitochondria: Protection against neurodegeneration and ageing
-
Tatsuta T, Langer T. Quality control of mitochondria: protection against neurodegeneration and ageing. EMBO J. 2008;27:306-314.
-
(2008)
EMBO J
, vol.27
, pp. 306-314
-
-
Tatsuta, T.1
Langer, T.2
-
18
-
-
33748413303
-
Intracellular quality control by autophagy: How does autophagy prevent neurodegeneration?
-
Mizushima N, Hara T. Intracellular quality control by autophagy: how does autophagy prevent neurodegeneration? Autophagy. 2006;2:302-304.
-
(2006)
Autophagy
, vol.2
, pp. 302-304
-
-
Mizushima, N.1
Hara, T.2
-
19
-
-
1842583789
-
Development by self-digestion: Molecular mechanisms and biological functions of autophagy
-
Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 2004;6:463-477.
-
(2004)
Dev Cell
, vol.6
, pp. 463-477
-
-
Levine, B.1
Klionsky, D.J.2
-
20
-
-
13244256806
-
Escape of intracellular Shigella from autophagy
-
Ogawa M, Yoshimori T, Suzuki T, Sagara H, Mizushima N, Sasakawa C. Escape of intracellular Shigella from autophagy. Science. 2005;307:727-731.
-
(2005)
Science
, vol.307
, pp. 727-731
-
-
Ogawa, M.1
Yoshimori, T.2
Suzuki, T.3
Sagara, H.4
Mizushima, N.5
Sasakawa, C.6
-
21
-
-
0024797192
-
Mechanism and control of protein and RNA degradation in the rat hepatocyte: Two modes of autophagic sequestration
-
Mortimore GE, Lardeux BR, Heydrick SJ. Mechanism and control of protein and RNA degradation in the rat hepatocyte: two modes of autophagic sequestration. Revis Biol Celular. 1989;20:79-96.
-
(1989)
Revis Biol Celular
, vol.20
, pp. 79-96
-
-
Mortimore, G.E.1
Lardeux, B.R.2
Heydrick, S.J.3
-
22
-
-
0034757896
-
A novel assay to study autophagy: Regulation of autophagosome vacuole size by amino acid deprivation
-
Munafó DB, Colombo MI. A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. J Cell Sci. 2001;114:3619-3629.
-
(2001)
J Cell Sci
, vol.114
, pp. 3619-3629
-
-
Munafó, D.B.1
Colombo, M.I.2
-
23
-
-
0345742550
-
An electron microscopic and biochemical study of the effects of glucagon on glycogen autophagy in the liver and heart of newborn rats
-
Kondomerkos DJ, Kalamidas SA, Kotoulas OB. An electron microscopic and biochemical study of the effects of glucagon on glycogen autophagy in the liver and heart of newborn rats. Microsc Res Tech. 2004;63:87-93.
-
(2004)
Microsc Res Tech
, vol.63
, pp. 87-93
-
-
Kondomerkos, D.J.1
Kalamidas, S.A.2
Kotoulas, O.B.3
-
24
-
-
24744445331
-
Amino acid deprivation induces both apoptosis and autophagy in murine C2C12 muscle cells
-
Martinet W, De Meyer GR, Herman AG, Kockx MM. Amino acid deprivation induces both apoptosis and autophagy in murine C2C12 muscle cells. Biotechnol Lett. 2005;27:1157-1163.
-
(2005)
Biotechnol Lett
, vol.27
, pp. 1157-1163
-
-
Martinet, W.1
De Meyer, G.R.2
Herman, A.G.3
Kockx, M.M.4
-
25
-
-
62949091373
-
Autophagy: A lysosomal degradation pathway with a central role in health and disease
-
Eskelinen EL, Saftig P. Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta. 2009;1793:664-673.
-
(2009)
Biochim Biophys Acta
, vol.1793
, pp. 664-673
-
-
Eskelinen, E.L.1
Saftig, P.2
-
26
-
-
34848886914
-
Autophagosome formation: Core machinery and adaptations
-
Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol. 2007;9:1102-1109.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1102-1109
-
-
Xie, Z.1
Klionsky, D.J.2
-
27
-
-
50249154070
-
In vivo reconstitution of autophagy in Saccharomyces cerevisiae
-
Cao Y, Cheong H, Song H, Klionsky DJ. In vivo reconstitution of autophagy in Saccharomyces cerevisiae. J Cell Biol. 2008;182:703-713.
-
(2008)
J Cell Biol
, vol.182
, pp. 703-713
-
-
Cao, Y.1
Cheong, H.2
Song, H.3
Klionsky, D.J.4
-
28
-
-
34548482499
-
SiRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy
-
Chan EY, Kir S, Tooze SA. siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem. 2007;282:25464-25474.
-
(2007)
J Biol Chem
, vol.282
, pp. 25464-25474
-
-
Chan, E.Y.1
Kir, S.2
Tooze, S.A.3
-
29
-
-
58149473473
-
Kinaseinactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism
-
Chan EY, Longatti A, McKnight NC, Tooze SA. Kinaseinactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol. 2009;29:157-171.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 157-171
-
-
Chan, E.Y.1
Longatti, A.2
McKnight, N.C.3
Tooze, S.A.4
-
30
-
-
4344563878
-
Role and regulation of starvation-induced autophagy in the Drosophila fat body
-
Scott RC, Schuldiner O, Neufeld TP. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell. 2004;7:167-178.
-
(2004)
Dev Cell
, vol.7
, pp. 167-178
-
-
Scott, R.C.1
Schuldiner, O.2
Neufeld, T.P.3
-
31
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
-
Jung CH, Jun CB, Ro SH, et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell. 2009;20:1992-2003.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1992-2003
-
-
Jung, C.H.1
Jun, C.B.2
Ro, S.H.3
-
32
-
-
33846514235
-
Hierarchy of Atg proteins in pre-autophagosomal structure organization
-
Suzuki K, Kubota Y, Sekito T, Ohsumi Y. Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells. 2007;12:209-218.
-
(2007)
Genes Cells
, vol.12
, pp. 209-218
-
-
Suzuki, K.1
Kubota, Y.2
Sekito, T.3
Ohsumi, Y.4
-
33
-
-
0026556814
-
Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast
-
Dever TE, Feng L, Wek RC, Cigan AM, Donahue TF, Hinnebusch AG. Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell. 1992;68:585-596.
-
(1992)
Cell
, vol.68
, pp. 585-596
-
-
Dever, T.E.1
Feng, L.2
Wek, R.C.3
Cigan, A.M.4
Donahue, T.F.5
Hinnebusch, A.G.6
-
34
-
-
0037039442
-
Regulation of starvationand virus-induced autophagy by the eIF2alpha kinase signaling pathway
-
Tallóczy Z, Jiang W, Virgin HW, et al. Regulation of starvationand virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci USA. 2002;99:190-195.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 190-195
-
-
Tallóczy, Z.1
Jiang, W.2
Virgin, H.W.3
-
35
-
-
4344650113
-
Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2
-
Anthony TG, McDaniel BJ, Byerley RL, et al. Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem. 2004;279:36553-36561.
-
(2004)
J Biol Chem
, vol.279
, pp. 36553-36561
-
-
Anthony, T.G.1
McDaniel, B.J.2
Byerley, R.L.3
-
36
-
-
11144245626
-
The role of autophagy during the early neonatal starvation period
-
Kuma A, Hatano M, Matsui M, et al. The role of autophagy during the early neonatal starvation period. Nature. 2004;432:1032-1036.
-
(2004)
Nature
, vol.432
, pp. 1032-1036
-
-
Kuma, A.1
Hatano, M.2
Matsui, M.3
-
37
-
-
21044455137
-
Impairment of starvationinduced and constitutive autophagy in Atg7-deficient mice
-
Komatsu M,Waguri S, Ueno T, et al. Impairment of starvationinduced and constitutive autophagy in Atg7-deficient mice. J Cell Biol. 2005;169:425-434.
-
(2005)
J Cell Biol
, vol.169
, pp. 425-434
-
-
Komatsu, M.1
Waguri, S.2
Ueno, T.3
-
38
-
-
21644475161
-
Glycogen autophagy in the liver and heart of newborn rats. The effects of glucagon, adrenalin or rapamycin
-
Kondomerkos DJ, Kalamidas SA, Kotoulas OB, Hann AC. Glycogen autophagy in the liver and heart of newborn rats. The effects of glucagon, adrenalin or rapamycin. Histol Histopathol. 2005;20:689-696.
-
(2005)
Histol Histopathol
, vol.20
, pp. 689-696
-
-
Kondomerkos, D.J.1
Kalamidas, S.A.2
Kotoulas, O.B.3
Hann, A.C.4
-
39
-
-
0035503594
-
The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation
-
Suzuki K, Kirisako T, Kamada Y, Mizushima N, Noda T, Ohsumi Y. The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J. 2001;20:5971-5981.
-
(2001)
EMBO J
, vol.20
, pp. 5971-5981
-
-
Suzuki, K.1
Kirisako, T.2
Kamada, Y.3
Mizushima, N.4
Noda, T.5
Ohsumi, Y.6
-
40
-
-
43149125546
-
Organization of the pre-autophagosomal structure responsible for autophagosome formation
-
Kawamata T, Kamada Y, Kabeya Y, Sekito T, Ohsumi Y. Organization of the pre-autophagosomal structure responsible for autophagosome formation. Mol Biol Cell. 2008;19:2039-2050.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 2039-2050
-
-
Kawamata, T.1
Kamada, Y.2
Kabeya, Y.3
Sekito, T.4
Ohsumi, Y.5
-
41
-
-
50249084987
-
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
-
Axe EL,Walker SA, Manifava M, et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol. 2008;182:685-701.
-
(2008)
J Cell Biol
, vol.182
, pp. 685-701
-
-
Axe, E.L.1
Walker, S.A.2
Manifava, M.3
-
42
-
-
0035911162
-
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
-
Mizushima N, Yamamoto A, Hatano M, et al. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol. 2001;152:657-668.
-
(2001)
J Cell Biol
, vol.152
, pp. 657-668
-
-
Mizushima, N.1
Yamamoto, A.2
Hatano, M.3
-
43
-
-
0038325675
-
Mouse Apg16L, a novelWD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
-
Mizushima N, Kuma A, Kobayashi Y, et al. Mouse Apg16L, a novelWD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci. 2003;116:1679-1688.
-
(2003)
J Cell Sci
, vol.116
, pp. 1679-1688
-
-
Mizushima, N.1
Kuma, A.2
Kobayashi, Y.3
-
44
-
-
33750366092
-
Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes
-
Young AR, Chan EY, Hu XW, et al. Starvation and ULK1- dependent cycling of mammalian Atg9 between the TGN and endosomes. J Cell Sci. 2006;119:3888-3900.
-
(2006)
J Cell Sci
, vol.119
, pp. 3888-3900
-
-
Young, A.R.1
Chan, E.Y.2
Hu, X.W.3
-
45
-
-
0034687074
-
Double FYVE-containing protein 1 (DFCP1): Isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library
-
Derubeis AR, Young MF, Jia L, Robey PG, Fisher LW. Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library. Gene. 2000;255:195-203.
-
(2000)
Gene
, vol.255
, pp. 195-203
-
-
Derubeis, A.R.1
Young, M.F.2
Jia, L.3
Robey, P.G.4
Fisher, L.W.5
-
46
-
-
0035310983
-
Characterization of a novel phosphatidylinositol 3-phosphatebinding protein containing two FYVE fingers in tandem that is targeted to the Golgi
-
Cheung PC, Trinkle-Mulcahy L, Cohen P, Lucocq JM. Characterization of a novel phosphatidylinositol 3-phosphatebinding protein containing two FYVE fingers in tandem that is targeted to the Golgi. Biochem J. 2001;355:113-121.
-
(2001)
Biochem J
, vol.355
, pp. 113-121
-
-
Cheung, P.C.1
Trinkle-Mulcahy, L.2
Cohen, P.3
Lucocq, J.M.4
-
47
-
-
0035199161
-
FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments
-
Ridley SH, Ktistakis N, Davidson K, et al. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. J Cell Sci. 2001;114:3991-4000.
-
(2001)
J Cell Sci
, vol.114
, pp. 3991-4000
-
-
Ridley, S.H.1
Ktistakis, N.2
Davidson, K.3
-
48
-
-
58149097286
-
Making autophagosomes: Localized synthesis of phosphatidylinositol 3-phosphate holds the clue
-
Walker S, Chandra P, Manifava M, Axe E, Ktistakis NT. Making autophagosomes: localized synthesis of phosphatidylinositol 3-phosphate holds the clue. Autophagy. 2008;4:1093-1096.
-
(2008)
Autophagy
, vol.4
, pp. 1093-1096
-
-
Walker, S.1
Chandra, P.2
Manifava, M.3
Axe, E.4
Ktistakis, N.T.5
-
49
-
-
0035809160
-
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
-
Kihara A, Noda T, Ishihara N, Ohsumi Y. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol. 2001;152:519-530.
-
(2001)
J Cell Biol
, vol.152
, pp. 519-530
-
-
Kihara, A.1
Noda, T.2
Ishihara, N.3
Ohsumi, Y.4
-
50
-
-
0035032723
-
Beclinphosphatidylinositol 3-kinase complex functions at the trans-Golgi network
-
Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. Beclinphosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep. 2001;2:330-335.
-
(2001)
EMBO Rep
, vol.2
, pp. 330-335
-
-
Kihara, A.1
Kabeya, Y.2
Ohsumi, Y.3
Yoshimori, T.4
-
51
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
Pattingre S, Tassa A, Qu X, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 2005;122:927-939.
-
(2005)
Cell
, vol.122
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
-
52
-
-
59849113021
-
HVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells
-
Yan Y, Flinn RJ, Wu H, Schnur RS, Backer JM. hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells. Biochem J. 2009;417:747-755.
-
(2009)
Biochem J
, vol.417
, pp. 747-755
-
-
Yan, Y.1
Flinn, R.J.2
Wu, H.3
Schnur, R.S.4
Backer, J.M.5
-
53
-
-
64049113909
-
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex
-
Zhong Y, Wang QJ, Li X, et al. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol. 2009;11:468-476.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 468-476
-
-
Zhong, Y.1
Wang, Q.J.2
Li, X.3
-
54
-
-
24044513985
-
Endothelial nitricoxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast
-
Yamada T, Carson AR, Caniggia I, et al. Endothelial nitricoxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast. J Biol Chem. 2005;280:18283-18290.
-
(2005)
J Biol Chem
, vol.280
, pp. 18283-18290
-
-
Yamada, T.1
Carson, A.R.2
Caniggia, I.3
-
56
-
-
26244457185
-
PpATG9 encodes a novel membrane protein that traffics to vacuolar membranes, which sequester peroxisomes during pexophagy in Pichia pastoris
-
Chang T, Schroder LA, Thomson JM, et al. PpATG9 encodes a novel membrane protein that traffics to vacuolar membranes, which sequester peroxisomes during pexophagy in Pichia pastoris. Mol Biol Cell. 2005;16:4941-4953.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 4941-4953
-
-
Chang, T.1
Schroder, L.A.2
Thomson, J.M.3
-
57
-
-
59449097721
-
Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy
-
He C, Baba M, Cao Y, Klionsky DJ. Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy. Mol Biol Cell. 2008;19:5506-5516.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 5506-5516
-
-
He, C.1
Baba, M.2
Cao, Y.3
Klionsky, D.J.4
-
58
-
-
0346503885
-
The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure
-
Reggiori F, Tucker KA, Stromhaug PE, Klionsky DJ. The Atg1- Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev Cell. 2004;6:79-90.
-
(2004)
Dev Cell
, vol.6
, pp. 79-90
-
-
Reggiori, F.1
Tucker, K.A.2
Stromhaug, P.E.3
Klionsky, D.J.4
-
59
-
-
34447276502
-
Human WIPI-1 puncta-formation: A novel assay to assess mammalian autophagy
-
Proikas-Cezanne T, Ruckerbauer S, Stierhof YD, Berg C, Nordheim A. Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy. FEBS Lett. 2007;581:3396-3404.
-
(2007)
FEBS Lett
, vol.581
, pp. 3396-3404
-
-
Proikas-Cezanne, T.1
Ruckerbauer, S.2
Stierhof, Y.D.3
Berg, C.4
Nordheim, A.5
-
60
-
-
11244289333
-
WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy
-
Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A. WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. Oncogene. 2004;23:9314-9325.
-
(2004)
Oncogene
, vol.23
, pp. 9314-9325
-
-
Proikas-Cezanne, T.1
Waddell, S.2
Gaugel, A.3
Frickey, T.4
Lupas, A.5
Nordheim, A.6
-
61
-
-
53049102656
-
The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function
-
Obara K, Sekito T, Niimi K, Ohsumi Y. The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function. J Biol Chem. 2008;283:23972-23980.
-
(2008)
J Biol Chem
, vol.283
, pp. 23972-23980
-
-
Obara, K.1
Sekito, T.2
Niimi, K.3
Ohsumi, Y.4
-
62
-
-
53549100450
-
Dynamics and function of PtdIns(3)P in autophagy
-
Obara K, Ohsumi Y. Dynamics and function of PtdIns(3)P in autophagy. Autophagy. 2008;4:952-954.
-
(2008)
Autophagy
, vol.4
, pp. 952-954
-
-
Obara, K.1
Ohsumi, Y.2
-
63
-
-
3342951135
-
Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy
-
Strømhaug PE, Reggiori F, Guan J, Wang CW, Klionsky DJ. Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy. Mol Biol Cell. 2004;15:3553-3566.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 3553-3566
-
-
Strømhaug, P.E.1
Reggiori, F.2
Guan, J.3
Wang, C.W.4
Klionsky, D.J.5
-
64
-
-
0032563798
-
A protein conjugation system essential for autophagy
-
Mizushima N, Noda T, Yoshimori T, et al. A protein conjugation system essential for autophagy. Nature. 1998;395:395-398.
-
(1998)
Nature
, vol.395
, pp. 395-398
-
-
Mizushima, N.1
Noda, T.2
Yoshimori, T.3
-
65
-
-
0033214582
-
Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast
-
DOI 10.1093/emboj/18.19.5234
-
Shintani T, Mizushima N, Ogawa Y, Matsuura A, Noda T, Ohsumi Y. Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast. EMBO J. 1999;18:5234-5241. (Pubitemid 29465574)
-
(1999)
EMBO Journal
, vol.18
, Issue.19
, pp. 5234-5241
-
-
Shintani, T.1
Mizushima, N.2
Ogawa, Y.3
Matsuura, A.4
Noda, T.5
Ohsumi, Y.6
-
66
-
-
0032898636
-
Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy
-
Tanida I,Mizushima N, KiyookaM, et al. Apg7p/Cvt2p: a novel protein-activating enzyme essential for autophagy. Mol Biol Cell. 1999;10:1367-1379. (Pubitemid 29230896)
-
(1999)
Molecular Biology of the Cell
, vol.10
, Issue.5
, pp. 1367-1379
-
-
Tanida, I.1
Mizushima, N.2
Kiyooka, M.3
Ohsumi, M.4
Ueno, T.5
Ohsumi, Y.6
Kominami, E.7
-
67
-
-
0037134443
-
Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p
-
Tanida I, Tanida-Miyake E, Komatsu M, Ueno T, Kominami E. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. J Biol Chem. 2002;277:13739-13744.
-
(2002)
J Biol Chem
, vol.277
, pp. 13739-13744
-
-
Tanida, I.1
Tanida-Miyake, E.2
Komatsu, M.3
Ueno, T.4
Kominami, E.5
-
69
-
-
0034707036
-
A ubiquitin-like system mediates protein lipidation
-
Ichimura Y, Kirisako T, Takao T, et al. A ubiquitin-like system mediates protein lipidation. Nature. 2000;408:488-492.
-
(2000)
Nature
, vol.408
, pp. 488-492
-
-
Ichimura, Y.1
Kirisako, T.2
Takao, T.3
-
70
-
-
0035286734
-
Molecular dissection of autophagy: Two ubiquitinlike systems
-
Ohsumi Y. Molecular dissection of autophagy: two ubiquitinlike systems. Nat Rev Mol Cell Biol. 2001;2:211-216.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 211-216
-
-
Ohsumi, Y.1
-
71
-
-
33846207543
-
Stimulation of ATG12-ATG5 conjugation by ribonucleic acid
-
Shao Y, Gao Z, Feldman T, Jiang X. Stimulation of ATG12-ATG5 conjugation by ribonucleic acid. Autophagy. 2007;3:10-16.
-
(2007)
Autophagy
, vol.3
, pp. 10-16
-
-
Shao, Y.1
Gao, Z.2
Feldman, T.3
Jiang, X.4
-
72
-
-
4344696843
-
The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8
-
Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F. The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8. Genes Cells. 2004;9:611-618.
-
(2004)
Genes Cells
, vol.9
, pp. 611-618
-
-
Sugawara, K.1
Suzuki, N.N.2
Fujioka, Y.3
Mizushima, N.4
Ohsumi, Y.5
Inagaki, F.6
-
73
-
-
33644590635
-
The crystal structure of plant ATG12 and its biological implication in autophagy
-
Suzuki NN, Yoshimoto K, Fujioka Y, Ohsumi Y, Inagaki F. The crystal structure of plant ATG12 and its biological implication in autophagy. Autophagy. 2005;1:119-126.
-
(2005)
Autophagy
, vol.1
, pp. 119-126
-
-
Suzuki, N.N.1
Yoshimoto, K.2
Fujioka, Y.3
Ohsumi, Y.4
Inagaki, F.5
-
74
-
-
38049098543
-
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy
-
Hanada T, Noda NN, Satomi Y, et al. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem. 2007;282:37298-37302.
-
(2007)
J Biol Chem
, vol.282
, pp. 37298-37302
-
-
Hanada, T.1
Noda, N.N.2
Satomi, Y.3
-
75
-
-
43949143804
-
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy
-
Fujita N, Itoh T, Omori H, Fukuda M, Noda T, Yoshimori T. The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell. 2008;19:2092-2100.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 2092-2100
-
-
Fujita, N.1
Itoh, T.2
Omori, H.3
Fukuda, M.4
Noda, T.5
Yoshimori, T.6
-
76
-
-
47549092694
-
Atg8 controls phagophore expansion during autophagosome formation
-
Xie Z, Nair U, Klionsky DJ. Atg8 controls phagophore expansion during autophagosome formation. Mol Biol Cell. 2008;19:3290-3298.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 3290-3298
-
-
Xie, Z.1
Nair, U.2
Klionsky, D.J.3
-
77
-
-
57549094368
-
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice
-
Sou YS, Waguri S, Iwata J, et al. The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell. 2008;19:4762-4775.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 4762-4775
-
-
Sou, Y.S.1
Waguri, S.2
Iwata, J.3
-
78
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000;19:5720-5728.
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
-
79
-
-
0034676037
-
The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
-
Kirisako T, Ichimura Y, Okada H, et al. The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol. 2000;151:263-276.
-
(2000)
J Cell Biol
, vol.151
, pp. 263-276
-
-
Kirisako, T.1
Ichimura, Y.2
Okada, H.3
-
80
-
-
9144224360
-
Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes
-
Tanida I, Ueno T, Kominami E. Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. J Biol Chem. 2004;279:47704-47710.
-
(2004)
J Biol Chem
, vol.279
, pp. 47704-47710
-
-
Tanida, I.1
Ueno, T.2
Kominami, E.3
-
81
-
-
4344604111
-
HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidatesmicrotubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates
-
Tanida I, Sou YS, Ezaki J, Minematsu-Ikeguchi N, Ueno T, Kominami E. HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidatesmicrotubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. J Biol Chem. 2004;279:36268-36276.
-
(2004)
J Biol Chem
, vol.279
, pp. 36268-36276
-
-
Tanida, I.1
Sou, Y.S.2
Ezaki, J.3
Minematsu-Ikeguchi, N.4
Ueno, T.5
Kominami, E.6
-
82
-
-
0034050457
-
The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways
-
Huang WP, Scott SV, Kim J, Klionsky DJ. The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways. J Biol Chem. 2000;275:5845-5851.
-
(2000)
J Biol Chem
, vol.275
, pp. 5845-5851
-
-
Huang, W.P.1
Scott, S.V.2
Kim, J.3
Klionsky, D.J.4
-
83
-
-
27944504351
-
P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
-
Bjørkøy G, Lamark T, Brech A, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol. 2005;171:603-614.
-
(2005)
J Cell Biol
, vol.171
, pp. 603-614
-
-
Bjørkøy, G.1
Lamark, T.2
Brech, A.3
-
84
-
-
34548259958
-
P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
-
Pankiv S, Clausen TH, Lamark T, et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem. 2007;282: 24131-24145.
-
(2007)
J Biol Chem
, vol.282
, pp. 24131-24145
-
-
Pankiv, S.1
Clausen, T.H.2
Lamark, T.3
-
86
-
-
61649083269
-
Indirect estimation of the area density of Atg8 on the phagophore
-
Xie Z, Nair U, Geng J, Szefler MB, Rothman ED, Klionsky DJ. Indirect estimation of the area density of Atg8 on the phagophore. Autophagy. 2009;5:217-220.
-
(2009)
Autophagy
, vol.5
, pp. 217-220
-
-
Xie, Z.1
Nair, U.2
Geng, J.3
Szefler, M.B.4
Rothman, E.D.5
Klionsky, D.J.6
-
87
-
-
40449139980
-
The itinerary of autophagosomes: From peripheral formation to kiss-and-run fusion with lysosomes
-
Jahreiss L, Menzies FM, Rubinsztein DC. The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes. Traffic. 2008;9:574-587.
-
(2008)
Traffic
, vol.9
, pp. 574-587
-
-
Jahreiss, L.1
Menzies, F.M.2
Rubinsztein, D.C.3
-
88
-
-
24744441497
-
Autophagy is required formaintenance of amino acid levels and protein synthesis under nitrogen starvation
-
Onodera J, Ohsumi Y. Autophagy is required formaintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem. 2005;280:31582-31586.
-
(2005)
J Biol Chem
, vol.280
, pp. 31582-31586
-
-
Onodera, J.1
Ohsumi, Y.2
-
89
-
-
0005677775
-
3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
-
Seglen PO, Gordon PB. 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci USA. 1982;79:1889-1892.
-
(1982)
Proc Natl Acad Sci USA
, vol.79
, pp. 1889-1892
-
-
Seglen, P.O.1
Gordon, P.B.2
-
90
-
-
1542283812
-
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
-
Mizushima N, Yamamoto A,Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell. 2004;15:1101-1111.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 1101-1111
-
-
Mizushima, N.1
Yamamoto, A.2
Matsui, M.3
Yoshimori, T.4
Ohsumi, Y.5
|