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Volumn 393, Issue 2, 2014, Pages 270-281

Dynamics of BMP signaling in limb bud mesenchyme and polydactyly

Author keywords

BMP; Chondrogenesis; FGF; Gremlin; Limb development; Polydactyly; Sox9

Indexed keywords

BONE MORPHOGENETIC PROTEIN; GREMLIN; MEMBRANE PROTEIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG; BMP2 PROTEIN, MOUSE; BMP4 PROTEIN, MOUSE; BMP7 PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CKTSF1B1 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR; GREM1 PROTEIN, MOUSE; OSTEOGENIC PROTEIN 1; SIGNAL PEPTIDE; SOX9 PROTEIN, MOUSE;

EID: 84921667169     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2014.07.003     Document Type: Article
Times cited : (27)

References (72)
  • 1
    • 0035204194 scopus 로고    scopus 로고
    • BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb
    • Ahn K., Mishina Y., Hanks M.C., Behringer R.R., Crenshaw E.B. BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb. Development 2001, 128:4449-4461.
    • (2001) Development , vol.128 , pp. 4449-4461
    • Ahn, K.1    Mishina, Y.2    Hanks, M.C.3    Behringer, R.R.4    Crenshaw, E.B.5
  • 2
    • 79958207835 scopus 로고    scopus 로고
    • Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function
    • Allen B.L., Song J.Y., Izzi L., Althaus I.W., Kang J.S., Charron F., Krauss R.S., McMahon A.P. Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. Dev. Cell 2011, 20:775-787.
    • (2011) Dev. Cell , vol.20 , pp. 775-787
    • Allen, B.L.1    Song, J.Y.2    Izzi, L.3    Althaus, I.W.4    Kang, J.S.5    Charron, F.6    Krauss, R.S.7    McMahon, A.P.8
  • 3
    • 84871779767 scopus 로고    scopus 로고
    • Digit patterning during limb development as a result of the BMP-receptor interaction
    • Badugu A., Kraemer C., Germann P., Menshykau D., Iber D. Digit patterning during limb development as a result of the BMP-receptor interaction. Sci. Rep. 2012, 2:991.
    • (2012) Sci. Rep. , vol.2 , pp. 991
    • Badugu, A.1    Kraemer, C.2    Germann, P.3    Menshykau, D.4    Iber, D.5
  • 4
    • 33845971522 scopus 로고    scopus 로고
    • Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis
    • Bandyopadhyay A., Tsuji K., Cox K., Harfe B.D., Rosen V., Tabin C.J. Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet. 2006, 2:e216.
    • (2006) PLoS Genet. , vol.2 , pp. e216
    • Bandyopadhyay, A.1    Tsuji, K.2    Cox, K.3    Harfe, B.D.4    Rosen, V.5    Tabin, C.J.6
  • 5
    • 34249658452 scopus 로고    scopus 로고
    • Visualization of cartilage formation: insight into cellular properties of skeletal progenitors and chondrodysplasia syndromes
    • Barna M., Niswander L. Visualization of cartilage formation: insight into cellular properties of skeletal progenitors and chondrodysplasia syndromes. Dev. Cell 2007, 12:931-941.
    • (2007) Dev. Cell , vol.12 , pp. 931-941
    • Barna, M.1    Niswander, L.2
  • 6
    • 0037314332 scopus 로고    scopus 로고
    • Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge
    • Barrow J.R., Thomas K.R., Boussadia-Zahui O., Moore R., Kemler R., Capecchi M.R., McMahon A.P. Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev. 2003, 17:394-409.
    • (2003) Genes Dev. , vol.17 , pp. 394-409
    • Barrow, J.R.1    Thomas, K.R.2    Boussadia-Zahui, O.3    Moore, R.4    Kemler, R.5    Capecchi, M.R.6    McMahon, A.P.7
  • 7
    • 70450191821 scopus 로고    scopus 로고
    • A BMP-Shh negative-feedback loop restricts Shh expression during limb development
    • Bastida M.F., Sheth R., Ros M.A. A BMP-Shh negative-feedback loop restricts Shh expression during limb development. Development 2009, 136:3779-3789.
    • (2009) Development , vol.136 , pp. 3779-3789
    • Bastida, M.F.1    Sheth, R.2    Ros, M.A.3
  • 10
    • 84867856630 scopus 로고    scopus 로고
    • Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds
    • Benazet J.D., Pignatti E., Nugent A., Unal E., Laurent F., Zeller R. Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds. Development 2012, 139:4250-4260.
    • (2012) Development , vol.139 , pp. 4250-4260
    • Benazet, J.D.1    Pignatti, E.2    Nugent, A.3    Unal, E.4    Laurent, F.5    Zeller, R.6
  • 11
    • 84884710795 scopus 로고    scopus 로고
    • Dual requirement of ectodermal Smad4 during AER formation and termination of feedback signaling in mouse limb buds
    • Benazet J.D., Zeller R. Dual requirement of ectodermal Smad4 during AER formation and termination of feedback signaling in mouse limb buds. Genesis 2013, 51:660-666.
    • (2013) Genesis , vol.51 , pp. 660-666
    • Benazet, J.D.1    Zeller, R.2
  • 13
    • 79955002013 scopus 로고    scopus 로고
    • Polydactyly: how many disorders and how many genes? 2010 update
    • Biesecker L.G. Polydactyly: how many disorders and how many genes? 2010 update. Dev. Dyn. 2011, 240:931-942.
    • (2011) Dev. Dyn. , vol.240 , pp. 931-942
    • Biesecker, L.G.1
  • 15
    • 0033231553 scopus 로고    scopus 로고
    • Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin
    • Capdevila J., Tsukui T., Rodriquez Esteban C., Zappavigna V., Izpisua Belmonte J.C. Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Mol. Cell 1999, 4:839-849.
    • (1999) Mol. Cell , vol.4 , pp. 839-849
    • Capdevila, J.1    Tsukui, T.2    Rodriquez Esteban, C.3    Zappavigna, V.4    Izpisua Belmonte, J.C.5
  • 16
    • 84861470954 scopus 로고    scopus 로고
    • Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth
    • Choi K.S., Lee C., Maatouk D.M., Harfe B.D. Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth. PLoS One 2012, 7:e37826.
    • (2012) PLoS One , vol.7 , pp. e37826
    • Choi, K.S.1    Lee, C.2    Maatouk, D.M.3    Harfe, B.D.4
  • 17
    • 79957610561 scopus 로고    scopus 로고
    • Initiation of proximal-distal patterning in the vertebrate limb by signals and growth
    • Cooper K.L., Hu J.K., ten Berge D., Fernandez-Teran M., Ros M.A., Tabin C.J. Initiation of proximal-distal patterning in the vertebrate limb by signals and growth. Science 2011, 332:1083-1086.
    • (2011) Science , vol.332 , pp. 1083-1086
    • Cooper, K.L.1    Hu, J.K.2    ten Berge, D.3    Fernandez-Teran, M.4    Ros, M.A.5    Tabin, C.J.6
  • 18
    • 0031571651 scopus 로고    scopus 로고
    • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4
    • Dunn N.R., Winnier G.E., Hargett L.K., Schrick J.J., Fogo A.B., Hogan B.L. Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev. Biol. 1997, 188:235-247.
    • (1997) Dev. Biol. , vol.188 , pp. 235-247
    • Dunn, N.R.1    Winnier, G.E.2    Hargett, L.K.3    Schrick, J.J.4    Fogo, A.B.5    Hogan, B.L.6
  • 19
    • 0032740678 scopus 로고    scopus 로고
    • In Xenopus embryos, BMP heterodimers are not required for mesoderm induction, but BMP activity is necessary for dorsal/ventral patterning
    • Eimon P.M., Harland R.M. In Xenopus embryos, BMP heterodimers are not required for mesoderm induction, but BMP activity is necessary for dorsal/ventral patterning. Dev. Biol. 1999, 216:29-40.
    • (1999) Dev. Biol. , vol.216 , pp. 29-40
    • Eimon, P.M.1    Harland, R.M.2
  • 21
    • 84868293628 scopus 로고    scopus 로고
    • Use of LysoTracker to detect programmed cell death in embryos and differentiating embryonic stem cells
    • (Pubmed ID# 23092960)
    • Fogel J.L., Thein T.Z., Mariani F.V. Use of LysoTracker to detect programmed cell death in embryos and differentiating embryonic stem cells. J. Vis. Exp. 2012, 68:4254. (Pubmed ID# 23092960).
    • (2012) J. Vis. Exp. , vol.68 , pp. 4254
    • Fogel, J.L.1    Thein, T.Z.2    Mariani, F.V.3
  • 23
    • 78649320392 scopus 로고    scopus 로고
    • WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb bud
    • Gros J., Hu J.K., Vinegoni C., Feruglio P.F., Weissleder R., Tabin C.J. WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb bud. Curr. Biol. 2010, 20:1993-2002.
    • (2010) Curr. Biol. , vol.20 , pp. 1993-2002
    • Gros, J.1    Hu, J.K.2    Vinegoni, C.3    Feruglio, P.F.4    Weissleder, R.5    Tabin, C.J.6
  • 24
    • 4644328190 scopus 로고    scopus 로고
    • Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    • Harfe B.D., Scherz P.J., Nissim S., Tian H., McMahon A.P., Tabin C.J. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 2004, 118:517-528.
    • (2004) Cell , vol.118 , pp. 517-528
    • Harfe, B.D.1    Scherz, P.J.2    Nissim, S.3    Tian, H.4    McMahon, A.P.5    Tabin, C.J.6
  • 25
    • 0030828073 scopus 로고    scopus 로고
    • Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
    • Hendzel M.J., Wei Y., Mancini M.A., Van Hooser A., Ranalli T., Brinkley B.R., Bazett-Jones D.P., Allis C.D. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 1997, 106:348-360.
    • (1997) Chromosoma , vol.106 , pp. 348-360
    • Hendzel, M.J.1    Wei, Y.2    Mancini, M.A.3    Van Hooser, A.4    Ranalli, T.5    Brinkley, B.R.6    Bazett-Jones, D.P.7    Allis, C.D.8
  • 26
    • 0032039482 scopus 로고    scopus 로고
    • The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities
    • Hsu D.R., Economides A.N., Wang X., Eimon P.M., Harland R.M. The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol. Cell 1998, 1:673-683.
    • (1998) Mol. Cell , vol.1 , pp. 673-683
    • Hsu, D.R.1    Economides, A.N.2    Wang, X.3    Eimon, P.M.4    Harland, R.M.5
  • 28
    • 0037743636 scopus 로고    scopus 로고
    • Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning
    • Khokha M.K., Hsu D., Brunet L.J., Dionne M.S., Harland R.M. Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat. Genet. 2003, 34:303-307.
    • (2003) Nat. Genet. , vol.34 , pp. 303-307
    • Khokha, M.K.1    Hsu, D.2    Brunet, L.J.3    Dionne, M.S.4    Harland, R.M.5
  • 29
    • 0030249917 scopus 로고    scopus 로고
    • Sequential changes of programmed cell death in developing fetal mouse limbs and its possible roles in limb morphogenesis
    • Kimura S., Shiota K. Sequential changes of programmed cell death in developing fetal mouse limbs and its possible roles in limb morphogenesis. J. Morphol. 1996, 229:337-346.
    • (1996) J. Morphol. , vol.229 , pp. 337-346
    • Kimura, S.1    Shiota, K.2
  • 31
    • 23144435172 scopus 로고    scopus 로고
    • Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development
    • Lallemand Y., Nicola M.A., Ramos C., Bach A., Cloment C.S., Robert B. Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development. Development 2005, 132:3003-3014.
    • (2005) Development , vol.132 , pp. 3003-3014
    • Lallemand, Y.1    Nicola, M.A.2    Ramos, C.3    Bach, A.4    Cloment, C.S.5    Robert, B.6
  • 32
    • 0033673531 scopus 로고    scopus 로고
    • Fgf8 signalling from the AER is essential for normal limb development
    • Lewandoski M., Sun X., Martin G.R. Fgf8 signalling from the AER is essential for normal limb development. Nat. Genet. 2000, 26:460-463.
    • (2000) Nat. Genet. , vol.26 , pp. 460-463
    • Lewandoski, M.1    Sun, X.2    Martin, G.R.3
  • 33
    • 84902545767 scopus 로고    scopus 로고
    • Manipulating gene expression and signaling activity in cultured mouse limb bud cells
    • Lewandowski J.P., Pursell T.A., Rabinowitz A.H., Vokes S.A. Manipulating gene expression and signaling activity in cultured mouse limb bud cells. Dev. Dyn. 2014, 243:928-936.
    • (2014) Dev. Dyn. , vol.243 , pp. 928-936
    • Lewandowski, J.P.1    Pursell, T.A.2    Rabinowitz, A.H.3    Vokes, S.A.4
  • 34
    • 84899628610 scopus 로고    scopus 로고
    • A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud
    • Li Q., Lewandowski J.P., Powell M.B., Norrie J.L., Cho S.H., Vokes S.A. A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud. Development 2014, 141:1906-1914.
    • (2014) Development , vol.141 , pp. 1906-1914
    • Li, Q.1    Lewandowski, J.P.2    Powell, M.B.3    Norrie, J.L.4    Cho, S.H.5    Vokes, S.A.6
  • 35
    • 0037194765 scopus 로고    scopus 로고
    • Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
    • Litingtung Y., Dahn R.D., Li Y., Fallon J.F., Chiang C. Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature 2002, 418:979-983.
    • (2002) Nature , vol.418 , pp. 979-983
    • Litingtung, Y.1    Dahn, R.D.2    Li, Y.3    Fallon, J.F.4    Chiang, C.5
  • 36
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 37
    • 74549174645 scopus 로고    scopus 로고
    • Introduction to the quantitative analysis of two-dimensional fluorescence microscopy images for cell-based screening
    • Ljosa V., Carpenter A.E. Introduction to the quantitative analysis of two-dimensional fluorescence microscopy images for cell-based screening. PLoS Comput. Biol. 2009, 5:e1000603.
    • (2009) PLoS Comput. Biol. , vol.5 , pp. e1000603
    • Ljosa, V.1    Carpenter, A.E.2
  • 38
    • 0036076389 scopus 로고    scopus 로고
    • Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer
    • Logan M., Martin J.F., Nagy A., Lobe C., Olson E.N., Tabin C.J. Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 2002, 33:77-80.
    • (2002) Genesis , vol.33 , pp. 77-80
    • Logan, M.1    Martin, J.F.2    Nagy, A.3    Lobe, C.4    Olson, E.N.5    Tabin, C.J.6
  • 40
    • 31644445191 scopus 로고    scopus 로고
    • Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function
    • Lu P., Minowada G., Martin G.R. Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function. Development 2006, 133:33-42.
    • (2006) Development , vol.133 , pp. 33-42
    • Lu, P.1    Minowada, G.2    Martin, G.R.3
  • 41
    • 43749110077 scopus 로고    scopus 로고
    • Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning
    • Mariani F.V., Ahn C.P., Martin G.R. Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning. Nature 2008, 453:401-405.
    • (2008) Nature , vol.453 , pp. 401-405
    • Mariani, F.V.1    Ahn, C.P.2    Martin, G.R.3
  • 42
    • 4243180526 scopus 로고    scopus 로고
    • Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis
    • Michos O., Panman L., Vintersten K., Beier K., Zeller R., Zuniga A. Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 2004, 131:3401-3410.
    • (2004) Development , vol.131 , pp. 3401-3410
    • Michos, O.1    Panman, L.2    Vintersten, K.3    Beier, K.4    Zeller, R.5    Zuniga, A.6
  • 43
    • 0020962910 scopus 로고
    • Hereditary and induced modifications of the normal necrotic patterns in the developing limb buds of the rat and mouse - facts and hypotheses
    • Milaire J., Rooze M. Hereditary and induced modifications of the normal necrotic patterns in the developing limb buds of the rat and mouse - facts and hypotheses. Arch. Biol. 1983, 94:459-490.
    • (1983) Arch. Biol. , vol.94 , pp. 459-490
    • Milaire, J.1    Rooze, M.2
  • 45
    • 59649115857 scopus 로고    scopus 로고
    • Tamoxifen-dependent, inducible Hoxb6CreERT recombinase function in lateral plate and limb mesoderm, CNS isthmic organizer, posterior trunk neural crest, hindgut, and tailbud
    • Nguyen M.T., Zhu J., Nakamura E., Bao X., Mackem S. Tamoxifen-dependent, inducible Hoxb6CreERT recombinase function in lateral plate and limb mesoderm, CNS isthmic organizer, posterior trunk neural crest, hindgut, and tailbud. Dev. Dyn. 2009, 238:467-474.
    • (2009) Dev. Dyn. , vol.238 , pp. 467-474
    • Nguyen, M.T.1    Zhu, J.2    Nakamura, E.3    Bao, X.4    Mackem, S.5
  • 48
    • 34347329271 scopus 로고    scopus 로고
    • BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling
    • Pajni-Underwood S., Wilson C.P., Elder C., Mishina Y., Lewandoski M. BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling. Development 2007, 134:2359-2368.
    • (2007) Development , vol.134 , pp. 2359-2368
    • Pajni-Underwood, S.1    Wilson, C.P.2    Elder, C.3    Mishina, Y.4    Lewandoski, M.5
  • 49
    • 75149173505 scopus 로고    scopus 로고
    • Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development
    • Perez W.D., Weller C.R., Shou S., Stadler H.S. Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development. Dev. Dyn. 2010, 239:446-457.
    • (2010) Dev. Dyn. , vol.239 , pp. 446-457
    • Perez, W.D.1    Weller, C.R.2    Shou, S.3    Stadler, H.S.4
  • 51
    • 0035199029 scopus 로고    scopus 로고
    • BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb
    • Pizette S., Abate-Shen C., Niswander L. BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb. Development 2001, 128:4463-4474.
    • (2001) Development , vol.128 , pp. 4463-4474
    • Pizette, S.1    Abate-Shen, C.2    Niswander, L.3
  • 52
    • 0033042804 scopus 로고    scopus 로고
    • BMPs negatively regulate structure and function of the limb apical ectodermal ridge
    • Pizette S., Niswander L. BMPs negatively regulate structure and function of the limb apical ectodermal ridge. Development 1999, 126:883-894.
    • (1999) Development , vol.126 , pp. 883-894
    • Pizette, S.1    Niswander, L.2
  • 53
    • 84864050183 scopus 로고    scopus 로고
    • Integration of the transcriptional networks regulating limb morphogenesis
    • Rabinowitz A.H., Vokes S.A. Integration of the transcriptional networks regulating limb morphogenesis. Dev. Biol. 2012, 368:165-180.
    • (2012) Dev. Biol. , vol.368 , pp. 165-180
    • Rabinowitz, A.H.1    Vokes, S.A.2
  • 54
    • 84896301616 scopus 로고    scopus 로고
    • Diffusible signals and epigenetic timing cooperate in late proximo-distal limb patterning
    • Rosello-Diez A., Arques C.G., Delgado I., Giovinazzo G., Torres M. Diffusible signals and epigenetic timing cooperate in late proximo-distal limb patterning. Development 2014, 141:1534-1543.
    • (2014) Development , vol.141 , pp. 1534-1543
    • Rosello-Diez, A.1    Arques, C.G.2    Delgado, I.3    Giovinazzo, G.4    Torres, M.5
  • 55
    • 3142696904 scopus 로고    scopus 로고
    • The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells
    • Scherz P.J., Harfe B.D., McMahon A.P., Tabin C.J. The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science 2004, 305:396-399.
    • (2004) Science , vol.305 , pp. 396-399
    • Scherz, P.J.1    Harfe, B.D.2    McMahon, A.P.3    Tabin, C.J.4
  • 56
    • 0034646703 scopus 로고    scopus 로고
    • SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6
    • Sekiya I., Tsuji K., Koopman P., Watanabe H., Yamada Y., Shinomiya K., Nifuji A., Noda M. SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6. J. Biol. Chem. 2000, 275:10738-10744.
    • (2000) J. Biol. Chem. , vol.275 , pp. 10738-10744
    • Sekiya, I.1    Tsuji, K.2    Koopman, P.3    Watanabe, H.4    Yamada, Y.5    Shinomiya, K.6    Nifuji, A.7    Noda, M.8
  • 57
    • 9944245179 scopus 로고    scopus 로고
    • Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development
    • Selever J., Liu W., Lu M.F., Behringer R.R., Martin J.F. Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development. Dev. Biol. 2004, 276:268-279.
    • (2004) Dev. Biol. , vol.276 , pp. 268-279
    • Selever, J.1    Liu, W.2    Lu, M.F.3    Behringer, R.R.4    Martin, J.F.5
  • 60
    • 0035160003 scopus 로고    scopus 로고
    • Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs
    • Stadler H.S., Higgins K.M., Capecchi M.R. Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs. Development 2001, 128:4177-4188.
    • (2001) Development , vol.128 , pp. 4177-4188
    • Stadler, H.S.1    Higgins, K.M.2    Capecchi, M.R.3
  • 61
    • 0036682468 scopus 로고    scopus 로고
    • Functions of FGF signalling from the apical ectodermal ridge in limb development
    • Sun X., Mariani F.V., Martin G.R. Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature 2002, 418:501-508.
    • (2002) Nature , vol.418 , pp. 501-508
    • Sun, X.1    Mariani, F.V.2    Martin, G.R.3
  • 62
    • 0027484361 scopus 로고
    • Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20
    • Swiatek P.J., Gridley T. Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes. Dev. 1993, 7:2071-2084.
    • (1993) Genes. Dev. , vol.7 , pp. 2071-2084
    • Swiatek, P.J.1    Gridley, T.2
  • 64
    • 58149388206 scopus 로고    scopus 로고
    • Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development
    • ten Berge D., Brugmann S.A., Helms J.A., Nusse R. Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development. Development 2008, 135:3247-3257.
    • (2008) Development , vol.135 , pp. 3247-3257
    • ten Berge, D.1    Brugmann, S.A.2    Helms, J.A.3    Nusse, R.4
  • 65
    • 42249088278 scopus 로고    scopus 로고
    • Integration of growth and specification in chick wing digit-patterning
    • Towers M., Mahood R., Yin Y., Tickle C. Integration of growth and specification in chick wing digit-patterning. Nature 2008, 452:882-886.
    • (2008) Nature , vol.452 , pp. 882-886
    • Towers, M.1    Mahood, R.2    Yin, Y.3    Tickle, C.4
  • 68
    • 27644470220 scopus 로고    scopus 로고
    • Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning
    • Verheyden J.M., Lewandoski M., Deng C., Harfe B.D., Sun X. Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development 2005, 132:4235-4245.
    • (2005) Development , vol.132 , pp. 4235-4245
    • Verheyden, J.M.1    Lewandoski, M.2    Deng, C.3    Harfe, B.D.4    Sun, X.5
  • 69
    • 48349106444 scopus 로고    scopus 로고
    • An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth
    • Verheyden J.M., Sun X. An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Nature 2008, 454:638-641.
    • (2008) Nature , vol.454 , pp. 638-641
    • Verheyden, J.M.1    Sun, X.2
  • 70
    • 53549125545 scopus 로고    scopus 로고
    • A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
    • Vokes S.A., Ji H., Wong W.H., McMahon A.P. A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes. Dev. 2008, 22:2651-2663.
    • (2008) Genes. Dev. , vol.22 , pp. 2651-2663
    • Vokes, S.A.1    Ji, H.2    Wong, W.H.3    McMahon, A.P.4
  • 71
    • 0037414825 scopus 로고    scopus 로고
    • Regulation of human COL9A1 gene expression. Activation of the proximal promoter region by SOX9
    • Zhang P., Jimenez S.A., Stokes D.G. Regulation of human COL9A1 gene expression. Activation of the proximal promoter region by SOX9. J. Biol. Chem. 2003, 278:117-123.
    • (2003) J. Biol. Chem. , vol.278 , pp. 117-123
    • Zhang, P.1    Jimenez, S.A.2    Stokes, D.G.3
  • 72
    • 41649094573 scopus 로고    scopus 로고
    • Uncoupling sonic hedgehog control of pattern and expansion of the developing limb bud
    • Zhu J., Nakamura E., Nguyen M.T., Bao X., Akiyama H., Mackem S. Uncoupling sonic hedgehog control of pattern and expansion of the developing limb bud. Dev. Cell 2008, 14:624-632.
    • (2008) Dev. Cell , vol.14 , pp. 624-632
    • Zhu, J.1    Nakamura, E.2    Nguyen, M.T.3    Bao, X.4    Akiyama, H.5    Mackem, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.