Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod

Development

Volumn 122, Issue 10, 1996, Pages 2997-3011

  Fromental Ramain, Catherine ^a   Warot, Xavier ^a   Messadecq, Nadia ^a   LeMeur, Marianne ^a   Dollé, Pascal ^a   Chambon, Pierre ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Autopod; Digit formation; Gene disruption; Hox 13; Limb; Mouse; Patterning

Indexed keywords

HOMEODOMAIN PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARPAL BONE; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; EMBRYO PATTERN FORMATION; FETUS; FORELIMB; GENE MUTATION; HINDLIMB; HOMEOBOX; LIMB BUD; LIMB DEVELOPMENT; MORPHOGENESIS; MULTIGENE FAMILY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SEQUENCE HOMOLOGY; TARSAL BONE;

ANIMALS; CELL LINE; FEMALE; FORELIMB; GENE DELETION; HETEROZYGOTE; HINDLIMB; HOMEODOMAIN PROTEINS; HOMOZYGOTE; MALE; MICE; MICE, INBRED C57BL; PHENOTYPE; TRANSCRIPTION FACTORS;

ANIMALIA; TETRAPODA;

EID: 0029851376     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Archer, C.W., Cottril, C. and Rooney, P. (1984). Cellular aspects of cartilage differentiation and morphogenesis. In Matrices and Differentiation (ed R. Kemp and J.R. Hinchcliffe), pp. 305-322. New York: A. R. Liss.
2. Burke, A.C. and Alberch, P. (1985). The development and homologies of the chelonian carpus and tarsus. J. Morphology 186, 119-131.
3. Coates, M.I. (1991). New paleontological contributions to limb ontogeny and phylogeny. In Developmental Patterning of the Vertebrate Limb (ed. J.R. Hinchliffe, J.M. Hurle, D. Sumrnerbell), pp. 347-354. New York: Plenum.
4. Coates, M.I. (1995). Fish fins or tetrapod limbs - a simple twist of fate? Current Biol. 5, 844-848.
5. Coates, M.I. and Clack, J.A. (1990). Polydactyly in the earliest known tetrapod limbs. Nature 347, 66-68.
6. Crossley, P.H., Minowada, G., MacArthur, C.A. and Martin, G.R. (1996). Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell 84, 127-136.
7. Davis, A.P. and Capecchi, M.R. (1994). Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of Hoxd-11. Development 120,2187-2198.
8. Davis, A.P., Witte, D.P., Hsieh-Li, H.M., Potter, S.S. and Capecchi, M.R. (1995). Absence of radius and ulna in mice lacking Hoxa-11 and Hoxd-11. Nature 375, 791-795.
9. Davis, A.P. and Capecchi, M.R. (1996). A mutational analysis of the 5′ HoxD genes: dissection of genetic interactions during limb development in the mouse. Development 122, 1175-1185.
10. Dollé, P. and Duboule, D. (1993). Structural functional aspects of mammalian Hox genes. Adv. Dev. Biochem. 2,55-106.
11. Dollé, P., Dierich, A., LeMeur, M., Schimmang, T., Schuhbaur, B., Chambon, P. and Duboule, D. (1993). Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 75,431-441.
12. Dollé, P., Izpisua-Belmonte, J.C., Falkenstein, H., Renucci, A. and Duboule, D. (1989). Coordinate expression of the murine Hox-5 complex homeobox-containing genes during limb pattern formation. Nature 342, 767-772.
13. Duboule, D. and Dollé, P. (1989). The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J. 8,1497-1505.
14. Duboule, D. (1994). How to make a limb. Science 266, 575-576.
15. Favier, B., Lemeur, M., Chambon, P. and Dollé, P. (1995). Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice. Proc. Natl. Acad Sci. USA 92,310-314.
16. Favier, B., Rijli F.M., Fromental-Ramain C., Fraulob V., Chambon P. and Dollé, P. (1996). Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton. Development 122, 449-460.
17. Francis, P.H., Richardson, M.K., Brickell, P.M. and Tickle, C. (1994). Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb. Development 120, 209-218.
18. Fromental-Ramain, C., Warot, X., Lakkaraju, S., Favier, B., Haack, H., Birling, C., Dierich, A., Dollé, P. and Chambon, P. (1996). Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning. Development 122, 461-472.
19. Gossler, A., Doetschman, T., Korn, R., Serfling, E. and Kemler, R. (1986) Transgenesis by means of blastocyst-derived embryonic stem cell lines. Proc. Natl Acad. Sci. USA 83, 9065-9069.
20. Graham, A., Papalopulu, N. and Krumlauf, R. (1989). The murine and Drosophila homeobox gene complexes have common features of organization and expression. Cell 57, 367-378.
21. Greer, A.E. (1990). Limb reduction in the Scincid lizard genus. Lerista. 2. Variations in the bone complements of the front and rear limbs and the number of post-sacral vertebrae. J. Herpetol. 24, 142-150.
22. Grüneberg, H. (1962). Genetical studies on the skeleton of the mouse. XXV. The development of shaker with syndactylism. Genet. Res. Camb. 3, 157-166.
23. Haack, H. and Gruss, P. (1993). The establishment of murine Hox-1 expression domains during patterning of the limb. Dev. Biol. 157, 410-422.
24. Hays, T.S., Duering, R., Robertson, B., Prout, M. and Fuller, M.T. (1989) Interacting proteins identified by genetic interactions: A missense mutation in α-tubulin fails to complement ulleles of the testis-specific β-tubulin gene of Drosophila melanogaster. Mol. Cell. Biol. 9, 875-884.
25. Hinchiffe, J.R. and Johnson, D.R. (1980). The Development of the Vertebrate Limb. Oxford, UK: Oxford University Press.
26. Hummel, K. P. (1970). Hypodactyly, a semidominant lethal mutation in mice. J. Hered. 61, 219-220.
27. Jegalian, B.C. and De Robertis, E.M. (1992). Homeotic transformation in the mouse induced by overexpression of a human Hox-3.3 transgene. Cell 71, 901-910.
28. Kondo, T., Dollé, P., Zakany, J. and Duboule, D. (1996). Function of posterior HoxD genes in the morphogenesis of the anal sphincter. Development, in press.
29. McCarrick III, J.W., Parnes, J.R., Seong, R.H., Solter, D. and Knowles, B.B. (1993). Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells. Transgenic Res. 2,183-190.
30. McGinnis, W. and Krumlauf, R. (1992). Homeobox genes and axial patterning. Cell 68, 283-302.
31. Milaire, J. (1967). Histological observations on the developing foot of normal oligosyndactylous (Os/+) and syndactylous (Sm/Sm) mouse embryos. Archs. Biol. Liège 78, 223-288.
32. Morgan, B.A., Izpisua-Belmonte, J.C., Duboule, D. and Tabin, C. (1992). Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations. Nature 358,236-239.
33. Mortlock, D. P., Post, L. C. and Innis, J. W. (1996). The molecular basis of Hypodactyly (Hd): a deletion in Hoxa-13 leads to arrest of digital arch formation. Nature genet. 13, 284-289.
34. Müller, G.B. (1991). Evolutionary transformation of limb pattern: heterochrony and secondary fusion. In Developmental Patterning of the Vertebrate Limb (ed. J.R. Hinchcliffe, J.M. Hurle and D. Summerbell), pp 395-405. New York: Plenum Publishing Corp.
35. Muragaki, Y., Mundlos, S., Upton, J. and Olsen, B. R. (1996). Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13. Science 272, 448-451.
36. Olson, E.N., Arnold, H.-H., Rigby, P.W.J. and Wold, B.J. (1996). Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4. Cell, 85,1-4.
37. Parr, B.A. and McMahon, A.P. (1995). Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 374, 350-353.
38. Peterson, R.L., Papenbrock, T., Davda, M.M. and Awgulewitsch, A. (1994). The murine HOXC cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions. Mech. Dev. 47, 253-260.
39. Raynaud, A. and Clergue-Gazeau, M. (1986). Identification des doigts réduits ou manquants dans les pattes des embryons de lézard vert (Lacerta viridis) traités par la cytosine-arabinofuranoside. Comparaison avec les réductions digitales naturelles des espèces de reptiles serpentiformes. Arch. Biol. 97, 279-299.
40. Riddle, R.D., Johnson, R.L., Laufer, E. and Tabin, C. (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.
41. Rijli, P.M., Dollé, P., Fraulob, V., LeMeur, M. and Chambon, P. (1994). Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression. Dev. Dynamics 201, 366-377.
42. Rine, J. and Herskowitz, I. (1987). Four genes responsible for a position affect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116,9-22.
43. Shubin, N.H. (1991). The implications of the bauplan for development and evolution of the tetrapod limb. In Developmental Patterning of the Vertebrate Limb (ed. J.R. Hinchcliffe. J.M. Hurle and D. Summerbell). pp 411-422. New York: Plenum Publishing Corp.
44. Shubin, N.H. and Alberch, P. (1986). A morphogenetic approach to the origin and basic organization of the tetrapod limb. Evol. Biol. 20, 319-387.
45. Small, K.M. and Potter, S.S. (1993). Homeotic transformations and limb defects in Hoxa-11 mutant mice. Genes Dev. 7, 2318-2328.
46. Sordino, P., van der Hoeven, F. and Duboule, D. (1995). Hox gene expression in teleost fins and the origin of vertebrate digits. Nature 375, 678-681.
47. Stearns, T. and Bolstein, D. (1988). Unlinked noncomplementation: Isolation of new conditional-lethal mutations in each of the tubulin genes of Saccharomyces cerevisiae. Genetics 119,249-260.
48. Thomas, K.R. and Capecchi, M.R. (1987). Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51,503-512.
49. Yokouchi, Y., Sasaki, H. and Kuroiwa, A. (1991). Homeobox gene expression correlated with the bifurcation process of limb cartilage development. Nature 353, 443-445.
50. Yokouchi, Y., Nakazato, S., Yamamoto, M., Goto, Y., Kameda, T., Iba, H. and Kuroiwa, A. (1995). Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds. Genes Dev. 9, 2509-2522.
51. Zappavigna, V., Sartori, D. and Mavilio, F. (1994). Specificity of Hox protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeodomain. Genes Dev. 8, 732-744.