Mutant Hoxd13 induces extra digits in a mouse model of synpolydactyly directly and by decreasing retinoic acid synthesis

Journal of Clinical Investigation

Volumn 119, Issue 1, 2009, Pages 146-156

  Kuss, Pia ^a,b,c   Villavicencio Lorini, Pablo ^a,b   Witte, Florian ^a,b,c   Klose, Joachim ^b   Albrecht, Andrea N ^a   Seemann, Petra ^a   Hecht, Jochen ^b   Mundlos, Stefan ^a,b  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; RETINAL DEHYDROGENASE; RETINOIC ACID; TRANSCRIPTION FACTOR SOX6; TRANSCRIPTION FACTOR SOX9; ALDEHYDE DEHYDROGENASE; HOXD13 PROTEIN, MOUSE; RALDH2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CHONDROGENESIS; EXPERIMENT; FEMALE; LIMB; LIMB MALFORMATION; LOSS OF FUNCTION MUTATION; MALE; MESENCHYME; MESENCHYME CELL; MOUSE; MOUSE STRAIN; MUTATION; NONHUMAN; PENTADACTYLY; POLYDACTYLY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; SYNPOLYDACTYLY; TRANSGENIC MOUSE; ANIMAL; CELL CULTURE; CONGENITAL MALFORMATION; DISEASE MODEL; GENETICS; HUMAN; METABOLISM; PHENOTYPE; PHYSIOLOGY; SYNDACTYLY; TOE;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; CELLS, CULTURED; CHONDROGENESIS; DISEASE MODELS, ANIMAL; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; MALE; MICE; MICE, TRANSGENIC; MUTATION; PHENOTYPE; POLYDACTYLY; SYNDACTYLY; TOES; TRANSCRIPTION FACTORS; TRETINOIN;

EID: 61749104339     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI36851     Document Type: Article

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