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Volumn 358, Issue 2, 2015, Pages 107-114

The role of IL-21 in immunity and cancer

Author keywords

Cancer; IL 21; Immune response

Indexed keywords

INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2D; RADIOSENSITIZING AGENT; INTERLEUKIN DERIVATIVE;

EID: 84921609249     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.12.047     Document Type: Review
Times cited : (125)

References (91)
  • 1
    • 42649134105 scopus 로고    scopus 로고
    • Interleukin-21: basic biology and implications for cancer and autoimmunity
    • Spolski R., Leonard W.J. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol 2008, 26:57-79.
    • (2008) Annu. Rev. Immunol , vol.26 , pp. 57-79
    • Spolski, R.1    Leonard, W.J.2
  • 2
    • 45449104408 scopus 로고    scopus 로고
    • The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer
    • Spolski R., Leonard W.J. The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Curr. Opin. Immunol 2008, 20:295-301.
    • (2008) Curr. Opin. Immunol , vol.20 , pp. 295-301
    • Spolski, R.1    Leonard, W.J.2
  • 3
    • 0038655228 scopus 로고    scopus 로고
    • Cytokine control of memory T-cell development and survival
    • Schluns K.S., Lefrançois L. Cytokine control of memory T-cell development and survival. Nat. Rev. Immunol 2003, 3:269-279.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 269-279
    • Schluns, K.S.1    Lefrançois, L.2
  • 4
    • 84857646605 scopus 로고    scopus 로고
    • The role of interleukin-2 during homeostasis and activation of the immune system
    • Boyman O., Sprent J. The role of interleukin-2 during homeostasis and activation of the immune system. Nat. Rev. Immunol 2012, 12:180-190.
    • (2012) Nat. Rev. Immunol , vol.12 , pp. 180-190
    • Boyman, O.1    Sprent, J.2
  • 5
    • 0034332403 scopus 로고    scopus 로고
    • Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo
    • Schluns K.S., Kieper W.C., Jameson S.C., Lefrançois L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol 2000, 1:426-432.
    • (2000) Nat. Immunol , vol.1 , pp. 426-432
    • Schluns, K.S.1    Kieper, W.C.2    Jameson, S.C.3    Lefrançois, L.4
  • 6
    • 0035902513 scopus 로고    scopus 로고
    • IL-7 is critical for homeostatic proliferation and survival of naive T cells
    • Tan J.T., Dudl E., LeRoy E., Murray R., Sprent J., Weinberg K.I., et al. IL-7 is critical for homeostatic proliferation and survival of naive T cells. PNAS 2001, 98:8732-8737.
    • (2001) PNAS , vol.98 , pp. 8732-8737
    • Tan, J.T.1    Dudl, E.2    LeRoy, E.3    Murray, R.4    Sprent, J.5    Weinberg, K.I.6
  • 7
    • 0037124366 scopus 로고    scopus 로고
    • Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells
    • Tan J.T., Ernst B., Kieper W.C., LeRoy E., Sprent J., Surh C.D. Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J. Exp. Med 2002, 195:1523-1532.
    • (2002) J. Exp. Med , vol.195 , pp. 1523-1532
    • Tan, J.T.1    Ernst, B.2    Kieper, W.C.3    LeRoy, E.4    Sprent, J.5    Surh, C.D.6
  • 8
    • 0037037568 scopus 로고    scopus 로고
    • Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8+ T cells
    • Judge A.D., Zhang X., Fujii H., Surh C.D., Sprent J. Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8+ T cells. J. Exp. Med 2002, 196:935-946.
    • (2002) J. Exp. Med , vol.196 , pp. 935-946
    • Judge, A.D.1    Zhang, X.2    Fujii, H.3    Surh, C.D.4    Sprent, J.5
  • 9
    • 0027751556 scopus 로고
    • Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor
    • Noguchi M., Nakamura Y., Russell S.M., Ziegler S.F., Tsang M., Cao X., et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science 1993, 262:1877-1880.
    • (1993) Science , vol.262 , pp. 1877-1880
    • Noguchi, M.1    Nakamura, Y.2    Russell, S.M.3    Ziegler, S.F.4    Tsang, M.5    Cao, X.6
  • 12
    • 27944505913 scopus 로고    scopus 로고
    • Structure of the quaternary complex of interleukin-2 with its α, ß, and γc receptors
    • Wang X., Rickert M., Garcia K.C. Structure of the quaternary complex of interleukin-2 with its α, ß, and γc receptors. Science 2005, 310:1159-1163.
    • (2005) Science , vol.310 , pp. 1159-1163
    • Wang, X.1    Rickert, M.2    Garcia, K.C.3
  • 13
    • 5444239242 scopus 로고    scopus 로고
    • Coordinate expression and trans presentation of interleukin (IL)-15Rα and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis
    • Burkett P.R., Koka R., Chien M., Chai S., Boone D.L., Ma A. Coordinate expression and trans presentation of interleukin (IL)-15Rα and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis. J. Exp. Med 2004, 200:825-834.
    • (2004) J. Exp. Med , vol.200 , pp. 825-834
    • Burkett, P.R.1    Koka, R.2    Chien, M.3    Chai, S.4    Boone, D.L.5    Ma, A.6
  • 14
    • 0035400054 scopus 로고    scopus 로고
    • Cutting edge: the common γ-chain is an indispensable subunit of the IL-21 receptor complex
    • Asao H., Okuyama C., Kumaki S., Ishii N., Tsuchiya S., Foster D., et al. Cutting edge: the common γ-chain is an indispensable subunit of the IL-21 receptor complex. J. Immunol 2001, 167:1-5.
    • (2001) J. Immunol , vol.167 , pp. 1-5
    • Asao, H.1    Okuyama, C.2    Kumaki, S.3    Ishii, N.4    Tsuchiya, S.5    Foster, D.6
  • 15
    • 84893933808 scopus 로고    scopus 로고
    • STAT3 Activation in glioblastoma: biochemical and therapeutic implications
    • Kim J.E., Patel M., Ruzevick J., Jackson C.M., Lim M. STAT3 Activation in glioblastoma: biochemical and therapeutic implications. Cancers 2014, 6:376-395.
    • (2014) Cancers , vol.6 , pp. 376-395
    • Kim, J.E.1    Patel, M.2    Ruzevick, J.3    Jackson, C.M.4    Lim, M.5
  • 16
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R., Mora L.B., Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin. Cancer Res 2002, 8:945-954.
    • (2002) Clin. Cancer Res , vol.8 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 17
    • 85047698100 scopus 로고    scopus 로고
    • Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells
    • Burke W.M., Jin X., Lin H.-J., Huang M., Liu R., Reynolds R.K., et al. Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. Oncogene 2001, 20:7925-7934.
    • (2001) Oncogene , vol.20 , pp. 7925-7934
    • Burke, W.M.1    Jin, X.2    Lin, H.-J.3    Huang, M.4    Liu, R.5    Reynolds, R.K.6
  • 18
    • 22044437986 scopus 로고    scopus 로고
    • Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth
    • Corvinus F.M., Orth C., Moriggl R., Tsareva S.A., Wagner S., Pfitzner E.B., et al. Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia 2005, 7:545-555.
    • (2005) Neoplasia , vol.7 , pp. 545-555
    • Corvinus, F.M.1    Orth, C.2    Moriggl, R.3    Tsareva, S.A.4    Wagner, S.5    Pfitzner, E.B.6
  • 19
    • 0037028249 scopus 로고    scopus 로고
    • Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
    • Rahaman S.O., Harbor P.C., Chernova O., Barnett G.H., Vogelbaum M.A., Haque S.J. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 2002, 21:8404-8413.
    • (2002) Oncogene , vol.21 , pp. 8404-8413
    • Rahaman, S.O.1    Harbor, P.C.2    Chernova, O.3    Barnett, G.H.4    Vogelbaum, M.A.5    Haque, S.J.6
  • 20
    • 80053102518 scopus 로고    scopus 로고
    • Superresolution imaging of multiple fluorescent proteins with highly overlapping emission spectra in living cells
    • Gunewardene M.S., Subach F.V., Gould T.J., Penoncello G.P., Gudheti M.V., Verkhusha V.V., et al. Superresolution imaging of multiple fluorescent proteins with highly overlapping emission spectra in living cells. Biophys. J. 2011, 101:1522-1528.
    • (2011) Biophys. J. , vol.101 , pp. 1522-1528
    • Gunewardene, M.S.1    Subach, F.V.2    Gould, T.J.3    Penoncello, G.P.4    Gudheti, M.V.5    Verkhusha, V.V.6
  • 21
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: a leading role for STAT3
    • Yu H., Pardoll D., Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat. Rev. Cancer 2009, 9:798-809.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 22
    • 33644526633 scopus 로고    scopus 로고
    • Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells
    • Itoh M., Murata T., Suzuki T., Shindoh M., Nakajima K., Imai K., et al. Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells. Oncogene 2005, 25:1195-1204.
    • (2005) Oncogene , vol.25 , pp. 1195-1204
    • Itoh, M.1    Murata, T.2    Suzuki, T.3    Shindoh, M.4    Nakajima, K.5    Imai, K.6
  • 23
    • 84893494824 scopus 로고    scopus 로고
    • IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts
    • Berglund L.J., Avery D.T., Ma C.S., Moens L., Deenick E.K., Bustamante J., et al. IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts. Blood 2013, 122:3940-3950.
    • (2013) Blood , vol.122 , pp. 3940-3950
    • Berglund, L.J.1    Avery, D.T.2    Ma, C.S.3    Moens, L.4    Deenick, E.K.5    Bustamante, J.6
  • 24
    • 77149122105 scopus 로고    scopus 로고
    • IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
    • Linterman M.A., Beaton L., Yu D., Ramiscal R.R., Srivastava M., Hogan J.J., et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J. Exp. Med 2010, 207:353-363.
    • (2010) J. Exp. Med , vol.207 , pp. 353-363
    • Linterman, M.A.1    Beaton, L.2    Yu, D.3    Ramiscal, R.R.4    Srivastava, M.5    Hogan, J.J.6
  • 25
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    • Parrish-Novak J., Dillon S.R., Nelson A., Hammond A., Sprecher C., Gross J.A., et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000, 408:57-63.
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1    Dillon, S.R.2    Nelson, A.3    Hammond, A.4    Sprecher, C.5    Gross, J.A.6
  • 26
    • 0036852893 scopus 로고    scopus 로고
    • Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses
    • Parrish-Novak J., Foster D.C., Holly R.D., Clegg C.H. Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J. Leukoc. Biol 2002, 72:856-863.
    • (2002) J. Leukoc. Biol , vol.72 , pp. 856-863
    • Parrish-Novak, J.1    Foster, D.C.2    Holly, R.D.3    Clegg, C.H.4
  • 28
    • 79952637807 scopus 로고    scopus 로고
    • IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation
    • e17739
    • Eto D., Lao C., DiToro D., Barnett B., Escobar T.C., Kageyama R., et al. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS ONE 2011, 6. e17739.
    • (2011) PLoS ONE , vol.6
    • Eto, D.1    Lao, C.2    DiToro, D.3    Barnett, B.4    Escobar, T.C.5    Kageyama, R.6
  • 29
    • 84885129176 scopus 로고    scopus 로고
    • IL-21-producing Th cells in immunity and autoimmunity
    • Liu S.M., King C. IL-21-producing Th cells in immunity and autoimmunity. J. Immunol 2013, 191:3501-3506.
    • (2013) J. Immunol , vol.191 , pp. 3501-3506
    • Liu, S.M.1    King, C.2
  • 30
    • 33745308424 scopus 로고    scopus 로고
    • Differential effects of IL-15 and IL-21 in myeloid (CD11b+) and lymphoid (CD11b-) bone marrow cells
    • Pelletier M., Girard D. Differential effects of IL-15 and IL-21 in myeloid (CD11b+) and lymphoid (CD11b-) bone marrow cells. J. Immunol 2006, 177:100-108.
    • (2006) J. Immunol , vol.177 , pp. 100-108
    • Pelletier, M.1    Girard, D.2
  • 32
    • 27644461409 scopus 로고    scopus 로고
    • Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity
    • Wu Z., Kim H.-P., Xue H.-H., Liu H., Zhao K., Leonard W.J. Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. Mol. Cell. Biol 2005, 25:9741-9752.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 9741-9752
    • Wu, Z.1    Kim, H.-P.2    Xue, H.-H.3    Liu, H.4    Zhao, K.5    Leonard, W.J.6
  • 33
    • 70449334555 scopus 로고    scopus 로고
    • IL-21: roles in immunopathology and cancer therapy
    • Søndergaard H., Skak K. IL-21: roles in immunopathology and cancer therapy. Tissue Antigens 2009, 74:467-479.
    • (2009) Tissue Antigens , vol.74 , pp. 467-479
    • Søndergaard, H.1    Skak, K.2
  • 34
    • 48649083489 scopus 로고    scopus 로고
    • Interleukin 21: a cytokine/cytokine receptor system that has come of age
    • Leonard W.J., Zeng R., Spolski R. Interleukin 21: a cytokine/cytokine receptor system that has come of age. J. Leukoc. Biol 2008, 84:348-356.
    • (2008) J. Leukoc. Biol , vol.84 , pp. 348-356
    • Leonard, W.J.1    Zeng, R.2    Spolski, R.3
  • 35
    • 84878257992 scopus 로고    scopus 로고
    • The good, the bad and the ugly [mdash] TFH cells in human health and disease
    • Tangye S.G., Ma C.S., Brink R., Deenick E.K. The good, the bad and the ugly [mdash] TFH cells in human health and disease. Nat. Rev. Immunol 2013, 13:412-426.
    • (2013) Nat. Rev. Immunol , vol.13 , pp. 412-426
    • Tangye, S.G.1    Ma, C.S.2    Brink, R.3    Deenick, E.K.4
  • 36
    • 38049101408 scopus 로고    scopus 로고
    • Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells
    • Bryant V.L., Ma C.S., Avery D.T., Li Y., Good K.L., Corcoran L.M., et al. Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J. Immunol 2007, 179:8180-8190.
    • (2007) J. Immunol , vol.179 , pp. 8180-8190
    • Bryant, V.L.1    Ma, C.S.2    Avery, D.T.3    Li, Y.4    Good, K.L.5    Corcoran, L.M.6
  • 37
    • 29144519767 scopus 로고    scopus 로고
    • IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    • Ettinger R., Sims G.P., Fairhurst A.-M., Robbins R., da Silva Y.S., Spolski R., et al. IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J. Immunol 2005, 175:7867-7879.
    • (2005) J. Immunol , vol.175 , pp. 7867-7879
    • Ettinger, R.1    Sims, G.P.2    Fairhurst, A.-M.3    Robbins, R.4    da Silva, Y.S.5    Spolski, R.6
  • 38
    • 2942709751 scopus 로고    scopus 로고
    • Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis
    • Jin H., Carrio R., Yu A., Malek T.R. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J. Immunol 2004, 173:657-665.
    • (2004) J. Immunol , vol.173 , pp. 657-665
    • Jin, H.1    Carrio, R.2    Yu, A.3    Malek, T.R.4
  • 40
    • 49649120932 scopus 로고    scopus 로고
    • IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4
    • Avery D.T., Bryant V.L., Ma C.S., de Waal Malefyt R., Tangye S.G. IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4. J. Immunol 2008, 181:1767-1779.
    • (2008) J. Immunol , vol.181 , pp. 1767-1779
    • Avery, D.T.1    Bryant, V.L.2    Ma, C.S.3    de Waal Malefyt, R.4    Tangye, S.G.5
  • 41
    • 0037093258 scopus 로고    scopus 로고
    • Interleukin-21 is a growth and survival factor for human myeloma cells
    • Brenne A.-T., Ro T.B., Waage A., Sundan A., Borset M., Hjorth-Hansen H. Interleukin-21 is a growth and survival factor for human myeloma cells. Blood 2002, 99:3756-3762.
    • (2002) Blood , vol.99 , pp. 3756-3762
    • Brenne, A.-T.1    Ro, T.B.2    Waage, A.3    Sundan, A.4    Borset, M.5    Hjorth-Hansen, H.6
  • 42
    • 77149142640 scopus 로고    scopus 로고
    • IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    • Zotos D., Coquet J.M., Zhang Y., Light A., D'Costa K., Kallies A., et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J. Exp. Med 2010, 207:365-378.
    • (2010) J. Exp. Med , vol.207 , pp. 365-378
    • Zotos, D.1    Coquet, J.M.2    Zhang, Y.3    Light, A.4    D'Costa, K.5    Kallies, A.6
  • 43
    • 6344269331 scopus 로고    scopus 로고
    • Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
    • Ozaki K., Spolski R., Ettinger R., Kim H.-P., Wang G., Qi C.-F., et al. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J. Immunol 2004, 173:5361-5371.
    • (2004) J. Immunol , vol.173 , pp. 5361-5371
    • Ozaki, K.1    Spolski, R.2    Ettinger, R.3    Kim, H.-P.4    Wang, G.5    Qi, C.-F.6
  • 44
    • 76149139419 scopus 로고    scopus 로고
    • B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
    • Avery D.T., Deenick E.K., Ma C.S., Suryani S., Simpson N., Chew G.Y., et al. B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J. Exp. Med 2010, 207:155-171.
    • (2010) J. Exp. Med , vol.207 , pp. 155-171
    • Avery, D.T.1    Deenick, E.K.2    Ma, C.S.3    Suryani, S.4    Simpson, N.5    Chew, G.Y.6
  • 45
    • 11144355735 scopus 로고    scopus 로고
    • Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells
    • Pène J., Gauchat J.-F., Lécart S., Drouet E., Guglielmi P., Boulay V., et al. Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells. J. Immunol 2004, 172:5154-5157.
    • (2004) J. Immunol , vol.172 , pp. 5154-5157
    • Pène, J.1    Gauchat, J.-F.2    Lécart, S.3    Drouet, E.4    Guglielmi, P.5    Boulay, V.6
  • 46
    • 0026445919 scopus 로고
    • Human B lymphocytes: phenotype, proliferation, and differentiation
    • Banchereau J., Rousset F. Human B lymphocytes: phenotype, proliferation, and differentiation. Adv. Immunol 1992, 52:125-262.
    • (1992) Adv. Immunol , vol.52 , pp. 125-262
    • Banchereau, J.1    Rousset, F.2
  • 47
    • 18344394955 scopus 로고    scopus 로고
    • IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity
    • Kasaian M.T., Whitters M.J., Carter L.L., Lowe L.D., Jussif J.M., Deng B., et al. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 2002, 16:559-569.
    • (2002) Immunity , vol.16 , pp. 559-569
    • Kasaian, M.T.1    Whitters, M.J.2    Carter, L.L.3    Lowe, L.D.4    Jussif, J.M.5    Deng, B.6
  • 48
    • 33845903869 scopus 로고    scopus 로고
    • IL-21-induced Bε cell apoptosis mediated by natural killer T cells suppresses IgE responses
    • Harada M., Magara-Koyanagi K., Watarai H., Nagata Y., Ishii Y., Kojo S., et al. IL-21-induced Bε cell apoptosis mediated by natural killer T cells suppresses IgE responses. J. Exp. Med 2006, 203:2929-2937.
    • (2006) J. Exp. Med , vol.203 , pp. 2929-2937
    • Harada, M.1    Magara-Koyanagi, K.2    Watarai, H.3    Nagata, Y.4    Ishii, Y.5    Kojo, S.6
  • 49
    • 40049086595 scopus 로고    scopus 로고
    • IL-21 induces inhibitor of differentiation 2 and leads to complete abrogation of anaphylaxis in mice
    • Kishida T., Hiromura Y., Shin-Ya M., Asada H., Kuriyama H., Sugai M., et al. IL-21 induces inhibitor of differentiation 2 and leads to complete abrogation of anaphylaxis in mice. J. Immunol 2007, 179:8554-8561.
    • (2007) J. Immunol , vol.179 , pp. 8554-8561
    • Kishida, T.1    Hiromura, Y.2    Shin-Ya, M.3    Asada, H.4    Kuriyama, H.5    Sugai, M.6
  • 50
    • 38049110981 scopus 로고    scopus 로고
    • Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration
    • Kuchen S., Robbins R., Sims G.P., Sheng C., Phillips T.M., Lipsky P.E., et al. Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J. Immunol 2007, 179:5886-5896.
    • (2007) J. Immunol , vol.179 , pp. 5886-5896
    • Kuchen, S.1    Robbins, R.2    Sims, G.P.3    Sheng, C.4    Phillips, T.M.5    Lipsky, P.E.6
  • 51
    • 34249806717 scopus 로고    scopus 로고
    • Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment
    • Kryczek I., Wei S., Zou L., Altuwaijri S., Szeliga W., Kolls J., et al. Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J. Immunol 2007, 178:6730-6733.
    • (2007) J. Immunol , vol.178 , pp. 6730-6733
    • Kryczek, I.1    Wei, S.2    Zou, L.3    Altuwaijri, S.4    Szeliga, W.5    Kolls, J.6
  • 52
    • 84873700983 scopus 로고    scopus 로고
    • IL-21 promotes the expansion of CD27 CD28 tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells
    • Santegoets S.J., Turksma A.W., Suhoski M.M., Stam A.G., Albelda S.M., Hooijberg E., et al. IL-21 promotes the expansion of CD27 CD28 tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells. J. Transl. Med 2013, 11:37.
    • (2013) J. Transl. Med , vol.11 , pp. 37
    • Santegoets, S.J.1    Turksma, A.W.2    Suhoski, M.M.3    Stam, A.G.4    Albelda, S.M.5    Hooijberg, E.6
  • 53
    • 0842278642 scopus 로고    scopus 로고
    • IL-21 induces the functional maturation of murine NK cells
    • Brady J., Hayakawa Y., Smyth M.J., Nutt S.L. IL-21 induces the functional maturation of murine NK cells. J. Immunol 2004, 172:2048-2058.
    • (2004) J. Immunol , vol.172 , pp. 2048-2058
    • Brady, J.1    Hayakawa, Y.2    Smyth, M.J.3    Nutt, S.L.4
  • 55
    • 0347320749 scopus 로고    scopus 로고
    • In vivo antitumor activity of interleukin 21 mediated by natural killer cells
    • Wang G., Tschoi M., Spolski R., Lou Y., Ozaki K., Feng C., et al. In vivo antitumor activity of interleukin 21 mediated by natural killer cells. Cancer Res 2003, 63:9016-9022.
    • (2003) Cancer Res , vol.63 , pp. 9016-9022
    • Wang, G.1    Tschoi, M.2    Spolski, R.3    Lou, Y.4    Ozaki, K.5    Feng, C.6
  • 56
    • 12444328351 scopus 로고    scopus 로고
    • Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and-independent antitumor effects
    • Ugai S.-I., Shimozato O., Yu L., Wang Y.-Q., Kawamura K., Yamamoto H., et al. Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and-independent antitumor effects. Cancer Gene Ther 2003, 10:771-778.
    • (2003) Cancer Gene Ther , vol.10 , pp. 771-778
    • Ugai, S.-I.1    Shimozato, O.2    Yu, L.3    Wang, Y.-Q.4    Kawamura, K.5    Yamamoto, H.6
  • 57
    • 33646489777 scopus 로고    scopus 로고
    • IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy
    • Smyth M.J., Hayakawa Y., Cretney E., Zerafa N., Sivakumar P., Yagita H., et al. IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy. J. Immunol 2006, 176:6347-6355.
    • (2006) J. Immunol , vol.176 , pp. 6347-6355
    • Smyth, M.J.1    Hayakawa, Y.2    Cretney, E.3    Zerafa, N.4    Sivakumar, P.5    Yagita, H.6
  • 58
  • 59
    • 33745298650 scopus 로고    scopus 로고
    • Interleukin-21 enhances NK cell activation in response to antibody-coated targets
    • Roda J.M., Parihar R., Lehman A., Mani A., Tridandapani S., Carson W.E. Interleukin-21 enhances NK cell activation in response to antibody-coated targets. J. Immunol 2006, 177:120-129.
    • (2006) J. Immunol , vol.177 , pp. 120-129
    • Roda, J.M.1    Parihar, R.2    Lehman, A.3    Mani, A.4    Tridandapani, S.5    Carson, W.E.6
  • 60
    • 1642444178 scopus 로고    scopus 로고
    • IL-21 induces tumor rejection by specific CTL and IFN-γ-dependent CXC chemokines in syngeneic mice
    • Di Carlo E., Comes A., Orengo A.M., Rosso O., Meazza R., Musiani P., et al. IL-21 induces tumor rejection by specific CTL and IFN-γ-dependent CXC chemokines in syngeneic mice. J. Immunol 2004, 172:1540-1547.
    • (2004) J. Immunol , vol.172 , pp. 1540-1547
    • Di Carlo, E.1    Comes, A.2    Orengo, A.M.3    Rosso, O.4    Meazza, R.5    Musiani, P.6
  • 61
    • 45449087723 scopus 로고    scopus 로고
    • IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
    • Hinrichs C.S., Spolski R., Paulos C.M., Gattinoni L., Kerstann K.W., Palmer D.C., et al. IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood 2008, 111:5326-5333.
    • (2008) Blood , vol.111 , pp. 5326-5333
    • Hinrichs, C.S.1    Spolski, R.2    Paulos, C.M.3    Gattinoni, L.4    Kerstann, K.W.5    Palmer, D.C.6
  • 62
    • 2542595794 scopus 로고    scopus 로고
    • IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21
    • Moroz A., Eppolito C., Li Q., Tao J., Clegg C.H., Shrikant P.A. IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21. J. Immunol 2004, 173:900-909.
    • (2004) J. Immunol , vol.173 , pp. 900-909
    • Moroz, A.1    Eppolito, C.2    Li, Q.3    Tao, J.4    Clegg, C.H.5    Shrikant, P.A.6
  • 64
    • 38049120319 scopus 로고    scopus 로고
    • IL-21-mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes
    • Li Y., Yee C. IL-21-mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes. Blood 2008, 111:229-235.
    • (2008) Blood , vol.111 , pp. 229-235
    • Li, Y.1    Yee, C.2
  • 65
  • 66
    • 0037082487 scopus 로고    scopus 로고
    • Sequential production of interferon-γ by NK1. 1 + T cells and natural killer cells is essential for the antimetastatic effect of α-galactosylceramide
    • Smyth M.J., Crowe N.Y., Pellicci D.G., Kyparissoudis K., Kelly J.M., Takeda K., et al. Sequential production of interferon-γ by NK1. 1 + T cells and natural killer cells is essential for the antimetastatic effect of α-galactosylceramide. Blood 2002, 99:1259-1266.
    • (2002) Blood , vol.99 , pp. 1259-1266
    • Smyth, M.J.1    Crowe, N.Y.2    Pellicci, D.G.3    Kyparissoudis, K.4    Kelly, J.M.5    Takeda, K.6
  • 67
    • 22344451592 scopus 로고    scopus 로고
    • Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
    • Smyth M.J., Wallace M.E., Nutt S.L., Yagita H., Godfrey D.I., Hayakawa Y. Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer. J. Exp. Med 2005, 201:1973-1985.
    • (2005) J. Exp. Med , vol.201 , pp. 1973-1985
    • Smyth, M.J.1    Wallace, M.E.2    Nutt, S.L.3    Yagita, H.4    Godfrey, D.I.5    Hayakawa, Y.6
  • 68
    • 84902191817 scopus 로고    scopus 로고
    • IL-2: the first effective immunotherapy for human cancer
    • Rosenberg S.A. IL-2: the first effective immunotherapy for human cancer. J. Immunol 2014, 192:5451-5458.
    • (2014) J. Immunol , vol.192 , pp. 5451-5458
    • Rosenberg, S.A.1
  • 69
    • 84904171391 scopus 로고    scopus 로고
    • In vitro effect of IL-2 in combination with pazopanib or sunitinib on lymphocytes function and apoptosis of RCC cells
    • Shablak A., Gilham D.E., Hawkins R.E., Elkord E. In vitro effect of IL-2 in combination with pazopanib or sunitinib on lymphocytes function and apoptosis of RCC cells. Expert Opin. Pharmacother 2014, 1-11.
    • (2014) Expert Opin. Pharmacother , pp. 1-11
    • Shablak, A.1    Gilham, D.E.2    Hawkins, R.E.3    Elkord, E.4
  • 71
    • 84897832209 scopus 로고    scopus 로고
    • Combinations of radiation therapy and immunotherapy for melanoma: a review of clinical outcomes
    • Barker C.A., Postow M.A. Combinations of radiation therapy and immunotherapy for melanoma: a review of clinical outcomes. Int. J. Radiat. Oncol. Biol. Phys 2014, 88:986-997.
    • (2014) Int. J. Radiat. Oncol. Biol. Phys , vol.88 , pp. 986-997
    • Barker, C.A.1    Postow, M.A.2
  • 72
    • 0031812910 scopus 로고    scopus 로고
    • Trends in the safety of high dose bolus interleukin-2 administration in patients with metastatic cancer
    • Kammula U.S., White D.E., Rosenberg S.A. Trends in the safety of high dose bolus interleukin-2 administration in patients with metastatic cancer. Cancer 1998, 83:797-805.
    • (1998) Cancer , vol.83 , pp. 797-805
    • Kammula, U.S.1    White, D.E.2    Rosenberg, S.A.3
  • 73
    • 0034852781 scopus 로고    scopus 로고
    • Guidelines for the safe administration of high-dose interleukin-2
    • Schwartzentruber D.J. Guidelines for the safe administration of high-dose interleukin-2. J. Immunother 2001, 24:287-293.
    • (2001) J. Immunother , vol.24 , pp. 287-293
    • Schwartzentruber, D.J.1
  • 74
    • 84900526697 scopus 로고    scopus 로고
    • High-dose interleukin 2-induced myocarditis: can myocardial damage reversibility be assessed by cardiac MRI?
    • Chow S., Cove-Smith L., Schmitt M., Hawkins R. High-dose interleukin 2-induced myocarditis: can myocardial damage reversibility be assessed by cardiac MRI?. J. Immunother 2014, 37:304-308.
    • (2014) J. Immunother , vol.37 , pp. 304-308
    • Chow, S.1    Cove-Smith, L.2    Schmitt, M.3    Hawkins, R.4
  • 75
    • 84866772544 scopus 로고    scopus 로고
    • Interleukin-21 has activity in patients with metastatic melanoma: a phase II study
    • Petrella T.M., Tozer R., Belanger K., Savage K.J., Wong R., Smylie M., et al. Interleukin-21 has activity in patients with metastatic melanoma: a phase II study. J. Clin. Oncol 2012, 30:3396-3401.
    • (2012) J. Clin. Oncol , vol.30 , pp. 3396-3401
    • Petrella, T.M.1    Tozer, R.2    Belanger, K.3    Savage, K.J.4    Wong, R.5    Smylie, M.6
  • 77
    • 63749092527 scopus 로고    scopus 로고
    • Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease
    • Monteleone G., Pallone F., Macdonald T.T. Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease. Cytok. Growth Fac. Rev 2009, 20:185-191.
    • (2009) Cytok. Growth Fac. Rev , vol.20 , pp. 185-191
    • Monteleone, G.1    Pallone, F.2    Macdonald, T.T.3
  • 78
    • 79952220107 scopus 로고    scopus 로고
    • IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B
    • Publicover J., Goodsell A., Nishimura S., Vilarinho S., Wang Z.-E., Avanesyan L., et al. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J. Clin. Invest 2011, 121:1154-1162.
    • (2011) J. Clin. Invest , vol.121 , pp. 1154-1162
    • Publicover, J.1    Goodsell, A.2    Nishimura, S.3    Vilarinho, S.4    Wang, Z.-E.5    Avanesyan, L.6
  • 79
    • 33748114343 scopus 로고    scopus 로고
    • The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
    • Perz J.F., Armstrong G.L., Farrington L.A., Hutin Y.J., Bell B.P. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J. Hepatol 2006, 45:529-538.
    • (2006) J. Hepatol , vol.45 , pp. 529-538
    • Perz, J.F.1    Armstrong, G.L.2    Farrington, L.A.3    Hutin, Y.J.4    Bell, B.P.5
  • 80
    • 0025907983 scopus 로고
    • HBx gene of hepatitis B virus induces liver cancer in transgenic mice
    • Kim C.-M., Koike K., Saito I., Miyamura T., Jay G. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 1991, 351:317-320.
    • (1991) Nature , vol.351 , pp. 317-320
    • Kim, C.-M.1    Koike, K.2    Saito, I.3    Miyamura, T.4    Jay, G.5
  • 81
    • 84866735170 scopus 로고    scopus 로고
    • Paths to stemness: building the ultimate antitumour T cell
    • Gattinoni L., Klebanoff C.A., Restifo N.P. Paths to stemness: building the ultimate antitumour T cell. Nat. Rev. Cancer 2012, 12:671-684.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 671-684
    • Gattinoni, L.1    Klebanoff, C.A.2    Restifo, N.P.3
  • 82
    • 84877836562 scopus 로고    scopus 로고
    • Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails
    • Yang S., Ji Y., Gattinoni L., Zhang L., Yu Z., Restifo N.P., et al. Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails. Cancer Immunol. Immunother 2013, 62:727-736.
    • (2013) Cancer Immunol. Immunother , vol.62 , pp. 727-736
    • Yang, S.1    Ji, Y.2    Gattinoni, L.3    Zhang, L.4    Yu, Z.5    Restifo, N.P.6
  • 83
    • 34250761481 scopus 로고    scopus 로고
    • An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma
    • Davis I.D., Skrumsager B.K., Cebon J., Nicholaou T., Barlow J.W., Moller N.P.H., et al. An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma. Clin. Cancer Res 2007, 13:3630-3636.
    • (2007) Clin. Cancer Res , vol.13 , pp. 3630-3636
    • Davis, I.D.1    Skrumsager, B.K.2    Cebon, J.3    Nicholaou, T.4    Barlow, J.W.5    Moller, N.P.H.6
  • 84
    • 42949139835 scopus 로고    scopus 로고
    • Phase I study of recombinant interleukin-21 in patients with metastatic melanoma and renal cell carcinoma
    • Thompson J.A., Curti B.D., Redman B.G., Bhatia S., Weber J.S., Agarwala S.S., et al. Phase I study of recombinant interleukin-21 in patients with metastatic melanoma and renal cell carcinoma. J. Clin. Oncol 2008, 26:2034-2039.
    • (2008) J. Clin. Oncol , vol.26 , pp. 2034-2039
    • Thompson, J.A.1    Curti, B.D.2    Redman, B.G.3    Bhatia, S.4    Weber, J.S.5    Agarwala, S.S.6
  • 85
    • 84857786741 scopus 로고    scopus 로고
    • A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer
    • Steele N., Anthony A., Saunders M., Esmarck B., Ehrnrooth E., Kristjansen P., et al. A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer. Br. J. Cancer 2012, 106:793-798.
    • (2012) Br. J. Cancer , vol.106 , pp. 793-798
    • Steele, N.1    Anthony, A.2    Saunders, M.3    Esmarck, B.4    Ehrnrooth, E.5    Kristjansen, P.6
  • 86
    • 77951134921 scopus 로고    scopus 로고
    • Interleukin-21: updated review of Phase I and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkin's lymphoma
    • Hashmi M.H., Van Veldhuizen P.J. Interleukin-21: updated review of Phase I and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkin's lymphoma. Expert Opin. Biol. Ther 2010, 10:807-817.
    • (2010) Expert Opin. Biol. Ther , vol.10 , pp. 807-817
    • Hashmi, M.H.1    Van Veldhuizen, P.J.2
  • 87
    • 34848927882 scopus 로고    scopus 로고
    • IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells
    • Liu S., Lizée G., Lou Y., Liu C., Overwijk W.W., Wang G., et al. IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells. Int. Immunol 2007, 19:1213-1221.
    • (2007) Int. Immunol , vol.19 , pp. 1213-1221
    • Liu, S.1    Lizée, G.2    Lou, Y.3    Liu, C.4    Overwijk, W.W.5    Wang, G.6
  • 88
    • 23244444668 scopus 로고    scopus 로고
    • IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells
    • Alves N.L., Arosa F.A., van Lier R.A. IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells. J. Immunol 2005, 175:755-762.
    • (2005) J. Immunol , vol.175 , pp. 755-762
    • Alves, N.L.1    Arosa, F.A.2    van Lier, R.A.3
  • 89
    • 0037514399 scopus 로고    scopus 로고
    • IL-21 in synergy with IL-15 or IL-18 enhances IFN-γ production in human NK and T cells
    • Strengell M., Matikainen S., Sirén J., Lehtonen A., Foster D., Julkunen I., et al. IL-21 in synergy with IL-15 or IL-18 enhances IFN-γ production in human NK and T cells. J. Immunol 2003, 170:5464-5469.
    • (2003) J. Immunol , vol.170 , pp. 5464-5469
    • Strengell, M.1    Matikainen, S.2    Sirén, J.3    Lehtonen, A.4    Foster, D.5    Julkunen, I.6
  • 90
    • 84892472598 scopus 로고    scopus 로고
    • Gene therapy of ovarian cancer using IL-21-secreting human umbilical cord mesenchymal stem cells in nude mice
    • Zhang Y., Wang J., Ren M., Li M., Chen D., Chen J., et al. Gene therapy of ovarian cancer using IL-21-secreting human umbilical cord mesenchymal stem cells in nude mice. J. Ovar. Res 2014, 7.
    • (2014) J. Ovar. Res , vol.7
    • Zhang, Y.1    Wang, J.2    Ren, M.3    Li, M.4    Chen, D.5    Chen, J.6


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