Insulin-like growth factors and kidney disease

American Journal of Kidney Diseases

Volumn 65, Issue 2, 2015, Pages 327-336

  Bach, Leon A ^a,b   Hale, Lorna J ^c  

^a ALFRED HOSPITAL   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

chronic kidney disease (CKD); growth hormone (GH); Insulin like growth factor (IGF); kidney development; kidney disease diabetic nephropathy; kidney function

Indexed keywords

AMLODIPINE; CALCIUM; CALCIUM CARBONATE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEMOGLOBIN A1C; HYDROCHLOROTHIAZIDE; INSULIN; MANNOSE 6 PHOSPHATE; PHOSPHORUS; SERUM ALBUMIN; SOMATOMEDIN B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ACROMEGALY; ACUTE KIDNEY FAILURE; ADULT; ANKLE EDEMA; ANOREXIA; ARTICLE; BINDING AFFINITY; CASE REPORT; CELL FUNCTION; CHRONIC KIDNEY FAILURE; CREATININE CLEARANCE; DIABETIC NEPHROPATHY; DYSPNEA; END STAGE RENAL DISEASE; FIBROSIS; GENE EXPRESSION; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERTENSION; KIDNEY BLOOD FLOW; KIDNEY DEVELOPMENT; KIDNEY DISEASE; KIDNEY FUNCTION; KIDNEY POLYCYSTIC DISEASE; LOW DRUG DOSE; MALE; MICROALBUMINURIA; MIDDLE AGED; NAUSEA; PATHOGENESIS; PODOCYTE; PROTEIN URINE LEVEL; PROTEINURIA; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STEM CELL TRANSPLANTATION; KIDNEY FAILURE, CHRONIC; URINE;

HUMANS; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED;

EID: 84921558441     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2014.05.024     Document Type: Article

References (117)

1. D.R. Clemmons Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer Nat Rev Drug Discov 6 10 2007 821 833
2. A. Denley, L.J. Cosgrove, G.W. Booker, J.C. Wallace, and B.E. Forbes Molecular interactions of the IGF system Cytokine Growth Factor Rev 16 4-5 2005 421 439
3. L.A. Bach, S.J. Headey, and R.S. Norton IGF-binding proteins - the pieces are falling into place Trends Endocrinol Metab 16 5 2005 228 234
4. L.A. Bach The insulin-like growth factor system in kidney disease and hypertension Curr Opin Nephrol Hypertens 21 1 2012 86 91
5. A. Ward Beckwith-Wiedemann syndrome and Wilms' tumour Mol Hum Reprod 3 2 1997 157 168
6. S.A. Rogers, G. Ryan, and M.R. Hammerman Insulin-like growth factors I and II are produced in the metanephros and are required for growth and development in vitro J.Cell Biol 113 1991 1447 1453
7. D.G. Matsell, P.J. Delhanty, O. Stepaniuk, C. Goodyear, and V.K. Han Expression of insulin-like growth factor and binding protein genes during nephrogenesis Kidney Int 46 4 1994 1031 1042
8. G.J. Price, J.L. Berka, S.R. Edmonson, G.A. Werther, and L.A. Bach Localization of mRNAs for insulin-like growth factor binding proteins 1 to 6 in rat kidney Kidney Int 48 1995 402 411
9. R. Rabkin, and F. Schaefer New concepts: growth hormone, insulin-like growth factor-I and the kidney Growth Horm IGF Res 14 4 2004 270 276
10. D.J. Lindenbergh-Kortleve, R.R. Rosato, and J.W. van Neck Gene expression of the insulin-like growth factor system during mouse kidney development Mol Cell Endocrinol 132 1-2 1997 81 91
11. F. Lupu, J.D. Terwilliger, K. Lee, G.V. Segre, and A. Efstratiadis Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth Dev Biol 229 1 2001 141 162
12. C. Moerth, M.R. Schneider, and I. Renner-Mueller Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weight Endocrinology 148 1 2007 441 451
13. S.A. Rogers, L. Powell-Braxton, and M.R. Hammerman Insulin-like growth factor I regulates renal development in rodents Dev Genet 24 3-4 1999 293 298
14. E. Wolf, R. Kramer, W.F. Blum, J. Foll, and G. Brem Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth Endocrinology 135 5 1994 1877 1886
15. L.S. Mathews, R.E. Hammer, and R.R. Behringer Growth enhancement of transgenic mice expressing human insulin-like growth factor I Endocrinology 123 1989 2827 2833
16. T. Doi, L.J. Striker, and C. Quaife Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulinlike growth factor-1 Am J Pathol 131 1988 398 403
17. W.D. Salmon Jr., and W.H. Daughaday A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro J Lab Clin Med 49 1957 825 836
18. C. Ohlsson, S. Mohan, and K. Sjogren The role of liver-derived insulin-like growth factor-I Endocr Rev 30 5 2009 494 535
19. K. Sjogren, J.L. Liu, and K. Blad Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice Proc Natl Acad Sci U S A 96 12 1999 7088 7092
20. J. Svensson, A. Tivesten, and K. Sjogren Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression J Endocrinol 193 3 2007 359 366
21. S.M. Nordstrom, J.L. Tran, B.C. Sos, K.U. Wagner, and E.J. Weiss Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH Mol Endocrinol 25 2011 1223 1230
22. S. Doublier, D. Seurin, and B. Fouqueray Glomerulosclerosis in mice transgenic for human insulin-like growth factor-binding protein-1 Kidney Int 57 6 2000 2299 2307
23. S. Doublier, K. Amri, and D. Seurin Overexpression of human insulin-like growth factor binding protein-1 in the mouse leads to nephron deficit Pediatr Res 49 5 2001 660 666
24. A. Hoeflich, M.Y. Wu, and S. Mohan Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain Endocrinology 140 12 1999 5488 5496
25. T. Modric, J.V. Silha, and Z.D. Shi Phenotypic manifestations of insulin-like growth factor-binding protein-3 overexpression in transgenic mice Endocrinology 142 5 2001 1958 1967
26. J.V. Silha, Y.T. Gui, S. Mishra, A. Leckstrom, P. Cohen, and L.J. Murphy Overexpression of Gly(56)/Gly(80)/Gly(81)-mutant insulin-like growth factor-binding protein-3 in transgenic mice Endocrinology 146 3 2005 1523 1531
27. G. Tripathi, D.A.M. Salih, A.C. Drozd, R.A. Cosgrove, L.J. Cobb, and J.M. Pell IGF-independent effects of insulin-like growth factor binding protein-5 (IGFBP5) in vivo FASEB J 23 8 2009 2616 2626
28. R. Zhou, H. Flaswinkel, and M. Schneider Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice J Mol Endocrinol 32 2 2004 349 364
29. R. Hirschberg, and J.D. Kopple Evidence that insulin-like growth factor I increases renal plasma flow and glomerular filtration rate in fasted rats J Clin Invest 83 1989 326 330
30. R. Hirschberg, G. Brunori, J.D. Kopple, and H.-P. Guler Effects of insulin-like growth factor I on renal function in normal men Kidney Int 43 1993 387 397
31. R. Hirschberg, J.D. Kopple, R.C. Blantz, and B.J. Tucker Effects of recombinant human insulin-like growth factor I on glomerular dynamics in the rat J Clin Invest 87 4 1991 1200 1206
32. B. Tonshoff, F.J. Kaskel, and L.C. Moore Effects of insulin-like growth factor I on the renal juxtamedullary microvasculature Am J Physiol Cell Physiol 43 1 1998 F120 F128
33. S. Feld, and R. Hirschberg Growth hormone, the insulin-like growth factor system, and the kidney Endocr Rev 17 5 1996 423 480
34. P. Kamenicky, G. Mazziotti, M. Lombes, A. Giustina, and P. Chanson Growth hormone, insulin-like growth factor-1, and the kidney: pathophysiological and clinical implications Endocr Rev 35 2 2014 234 281
35. H. Nagasu, M. Satoh, and A. Kuwabara Overexpression of klotho protein modulates uninephrectomy-induced compensatory renal hypertrophy by suppressing IGF-I signals Biochem Biophys Res Commun 407 1 2011 39 43
36. M.R. Hammerman, and S.B. Miller The growth hormone insulin-like growth factor axis in kidney revisited Am J Physiol 265 1, pt 2 1993 F1 F14
37. D.C. Aron, J.L. Rosenzweig, and H.E. Abboud Synthesis and binding of insulin-like growth factor I by human glomerular mesangial cells J Clin Endocrinol Metab 68 1989 585 591
38. F.G. Conti, L.J. Striker, S.J. Elliot, D. Andreani, and G.E. Striker Synthesis and release of insulinlike growth factor I by mesangial cells in culture Am J Physiol 255 6, pt 2 1988 F1214 F1219
39. F.G. Conti, L.J. Striker, M.A. Lesniak, K. MacKay, J. Roth, and G.E. Striker Studies on binding and mitogenic effect of insulin and insulin-like growth factor I in glomerular mesangial cells Endocrinology 122 6 1988 2788 2795
40. E. Lupia, S.J. Elliot, and O. Lenz IGF-1 decreases collagen degradation in diabetic NOD mesangial cells: implications for diabetic nephropathy Diabetes 48 8 1999 1638 1644
41. T. Doi, L.J. Striker, S.J. Elliot, F.G. Conti, and G.E. Striker Insulinlike growth factor-1 is a progression factor for human mesangial cells Am J Pathol 134 2 1989 395 404
42. B.D. Schreiber, M.L. Hughes, and G.C. Groggel Insulin-like growth factor-1 stimulates production of mesangial cell matrix components Clin Nephrol 43 6 1995 368 374
43. B.P. Kang, S. Frencher, V. Reddy, A. Kessler, A. Malhotra, and L.G. Meggs High glucose promotes mesangial cell apoptosis by oxidant-dependent mechanism Am J Physiol Renal Physiol 284 3 2003 F455 F466
44. B.P. Kang, A. Urbonas, A. Baddoo, S. Baskin, A. Malhotra, and L.G. Meggs IGF-1 inhibits the mitochondrial apoptosis program in mesangial cells exposed to high glucose Ame J Physiol Renal Physiol 285 5 2003 F1013 F1024
45. M.E. Pagtalunan, P.L. Miller, and S. Jumping-Eagle Podocyte loss and progressive glomerular injury in type II diabetes J Clin Invest 99 2 1997 342 348
46. Y.H. Kim, M. Goyal, and D. Kurnit Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat Kidney Int 60 3 2001 957 968
47. G.R. Reddy, M.J. Pushpanathan, and R.F. Ransom Identification of the glomerular podocyte as a target for growth hormone action Endocrinology 148 5 2007 2045 2055
48. J.A. Mohammed, A.Y. Mok, A. Parbtani, and D.G. Matsell Increased expression of insulin-like growth factors in progressive glomerulonephritis of the MRL/lpr mouse Lupus 12 8 2003 584 590
49. I. Tack, S.J. Elliot, M. Potier, A. Rivera, G.E. Striker, and L.J. Striker Autocrine activation of the IGF-I signaling pathway in mesangial cells isolated from diabetic NOD mice Diabetes 51 1 2002 182 188
50. D.G. Matsell, T. Bennett, R.A. Armstrong, P. Goodyer, C. Goodyer, and V.K. Han Insulin-like growth factor (IGF) and IGF binding protein gene expression in multicystic renal dysplasia J Am Soc Nephrol 8 1 1997 85 94
51. H. Fujinaka, K. Katsuyama, and K. Yamamoto Expression and localization of insulin-like growth factor binding proteins in normal and proteinuric kidney glomeruli Nephrology (Carlton) 15 7 2010 700 709
52. D.J. Bridgewater, J.M. Dionne, M.J. Butt, C.L. Pin, and D.G. Matsell The role of the type I insulin-like growth factor receptor (IGF-IR) in glomerular integrity Growth Horm IGF Res 18 1 2008 26 37
53. D.J. Bridgewater, J. Ho, V. Sauro, and D.G. Matsell Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway Kidney Int 67 4 2005 1308 1314
54. P. Kamenicky, S. Viengchareun, and A. Blanchard Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly Endocrinology 149 7 2008 3294 3305
55. P. Kamenicky, A. Blanchard, and M. Frank Body fluid expansion in acromegaly is related to enhanced epithelial sodium channel (ENaC) activity J Clin Endocrinol Metab 96 7 2011 2127 2135
56. P. Kamenicky, A. Blanchard, and C. Gauci Pathophysiology of renal calcium handling in acromegaly: what lies behind hypercalciuria? J Clin Endocrinol Metab 97 6 2012 2124 2133
57. A. Giustina, S. Bossoni, A. Cimino, G. Pizzocolo, G. Romanelli, and W.B. Wehrenberg Impaired growth hormone (GH) response to pyridostigmine in type 1 diabetic patients with exaggerated GH-releasing hormone-stimulated GH secretion J Clin Endocrinol Metab 71 6 1990 1486 1490
58. A. Giustina, and W.B. Wehrenberg Growth hormone neuroregulation in diabetes mellitus Trends Endocrinol Metab 5 2 1994 73 78
59. A. Flyvbjerg Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease Diabetologia 43 10 2000 1205 1223
60. A. Flyvbjerg, K.E. Bornfeldt, S.M. Marshall, H.J. Arnqvist, and H. Orskov Kidney IGF-I mRNA in initial renal hypertrophy in experimental diabetes in rats Diabetologia 33 6 1990 334 338
61. L.A. Bach, and G. Jerums Effect of puberty on initial kidney growth and rise in kidney IGF-1 in diabetic rats Diabetes 39 1990 557 562
62. A. Flyvbjerg, W.F. Bennett, R. Rasch, J.J. Kopchick, and J.A. Scarlett Inhibitory effect of a growth hormone receptor antagonist (G120K-PEG) on renal enlargement, glomerular hypertrophy, and urinary albumin excretion in experimental diabetes in mice Diabetes 48 2 1999 377 382
63. D. Landau, Y. Segev, R. Eshet, A. Flyvbjerg, and M. Phillip Changes in the growth hormone-IGF-I axis in non-obese diabetic mice Int J Exp Diabetes Res 1 1 2000 9 18
64. D. Landau, Y. Segev, and M. Afargan A novel somatostatin analogue prevents early renal complications in the nonobese diabetic mouse Kidney Int 60 2 2001 505 512
65. Y. Segev, D. Landau, M. Marbach, N. Shehadeh, A. Flyvbjerg, and M. Phillip Renal hypertrophy in hyperglycemic non-obese diabetic mice is associated with persistent renal accumulation of insulin-like growth factor I J Am Soc Nephrol 8 3 1997 436 444
66. L.A. Bach, J.L. Stevenson, T.J. Allen, G. Jerums, and A.C. Herington Kidney insulinlike growth factor-I mRNA levels are increased in postpubertal diabetic rats J Endocrinol 129 1991 5 10
67. A. Flyvbjerg, U. Kessler, B. Dorka, B. Funk, H. Orskov, and W. Kiess Transient increase in renal insulin-like growth factor binding proteins during initial kidney hypertrophy in experimental diabetes in rats Diabetologia 35 1992 589 593
68. L.A. Bach, A.J. Cox, F.A.O. Mendelsohn, A.C. Herington, G.A. Werther, and G. Jerums Focal induction of IGF-I binding proteins in proximal tubules of diabetic rat kidney Diabetes 41 1992 499 507
69. D. Landau, E. Chin, and C. Bondy Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes Endocrinology 136 1995 1835 1842
70. G.J. Price, J.L. Berka, G.A. Werther, and L.A. Bach Cell-specific regulation of mRNAs for IGF-I and IGF-binding proteins-4 and -5 in streptozotocin-diabetic rat kidney J Mol Endocrinol 18 1 1997 5 14
71. H. Werner, Z. Shen-Orr, B. Stannard, B. Burguera, C.T. Roberts Jr., and D. LeRoith Experimental diabetes increases insulinlike growth factor I and II receptor concentration and gene expression in kidney Diabetes 39 1990 1490 1497
72. M. Shinada, A. Akdeniz, S. Panagiotopoulos, G. Jerums, and L.A. Bach Proteolysis of insulin-like growth factor-binding protein-3 is increased in urine from patients with diabetic nephropathy J Clin Endocrinol Metab 85 3 2000 1163 1169
73. N. Levin-Iaina, A. Iaina, and I. Raz The emerging role of NO and IGF-1 in early renal hypertrophy in STZ-induced diabetic rats Diabetes Metab Res Rev 27 3 2011 235 243
74. L.A. Bach, R. Dean, S. Youssef, and M.E. Cooper Aminoguanidine ameliorates changes in the IGF system in experimental diabetic nephropathy Nephrol Dial Transplant 15 3 2000 347 354
75. H. Gronbaek, B. Nielsen, B. Schrijvers, I. Vogel, R. Rasch, and A. Flyvbjerg Inhibitory effects of octreotide on renal and glomerular growth in early experimental diabetes in mice J Endocrinol 172 3 2002 637 643
76. L.L. Bellush, S. Doublier, A.N. Holland, L.J. Striker, G.E. Striker, and J.J. Kopchick Protection against diabetes-induced nephropathy in growth hormone receptor/binding protein gene-disrupted mice Endocrinology 141 1 2000 163 168
77. V. Cingel-Ristic, B.F. Schrijvers, and A.K. van Vliet Kidney growth in normal and diabetic mice is not affected by human insulin-like growth factor binding protein-1 administration Exp Biol Med 230 2 2005 135 143
78. O. Serri, H. Beauregard, and P. Brazeau Somatostatin analogue, octreotide, reduces increased glomerular filtration rate and kidney size in insulin-dependent diabetes JAMA 265 1991 888 892
79. R.H. Mak, W.W. Cheung, and C.T. Roberts Jr. The growth hormone-insulin-like growth factor-I axis in chronic kidney disease Growth Horm IGF Res 18 1 2008 17 25
80. F. Kaskel Chronic renal disease: a growing problem Kidney Int 64 3 2003 1141 1151
81. O. Mehls, F. Schaefer, B. Tonshoff, and E. Wuhl Effectiveness of growth hormone treatment in short children with chronic renal failure J Pediatr 141 1 2002 147 148
82. E. Wuhl, and F. Schaefer Effects of growth hormone in patients with chronic renal failure: experience in children and adults Horm Res 58 suppl 3 2002 35 38
83. B. Tonshoff, W.F. Blum, A.M. Wingen, and O. Mehls Serum insulin-like growth factors (IGFs) and IGF binding proteins 1, 2, and 3 in children with chronic renal failure: relationship to height and glomerular filtration rate. The European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood J Clin Endocrinol Metab 80 9 1995 2684 2691
84. T. Ulinski, S. Mohan, and D. Kiepe Serum insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5 in children with chronic renal failure: relationship to growth and glomerular filtration rate. The European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. German Study Group for Growth Hormone Treatment in Chronic Renal Failure Pediatr Nephrol 14 7 2000 589 597
85. D.R. Powell, F. Liu, and B.K. Baker Insulin-like growth factor-binding protein-6 levels are elevated in serum of children with chronic renal failure: a report of the Southwest Pediatric Nephrology Study Group J Clin Endocrinol Metab 82 9 1997 2978 2984
86. D.R. Powell, F. Liu, and B.K. Baker Effect of chronic renal failure and growth hormone therapy on the insulin-like growth factors and their binding proteins Pediatr Nephrol 14 7 2000 579 583
87. B. Tonshoff, D.R. Powell, and D. Zhao Decreased hepatic insulin-like growth factor (IGF)-I and increased IGF binding protein-1 and -2 gene expression in experimental uremia Endocrinology 138 3 1997 938 946
88. J. Woelfle, J. Billiard, and P. Rotwein Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b J Biol Chem 278 25 2003 22696 22702
89. D.F. Sun, Z. Zheng, P. Tummala, J. Oh, F. Schaefer, and R. Rabkin Chronic uremia attenuates growth hormone-induced signal transduction in skeletal muscle J Am Soc Nephrol 15 10 2004 2630 2636
90. X.H. Wang, and W.E. Mitch Muscle wasting from kidney failure - a model for catabolic conditions Int J Biochem Cell Biol 45 10 2013 2230 2238
91. B. Tonshoff, D. Kiepe, and S. Ciarmatori Growth hormone/insulin-like growth factor system in children with chronic renal failure Pediatr Nephrol 20 3 2005 279 289
92. J.D. Mahan, B.A. Warady Consensus Committee Assessment and treatment of short stature in pediatric patients with chronic kidney disease: a consensus statement Pediatr Nephrol 21 7 2006 917 930
93. B. Feldt-Rasmussen, and M. El Nahas Potential role of growth factors with particular focus on growth hormone and insulin-like growth factor-1 in the management of chronic kidney disease Semin Nephrol 29 1 2009 50 58
94. F. Guebre-Egziabher, L. Juillard, Y. Boirie, M. Laville, B. Beaufrere, and D. Fouque Short-term administration of a combination of recombinant growth hormone and insulin-like growth factor-I induces anabolism in maintenance hemodialysis J Clin Endocrinol Metab 94 7 2009 2299 2305
95. J. Lepenies, Z. Wu, P.M. Stewart, C.J. Strasburger, and M. Quinkler IGF-1, IGFBP-3 and ALS in adult patients with chronic kidney disease Growth Horm IGF Res 20 2 2010 93 100
96. T. Jia, T. Gama Axelsson, and O. Heimburger IGF-1 and survival in ESRD Clin J Am Soc Nephrol 9 1 2014 120 127
97. S.B. Miller, D.R. Martin, J. Kissane, and M.R. Hammerman Insulin-like growth factor I accelerates recovery from ischemic acute tubular necrosis in the rat Proc Natl Acad Sci U S A 89 1992 11876 11880
98. R. Hirschberg, G. Brunori, J.D. Kopple, and H.P. Guler Effects of insulin-like growth factor I on renal function in normal men Kidney Int 43 2 1993 387 397
99. S.C. Franklin, M. Moulton, G.A. Sicard, M.R. Hammerman, and S.B. Miller Insulin-like growth factor I preserves renal function postoperatively Am J Physiol 272 2, pt 2 1997 F257 F259
100. M.A. Hladunewich, G. Corrigan, and G.C. Derby A randomized, placebo-controlled trial of IGF-1 for delayed graft function: a human model to study postischemic ARF Kidney Int 64 2 2003 593 602
101. P. Igarashi, and S. Somlo Polycystic kidney disease J Am Soc Nephrol 18 5 2007 1371 1373
102. X. Song, V. Di Giovanni, and N. He Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks Hum Mol Genet 18 13 2009 2328 2343
103. C. Liu, Y. Zhang, L. Yuan, L. Fu, and C. Mei Rosiglitazone inhibits insulin-like growth factor 1-induced polycystic kidney disease cell growth and p70S6 kinase activation Mol Med Rep 8 3 2013 861 864
104. I. Peters, I. Tossidou, and J. Achenbach IGF-binding protein-3 modulates TGF-beta/BMP-signaling in glomerular podocytes J Am Soc Nephrol 17 6 2006 1644 1656
105. K. Worthmann, I. Peters, and P. Kumpers Urinary excretion of IGFBP-1 and -3 correlates with disease activity and differentiates focal segmental glomerulosclerosis and minimal change disease Growth Factors 28 2 2010 129 138
106. K. Tokunaga, H. Uto, and Y. Takami Insulin-like growth factor binding protein-1 levels are increased in patients with IgA nephropathy Biochem Biophys Res Commun 399 2 2010 144 149
107. M. Pollak The insulin and insulin-like growth factor receptor family in neoplasia: an update Nat Rev Cancer 12 3 2012 159 169
108. B.D. Humphreys Kidney injury, stem cells and regeneration Curr Opin Nephrol Hypertens 23 1 2014 25 31
109. B. Imberti, M. Morigi, and S. Tomasoni Insulin-like growth factor-1 sustains stem cell mediated renal repair J Am Soc Nephrol 18 11 2007 2921 2928
110. C. Xinaris, M. Morigi, and V. Benedetti A novel strategy to enhance mesenchymal stem cell migration capacity and promote tissue repair in an injury specific fashion Cell Transplant 22 3 2013 423 436
111. S. Tomasoni, L. Longaretti, and C. Rota Transfer of growth factor receptor mRNA via exosomes unravels the regenerative effect of mesenchymal stem cells Stem Cells Dev 22 5 2013 772 780
112. L. Hale, G. Welsh, and C. Perks Insulin-like growth factor-II is produced by, signals to, and is an important survival factor for the mature podocyte in man and mouse J Pathol 230 1 2013 95 106
113. L. Ivanova, M.J. Butt, and D.G. Matsell Mesenchymal transition in kidney collecting duct epithelial cells Am J Physiol Renal Physiol 294 5 2008 F1238 F1248
114. D. Chen, Z. Chen, and C. Park Aldosterone stimulates fibronectin synthesis in renal fibroblasts through mineralocorticoid receptor-dependent and independent mechanisms Gene 531 1 2013 23 30
115. D.D. New, K. Block, B. Bhandhari, Y. Gorin, and H.E. Abboud IGF-I increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells Am J Physiol Cell Physiol 302 2012 C122 C130
116. V. Luque, J. Escribano, and V. Grote Does insulin-like growth factor-1 mediate protein-induced kidney growth in infants? A secondary analysis from a randomized controlled trial Pediatr Res 74 2 2013 223 229
117. J.R. Charlton, V.F. Norwood, S.C. Kiley, M.J. Gurka, and R.L. Chevalier Evolution of the urinary proteome during human renal development and maturation: variations with gestational and postnatal age Pediatr Res 72 2 2012 179 185