Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice

Journal of Molecular Endocrinology

Volumn 32, Issue 2, 2004, Pages 349-364

  Zhou, R ^a,b   Flaswinkel, H ^a   Schneider, M R ^a   Lahm, H ^c   Hoeflich, A ^a   Wanke, R ^a   Wolf, E ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^c Thoraxklinik Heidelberg gGmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; COMPLEMENTARY DNA; SOMATOMEDIN BINDING PROTEIN 4;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BODY WEIGHT; CELL GROWTH; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE CASSETTE; GENE CONSTRUCT; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GROWTH INHIBITION; IMMUNOHISTOCHEMISTRY; KIDNEY MASS; LUNG WEIGHT; MOUSE; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; SPLEEN WEIGHT; T LYMPHOCYTE; THYMUS; TISSUE GROWTH; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; AUTOANTIBODIES; CELL PROLIFERATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 4; LYMPHOCYTES; MICE; MICE, TRANSGENIC; ORGAN SIZE; PROMOTER REGIONS (GENETICS); SPLEEN; THYMUS GLAND;

EID: 2342614217     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0320349     Document Type: Article

References (51)

1. Beschorner WE, Divic J, Pulido H, Yao X, Kenworthy P & Bruce G 1991 Enhancement of thymic recovery after cyclosporine by recombinant human growth hormone and insulin-like growth factor I. Transplantation 52 879-884.
2. Besedovsky HO & del Rey A 1996 Immune-neuro-endocrine interactions: facts and hypotheses. Endocrine Reviews 17 64-102.
3. Binz K, Joller P, Froesch P, Binz H, Zapf J & Froesch ER 1990 Repopulation of the atrophied thymus in diabetic rats by insulin-like growth factor I. PNAS 87 3690-3694.
4. Blalock JE 1994 The syntax of immune-neuroendocrine communication. Immunology Today 15 504-511.
5. Buul-Offers SC & Kooijman R 1998 The role of growth hormone and insulin-like growth factors in the immune system. Cellular and Molecular Life Sciences 54 1083-1094.
6. Buul-Offers SC, Reijnen-Gresnigt MG, Hoogerbrugge CM, Bloemen RJ, Kuper CF & van den Brande JL 1994 Recombinant insulin-like growth factor-II inhibits the growth-stimulating effect of growth hormone on the liver of Snell dwarf mice. Endocrinology 135 977-985.
7. Buul-Offers SC, de Haan K, Reijnen-Gresnigt MG, Meinsma D, Jansen M, Oei SL, Bonte EJ, Sussenbach JS & van den Brande JL 1995 Overexpression of human insulin-like growth factor-II in transgenic mice causes increased growth of the thymus. Journal of Endocrinology 144 491-502.
8. Clark R, Strasser J, McCabe S, Robbins K & Jardieu P 1993 Insulin-like growth factor-1 stimulation of lymphopoiesis. Journal of Clinical Investigation 92 540-548.
9. Conlon MA, Francis GL, Tomas FM, Wallace JC, Howarth GS & Ballard FJ 1995 Continuous 14 day infusion of IGF-II increases the growth of normal female rats, but exhibits a lower potency than IGF-I. Journal of Endocrinology 144 91-98.
10. Dai Z, Xing Y, Boney CM, Clemmons DR & D'Ercole AJ 1994 Human insulin-like growth factor-binding protein-1 (hIGFBP-1) in transgenic mice: characterization and insights into the regulation of IGFBP-1 expression. Endocrinology 135 1316-1327.
11. Dorshkind K & Horseman ND 2000 The roles of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones in lymphocyte development and function: insights from genetic models of hormone and hormone receptor deficiency. Endocrine Reviews 21 292-312.
12. Firth SM & Baxter RC 2002 Cellular actions of the insulin-like growth factor binding proteins. Endocrine Reviews 23 824-854.
13. Flaswinkel H, Alessandrini F, Rathkolb B, Decker T, Kremmer E, Servatius A, Jakob T, Soewarto D, Marschall S, Fella C et al. 2000 Identification of immunological relevant phenotypes in ENU mutagenized mice. Mammalian Genome 11 526-527.
14. Grellier P, Yee D, Gonzalez M & Abboud SL 1995 Characterization of insulin-like growth factor binding proteins (IGFBP) and regulation of IGFBP-4 in bone marrow stromal cells. British Journal of Haematology 90 249-257.
15. Gundersen HJ & Jensen EB 1987 The efficiency of systematic sampling in stereology and its prediction. Journal of Microscopy 147 229-263.
16. Hinton PS, Peterson CA, Lo HC, Yang H, McCarthy D & Ney DM 1995 Insulin-like growth factor-I enhances immune response in dexamethasone-treated or surgically stressed rats maintained with total parenteral nutrition. Journal of Parenteral and Enteral Nutrition 19 444-452.
17. Hinton PS, Peterson CA, Dahly EM & Ney DM 1998 IGF-I alters lymphocyte survival and regeneration in thymus and spleen after dexamethasone treatment. American Journal of Physiology 274 R912-R920.
18. Hoeflich A, Wu M, Mohan S, Foll J, Wanke R, Froehlich T, Arnold GJ, Lahm H, Kolb HJ & Wolf E 1999 Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain. Endocrinology 140 5488-5496.
19. Hwa V, Oh Y & Rosenfeld RG 1999 The insulin-like growth factor-binding protein (IGFBP) superfamily. Endocrine Reviews 20 761-787.
20. Jardieu P, Clark R, Mortensen D & Dorshkind K 1994 In vivo administration of insulin-like growth factor-I stimulates primary B lymphopoiesis and enhances lymphocyte recovery after bone marrow transplantation. Journal of Immunology 152 4320-4327.
21. Jeay S, Sonenshein GE, Postel-Vinay MC, Kelly PA & Baixeras E 2002 Growth hormone can act as a cytokine controlling survival and proliferation of immune cells: new insights into signaling pathways. Molecular and Cellular Endocrinology 188 1-7.
22. Kecha O, Martens H, Franchimont N, Achour I, Hazee-Hagelstein MT, Charlet-Renard C, Geenen V & Winkler R 1999 Characterization of the insulin-like growth factor axis in the human thymus. Journal of Neuroendocrinology 11 435-440.
23. Kooijman R, Buul-Offers SC, Scholtens LE, Schuurman HJ, Van den Brande LJ & Zegers BJ 1995 T cell development in insulin-like growth factor-II transgenic mice. Journal of Immunology 154 5736-5745.
24. Kooijman R, Buul-Offers SC, Scholtens LE, Reijnen-Gresnigt RG & Zegers BJ 1997 T and B cell development in pituitary deficient insulin-like growth factor-II transgenic dwarf mice. Journal of Endocrinology 155 165-170.
25. Li YM, Arkins S, McCusker RH Jr, Donovan SM, Liu Q, Jayaraman S, Dantzer R & Kelley KW 1996 Macrophages synthesize and secrete a 25-kilodalton protein that binds insulin-like growth factor-I. Journal of Immunology 156 64-72.
26. Madden KS & Felten DL 1995 Experimental basis for neural-immune interactions. Physiological Reviews 75 77-106.
27. Miyakoshi N, Richman C, Qin X, Baylink DJ & Mohan S 1999 Effects of recombinant insulin-like growth factor-binding protein-4 on bone formation parameters in mice. Endocrinology 140 5719-5728.
28. Miyakoshi N, Qin X, Kasukawa Y, Richman C, Srivastava AK, Baylink DJ & Mohan S 2001 Systemic administration of insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) increases bone formation parameters in mice by increasing IGF bioavailability via an IGFBP-4 protease-dependent mechanism. Endocrinology 142 2641-2648.
29. Mohan S & Baylink DJ 2002 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. Journal of Endocrinology 175 19-31.
30. Mohan S, Bautista CM, Wergedal J & Baylink DJ 1989 Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell-conditioned medium: a potential local regulator of IGF action. PNAS 86 8338-8342.
31. Morello D, Moore G, Salmon AM, Yaniv M & Babinet C 1986 Studies on the expression of an H-2K/human growth hormone fusion gene in giant transgenic mice. EMBO Journal 5 1877-1883.
32. Morello D, Asselin C, Lavenu A, Marcu KB & Babinet C 1989 Tissue-specific post-transcriptional regulation of c-myc expression in normal and H-2K/human c-myc transgenic mice. Oncogene 4 955-961.
33. Murphy WJ, Durum SK & Longo DL 1992 Role of neuroendocrine hormones in murine T cell development. Growth hormone exerts thymopoietic effects in vivo. Journal of Immunology 149 3851-3857.
34. Murphy LJ, Rajkumar K & Molnar P 1995a Phenotypic manifestations of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 overexpression in transgenic mice. Progress in Growth Factor Research 6 425-432.
35. Murphy LJ, Molnar P, Lu X & Huang H 1995b Expression of human insulin-like growth factor-binding protein-3 in transgenic mice. Journal of Molecular Endocrinology 15 293-303.
36. Plitz T, Huffstadt U, Endres R, Schaller E, Mak TW, Wagner H & Pfeffer K 1999 The resistance against Listeria monocytogenes and the formation of germinal centers depend on a functional death domain of the 55 kDa tumor necrosis factor receptor. European Journal of Immunology 29 581-591.
37. Rajkumar K, Barron D, Lewitt MS & Murphy LJ 1995 Growth retardation and hyperglycemia in insulin-like growth factor binding protein-1 transgenic mice. Endocrinology 136 4029-4034.
38. Robbins K, McCabe S, Scheiner T, Strasser J, Clark R & Jardieu P 1994 Immunological effects of insulin-like growth factor-I-enhancement of immunoglobulin synthesis. Clinical and Experimental Immunology 95 337-342.
39. Ruther U, Muller W, Sumida T, Tokuhisa T, Rajewsky K & Wagner EF 1988 c-fos expression interferes with thymus development in transgenic mice. Cell 53 847-856.
40. Scherle W 1970 A simple method for volumetry of organs in quantitative stereology. Mikroskopie 26 57-60.
41. Schneider MR, Zhou R, Hoeflich A, Krebs O, Schmidt J, Mohan S, Wolf E & Lahm H 2001 Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells. Biochemical and Biophysical Research Communications 288 435-442.
42. Silva CM, Isgaard J & Thorner MO 1998 Cytokines in endocrine function. Advances in Protein Chemistry 52 199-221.
43. Smink JJ, Koster JG, Hendriks-Stegeman BI & Buul-Offers SC 1999 Insulin-like growth factor (IGF) II induced changes in expression of IGF binding proteins in lymphoid tissues of hIGF-II transgenic mice. Endocrinology 140 5876-5882.
44. Stewart CE & Rotwein P 1996 Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiological Reviews 76 1005-1026.
45. Ui M, Shimonaka M, Shimasaki S & Ling N 1989 An insulin-like growth factor-binding protein in ovarian follicular fluid blocks follicle-stimulating hormone-stimulated steroid production by ovarian granulosa cells. Endocrinology 125 912-916.
46. Van der Ven LT, Roholl PJ, Reijnen-Gresnigt MG, Bloemen RJ & Buul-Offers SC 1997 Expression of insulin-like growth factor II (IGF-II) and histological changes in the thymus and spleen of transgenic mice overexpressing IGF-II. Histochemistry and Cell Biology 107 193-203.
47. Wang J, Niu W, Nikiforov Y, Naito S, Chernausek S, Witte D, LeRoith D, Strauch A & Fagin JA 1997 Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice. Journal of Clinical Investigation 100 1425-1439.
48. Wang J, Niu W, Witte DP, Chernausek SD, Nikiforov YE, Clemens TL, Sharifi B, Strauch AR & Fagin JA 1998 Overexpression of insulin-like growth factor-binding protein-4 (IGFBP- 4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinology 139 2605-2614.
49. Wood TL, Rogler LE, Czick ME, Schuller AG & Pintar JE 2000 Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene. Molecular Endocrinology 14 1472-1482.
50. Zhang M, Smith EP, Kuroda H, Banach W, Chernausek SD & Fagin JA 2002 Targeted expression of a protease-resistant IGFBP-4 mutant in smooth muscle of transgenic mice results in IGFBP-4 stabilization and smooth muscle hypotrophy. Journal of Biological Chemistry 277 21285-21290.
51. Zhou R, Diehl D, Hoeflich A, Lahm H & Wolf E 2003 IGF-binding protein-4: biochemical characteristics and functional consequences. Journal of Endocrinology 178 177-193.