The role of the type I insulin-like growth factor receptor (IGF-IR) in glomerular integrity

Growth Hormone and IGF Research

Volumn 18, Issue 1, 2008, Pages 26-37

  Bridgewater, Darren J ^a   Dionne, Janis M ^b   Butt, Michael J ^b   Pin, Christopher L ^a   Matsell, Douglas G ^b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Insulin like growth factor receptor; Nephrin; Podocyte; Transgenic mouse

Indexed keywords

NEPHRIN; PODOCIN; SOMATOMEDIN; SOMATOMEDIN C RECEPTOR;

ALPHA CHAIN; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA CHAIN; CELL NUCLEUS; CONTROLLED STUDY; GLOMERULOPATHY; GLOMERULUS CAPILLARY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PHENOTYPE; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SOUTHERN BLOTTING; TRANSGENIC MOUSE; ULTRASTRUCTURE; WILD TYPE;

ANIMALS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY GLOMERULUS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; PODOCYTES; PROMOTER REGIONS (GENETICS); RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION;

EID: 38949098281     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2007.06.003     Document Type: Article

References (42)

1. Shankland S.J. The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int. 69 (2006) 2131-2147
2. Kriz W. Progression of chronic renal failure in focal segmental glomerulosclerosis: consequence of podocyte damage or of tubulointerstitial fibrosis?. Pediatr. Nephrol. 18 (2003) 617-622
3. Barisoni L., and Kopp J.B. Update in podocyte biology: putting one's best foot forward. Curr. Opin. Nephrol. Hypertens. 12 (2003) 251-258
4. Pavenstadt H., Kriz W., and Kretzler M. Cell biology of the glomerular podocyte. Physiol. Rev. 83 (2003) 253-307
5. Lahdenkari A.T., Lounatmaa K., Patrakka J., Holmberg C., Wartiovaara J., Kestila M., et al. Podocytes are firmly attached to glomerular basement membrane in kidneys with heavy proteinuria. J. Am. Soc. Nephrol. 15 (2004) 2611-2618
6. van den Berg J.G., van den Bergh Weerman M.A., Weening J.J., and Florquin S. Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulopathies. Kidney Int. 66 (2004) 1901-1906
7. Chen C.A., Hwang J.C., Guh J.Y., Chang J.M., Lai Y.H., and Chen H.C. Reduced podocyte expression of alpha3beta1 integrins and podocyte depletion in patients with primary focal segmental glomerulosclerosis and chronic PAN-treated rats. J. Lab. Clin. Med. 147 (2006) 74-82
8. Amri K., Freund N., Van Huyen J.P., Merlet-Benichou C., and Lelievre-Pegorier M. Altered nephrogenesis due to maternal diabetes is associated with increased expression of IGF-II/mannose-6-phosphate receptor in the fetal kidney. Diabetes 50 (2001) 1069-1075
9. Matsell D.G., Delhanty P.J., Stepaniuk O., Goodyear C., and Han V.K. Expression of insulin-like growth factor and binding protein genes during nephrogenesis. Kidney Int. 46 (1994) 1031-1042
10. Bridgewater D.J., and Matsell D.G. Insulin-like growth factor binding protein-2 modulates podocyte mitogenesis. Pediatr. Nephrol. 18 (2003) 1109-1115
11. Bridgewater D.J., Ho J., Sauro V., and Matsell D.G. Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway. Kidney Int. 67 (2005) 1308-1314
12. Parrizas M., Saltiel A.R., and LeRoith D. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. J. Biol. Chem. 272 (1997) 154-161
13. Navarro P., Valverde A.M., Benito M., and Lorenzo M. Insulin/IGF-I rescues immortalized brown adipocytes from apoptosis down-regulating Bcl-xS expression, in a PI 3-kinase and map kinase-dependent manner. Exp. Cell Res. 243 (1998) 213-221
14. Fornoni A., Li H., Foschi A., Striker G.E., and Striker L.J. Hepatocyte growth factor, but not insulin-like growth factor I, protects podocytes against cyclosporin A-induced apoptosis. Am. J. Pathol. 158 (2001) 275-280
15. Bentov I., and Werner H. IGF, IGF receptor and overgrowth syndromes. Pediatr. Endocrinol. Rev. 1 (2004) 352-360
16. Eggenschwiler J., Ludwig T., Fisher P., Leighton P.A., Tilghman S.M., and Efstratiadis A. Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes. Genes Dev. 11 (1997) 3128-3142
17. Prawitt D., Enklaar T., Gartner-Rupprecht B., Spangenberg C., Lausch E., Reutzel D., et al. Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms' tumor. Nat. Genet. 37 (2005) 785-786
18. Mohammed J.A., Mok A.Y., Parbtani A., and Matsell D.G. Increased expression of insulin-like growth factors in progressive glomerulonephritis of the MRL/lpr mouse. Lupus 12 (2003) 584-590
19. Matsell D.G., Bennett T., Armstrong R.A., Goodyer P., Goodyer C., and Han V.K. Insulin-like growth factor (IGF) and IGF binding protein gene expression in multicystic renal dysplasia. J. Am. Soc. Nephrol. 8 (1997) 85-94
20. Tack I., Elliott S.J., Potier M., Rivera A., Striker G.E., and Striker L.J. Autocrine activation of the IGF-I signaling pathway in mesangial cells isolated from diabetic NOD mice. Diabetes 51 (2002) 182-188
21. Valentinis B., and Baserga R. IGF-I receptor signalling in transformation and differentiation. Mol. Pathol. 54 (2001) 133-137
22. Reiss K., Tu X., Romano G., Peruzzi F., Wang J.Y., and Baserga R. Intracellular association of a mutant insulin-like growth factor receptor with endogenous receptors. Clin. Cancer Res. 7 (2001) 2134-2144
23. Eremina V., Wong M.A., Cui S., Schwartz L., and Quaggin S.E. Glomerular-specific gene excision in vivo. J. Am. Soc. Nephrol. 13 (2002) 788-793
24. Michaud J.L., Lemieux L.I., Dube M., Vanderhyden B.C., Robertson S.J., and Kennedy C.R. Focal and segmental glomerulosclerosis in mice with podocyte-specific expression of mutant alpha-actinin-4. J. Am. Soc. Nephrol. 14 (2003) 1200-1211
25. Eremina V., Sood M., Haigh J., Nagy A., Lajoie G., Ferrara N., et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J. Clin. Invest. 111 (2003) 707-716
26. Hogan B.B. Manipulating the Mouse Embryo: A Laboratory Manual (1994), Cold Spring Harbor Laboratory Press, Cold Spring Harbor
27. Matsell D.G., Gaber L.W., and Malik K.U. stimulation of prostaglandin production inhibits the proliferation of serum-stimulated mesangial cells. Kidney Int. 45 (1994) 159-165
28. Nishimoto K., Shiiki H., Nishino T., Kimura T., Sasaki Y., Yamasaki M., et al. Glomerular hypertrophy in preeclamptic patients with focal segmental glomerulosclerosis. A morphometric analysis. Clin. Nephrol. 51 (1999) 209-219
29. Durvasula R.V., and Shankland S.J. Podocyte injury and targeting therapy: an update. Curr. Opin. Nephrol. Hypertens. 15 (2006) 1-7
30. Boute N., Gribouval O., Roselli S., Benessy F., Lee H., Fuchshuber A., et al. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat. Genet. 24 (2000) 349-354
31. Kaplan J.M., Kim S.H., North K.N., Rennke H., Correia L.A., Tong H.Q., et al. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat. Genet. 24 (2000) 251-256
32. Shih N.Y., Li J., Karpitskii V., Dustin M.L., Kanagawa O., Miner J.H., et al. Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science 286 (1999) 312-315
33. Kestila M., Lenkkeri U., Mannikko M., Lamerdin J., McCready P., Putaala H., et al. Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol. Cell 1 (1998) 575-582
34. Winn M.P., Conlon P.J., Lynn K.L., Farrington M.K., Creazzo T., Hawkins A.F., et al. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 308 (2005) 1801-1804
35. Liu J.P., Baker J., Perkins A.S., Robertson E.J., and Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (IGF-1) and type 1 IGF receptor (IGF1r). Cell 75 (1993) 59-72
36. Rogers S.A., Powell-Braxton L., and Hammerman M.R. Insulin-like growth factor I regulates renal development in rodents. Dev. Genet. 24 (1999) 293-298
37. D'Ambrosio C., Ferber A., Resnicoff M., and Baserga R. A soluble insulin-like growth factor I receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis. Cancer Res. 56 (1996) 4013-4020
38. Reiss K., Wang J.Y., Romano G., Tu X., Peruzzi F., and Baserga R. Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells. Oncogene 20 (2001) 490-500
39. Huber T.B., Hartleben B., Kim J., Schmidts M., Schermer B., Keil A., et al. Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol. Cell Biol. 23 (2003) 4917-4928
40. Neuenschwander S., Schwartz A., Wood T.L., Roberts Jr. C.T., Hennighausen L., and LeRoith D. Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model. J. Clin. Invest. 97 (1996) 2225-2232
41. Meyer G., Kim B., van Golen C., and Feldman E.L. Cofilin activity during insulin-like growth factor I-stimulated neuroblastoma cell motility. Cell Mol. Life Sci. 62 (2005) 461-470
42. Kreidberg J.A., Donovan M.J., Goldstein S.L., Rennke H., Shepherd K., Jones R.C., et al. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development 122 (1996) 3537-3547