IGF-1 inhibits the mitochondrial apoptosis program in mesangial cells exposed to high glucose

American Journal of Physiology - Renal Physiology

Volumn 285, Issue 5 54-5, 2003, Pages

  Kang, Barinder P S ^a   Urbonas, Arunas ^a   Baddoo, Andrew ^a   Baskin, Stuart ^a   Malhotra, Ashwani ^a   Meggs, Leonard G ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Bad; Bcl 2; Cytochrome c; Mitochondria; Reactive oxygen species

Indexed keywords

CYTOCHROME C; GLUCOSE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C; SUPEROXIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; MEMBRANE POTENTIAL; MESANGIUM CELL; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REDUCTION;

EID: 0142089080     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00209.2003     Document Type: Article

References (54)

1. Akao M, Ohler A, O'Rourke B, and Marban E. Mitochondrial sensitive potassium channels inhibit apoptosis induced by oxidant stress in cardiac cells. Circ Res 88: 1267-1275, 2001.
2. Baines CP, Zhang J, Wang GW, Zheng YT, Xiu JX, Cardwell EM, Bolli R, and Ping P. Mitochondrial PKCε and MAPK form signaling modules in the murine heart. Circ Res 90: 390-397, 2002.
3. Baker AJ, Mooney A, Hughes J, Lombardi D, Johnson RJ, and Savill J. Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in mesangial proliferative nephritis. J Clin Invest 94: 2105-2116, 1994.
4. Baynes J and Thorpe S. The role of oxidative stress in diabetic complications: a new perspective of an old paradigm. Diabetes 48: 1-19, 1999.
5. Bendtsen TF and Nyengaard JR. The number of glomeruli in type 1 and type 2 diabetic patients. Diabetologia 35: 844-850, 1992.
6. Brenner BM. Remission of renal disease: recounting the challenge, acquiring the goal. J Clin Invest 110: 1753-1758, 2002.
7. 2+ superoxide dismutase protects against early diabetic glomerular injury. Diabetes 50: 2114-2125, 2001.
8. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, and Greenberg ME. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275: 661-665, 1997.
9. Dunn SE, Hardman RA, Kari FW, and Barrett CJ. Insulin-like growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse cancer drugs. Cancer Res 57: 2687-2693, 1997.
10. Fiordaliso F, Leri A, Cesselli D, Limana F, Safai B, Nadal-Ginard B, Anversa P, and Kajstura J. Hyperglycemia activates p53 and p53 regulated genes leading to myocyte cell death. Diabetes 50: 2363-2375, 2001.
11. Flyvbjerg A. Role of growth hormone, insulin-like growth factors (IgFs) and IgF binding proteins in the renal complications of diabetes. Kidney Int 52: S12-S19, 1997.
12. Flyvbjerg A, Frystyk J, Osterby R, and Orskov H. Kidney IGF-I and renal hypertrophy in GH-deficient diabetic dwarf rats. Am J Physiol Endocrinol Metab 262: E956-E962, 1992.
13. Forbes RA, Steenbergen C, and Murphy E. Diazoxide induced cardioprotection requires signaling through a redox-sensitive mechanism. Circ Res 88: 802-809, 2001.
14. Green DR and Reed JC. Mitochondria and apoptosis. Science 281: 1309-1312, 1998.
15. Gronbaek H, Volmers P, Bjorn SF, Osterby R, Orskov H, and Flyvbjerg A. Effect of GH/IGF-I deficiency on long-term renal changes and urinary albumin excretion in diabetic dwarf rats. Am J Physiol Endocrinol Metab 272: E918-E924, 1997.
16. Guigliano DA, Ceriello A, and Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care 19: 257-267, 1996.
17. Harada H, Becknell B, and Wilm M. Phosphorylation and inactivation of BAD by mitochondria anchored protein kinase A. Mol Cell 3: 413-422, 1999.
18. Harrington EA, Bennett MR, Fanidi A, and Evan GI. c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J 13: 3286-3295, 1994.
19. Haunstetter A and Izumo S. Apoptosis basic mechanisms and implications for cardiovascular disease. Circ Res 82: 1111-1129, 1998.
20. Ito T, Deng X, Carr B, and May WS. Bcl-2 phosphorylation required for antiapoptosis function. J Biol Chem 272: 11671-11673, 1997.
21. Kang BPS, Frencher S, Reddy V, Kessler A, Malhotra A, and Meggs LG. High glucose promotes mesangial cell apoptosis by an oxidant-dependent mechanism. Am J Physiol Renal Physiol 284: F455-F466, 2003.
22. Kennedy SG, Wagner AJ, Conzen SD, Jordan J, Bellacosa A, Tsichlis PN, and Hay N. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev 11: 701-713, 1997.
23. Khwaja A. Akt is more than just a Bad kinase. Nature 401: 33-34, 1999.
24. Kiley SC, Thornhill BA, Tang SS, Ingelfinger JR, and Chevalier RL. Growth factor mediated phosphorylation of proapoptotic BAD reduces tubule cell death in vitro and in vivo. Kidney Int 63: 33-42, 2003.
25. Kulik G, Klippel A, and Weber MJ. Antiapoptotic signaling by the insulin like growth factor 1 receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 17: 1595-1606, 1997.
26. Kulik G and Weber MJ. Akt-dependent and independent survival signaling pathways utilized by insulin-like growth factor 1. Mol Cell Biol 18: 6711-6718, 1998.
27. Kunlin J, Xiao MO, Yonghua Z, and Greenberg DA. MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad. J Neurochem 80: 119-125, 2002.
28. Lando D, Pongratz I, and Whitelaw ML. A redox mechanism controls differential DNA binding activities of hypoxia inducible factor (HIF) 1ά and the HIF-like factor. J Biol Chem 275: 4618-4627, 2000.
29. Leri A, Yu L, Claudio PP, Kajstura J, Wang X, Wang S, Kang P, Malhotra A, and Anversa P. Insulin-like growth factor-1 induces Mdm2 and downregulates p53, attenuating myocyte renin angiotensin system and stretch-mediated apoptosis. Am J Pathol 154: 567-580, 1999.
30. Leri A, Yu L, Wang X, Kajstura J, Malhotra A, Meggs LG, and Anversa P. Overexpression of insulin like growth factor-1 attenuates the myocyte renin angiotensin system in transgenic mice. Circ Res 84: 752-762, 1999.
31. Marsden PA, Bitzan M, and Abraham A. Reactive nitrogen and oxygen intermediates and the kidney. In: Brenners and Rector's: The Kidney, edited by Brenner BM. Philadelphia, PA: W. B. Saunders, 2000, p. 735-737.
32. McCarthy NJ, Whyte KB, Gilbert CS, and Evan GI. Inhibition of Ced3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J Cell Biol 136: 215-227, 1997.
33. Mooney A, Jobson T, Bacon R, Kitamura M, and Savill J. Cytokines promote glomerular mesangial cell survival in vitro by stimulus dependent inhibition of apoptosis. J Immunol 159: 3949-3960, 1997.
34. Myers MG, Grammer TC, Wang LM, Sun XJ, Pierce JH, Blenis J, and White MF. Insulin receptor substrate-1 mediates phosphatidylinositol 3 kinase and p70S6K signaling during insulin, insulin-like growth factor-1 and interleukin-4 stimulation. J Biol Chem 269: 28783-28789, 1994.
35. Nakmura S, Watanabe H, Miura M, and Sasaki T. Effect of insulin-like growth factor 1 receptor on ionizing radiation-induced cell death in mouse embryo fibroblasts. Exp Cell Res 235: 287-294, 1997.
36. Nicolson DW and Thornberry NA. Life and death decisions. Science 299: 214-215, 2003.
37. Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matasumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, and Brownlee M. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404: 787-790, 2000.
38. Onozoto ML, Tojo A, Goto A, Fujita T, and Wilcox C. Oxidative stress and nitric oxide synthase in rat diabetic nephropathy. Kidney Int 61: 186-194, 2002.
39. Parrizas M and LeRoith D. Insulin-like growth factor 1 inhibition of apoptosis is associated with increased expression of the bcl-XL gene product. Endocrinology 138: 1355-1358, 1997.
40. Parrizas M, Saltiel AR, and LeRoith D. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3 kinase and mitogen activated protein kinase pathways. J Biol Chem 272: 154-161, 1997.
41. Perruzi F, Prisco M, Dews M, Salolmoni P, Grassilli E, Romano G, Calabretta B, and Baserga R. Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol 19: 7203-7215, 1999.
42. Pronk GJ, McGlade J, Pelicci G, Pawson T, and Bos JL. Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins. J Biol Chem 268: 5748-5753, 1993.
43. Sandau K, Pfeilschifter J, and Brune B. Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis. Kidney Int 52: 378-386, 1997.
44. Sharma P, Reddy K, Franki N, Sanwal V, Sankaran R, Ahuja TS, Gibbons N, Mattana J, and Singhal PC. Native and oxidized low density lipoproteins modulate mesangial cell apoptosis. Kidney Int 50: 1604-1611, 1996.
45. Singhal PC, Franki N, Kumari S, Sanwal V, Wagner JD, and Mattana J. Extracellular matrix modulates mesangial cell apoptosis and mRNA expression of cathepsin B and tissue transglutaminase. J Cell Biochem 68: 22-30, 1998.
46. Singleton JR, Dixit VM, and Feldman EL. Type 1 insulin-like growth factor receptor activation regulates apoptotic proteins. J Biol Chem 271: 31791-31794, 1996.
47. RSK blocks Bad-mediated cell dearth via a protein kinase C dependent pathway. J Biol Chem 49: 34859-34867, 1999.
48. Ting H, Timimi FK, and Boles KS. Vitamin C improves endothelium dependent vasodilation in patients with noninsulin dependent diabetes mellitus. J Clin Invest 97: 22-28, 1996.
49. Turner BC, Haffty BG, Narayanan L, Yuan J, Havre PA, Gumbs AA, Kaplan L, Burgaud L, Carter D, Baserga R, and Glazer PM. Insulin-like growth factor-1 receptor overexpression mediates cellular resistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res 57: 3079-3083, 1997.
50. VonHarsdorf R, Li PF, and Dietz R. Signaling pathways in reactive oxygen species induced cardiomyocyte apoptosis. Circulation 99: 2934-2941, 1999.
51. Wolf G, Haberstroh U, and Nielson EG. Angiotensin II stimulates the proliferation and biosynthesis of type 1 collagen in cultured murine mesangial cells. Am J Pathol 140: 95-107, 1992.
52. Yin C, Knudson M, Korsemeyer SJ, and VanDyke T. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385: 637-640, 1997.
53. Zhengui X, Dickens M, Raingeaud J, Davis RJ, and Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 24: 1326-1331, 1995.
54. Ziyadeh FN, Hoffman BB, Han DC, Iglesias-de la Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, and Sharma K. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransfroming growth factor-β antibody I db/ db diabetic mice. Proc Natl Acad Sci USA 97: 8015-8020, 2000.