Urinary excretion of IGFBP-1 and -3 correlates with disease activity and differentiates focal segmental glomerulosclerosis and minimal change disease

Growth Factors

Volumn 28, Issue 2, 2010, Pages 129-138

  Worthmann, Kirstin ^a   Peters, Imke ^a   Kmpers, Philipp ^a   Saleem, Moin ^b   Becker, Jan U ^a   Agustian, Putri A ^a   Achenbach, Johannes ^a   Haller, Hermann ^a   Schiffer, Mario ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

FSGS; IGFBP; Podocyte; TGF

Indexed keywords

BRADYKININ; MESSENGER RNA; PODOCALYXIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; TRANSFORMING GROWTH FACTOR BETA;

ADOLESCENT; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE ACTIVITY; ENDOTHELIUM CELL; FEMALE; FOCAL GLOMERULOSCLEROSIS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MINIMAL CHANGE GLOMERULONEPHRITIS; PATHOGENESIS; PODOCYTE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD; URINARY EXCRETION; VASCULAR ENDOTHELIUM;

ADOLESCENT; ADULT; CELLS, CULTURED; CHILD; DIAGNOSIS, DIFFERENTIAL; ENDOTHELIUM, VASCULAR; FEMALE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; KIDNEY GLOMERULUS; MALE; MIDDLE AGED; NEPHROSIS, LIPOID; PODOCYTES; YOUNG ADULT;

EID: 77949466251     PISSN: 08977194     EISSN: 10292292     Source Type: Journal    
DOI: 10.3109/08977190903512594     Document Type: Article

References (24)

1. Achenbach J, Mengel M, Tossidou I, Peters I, Park JK, Haubitz M, Ehrich JH, Haller H, Schiffer M. 2008. Parietal epithelia cells in the urine as a marker of disease activity in glomerular diseases. Nephrol Dial Transplant 23:3138-3145.
2. Bottinger EP, Bitzer M. 2002. TGF-beta signaling in renal disease. J Am Soc Nephrol 13:2600-2610.
3. Cohen P. 2006. Overview of the IGF-I system. Horm Res 65(Suppl. 1):3-8.
4. Cohen P, Lamson G, Okajima T, Rosenfeld RG. 1993. Transfection of the human insulin-like growth factor binding protein-3 gene into Balb/c fibroblasts inhibits cellular growth. Mol Endocrinol 7:380-386.
5. Devi GR, Yang DH, Rosenfeld RG, Oh Y. 2000. Differential effects of insulin-like growth factor (IGF)-binding protein-3 and its proteolytic fragments on ligand binding, cell surface association, and IGF-I receptor signaling. Endocrinology 141: 4171-4179.
6. Duan C. 2002. Specifying the cellular responses to IGF signals: Roles of IGF-binding proteins. J Endocrinol 175:41-54.
7. Eremina V, Quaggin SE. 2004. The role of VEGF-A in glomerular development and function. Curr Opin Nephrol Hypertens 13:9-15.
8. Garovic VD, Wagner SJ, Turner ST, Rosenthal DW, Watson WJ, Brost BC, Rose CH, Gavrilova L, Craigo P, Bailey KR, Achenbach J, Schiffer M, Grande JP. 2007. Urinary podocyte excretion as a marker for preeclampsia. Am J Obstet Gynecol 196:320-327.
9. Haspolat K, Ece A, Gurkan F, Atamer Y, Tutanc M, Yolbas I. 2007. Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition. Clin Biochem 40:201-205.
10. Hong J, Zhang G, Dong F, Rechler MM. 2002. Insulin-like growth factor (IGF)-binding protein-3 mutants that do not bind IGF-I or IGF-II stimulate apoptosis in human prostate cancer cells. J Biol Chem 277:10489-10497.
11. Jones JI, Clemmons DR. 1995. Insulin-like growth factors and their binding proteins: Biological actions. Endocr Rev 16:3-34.
12. Karas M, Danilenko M, Fishman D, LeRoith D, Levy J, Sharoni Y. 1997. Membrane-associated insulin-like growth factor-binding protein-3 inhibits insulin-like growth factor-I-induced insulinlike growth factor-I receptor signaling in ishikawa endometrial cancer cells. J Biol Chem 272:16514-16520.
13. Kelley KM, Oh Y, Gargosky SE, Gucev Z, Matsumoto T, Hwa V, Ng L, Simpson DM, Rosenfeld RG. 1996. Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics. Int J Biochem Cell Biol 28:619-637.
14. Kim JH, Kim BK, Moon KC, Hong HK, Lee HS. 2003. Activation of the TGF-beta/Smad signaling pathway in focal segmental glomerulosclerosis. Kidney Int 64:1715-1721.
15. Lee HS, Song CY. 2009. Differential role of mesangial cells and podocytes in TGF-beta-induced mesangial matrix synthesis in chronic glomerular disease. Histol Histopathol 24:901-908.
16. Massague J. 2000. How cells read TGF-beta signals. Nat Rev Mol Cell Biol 1:169-178.
17. Oeseburg H, Iusuf D, van der HP, van Gilst WH, Henning RH, Roks AJ. 2009. Bradykinin protects against oxidative stressinduced endothelial cell senescence. Hypertension 53:417-422.
18. Perks CM, Bowen S, Gill ZP, Newcomb PV, Holly JM. 1999. Differential IGF-independent effects of insulin-like growth factor binding proteins (1-6) on apoptosis of breast epithelial cells. J Cell Biochem 75:652-664.
19. Peters I, Tossidou I, Achenbach J, Woroniecki R, Mengel M, Park JK, Paschy M, de Groot K, Haller H, Schiffer M. 2006. IGF-binding protein-3 modulates TGF-beta/BMP-signaling in glomerular podocytes. J Am Soc Nephrol 17:1644-1656.
20. Rajah R, Valentinis B, Cohen P. 1997. Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53-and IGF-independent mechanism. J Biol Chem 272:12181-12188.
21. Richmond EJ, Uzri A, Rogol AD. 2001. The insulin-like growth factor system in kidney diseases. Nephron 89:5-9.
22. Schiffer M, von GG, Bitzer M, Susztak K, Bottinger EP. 2000. Smad proteins and transforming growth factor-beta signaling. Kidney Int Suppl 77:S45-S52.
23. Tonshoff B, Blum WF, Vickers M, Kurilenko S, Mehls O, Ritz E. 1995. Quantification of urinary insulin-like growth factors (IGFs) and IGF binding protein 3 in healthy volunteers before and after stimulation with recombinant human growth hormone. Eur J Endocrinol 132:433-437.
24. Tripathi G, Salih DA, Drozd AC, Cosgrove RA, Cobb LJ, Pell JM. 2009. IGF-independent effects of insulin-like growth factor binding protein-5 (Igfbp5) in vivo. FASEB J 23:2616-2626.