Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1·Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter

Journal of Biological Chemistry

Volumn 283, Issue 8, 2008, Pages 4850-4865

  Porée, Benoît ^a   Kypriotou, Magdalini ^a   Chadjichristos, Christos ^a   Beauchef, Gallic ^a   Renard, Emmanuelle ^a   Legendre, Florence ^a   Melin, Martine ^b,c   Gueret, Sylviane ^b,c   Hartmann, Daniel Jean ^b,c   Malléin Gerin, Frédéric ^d   Pujol, Jean Pierre ^a   Boumediene, Karim ^a   Galéra, Philippe ^a  

^a CAEN UNIVERSITY HOSPITAL   (France)

^b UNIVERSITÉ LYON 1   (France)

^c Novotec   (France)

^d INSTITUT DE BIOLOGIE ET CHIMIE DES PROTÉINES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICULAR CHONDROCYTES; BINDING ACTIVITIES; CARTILAGE MARKERS; CELL TYPES; CELLULAR MODELS; CHONDROCYTES; CHROMATIN IMMUNOPRECIPITATION; COMMON FEATURES; CYTOKINE; DNA BINDINGS; OSTEO ARTHRITISES; OVEREXPRESSION; PROMOTER ACTIVITIES; SMALL INTERFERENCE RNAS; TARGET GENES; TRANSCRIPTIONAL CONTROLS; TYPE II COLLAGENS;

BINDING SITES; BODY FLUIDS; CELL MEMBRANES; COLLAGEN; ELECTRIC LOAD MANAGEMENT; GENE EXPRESSION; NUCLEIC ACIDS; ORGANIC ACIDS; RNA;

TRANSCRIPTION;

COLLAGEN TYPE 2; COMPLEMENTARY DNA; CYTOKINE; INTERLEUKIN 6; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; COL2A1 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; INTERLEUKIN 6 RECEPTOR; SP3 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CHROMATIN IMMUNOPRECIPITATION; COL2A1 GENE; CONTROLLED STUDY; DOWN REGULATION; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE REPRESSION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN SYNTHESIS; WESTERN BLOTTING; ANIMAL; ARTICULAR CARTILAGE; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL CULTURE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; OSTEOARTHRITIS; PATHOLOGY; RABBIT;

ORYCTOLAGUS CUNICULUS;

ANIMALS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-6; MODELS, BIOLOGICAL; OSTEOARTHRITIS; PROMOTER REGIONS (GENETICS); RABBITS; RECEPTORS, INTERLEUKIN-6; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC;

EID: 41949096220     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M706387200     Document Type: Article

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