Interleukin-6 and tumour necrosis factor in synovial fluid from horses with carpal joint pathology

Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine

Volumn 54, Issue 7, 2007, Pages 346-351

  Ley, C ^a   Ekman, S ^a   Elmen A ^a   Nilsson, G ^a,b   Eloranta, M L ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b Hästsjukhuset Solvalla   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ANIMAL DISEASE; ARTHROSCOPY; ARTICLE; CARPAL JOINT; FORELIMB; FRACTURE; HORSE; HORSE DISEASE; IMMUNOLOGY; METABOLISM; PATHOLOGY; SYNOVIAL FLUID; SYNOVITIS;

ANIMALS; ARTHROSCOPY; BIOLOGICAL MARKERS; CARPAL JOINTS; CARPUS, ANIMAL; FRACTURES, BONE; HORSE DISEASES; HORSES; INTERLEUKIN-6; SYNOVIAL FLUID; SYNOVITIS; TUMOR NECROSIS FACTOR-ALPHA;

EQUIDAE;

EID: 34548140516     PISSN: 0931184X     EISSN: 14390442     Source Type: Journal    
DOI: 10.1111/j.1439-0442.2007.00956.x     Document Type: Article

References (33)

1. Aarden, L. A., E. R. De Groot, O. L. Schaap P. M. Lansdorp, 1987 : Production of hybridoma growth factor by human monocytes. Eur. J. Immunol. 17, 1411 1416.
2. Armstrong, S. P. Lees, 2002 : Effects of carprofen (R and S enantiomers and racemate) on the production of IL-1, IL-6 and TNF-α by equine chondrocytes and synoviocytes. J. Vet. Pharmacol. Ther. 25, 145 153.
3. Bertone, A. L., J. L. Palmer J. Jones, 2001 : Synovial fluid cytokines and eicosanoids as markers of joint disease in horses. Vet. Surg. 30, 528 538.
4. Billinghurst, R. C., P. B. Fretz J. R. Gordon, 1995 : Induction of intra-articular tumour necrosis factor during acute inflammatory responses in equine arthritis. Equine Vet. J. 27, 208 216.
5. Burr, D. B. E. L. Radin, 2003 : Microfractures and microcracks in subchondral bone: are they relevant to osteoarthrosis? Rheum. Dis. Clin. North Am. 29, 675 685.
6. Caron, J. P., 1992 : Synovial joint biology and pathobiology. In : Auer, J. A. J. A. Stick (eds Equine Surgery, 2nd edn, pp. 665 678. W. B. Saunders Company, Philadelphia, PA.
7. Caron, J. P., 2003 : Osteoarthritis. In : Ross, M. W. S. J. Dyson (eds Diagnosis and Management of Lameness in the Horse, 1st edn, pp. 572 591. Saunders, St Louis, MO.
8. Frisbie, D. D., 2006 : Synovial joint biology and pathobiology. In : Auer, J. A. J. A. Stick (eds Equine Surgery, 3rd edn, pp. 1036 1055. Saunders, St Louis, MO.
9. Goldring, S. R. M. B. Goldring, 2004 : The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin. Orthop. Relat. Res. 427S, S27 S36.
10. Guerne, P.-A., B. L. Zuraw, J. H. Vaughan, D. A. Carson M. Lotz, 1989 : Synovium as a source of interleukin 6 in vitro. J. Clin. Invest. 83, 585 592.
11. Hardy, J., A. L. Bertone, S. E. Weisbrode, W. W. Muir, T. M. O'Dorisio J. Masty, 1998 : Cell trafficking, mediator release, and articular metabolism in acute inflammation of innervated or denervated isolated equine joints. Am. J. Vet. Res. 59, 88 100.
12. 2 values in horses. Am. J. Vet. Res. 54, 379 386.
13. Ishimi, Y., C. Miyaura, C. H. Jin, T. Akatsu, E. Abe, Y. Nakamura, A. Yamaguchi, S. Yoshiki, T. Matsuda, T. Hirano, T. Kishimoto T. Suda, 1990 : IL-6 is produced by osteoblasts and induces bone resorption. J. Immunol. 145, 3297 3303.
14. Jouglin, M., C. Robert, J.-P. Valette, F. Gavard, F. Quintin-Colonna J.-M. Denoix, 2000 : Metalloproteinases and tumor necrosis factor-alpha activities in synovial fluid of horses: correlation with articular cartilage alterations. Vet. Res. 31, 507 515.
15. Kawcak, C. E., C. W. McIlwraith, R. W. Norrdin, R. D. Park S. P. James, 2001 : The role of subchondral bone in joint disease: a review. Equine Vet. J. 33, 120 126.
16. McIlwraith, C. W., 1980 : Synovial fluid analysis in the diagnosis of equine joint disease. Equine Pract. 2, 44 48.
17. McIlwraith, C. W., 2002 : Diseases of joints, tendons, ligaments and related structures. In : Stashak, T. S. (ed Adams' Lameness in Horses, 5th edn, pp. 459 644. Lippincott Williams & Wilkins, Philadelphia, PA.
18. McIlwraith, C. W., 2005 : Use of synovial fluid and serum biomarkers in equine bone and joint disease: a review. Equine Vet. J. 37, 473 482.
19. McIlwraith, C. W. L. R. Bramlage, 1996 : Surgical treatment of joint injury. In : McIlwraith, C.W. G.W. Trotter (eds Joint Disease in the Horse, 1st edn, pp. 292 317. W. B. Saunders Company, Philadelphia, PA.
20. McIlwraith, C. W., D. D. Frisbie C. E. Kawcak, 2001 : Current treatments for traumatic synovitis, capsulitis, and osteoarthritis. Proceedings of the 47th Annu. Conv. American Association of Equine Practitioners, San Diego, CA, pp. 180 182.
21. Mohtai, M., M. K. Gupta, B. Donlon, B. Ellison, J. Cooke, G. Gibbons, D. J. Schurman R. Lane Smith, 1996 : Expression of interleukin-6 in osteoarthritic chondrocytes and effects of fluid-induced shear on this expression in normal human chondrocytes in vitro. J. Orthop. Res. 14, 67 73.
22. Norrdin, R. W., C. E. Kawcak, B. A. Capwell C. W. McIlwraith, 1998 : Subchondral bone failure in an equine model of overload arthrosis. Bone 22, 133 139.
23. Palmer, J. L. A. L. Bertone, 1994 : Joint structure, biochemistry and biochemical disequilibrium in synovitis and equine joint disease. Equine Vet. J. 26, 263 277.
24. Pool, R. R., 1996 : Pathologic manifestations of joint disease in the athletic horse. In : McIlwraith, C.W. G.W. Trotter (eds Joint Disease in the Horse, 1st edn, pp. 87 104. W. B. Saunders Company, Philadelphia, PA.
25. Pool, R. R. D. M. Meagher, 1990 : Pathologic findings and pathogenesis of racetrack injuries. In : Turner, A. S. N. L. Goodman (eds The Veterinary Clinics of North America: Equine Practice, Vol. 6, pp. 1 30. W. B. Saunders Company, Philadelphia, PA.
26. Radin, E. L., H. G. Parker, J. W. Pugh, R. S. Steinberg, I. L. Paul R. M. Rose, 1973 : Response of joints to impact loading-III: relationship between trabecular microfractures and cartilage degeneration. J. Biomech. 6, 51 57.
27. Skiöldebrand, E., D. Heinegård, M.-L. Eloranta, G. Nilsson, J. Dudhia, B. Sandgren S. Ekman, 2004 : Enhanced concentration of COMP (cartilage oligomeric matrix protein in osteochondral fractures from racing Thoroughbreds. J. Orthop. Res. 23, 156 163.
28. Skiöldebrand, E., D. Heinegård, B. Olofsson, G. Rucklidge, N. Roneus S. Ekman, 2006 : Altered homeostasis of extracellular matrix proteins in joints of Standardbred trotters during a long-term training programme. J. Vet. Med. A 53, 445 449.
29. Theoret, C. L., S. M. Barber J. R. Gordon, 1998 : The expression of IL-1, IL-6, and TGF-β in the synovial fluid of horses with surgically-induced transient synovitis. Vet. Comp. Orthop. Traumatol. 11, 141 145.
30. Van Den Boom, R., P. A. J. Brama, G. H. Kiers, J. De Groot, A. Barneveld P. R. Van Weeren, 2004 : The influence of repeated arthrocentesis and exercise on matrix metalloproteinase and tumour necrosis factor α activities in normal equine joints. Equine Vet. J. 36, 155 159.
31. Von Rechenberg, B., C. Leutenegger, K. Zlinsky, C. W. McIlwraith, M. K. Akens J. A. Auer, 2001 : Upregulation of mRNA of interleukin-1 and -6 in subchondral cystic lesions of four horses. Equine Vet. J. 33, 143 149.
32. Wang, A. M., A. A. Creasey, M. B. Ladner, L. S. Lin, J. Strickler, J. N. Van Arsdell, R. Yamamoto D. F. Mark, 1985 : Molecular cloning of the complementary DNA for human tumor necrosis factor. Science 228, 149 154.
33. Westacott, C. I. M. S. Sharif, 1996 : Cytokines in osteoarthritis: mediators or markers of joint destruction? Semin. Arthritis Rheum. 25, 254 272.