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Angewandte Chemie - International Edition

Volumn 54, Issue 5, 2015, Pages 1551-1555

Multidimensional de novo design reveals 5-HT2B receptor-selective ligands

(8) Rodrigues, Tiago a Hauser, Nadine a Reker, Daniel a Reutlinger, Michael a Wunderlin, Tiffany b Hamon, Jacques b Koch, Guido b Schneider, Gisbert a

a ETH ZURICH (Switzerland)

b NOVARTIS PHARMA AG (Switzerland)

Author keywords

Computer assisted molecular design; Drug discovery; GPCR; Microfluidics; Organic synthesis

Indexed keywords

BINDING ENERGY; METALS; MICROFLUIDICS; SYNTHESIS (CHEMICAL);

ACTIVITY PREDICTIONS; COMPUTER GENERATED; DRUG DISCOVERY; GPCR; MOLECULAR DESIGN; ORGANIC SYNTHESIS; RECEPTOR LIGANDS; SELECTIVE LIGANDS;

LIGANDS;

AMINE; LIGAND; PROTEIN BINDING; SEROTONIN 2 ANTAGONIST; SEROTONIN 2B RECEPTOR;

CHEMISTRY; COMPUTER AIDED DESIGN; DRUG DESIGN; HUMAN; METABOLISM; MICROFLUIDICS; SYNTHESIS;

AMINES; COMPUTER-AIDED DESIGN; DRUG DESIGN; HUMANS; LIGANDS; MICROFLUIDICS; PROTEIN BINDING; RECEPTOR, SEROTONIN, 5-HT2B; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS;

EID: 84921491980 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201410201 Document Type: Article

Times cited : (38)

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