1-((S)-2-aminopropyl)-1H-indazol-6-ol: A potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity

Journal of Medicinal Chemistry

Volumn 49, Issue 1, 2006, Pages 318-328

  May, Jesse A ^a   Dantanarayana, Anura P ^a   Zinke, Paul W ^a   McLaughlin, Marsha A ^a   Sharif, Najam A ^a  

^a ALCON RESEARCH LTD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 AMINOPROPYL) 1H INDAZOL 6 OL; ALPHA METHYLSEROTONIN; AMINE; ANTIHYPERTENSIVE AGENT; INDAZOLE DERIVATIVE; RECEPTOR SUBTYPE; SEROTONIN 2 AGONIST; SEROTONIN 2 RECEPTOR; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BINDING AFFINITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; GLAUCOMA; HUMAN; HUMAN CELL; IC 50; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; MALE; MONKEY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HAPLORHINI; HEAD MOVEMENTS; HUMANS; INDAZOLES; LASERS; MICE; MOLECULAR STRUCTURE; OCULAR HYPERTENSION; RABBITS; RATS; RECEPTORS, SEROTONIN, 5-HT2;

EID: 30444442996     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050663x     Document Type: Article

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