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Angewandte Chemie - International Edition

Volumn 52, Issue 17, 2013, Pages 4676-4681

Drugs by numbers: Reaction-driven de novo design of potent and selective anticancer leads

(10) Spänkuch, Birgit b Keppner, Sarah b Lange, Lisa b Rodrigues, Tiago a Zettl, Heiko a Koch, Christian P a Reutlinger, Michael a Hartenfeller, Markus a Schneider, Petra a Schneider, Gisbert a

a ETH ZURICH (Switzerland)

b UNIVERSITY HOSPITAL TÜBINGEN (Germany)

Author keywords

drug design; enzyme inhibitors; fragment based design; Polo like kinase; virtual synthesis

Indexed keywords

ANTICANCER TARGETS; ANTIPROLIFERATIVE EFFECT; DRUG DESIGN; ENZYME INHIBITORS; POLO-LIKE KINASE; POLO-LIKE KINASE 1; SELECTIVE INHIBITORS; TYPE II KINASE INHIBITOR;

DESIGN; ENZYMES;

SYNTHESIS (CHEMICAL);

ANTINEOPLASTIC AGENT; CELL CYCLE PROTEIN; ONCOPROTEIN; POLO LIKE KINASE 1; POLO-LIKE KINASE 1; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HELA CELL; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL CYCLE PROTEINS; DRUG DESIGN; HELA CELLS; HUMANS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876480311 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201206897 Document Type: Article

Times cited : (24)

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