Opposing effects of target overexpression reveal drug mechanisms

Nature Communications

Volumn 5, Issue , 2014, Pages

  Palmer, Adam C ^a   Kishony, Roy ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CEFSULODIN; CIPROFLOXACIN; COTRIMOXAZOLE; COUMAMYCIN A1; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; DNA TOPOISOMERASE (ATP HYDROLYSING); GAMMA GLUTAMYLTRANSFERASE; GLYCOSYLTRANSFERASE; MECILLINAM; PEPTIDOGLYCAN TRANSPEPTIDASE; PEROXISOMAL BIFUNCTIONAL ENZYME; TRICLOSAN; TRIMETHOPRIM; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ESCHERICHIA COLI PROTEIN;

BIOCHEMICAL COMPOSITION; COLIFORM BACTERIUM; DRUG RESISTANCE; GENE EXPRESSION; INHIBITOR; MOLECULAR ANALYSIS;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; DRUG EFFECT; DRUG MECHANISM; DRUG RESISTANCE; ENZYME INHIBITION; ESCHERICHIA COLI; GENE OVEREXPRESSION; IC 50; NONHUMAN; OPEN READING FRAME; ANTAGONISTS AND INHIBITORS; ANTIBIOTIC RESISTANCE; DRUG EFFECTS; GENETICS; METABOLISM;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS;

EID: 84903761687     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5296     Document Type: Article

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