Structural characterization of the mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase

Biochemistry

Volumn 49, Issue 31, 2010, Pages 6746-6760

  Dey, Sanghamitra ^a   Lane, James M ^b   Lee, Richard E ^c   Rubin, Eric J ^b   Sacchettini, James C ^a,d  

^a TEXAS A AND M UNIVERSITY   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BACILLUS SUBTILIS; BIOSYNTHETIC PATHWAY; BIOTIN BIOSYNTHESIS; DETHIOBIOTIN; DRUG TARGETS; ENZYME MECHANISM; GROWTH ARREST; HELICOBACTER PYLORI; HIGH RESOLUTION; IN-CELL; MYCOBACTERIUM TUBERCULOSIS; PUTATIVE BINDING SITES; SPECIFIC INHIBITORS; STRUCTURAL CHARACTERIZATION; SYNTHASES; SYNTHETASES;

ACIDS; BACTERIOLOGY; BINDING ENERGY; BIOCHEMISTRY; BIOSYNTHESIS; CATALYSTS; CELL DEATH; ENZYMES; ESCHERICHIA COLI; SUBSTRATES;

COENZYMES;

7,8 DIAMINOPELARGONIC ACID SYNTHASE; AMICLENOMYCIN; ANTIINFECTIVE AGENT; BIOTIN; BIOTIN SYNTHASE; DETHIOBIOTIN SYNTHASE; MYCOBACIDIN; NONANOIC ACID; SINEFUNGIN; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL SURVIVAL; BINDING SITE; CELL DEATH; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HELICOBACTER PYLORI; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE; AMINO ACIDS; BACILLUS SUBTILIS; BINDING SITES; BIOTIN; CARBON-NITROGEN LIGASES; CRYSTALLOGRAPHY, X-RAY; METABOLIC NETWORKS AND PATHWAYS; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BINDING; TRANSAMINASES;

BACILLUS SUBTILIS; ESCHERICHIA COLI; HELICOBACTER PYLORI; MYCOBACTERIUM TUBERCULOSIS;

EID: 77955234669     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi902097j     Document Type: Article

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