A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

EMBO Journal

Volumn 34, Issue 2, 2015, Pages 184-199

  Kim, Dong Hyun ^a   Xiao, Zhen ^b   Kwon, Sanghoon ^a   Sun, Xiaoxiao ^c   Ryerson, Daniel ^a   Tkac, David ^a   Ma, Ping ^c   Wu, Shwu Yuan ^d   Chiang, Cheng Ming ^d   Zhou, Edward ^e   Xu, H Eric ^e   Palvimo, Jorma J ^f   Chen, Lin Feng ^a   Kemper, Byron ^a   Kemper, Jongsook Kim ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b SAIC FREDERICK INC   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e VAN ANDEL RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Acetylation; NF B; PIASy; Steatosis; SUMO2

Indexed keywords

CELL NUCLEUS RECEPTOR; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; SUMO PROTEIN; TRIACYLGLYCEROL; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; MESSENGER RNA; SUMO2 PROTEIN, MOUSE;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLUCOSE INTOLERANCE; HEPATITIS; LIVER LEVEL; MACROPHAGE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN MODIFICATION; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CHEMISTRY; COMPLICATION; ENZYME IMMUNOASSAY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOPRECIPITATION; INFLAMMATION; LIVER DISEASES; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN PROCESSING; PROTEOMICS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SUMOYLATION; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING;

MUS;

ACETYLATION; AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CYTOKINES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; INFLAMMATION; LIVER DISEASES; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MOLECULAR SEQUENCE DATA; NF-KAPPA B; OBESITY; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOMICS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; SUMOYLATION; TANDEM MASS SPECTROMETRY;

EID: 84921022704     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201489527     Document Type: Article

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