New antiseptic peptides to protect against endotoxin-mediated shock

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 9, 2010, Pages 3817-3824

  Gutsmann, Thomas ^a   Razquin Olazarán, Iosu ^b   Kowalski, Ina ^a   Kaconis, Yani ^a   Howe, Jörg ^a   Bartels, Rainer ^a   Hornef, Mathias ^c   Schürholz, Tobias ^d   Rössle, Manfred ^e   Sanchez Gómez, Susana ^b   Moriyon, Ignacio ^b   De Tejada, Guillermo Martinez ^b   Brandenburg, Klaus ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

^b UNIVERSITY OF NAVARRA   (Spain)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIUM LIPOPOLYSACCHARIDE; LIPID A; PEPTIDE; POLYMYXIN B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; FEMALE; HUMAN; HUMAN CELL; IN VIVO CULTURE; LIMULUS; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SEPTIC SHOCK; SYSTEMIC CIRCULATION;

ANIMALS; ANTI-INFECTIVE AGENTS; BACTERIA; CALORIMETRY; CELLS, CULTURED; CYTOKINES; FEMALE; HEMOLYSIS; HUMANS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICROBIAL SENSITIVITY TESTS; PEPTIDES; SHOCK, SEPTIC;

EID: 77956128812     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00534-10     Document Type: Article

References (31)

1. Andrä, J., T. Gutsmann, P. Garidel, and K. Brandenburg. 2006. Mechanisms of endotoxin neutralization by synthetic cationic compounds. J. Endotoxin Res. 12:261-277. (Pubitemid 47471338)
2. Andrä, J., J. Howe, P. Garidel, M. Rossle, W. Richter, J. Leiva-Leon, I. Moriyon, R. Bartels, T. Gutsmann, and K. Brandenburg. 2007. Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis. Biochem. J. 406: 297-307.
3. Andrä, J., M. H. J. Koch, R. Bartels, and K. Brandenburg. 2004. Biophysical characterization of endotoxin inactivation by NK-2, an antimicrobial peptide derived from mammalian NK-lysin. Antimicrob. Agents Chemother. 48: 1593-1599.
4. Andrä, J., K. Lohner, S. E. Blondelle, R. Jerala, I. Moriyon, M. H. Koch, P. Garidel, and K. Brandenburg. 2005. Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide. Biochem. J. 385:135-143.
5. Bone, R. C. 1991. The pathogenesis of sepsis. Ann. Intern. Med. 115:457-469.
6. Brandenburg, K., S. S. Funari, M. H. J. Koch, and U. Seydel. 1999. Investigation into the acyl chain packing of endotoxins and phospholipids under near physiological conditions by WAXS and FTIR spectroscopy. J. Struct. Biol. 128:175-186.
7. Brandenburg, K., M. H. J. Koch, and U. Seydel. 1990. Phase diagram of lipid A from Salmonella minnesota and Escherichia coli rough mutant lipopolysaccharide. J. Struct. Biol. 105:11-21.
8. Brandenburg, K., and A. Wiese. 2004. Endotoxins: relationships between structure, function, and activity. Curr. Top. Med. Chem. 4:1127-1146.
9. Chen, X., J. Howe, J. Andrä, M. Rössle, W. Richter, A. P. da Silva, A. M. Krensky, C. Clayberger, and K. Brandenburg. 2007. Biophysical analysis of the interaction of granulysin-derived peptides with enterobacterial endotoxins. Biochim. Biophys. Acta 1768:2421-2431.
10. Dankesreiter, S., A. Hoess, J. Schneider-Mergener, H. Wagner, and T. Mietke. 2000. Synthetic endotoxin-binding peptides block endotoxin-triggered TNF-α production by macrophages in vitro and in vivo and prevent endotoxin-mediated toxic shock. J. Immunol. 164:4804-4811. (Pubitemid 30238083)
11. Evans, M. E., and M. Pollack. 1993. Effect of antibiotic class and concentration on the release of lipopolysaccharide from Escherichia coli. J. Infect. Dis. 167:1336-1343. (Pubitemid 23146181)
12. Galanos, C., M. A. Freudenberg, and W. Reutter. 1979. Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc. Natl. Acad. Sci. U. S. A. 76:5939-5943.
13. Galanos, C., O. Lüderitz, and O. Westphal. 1969. A new method for the extraction of R lipopolysaccharides. Eur. J. Biochem. 9:245-249.
14. Hirschfeld, M., Y. Ma, J. H. Weis, S. N. Vogel, and J. J. Weis. 2000. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2. J. Immunol. 165:618-622.
15. Jürgens, G., M. Müller, M. H. J. Koch, and K. Brandenburg. 2001. Interaction of hemoglobin with enterobacterial lipopolysaccharide and lipid A: physicochemical characterization and biological activity. Eur. J. Biochem. 268:4233-4242.
16. Koch, M. H. J., and J. Bordas. 1983. X-ray diffraction and scattering on disordered systems using synchrotron radiation. Nucl. Instrum. Methods 208:461-469.
17. Leong, D., R. Diaz, K. Milner, J. Rudbach, and J. B. Wilson. 1970. Some structural and biological properties of Brucella endotoxin. Infect. Immun. 1:174-182.
18. Mookherjee, N., L. M. Rehaume, and R. E. Hancock. 2007. Cathelicidins and functional analogues as antisepsis molecules. Expert Opin. Ther. Targets 11:993-1004.
19. Motzkus, D., S. Schulz-Maronde, A. Heitland, A. Schulz, W. G. Forssmann, M. Jubner, and E. Maronde. 2006. The novel beta-defensin DEFB123 prevents lipopolysaccharide-mediated effects in vitro and in vivo. FASEB J. 20:1701-1702.
20. NCCLS/CLSI. 2007. Standards 7. NCCLS/CLSI, Wayne, PA.
21. Ohtani, Y., T. Irie, K. Uekama, K. Kukunaja, and J. Pitha. 1989. Differential effects of alpha-, beta- and gamma-cyclodextrins on human erythrocytes. Eur. J. Biochem. 186:17-22.
22. Okuda, D., S. Yomogida, H. Tamura, and I. Nagaoka. 2006. Determination of the antibacterial and lipopolysaccharide-neutralizing regions of guinea pig neutrophil cathelicidin peptide CAP11. Antimicrob. Agents Chemother. 50: 2602-2607.
23. Rietschel, E. T., H. Brade, O. Holst, L. Brade, S. Müller-Loennies, U. Mamat, U. Zähringer, F. Beckmann, U. Seydel, K. Brandenburg, A. J. Ulmer, T. Mattern, H. Heine, J. Schletter, S. Hauschildt, H. Loppnow, U. Schönbeck, H.-D. Flad, U. F. Schade, F. Di Padova, S. Kusumoto, and R. R. Schumann. 1996. Bacterial endotoxin: chemical constitution, biological recognition, host response, and immunological detoxification. Curr. Top. Microbiol. Immunol. 216:39-81.
24. Rietschel, E. T., H. W. Wollenweber, H. Brade, U. Zähringer, B. Lindner, U. Seydel, H. Bradaczek, G. Barnickel, H. Labischinski, and P. Giesbrecht. 1980. Structure and conformation of the lipid A component of lipopolysaccharides, p. 187-218. In E. T. Rietschel (ed.), Handbook of endotoxin. Elsevier, Amsterdam, Netherlands.
25. Risco, C., J. L. Carrascosa, and M. A. Bosch. 1993. Visualization of lipopolysaccharide aggregates by freeze-fracture and negative staining. J. Electron Microsc. 42:202-204.
26. Roessle, M., R. Klaering, U. Ristau, B. Robrahn, D. Jahn, T. Gehrmann, P. Konarev, A. Round, S. Fiedler, C. Hermes, and D. Svergun. 2007. Upgrade of the small-angle X-ray scattering beamline at the European Molecular Biology Laboratory, Hamburg. J. Appl. Crystallogr. 40:190-194.
27. Rosenfeld, Y., N. Papo, and Y. Shai. 2006. Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action. J. Biol. Chem. 281:1636-1643.
28. Rosenfeld, Y., H. G. Sahl, and Y. Shai. 2008. Parameters involved in antimicrobial and endotoxin detoxification activities of antimicrobial peptides. Biochemistry 47:6468-6478.
29. Rosenfeld, Y., and Y. Shai. 2006. Lipopolysaccharide (endotoxin)-host defense antibacterial peptides interactions: role in bacterial resistance and prevention of sepsis. Biochim. Biophys. Acta 1758:1513-1522.
30. Sundaresan, R., and J. N. Sheagren. 1995. Current understanding and treatment of sepsis. Infect. Med. 12:261-268, 274.
31. Tapping, R. I., and P. S. Tobias. 1997. Cellular binding of soluble CD14 requires lipopolysaccharide (LPS) and LPS-binding protein. J. Biol. Chem. 272:23157-23164.