Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody

Structure

Volumn 23, Issue 1, 2015, Pages 104-115

  Udi, Yael ^a   Grossman, Moran ^a   Solomonov, Inna ^a   Dym, Orly ^a   Rozenberg, Haim ^a   Moreno, Vanessa ^b   Cuniasse, Philippe ^c   Dive, Vincent ^c   Arroyo, Alicia García ^b   Sagi, Irit ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^c DIF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 4; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN F(AB) FRAGMENT; LEM 15 ANTIBODY; LEM 2 ANTIBODY; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE 14; MONOCYTE CHEMOTACTIC PROTEIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG; ANTIBODY; MATRIX METALLOPROTEINASE INHIBITOR; PROTEIN BINDING;

ALLOSTERISM; ANTIBODY COMBINING SITE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CANCER CELL; CELL MEMBRANE; CELL SURFACE; COLLAGEN DEGRADATION; COMPLEMENTARITY DETERMINING REGION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; ENDOTHELIUM CELL; ENZYMATIC DEGRADATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME KINETIC ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME MECHANISM; FIBROSARCOMA CELL LINE; FLUORESCENCE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; IC50; IN VITRO STUDY; MECHANICAL TORSION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; STEREOSPECIFICITY; STRUCTURAL HOMOLOGY; SURFACE PLASMON RESONANCE; SURFACE PROPERTY; X RAY ABSORPTION SPECTROSCOPY; ANIMAL; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROTEIN QUATERNARY STRUCTURE; UMBILICAL VEIN ENDOTHELIAL CELL; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIBODIES; CATALYTIC DOMAIN; CELL MEMBRANE; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE INHIBITORS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY;

EID: 84920989731     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2014.10.012     Document Type: Article

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