Pivotal molecular determinants of peptidic and collagen triple helicase activities reside in the S3′ subsite of Matrix Metalloproteinase 8 (MMP-8): The role of hydrogen bonding potential of Asn 188 and Tyr189 and the connecting cis bond

Journal of Biological Chemistry

Volumn 280, Issue 3, 2005, Pages 2370-2377

  Pelman, Gayle R ^a   Morrison, Charlotte J ^a   Overall, Christopher M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; COLLAGEN; ENERGY TRANSFER; ENZYME KINETICS; HYDROGEN; HYDROPHOBICITY; RESONANCE; SUBSTRATES;

HELICAS; HELICASE ACTIVITY; MATRIX METALLOPROTEINASE (MMP); MOLECULAR DETERMINANTS;

MOLECULAR BIOLOGY;

COLLAGEN; COLLAGEN TYPE 1; HELICASE; HEMOPEXIN; INTERSTITIAL COLLAGENASE; NEUTROPHIL COLLAGENASE; PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; COLLAGEN DEGRADATION; ELECTROPHORESIS; ENZYME ACTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC TRANSFECTION; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; TRIPLE HELIX;

AMINO ACID SEQUENCE; ANIMALS; ASPARAGINE; BASE SEQUENCE; CHO CELLS; COLLAGEN; CRICETINAE; DNA HELICASES; HYDROGEN BONDING; MATRIX METALLOPROTEINASE 8; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; TYROSINE;

ANIMALIA;

EID: 12544256661     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409603200     Document Type: Article

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