Priming of microglia in a DNA-repair deficient model of accelerated aging

Neurobiology of Aging

Volumn 35, Issue 9, 2014, Pages 2147-2160

  Raj, Divya D A ^a   Jaarsma, Dick ^b   Holtman, Inge R ^a   Olah, Marta ^a   Ferreira, Filipa M ^b   Schaafsma, Wandert ^a   Brouwer, Nieske ^a   Meijer, Michel M ^a   De Waard, Monique C ^b   Van der Pluijm, Ingrid ^b   Brandt, Renata ^b   Kreft, Karim L ^b   Laman, Jon D ^b   De Haan, Gerald ^c   Biber, Knut P H ^a,d   Hoeijmakers, Jan H J ^b   Eggen, Bart J L ^a   Boddeke, Hendrikus W G M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Aging; DNA damage; Hyperactivation; Microglia; Neuroinflammation; Neuron glia interaction; Phagocytosis; Priming

Indexed keywords

EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; GALECTIN 3; INTERLEUKIN 1BETA; INTERLEUKIN 6; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; DNA BINDING PROTEIN; ENDONUCLEASE; ERCC1 PROTEIN, MOUSE; LIPOPOLYSACCHARIDE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; BRAIN REGION; CELL COUNT; CELL DENSITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VOLUME; CONTROLLED STUDY; DNA REPAIR; GENOTYPE; IMMUNOREACTIVITY; MEDULLA OBLONGATA; MICROGLIA; MOUSE; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; ANIMAL; DISEASE MODEL; DISORDERS OF DNA SYNTHESIS AND REPAIR; FOREBRAIN; GENETICS; INFLAMMATION; METABOLISM; MUTANT MOUSE STRAIN; MUTATION; PATHOLOGY; PREMATURE AGING;

AGING; AGING, PREMATURE; ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; DNA REPAIR-DEFICIENCY DISORDERS; DNA-BINDING PROTEINS; ENDONUCLEASES; INFLAMMATION; LIPOPOLYSACCHARIDES; MICE, MUTANT STRAINS; MICROGLIA; MUTATION; PHAGOCYTOSIS; PROSENCEPHALON;

EID: 84902072810     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.03.025     Document Type: Article

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