메뉴 건너뛰기




Volumn 6, Issue 10, 2014, Pages 859-871

Contemporary screening approaches to reaction discovery and development

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DRUG; ORGANIC COMPOUND;

EID: 84920927241     PISSN: 17554330     EISSN: 17554349     Source Type: Journal    
DOI: 10.1038/nchem.2062     Document Type: Review
Times cited : (188)

References (113)
  • 2
    • 0033019939 scopus 로고    scopus 로고
    • Discovery of new multi component reactions with combinatorial methods
    • Weber, L., Illgen, K., Almstetter, M. Discovery of new multi component reactions with combinatorial methods. Synlett 1999, 366-374 (1999).
    • (1999) Synlett 1999 , pp. 366-374
    • Weber, L.1    Illgen, K.2    Almstetter, M.3
  • 3
    • 0035910597 scopus 로고    scopus 로고
    • Combinatorial and evolution-based methods in the creation of enantioselective catalysts
    • Reetz, M. T. Combinatorial and evolution-based methods in the creation of enantioselective catalysts. Angew. Chem. Int. Ed. 40, 284-310 (2001).
    • (2001) Angew. Chem. Int. Ed. , vol.40 , pp. 284-310
    • Reetz, M.T.1
  • 4
    • 0001564142 scopus 로고    scopus 로고
    • Recent advances in the measurement of enantiomeric excesses
    • Tsukamoto, M., Kagan, H. B. Recent advances in the measurement of enantiomeric excesses. Adv. Synth. Catal. 344, 453-463 (2002).
    • (2002) Adv. Synth. Catal. , vol.344 , pp. 453-463
    • Tsukamoto, M.1    Kagan, H.B.2
  • 5
    • 82955190467 scopus 로고    scopus 로고
    • Rapid determination of enantiomeric excess: A focus on optical approaches
    • Leung, D., Kang, S. O., Anslyn, E. V. Rapid determination of enantiomeric excess: a focus on optical approaches. Chem. Soc. Rev. 41, 448-479 (2012).
    • (2012) Chem. Soc. Rev. , vol.41 , pp. 448-479
    • Leung, D.1    Kang, S.O.2    Anslyn, E.V.3
  • 6
    • 0000596050 scopus 로고
    • Phosphatase catalysis developed via combinatorial organic chemistry
    • Menger, F. M., Eliseev, A. V., Migulin, V. A. Phosphatase catalysis developed via combinatorial organic chemistry. J. Org. Chem. 60, 6666-6667 (1995).
    • (1995) J. Org. Chem. , vol.60 , pp. 6666-6667
    • Menger, F.M.1    Eliseev, A.V.2    Migulin, V.A.3
  • 7
    • 10244273514 scopus 로고
    • A general solid-phase synthesis strategy for the preparation of 2-pyrrolidinemethanol ligands
    • Liu, G., Ellman, J. A. A general solid-phase synthesis strategy for the preparation of 2-pyrrolidinemethanol ligands. J. Org. Chem. 60, 7712-7713 (1995).
    • (1995) J. Org. Chem. , vol.60 , pp. 7712-7713
    • Liu, G.1    Ellman, J.A.2
  • 8
    • 33748247343 scopus 로고    scopus 로고
    • New catalysts and conditions for a C-H insertion reaction identified by high throughput catalyst screening
    • Burgess, K., Lim, H-J., Porte, A. M., Sulikowski, G. A. New catalysts and conditions for a C-H insertion reaction identified by high throughput catalyst screening. Angew. Chem. Int. Ed. Engl. 35, 220-222 (1996).
    • (1996) Angew. Chem. Int. Ed. Engl. , vol.35 , pp. 220-222
    • Burgess, K.1    Lim, H.-J.2    Porte, A.M.3    Sulikowski, G.A.4
  • 9
    • 0032538022 scopus 로고    scopus 로고
    • Design and optimization of new phosphine oxazoline ligands via high-throughput catalyst screening
    • Porte, A. M., Reibenspies, J., Burgess, K. Design and optimization of new phosphine oxazoline ligands via high-throughput catalyst screening. J. Am. Chem. Soc. 120, 9180-9187 (1998).
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 9180-9187
    • Porte, A.M.1    Reibenspies, J.2    Burgess, K.3
  • 10
    • 0029764025 scopus 로고    scopus 로고
    • Discovery of chiral catalysts through ligand diversity: Ti-catalyzed enantioselective addition of TMSCN to meso epoxides
    • Cole, B. M. et al. Discovery of chiral catalysts through ligand diversity: Ti-catalyzed enantioselective addition of TMSCN to meso epoxides. Angew. Chem. Int. Ed. Engl. 35, 1668-1671 (1996).
    • (1996) Angew. Chem. Int. Ed. Engl. , vol.35 , pp. 1668-1671
    • Cole, B.M.1
  • 11
    • 0030565556 scopus 로고    scopus 로고
    • The combinatorial synthesis of chiral phosphine ligands
    • Gilbertson, S. R., Wang, X. The combinatorial synthesis of chiral phosphine ligands. Tetrahedron Lett. 37, 6475-6478 (1996).
    • (1996) Tetrahedron Lett , vol.37 , pp. 6475-6478
    • Gilbertson, S.R.1    Wang, X.2
  • 12
    • 0003554758 scopus 로고    scopus 로고
    • Schiff base catalysts for the asymmetric Strecker reaction identified and optimized from parallel synthetic libraries
    • Sigman, M. S., Jacobsen, E. N. Schiff base catalysts for the asymmetric Strecker reaction identified and optimized from parallel synthetic libraries. J. Am. Chem. Soc. 120, 4901-4902 (1998).
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 4901-4902
    • Sigman, M.S.1    Jacobsen, E.N.2
  • 13
    • 0029811207 scopus 로고    scopus 로고
    • Combinatorial approach to the discovery of novel coordination complexes
    • Francis, M. B., Finney, N. S., Jacobsen, E. N. Combinatorial approach to the discovery of novel coordination complexes. J. Am. Chem. Soc. 118, 8983-8984 (1996).
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 8983-8984
    • Francis, M.B.1    Finney, N.S.2    Jacobsen, E.N.3
  • 14
    • 0033118620 scopus 로고    scopus 로고
    • Discovery of novel catalysts for alkene epoxidation from metal-binding combinatorial libraries
    • Francis, M. B., Jacobsen, E. N. Discovery of novel catalysts for alkene epoxidation from metal-binding combinatorial libraries. Angew. Chem. Int. Ed. 38, 937-941 (1999).
    • (1999) Angew. Chem. Int. Ed. , vol.38 , pp. 937-941
    • Francis, M.B.1    Jacobsen, E.N.2
  • 15
    • 39549111287 scopus 로고    scopus 로고
    • Synergistic effect of binary component ligands in chiral catalyst library engineering for enantioselective reactions
    • Ding, K. Synergistic effect of binary component ligands in chiral catalyst library engineering for enantioselective reactions. Chem. Commun. 909-921 (2008).
    • (2008) Chem. Commun. , pp. 909-921
    • Ding, K.1
  • 16
    • 3042835317 scopus 로고    scopus 로고
    • Combinatorial chemistry approach to chiral catalyst engineering and screening: Rational design and serendipity
    • Ding, K., Du, H., Yuan, Y., Long, J. Combinatorial chemistry approach to chiral catalyst engineering and screening: rational design and serendipity. Chem. Eur. J. 10, 2872-2884 (2004).
    • (2004) Chem. Eur. J. , vol.10 , pp. 2872-2884
    • Ding, K.1    Du, H.2    Yuan, Y.3    Long, J.4
  • 17
    • 0037450022 scopus 로고    scopus 로고
    • A new principle in combinatorial asymmetric transition-metal catalysis: Mixtures of chiral monodentate P ligands
    • Reetz, M. T., Sell, T., Meiswinkel, A., Mehler, G. A new principle in combinatorial asymmetric transition-metal catalysis: mixtures of chiral monodentate P ligands. Angew. Chem. Int. Ed. 42, 790-793 (2003).
    • (2003) Angew. Chem. Int. Ed. , vol.42 , pp. 790-793
    • Reetz, M.T.1    Sell, T.2    Meiswinkel, A.3    Mehler, G.4
  • 18
    • 0038065528 scopus 로고    scopus 로고
    • Mixtures of chiral and achiral monodentate ligands in asymmetric Rh-catalyzed olefin hydrogenation: Reversal of enantioselectivity
    • Reetz, M. T., Mehler, G. Mixtures of chiral and achiral monodentate ligands in asymmetric Rh-catalyzed olefin hydrogenation: reversal of enantioselectivity. Tetrahedron Lett. 44, 4593-4596 (2003).
    • (2003) Tetrahedron Lett , vol.44 , pp. 4593-4596
    • Reetz, M.T.1    Mehler, G.2
  • 19
    • 0041495679 scopus 로고    scopus 로고
    • Improving conversion and enantioselectivity in hydrogenation by combining different monodentate phosphoramidites: A new combinatorial approach in asymmetric catalysis
    • Penã, D. et al. Improving conversion and enantioselectivity in hydrogenation by combining different monodentate phosphoramidites: a new combinatorial approach in asymmetric catalysis. Org. Biomol. Chem. 1, 1087-1089 (2003).
    • (2003) Org. Biomol. Chem. , vol.1 , pp. 1087-1089
    • Penã, D.1
  • 20
    • 38049033351 scopus 로고    scopus 로고
    • Asymmetric hydrogenation using monodentate phosphoramidite ligands
    • Minnaard, A. J., Feringa, B. L., Lefort, L., de Vries, J. G. Asymmetric hydrogenation using monodentate phosphoramidite ligands. Acc. Chem. Res. 40, 1267-1277 (2007).
    • (2007) Acc. Chem. Res. , vol.40 , pp. 1267-1277
    • Minnaard, A.J.1    Feringa, B.L.2    Lefort, L.3    De Vries, J.G.4
  • 21
    • 0025893762 scopus 로고
    • General method for rapid synthesis of multicomponent peptide mixtures
    • Furka, Á., Sebestyén, F., Asgedom, M., Dibó, G. General method for rapid synthesis of multicomponent peptide mixtures. Int. J. Pept. Prot. Res. 37, 487-493 (1991).
    • (1991) Int. J. Pept. Prot. Res. , vol.37 , pp. 487-493
    • Furka Á.1    Sebestyén, F.2    Asgedom, M.3    Dibó, G.4
  • 22
    • 0036603597 scopus 로고    scopus 로고
    • Proton-activated fluorescence as a tool for simultaneous screening of combinatorial chemical reactions
    • Evans, C. A., Miller, S. J. Proton-activated fluorescence as a tool for simultaneous screening of combinatorial chemical reactions. Curr. Opin. Chem. Biol. 6, 333-338 (2002).
    • (2002) Curr. Opin. Chem. Biol. , vol.6 , pp. 333-338
    • Evans, C.A.1    Miller, S.J.2
  • 23
    • 84870164672 scopus 로고    scopus 로고
    • Combinatorial evolution of site-and enantioselective catalysts for polyene epoxidation
    • Lichtor, P. A., Miller, S. J. Combinatorial evolution of site-and enantioselective catalysts for polyene epoxidation. Nature Chem. 4, 990-995 (2012).
    • (2012) Nature Chem , vol.4 , pp. 990-995
    • Lichtor, P.A.1    Miller, S.J.2
  • 24
    • 82255173962 scopus 로고    scopus 로고
    • Discovery of an ?-amino C-H arylation reaction using the strategy of accelerated serendipity
    • McNally, A., Prier, C. K., MacMillan, D. W. C. Discovery of an ?-amino C-H arylation reaction using the strategy of accelerated serendipity. Science 334, 1114-1117 (2011).
    • (2011) Science , vol.334 , pp. 1114-1117
    • McNally, A.1    Prier, C.K.2    MacMillan, D.W.C.3
  • 25
    • 65249100749 scopus 로고    scopus 로고
    • Strategies for innovation in multicomponent reaction design
    • Ganem, B. Strategies for innovation in multicomponent reaction design. Acc. Chem. Res. 42, 463-472 (2009).
    • (2009) Acc. Chem. Res. , vol.42 , pp. 463-472
    • Ganem, B.1
  • 26
    • 33846783006 scopus 로고    scopus 로고
    • Discovery of chemical reactions through multidimensional screening
    • Beeler, A. B., Su, S., Singleton, C. A., Porco, J. A. Discovery of chemical reactions through multidimensional screening. J. Am. Chem. Soc. 129, 1413-1419 (2007).
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 1413-1419
    • Beeler, A.B.1    Su, S.2    Singleton, C.A.3    Porco, J.A.4
  • 27
    • 77952026636 scopus 로고    scopus 로고
    • Tandem processes identified from reaction screening: Nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation
    • Kinoshita, H., Ingham, O. J., Ong, W. W., Beeler, A. B., Porco, J. A. Tandem processes identified from reaction screening: nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation. J. Am. Chem. Soc. 132, 6412-6418 (2010).
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 6412-6418
    • Kinoshita, H.1    Ingham, O.J.2    Ong, W.W.3    Beeler, A.B.4    Porco, J.A.5
  • 28
    • 84887706104 scopus 로고    scopus 로고
    • The past, present and potential for microfluidic reactor technology in chemical synthesis
    • Elvira, K. S., Casadevall i Solvas, X., Wootton, R. C. R., DeMello, A. J. The past, present and potential for microfluidic reactor technology in chemical synthesis. Nature Chem. 5, 905-915 (2013).
    • (2013) Nature Chem , vol.5 , pp. 905-915
    • Elvira, K.S.1    Casadevall, I.2    Solvas, X.3    Wootton, R.C.R.4    Demello, A.J.5
  • 29
    • 70349110510 scopus 로고    scopus 로고
    • Development of an automated microfluidic reaction platform for multidimensional screening: Reaction discovery employing bicyclo[3.2.1]octanoid scaffolds
    • Goodell, J. R. et al. Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds. J. Org. Chem. 74, 6169-6180 (2009).
    • (2009) J. Org. Chem. , vol.74 , pp. 6169-6180
    • Goodell, J.R.1
  • 30
    • 84899813739 scopus 로고    scopus 로고
    • Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes
    • Martin, V. I., Goodell, J. R., Ingham, O. J., Porco, J. A., Beeler, A. B. Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes. J. Org. Chem. 79, 3838-3846 (2014).
    • (2014) J. Org. Chem. , vol.79 , pp. 3838-3846
    • Martin, V.I.1    Goodell, J.R.2    Ingham, O.J.3    Porco, J.A.4    Beeler, A.B.5
  • 32
    • 77949809428 scopus 로고    scopus 로고
    • Reaction discovery using microfluidic-based multidimensional screening of polycyclic iminium ethers
    • Treece, J. L., Goodell, J. R., Vander Velde, D., Porco, J. A., Aubé, J. Reaction discovery using microfluidic-based multidimensional screening of polycyclic iminium ethers. J. Org. Chem. 75, 2028-2038 (2010).
    • (2010) J. Org. Chem. , vol.75 , pp. 2028-2038
    • Treece, J.L.1    Goodell, J.R.2    Vander Velde, D.3    Porco, J.A.4    Aubé, J.5
  • 33
    • 80052629313 scopus 로고    scopus 로고
    • A simple, multidimensional approach to high-throughput discovery of catalytic reactions
    • Robbins, D. W., Hartwig, J. F. A simple, multidimensional approach to high-throughput discovery of catalytic reactions. Science 333, 1423-1427 (2011).
    • (2011) Science , vol.333 , pp. 1423-1427
    • Robbins, D.W.1    Hartwig, J.F.2
  • 34
    • 0031929976 scopus 로고    scopus 로고
    • One-pot multi-substrate screening in asymmetric catalysis
    • Gao, X., Kagan, H. B. One-pot multi-substrate screening in asymmetric catalysis. Chirality 10, 120-124 (1998).
    • (1998) Chirality , vol.10 , pp. 120-124
    • Gao, X.1    Kagan, H.B.2
  • 35
    • 0000684017 scopus 로고    scopus 로고
    • Investigation of a new family of chiral ligands for enantioselective catalysis via parallel synthesis and high-throughput screening
    • Gennari, C., Ceccarelli, S., Piarulli, U., Montalbetti, C. A. G. N., Jackson, R. F. W. Investigation of a new family of chiral ligands for enantioselective catalysis via parallel synthesis and high-throughput screening. J. Org. Chem. 63, 5312-5313 (1998).
    • (1998) J. Org. Chem. , vol.63 , pp. 5312-5313
    • Gennari, C.1    Ceccarelli, S.2    Piarulli, U.3    Montalbetti, C.A.G.N.4    Jackson, R.F.W.5
  • 36
    • 20044392332 scopus 로고    scopus 로고
    • The multi-substrate screening of asymmetric catalysts
    • Satyanarayana, T., Kagan, H. B. The multi-substrate screening of asymmetric catalysts. Adv. Synth. Catal. 347, 737-748 (2005).
    • (2005) Adv. Synth. Catal. , vol.347 , pp. 737-748
    • Satyanarayana, T.1    Kagan, H.B.2
  • 37
    • 0037100318 scopus 로고    scopus 로고
    • One-pot multi-substrate enantioselective conjugate addition of diethylzinc to nitroalkenes
    • Duursma, A., Minnaard, A. J., Feringa, B. L. One-pot multi-substrate enantioselective conjugate addition of diethylzinc to nitroalkenes. Tetrahedron 58, 5773-5778 (2002).
    • (2002) Tetrahedron , vol.58 , pp. 5773-5778
    • Duursma, A.1    Minnaard, A.J.2    Feringa, B.L.3
  • 39
    • 53849095713 scopus 로고    scopus 로고
    • Insights into Sonogashira cross-coupling by high-throughput kinetics and descriptor modeling
    • an der Heiden, M. R. et al. Insights into Sonogashira cross-coupling by high-throughput kinetics and descriptor modeling. Chem. Eur. J 14, 2857-2866 (2008).
    • (2008) Chem. Eur. J , vol.14 , pp. 2857-2866
    • An Der Heiden, M.R.1
  • 40
    • 84896858522 scopus 로고    scopus 로고
    • Tailor-made N-heterocyclic carbenes for nanoparticle stabilization
    • Richter, C., Schaepe, K., Glorius, F., Ravoo, B. J. Tailor-made N-heterocyclic carbenes for nanoparticle stabilization. Chem. Commun. 50, 3204-3207 (2014).
    • (2014) Chem. Commun. , vol.50 , pp. 3204-3207
    • Richter, C.1    Schaepe, K.2    Glorius, F.3    Ravoo, B.J.4
  • 41
    • 0015116634 scopus 로고
    • Enzyme-linked immunosorbent assay (ELISA) quantitative assay of immunoglobulin G
    • Engvall, E., Perlmann, P. Enzyme-linked immunosorbent assay (ELISA) quantitative assay of immunoglobulin G. Immunochemistry 8, 871-874 (1971).
    • (1971) Immunochemistry , vol.8 , pp. 871-874
    • Engvall, E.1    Perlmann, P.2
  • 42
    • 3242832518 scopus 로고
    • Immunoassay using antigen-enzyme conjugates
    • Van Weemen, B. K., Schuurs, A. H. W. M. Immunoassay using antigen-enzyme conjugates. FEBS Lett. 15, 232-236 (1971).
    • (1971) FEBS Lett , vol.15 , pp. 232-236
    • Van Weemen, B.K.1    Schuurs, A.H.W.M.2
  • 43
    • 0037016257 scopus 로고    scopus 로고
    • High-throughput screening of enantioselective catalysts by immunoassay
    • Taran, F. et al. High-throughput screening of enantioselective catalysts by immunoassay. Angew. Chem. Int. Ed. 41, 124-127 (2002).
    • (2002) Angew. Chem. Int. Ed. , vol.41 , pp. 124-127
    • Taran, F.1
  • 44
    • 77949824989 scopus 로고    scopus 로고
    • Toward the limits of sandwich immunoassay of very low molecular weight molecules
    • Quinton, J. et al. Toward the limits of sandwich immunoassay of very low molecular weight molecules. Anal. Chem. 82, 2536-2540 (2010).
    • (2010) Anal. Chem. , vol.82 , pp. 2536-2540
    • Quinton, J.1
  • 45
    • 27544459398 scopus 로고    scopus 로고
    • Sandwich immunoassay as a high-throughput screening method for cross-coupling reactions
    • Vicennati, P., Bensel, N., Wagner, A., Créminon, C., Taran, F. Sandwich immunoassay as a high-throughput screening method for cross-coupling reactions. Angew. Chem. Int. Ed. 44, 6863-6866 (2005).
    • (2005) Angew. Chem. Int. Ed. , vol.44 , pp. 6863-6866
    • Vicennati, P.1    Bensel, N.2    Wagner, A.3    Créminon, C.4    Taran, F.5
  • 46
    • 84862668280 scopus 로고    scopus 로고
    • Reaction discovery by using a sandwich immunoassay
    • Quinton, J. et al. Reaction discovery by using a sandwich immunoassay. Angew. Chem. Int. Ed. 51, 6144-6148 (2012).
    • (2012) Angew. Chem. Int. Ed. , vol.51 , pp. 6144-6148
    • Quinton, J.1
  • 47
    • 84887426592 scopus 로고    scopus 로고
    • Discovery of chemoselective and biocompatible reactions using a high-throughput immunoassay screening
    • Kolodych, S. et al. Discovery of chemoselective and biocompatible reactions using a high-throughput immunoassay screening. Angew. Chem. Int. Ed. 52, 12056-12060 (2013).
    • (2013) Angew. Chem. Int. Ed. , vol.52 , pp. 12056-12060
    • Kolodych, S.1
  • 48
    • 0000096835 scopus 로고    scopus 로고
    • Click chemistry: Diverse chemical function from a few good reactions
    • Kolb, H. C., Finn, M. G., Sharpless, K. B. Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 40, 2004-2021 (2001).
    • (2001) Angew. Chem. Int. Ed. , vol.40 , pp. 2004-2021
    • Kolb, H.C.1    Finn, M.G.2    Sharpless, K.B.3
  • 49
    • 0034829726 scopus 로고    scopus 로고
    • The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules
    • Gartner, Z. J., Liu, D. R. The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules. J. Am. Chem. Soc. 123, 6961-6963 (2001).
    • (2001) J. Am. Chem. Soc. , vol.123 , pp. 6961-6963
    • Gartner, Z.J.1    Liu, D.R.2
  • 50
    • 4944255180 scopus 로고    scopus 로고
    • Reaction discovery enabled by DNA-templated synthesis and in vitro selection
    • Kanan, M. W., Rozenman, M. M., Sakurai, K., Snyder, T. M., Liu, D. R. Reaction discovery enabled by DNA-templated synthesis and in vitro selection. Nature 431, 545-549 (2004).
    • (2004) Nature , vol.431 , pp. 545-549
    • Kanan, M.W.1    Rozenman, M.M.2    Sakurai, K.3    Snyder, T.M.4    Liu, D.R.5
  • 51
    • 33847654631 scopus 로고    scopus 로고
    • Synthesis of acyclic alpha, beta-unsaturated ketones via Pd(II)-catalyzed intermolecular reaction of alkynamides and alkenes
    • Momiyama, N., Kanan, M. W., Liu, D. R. Synthesis of acyclic alpha, beta-unsaturated ketones via Pd(II)-catalyzed intermolecular reaction of alkynamides and alkenes. J. Am. Chem. Soc. 129, 2230-2231 (2007).
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 2230-2231
    • Momiyama, N.1    Kanan, M.W.2    Liu, D.R.3
  • 52
    • 67650001817 scopus 로고    scopus 로고
    • Reactivity-dependent PCR: Direct, solution-phase in vitro selection for bond formation
    • Gorin, D. J., Kamlet, A. S., Liu, D. R. Reactivity-dependent PCR: direct, solution-phase in vitro selection for bond formation. J. Am. Chem. Soc. 131, 9189-9191 (2009).
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 9189-9191
    • Gorin, D.J.1    Kamlet, A.S.2    Liu, D.R.3
  • 53
    • 36849070953 scopus 로고    scopus 로고
    • Development and initial application of a hybridization-independent DNA-encoded reaction discovery system compatible with organic solvents
    • Rozenman, M. M., Kanan, M. W., Liu, D. R. Development and initial application of a hybridization-independent, DNA-encoded reaction discovery system compatible with organic solvents. J. Am. Chem. Soc. 129, 14933-14938 (2007).
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 14933-14938
    • Rozenman, M.M.1    Kanan, M.W.2    Liu, D.R.3
  • 54
    • 79251640637 scopus 로고    scopus 로고
    • A biomolecule-compatible visible-light-induced azide reduction from a DNA-encoded reaction-discovery system
    • Chen, Y., Kamlet, A. S., Steinman, J. B., Liu, D. R. A biomolecule-compatible visible-light-induced azide reduction from a DNA-encoded reaction-discovery system. Nature Chem. 3, 146-153 (2011).
    • (2011) Nature Chem , vol.3 , pp. 146-153
    • Chen, Y.1    Kamlet, A.S.2    Steinman, J.B.3    Liu, D.R.4
  • 55
    • 84880124916 scopus 로고    scopus 로고
    • Visible light photoredox catalysis with transition metal complexes: Applications in organic synthesis
    • Prier, C. K., Rankic, D. A., MacMillan, D. W. C. Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. Chem. Rev. 113, 5322-5363 (2013).
    • (2013) Chem. Rev. , vol.113 , pp. 5322-5363
    • Prier, C.K.1    Rankic, D.A.2    MacMillan, D.W.C.3
  • 56
    • 84876846773 scopus 로고    scopus 로고
    • Label-assisted mass spectrometry for the acceleration of reaction discovery and optimization
    • Cabrera-Pardo, J. R., Chai, D. I., Liu, S., Mrksich, M., Kozmin, S. A. Label-assisted mass spectrometry for the acceleration of reaction discovery and optimization. Nature Chem. 5, 423-427 (2013).
    • (2013) Nature Chem , vol.5 , pp. 423-427
    • Cabrera-Pardo, J.R.1    Chai, D.I.2    Liu, S.3    Mrksich, M.4    Kozmin, S.A.5
  • 57
    • 83655197599 scopus 로고    scopus 로고
    • Three-component reaction discovery enabled by mass spectrometry of self-assembled monolayers
    • Montavon, T. J., Li, J., Cabrera-Pardo, J. R., Mrksich, M., Kozmin, S. A. Three-component reaction discovery enabled by mass spectrometry of self-assembled monolayers. Nature Chem. 4, 45-51 (2012).
    • (2012) Nature Chem , vol.4 , pp. 45-51
    • Montavon, T.J.1    Li, J.2    Cabrera-Pardo, J.R.3    Mrksich, M.4    Kozmin, S.A.5
  • 59
    • 0034798236 scopus 로고    scopus 로고
    • New fluorogenic probes for oxygen and carbene transfer: A sensitive assay for single bead-supported catalysts
    • Moreira, R., Havranek, M., Sames, D. New fluorogenic probes for oxygen and carbene transfer: a sensitive assay for single bead-supported catalysts. J. Am. Chem. Soc. 123, 3927-3931 (2001).
    • (2001) J. Am. Chem. Soc. , vol.123 , pp. 3927-3931
    • Moreira, R.1    Havranek, M.2    Sames, D.3
  • 60
    • 0033577277 scopus 로고    scopus 로고
    • A fluorescence-based assay for high-throughput screening of coupling reactions. Application to Heck chemistry
    • Shaughnessy, K. H., Kim, P., Hartwig, J. F. A fluorescence-based assay for high-throughput screening of coupling reactions. Application to Heck chemistry. J. Am. Chem. Soc. 121, 2123-2132 (1999).
    • (1999) J. Am. Chem. Soc. , vol.121 , pp. 2123-2132
    • Shaughnessy, K.H.1    Kim, P.2    Hartwig, J.F.3
  • 61
    • 0033526393 scopus 로고    scopus 로고
    • A chemosensor-based approach to catalyst discovery in solution and on solid support
    • Copeland, G. T., Miller, S. J. A chemosensor-based approach to catalyst discovery in solution and on solid support. J. Am. Chem. Soc. 121, 4306-4307 (1999).
    • (1999) J. Am. Chem. Soc. , vol.121 , pp. 4306-4307
    • Copeland, G.T.1    Miller, S.J.2
  • 62
    • 0035838880 scopus 로고    scopus 로고
    • Fluorescence-based screening of asymmetric acylation catalysts through parallel enantiomer analysis. Identification of a catalyst for tertiary alcohol resolution
    • Jarvo, E. R., Evans, C. A., Copeland, G. T., Miller, S. J. Fluorescence-based screening of asymmetric acylation catalysts through parallel enantiomer analysis. Identification of a catalyst for tertiary alcohol resolution. J. Org. Chem. 66, 5522-5527 (2001).
    • (2001) J. Org. Chem. , vol.66 , pp. 5522-5527
    • Jarvo, E.R.1    Evans, C.A.2    Copeland, G.T.3    Miller, S.J.4
  • 63
    • 0034669263 scopus 로고    scopus 로고
    • A polymeric and fluorescent gel for combinatorial screening of catalysts
    • Harris, R. F., Nation, A. J., Copeland, G. T., Miller, S. J. A polymeric and fluorescent gel for combinatorial screening of catalysts. J. Am. Chem. Soc. 122, 11270-11271 (2000).
    • (2000) J. Am. Chem. Soc. , vol.122 , pp. 11270-11271
    • Harris, R.F.1    Nation, A.J.2    Copeland, G.T.3    Miller, S.J.4
  • 64
    • 0034803619 scopus 로고    scopus 로고
    • Palladium-catalyzed arylation of ethyl cyanoacetate. Fluorescence resonance energy transfer as a tool for reaction discovery
    • Stauffer, S. R., Beare, N. A., Stambuli, J. P., Hartwig, J. F. Palladium-catalyzed arylation of ethyl cyanoacetate. Fluorescence resonance energy transfer as a tool for reaction discovery. J. Am. Chem. Soc. 123, 4641-4642 (2001).
    • (2001) J. Am. Chem. Soc. , vol.123 , pp. 4641-4642
    • Stauffer, S.R.1    Beare, N.A.2    Stambuli, J.P.3    Hartwig, J.F.4
  • 65
    • 0034837076 scopus 로고    scopus 로고
    • Screening of homogeneous catalysts by fluorescence resonance energy transfer. Identification of catalysts for room-temperature Heck reactions
    • Stambuli, J. P., Stauffer, S. R., Shaughnessy, K. H., Hartwig, J. F. Screening of homogeneous catalysts by fluorescence resonance energy transfer. Identification of catalysts for room-temperature Heck reactions. J. Am. Chem. Soc. 123, 2677-2678 (2001).
    • (2001) J. Am. Chem. Soc. , vol.123 , pp. 2677-2678
    • Stambuli, J.P.1    Stauffer, S.R.2    Shaughnessy, K.H.3    Hartwig, J.F.4
  • 66
    • 0037567569 scopus 로고    scopus 로고
    • Fluorescence resonance energy transfer (FRET) as a high-throughput assay for coupling reactions. Arylation of amines as a case study
    • Stauffer, S. R., Hartwig, J. F. Fluorescence resonance energy transfer (FRET) as a high-throughput assay for coupling reactions. Arylation of amines as a case study. J. Am. Chem. Soc. 125, 6977-6985 (2003).
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 6977-6985
    • Stauffer, S.R.1    Hartwig, J.F.2
  • 67
    • 3343006952 scopus 로고    scopus 로고
    • Discovery and characterization of catalysts for azide-alkyne cycloaddition by fluorescence quenching
    • Lewis, W. G., Magallon, F. G., Fokin, V. V, Finn, M. G. Discovery and characterization of catalysts for azide-alkyne cycloaddition by fluorescence quenching. J. Am. Chem. Soc. 126, 9152-9153 (2004).
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 9152-9153
    • Lewis, W.G.1    Magallon, F.G.2    Fokin, V.V.3    Finn, M.G.4
  • 68
    • 79952581003 scopus 로고    scopus 로고
    • ESIPT-mediated photocycloadditions of 3-hydroxyquinolinones: Development of a fluorescence quenching assay for reaction screening
    • Xia, B. et al. ESIPT-mediated photocycloadditions of 3-hydroxyquinolinones: development of a fluorescence quenching assay for reaction screening. Org. Lett. 13, 1346-1349 (2011).
    • (2011) Org. Lett. , vol.13 , pp. 1346-1349
    • Xia, B.1
  • 69
    • 38349178390 scopus 로고    scopus 로고
    • Fluorogenic transformations based on formation of C-C bonds catalyzed by palladium: An efficient approach for high throughput optimizations and kinetic studies
    • Rozhkov, R. V., Davisson, V. J., Bergstrom, D. E. Fluorogenic transformations based on formation of C-C bonds catalyzed by palladium: an efficient approach for high throughput optimizations and kinetic studies. Adv. Synth. Catal. 350, 71-75 (2008).
    • (2008) Adv. Synth. Catal. , vol.350 , pp. 71-75
    • Rozhkov, R.V.1    Davisson, V.J.2    Bergstrom, D.E.3
  • 70
    • 62949163625 scopus 로고    scopus 로고
    • Fluorophore tagged cross-coupling catalysts
    • Sashuk, V., Schoeps, D., Plenio, H. Fluorophore tagged cross-coupling catalysts. Chem. Commun. 770-772 (2009).
    • (2009) Chem. Commun. , pp. 770-772
    • Sashuk, V.1    Schoeps, D.2    Plenio, H.3
  • 71
    • 33846455826 scopus 로고    scopus 로고
    • Benchtop monitoring of reaction progress via visual recognition with a handheld UV lamp: In situ monitoring of boronic acids in the Suzuki-Miyaura reaction
    • Barder, T. E., Buchwald, S. L. Benchtop monitoring of reaction progress via visual recognition with a handheld UV lamp: in situ monitoring of boronic acids in the Suzuki-Miyaura reaction. Org. Lett. 9, 137-139 (2007).
    • (2007) Org. Lett. , vol.9 , pp. 137-139
    • Barder, T.E.1    Buchwald, S.L.2
  • 72
    • 0033517679 scopus 로고    scopus 로고
    • Discovery of novel catalysts for allylic alkylation with a visual colorimetric assay
    • Lavastre, O., Morken, J. P. Discovery of novel catalysts for allylic alkylation with a visual colorimetric assay. Angew. Chem. Int. Ed. 38, 3163-3165 (1999).
    • (1999) Angew. Chem. Int. Ed. , vol.38 , pp. 3163-3165
    • Lavastre, O.1    Morken, J.P.2
  • 73
    • 67649795138 scopus 로고    scopus 로고
    • Molecular recognition and self-assembly special feature: A general protocol for creating high-throughput screening assays for reaction yield and enantiomeric excess applied to hydrobenzoin
    • Shabbir, S. H., Regan, C. J., Anslyn, E. V. Molecular recognition and self-assembly special feature: a general protocol for creating high-throughput screening assays for reaction yield and enantiomeric excess applied to hydrobenzoin. Proc. Natl Acad. Sci. USA 106, 10487-10492 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 10487-10492
    • Shabbir, S.H.1    Regan, C.J.2    Anslyn, E.V.3
  • 74
    • 0034794048 scopus 로고    scopus 로고
    • Palladium-catalyzed hydroamination of 1, 3-Dienes: A colorimetric assay and enantioselective additions
    • Löber, O., Kawatsura, M., Hartwig, J. F. Palladium-catalyzed hydroamination of 1, 3-Dienes: A colorimetric assay and enantioselective additions. J. Am. Chem. Soc. 123, 4366-4367 (2001).
    • (2001) J. Am. Chem. Soc. , vol.123 , pp. 4366-4367
    • Löber, O.1    Kawatsura, M.2    Hartwig, J.F.3
  • 75
    • 0035858974 scopus 로고    scopus 로고
    • Transition metal-catalyzed addition of amines to acrylic acid derivatives A high-throughput method for evaluating hydroamination of primary and secondary alkylamines
    • Kawatsura, M., Hartwig, J. F. Transition metal-catalyzed addition of amines to acrylic acid derivatives. A high-throughput method for evaluating hydroamination of primary and secondary alkylamines. Organometallics 20, 1960-1964 (2001).
    • (2001) Organometallics , vol.20 , pp. 1960-1964
    • Kawatsura, M.1    Hartwig, J.F.2
  • 76
    • 84864670362 scopus 로고    scopus 로고
    • A simple, fast, and easy assay for transition metal-catalyzed coupling reactions using a paper-based colorimetric iodide sensor
    • Kim, S. et al. A simple, fast, and easy assay for transition metal-catalyzed coupling reactions using a paper-based colorimetric iodide sensor. Chem. Commun. 48, 8751-8753 (2012).
    • (2012) Chem. Commun. , vol.48 , pp. 8751-8753
    • Kim, S.1
  • 77
    • 79955520665 scopus 로고    scopus 로고
    • A colorimetric high-throughput screening method for palladium-catalyzed coupling reactions of aryl iodides using a gold nanoparticle-based iodide-selective probe
    • Jung, E. et al. A colorimetric high-throughput screening method for palladium-catalyzed coupling reactions of aryl iodides using a gold nanoparticle-based iodide-selective probe. Angew. Chem. Int. Ed. 50, 4386-4389 (2011).
    • (2011) Angew. Chem. Int. Ed. , vol.50 , pp. 4386-4389
    • Jung, E.1
  • 78
    • 0032502884 scopus 로고    scopus 로고
    • Thermographic selection of effective catalysts from an encoded polymer-bound library
    • Taylor, S. J., Morken, J. P. Thermographic selection of effective catalysts from an encoded polymer-bound library. Science 280, 267-270 (1998).
    • (1998) Science , vol.280 , pp. 267-270
    • Taylor, S.J.1    Morken, J.P.2
  • 79
    • 0034599407 scopus 로고    scopus 로고
    • IR-thermographic screening of thermoneutral or endothermic transformations: The ring-closing olefin metathesis reaction
    • Reetz, M., Becker, M. M., Liebl, M., Fürstner, A. IR-thermographic screening of thermoneutral or endothermic transformations: the ring-closing olefin metathesis reaction. Angew. Chem. Int. Ed. 39, 1236-1239 (2000).
    • (2000) Angew. Chem. Int. Ed. , vol.39 , pp. 1236-1239
    • Reetz, M.1    Becker, M.M.2    Liebl, M.3    Fürstner, A.4
  • 80
    • 0032538361 scopus 로고    scopus 로고
    • Time-resolved IR-thermographic detection and screening of enantioselectivity in catalytic reactions
    • Reetz, M. T., Becker, M. H., Kühling, K. M., Holzwarth, A. Time-resolved IR-thermographic detection and screening of enantioselectivity in catalytic reactions. Angew. Chem. Int. Ed. 37, 2647-2650 (1998).
    • (1998) Angew. Chem. Int. Ed. , vol.37 , pp. 2647-2650
    • Reetz, M.T.1    Becker, M.H.2    Kühling, K.M.3    Holzwarth, A.4
  • 81
    • 0035800494 scopus 로고    scopus 로고
    • Comparative investigation of ruthenium-based metathesis catalysts bearing N-heterocyclic carbene (NHC) ligands
    • Fürstner, A. et al. Comparative investigation of ruthenium-based metathesis catalysts bearing N-heterocyclic carbene (NHC) ligands. Chem. Eur. J. 7, 3236-3253 (2001).
    • (2001) Chem. Eur. J. , vol.7 , pp. 3236-3253
    • Fürstner, A.1
  • 82
    • 0034605911 scopus 로고    scopus 로고
    • Catalyst screening using an array of thermistors
    • Connolly, A. R., Sutherland, J. D. Catalyst screening using an array of thermistors. Angew. Chem. Int. Ed. 39, 4268-4271 (2000).
    • (2000) Angew. Chem. Int. Ed. , vol.39 , pp. 4268-4271
    • Connolly, A.R.1    Sutherland, J.D.2
  • 83
    • 0037012762 scopus 로고    scopus 로고
    • In situ enzymatic screening (ISES): A tool for catalyst discovery and reaction development
    • Berkowitz, D. B., Bose, M., Choi, S. In situ enzymatic screening (ISES): a tool for catalyst discovery and reaction development. Angew. Chem. Int. Ed. 41, 1603-1607 (2002).
    • (2002) Angew. Chem. Int. Ed. , vol.41 , pp. 1603-1607
    • Berkowitz, D.B.1    Bose, M.2    Choi, S.3
  • 84
    • 4344564985 scopus 로고    scopus 로고
    • Following an ISES lead: The first examples of asymmetric Ni(0)-mediated allylic amination
    • Berkowitz, D. B., Maiti, G. Following an ISES lead: the first examples of asymmetric Ni(0)-mediated allylic amination. Org. Lett. 6, 2661-2664 (2004).
    • (2004) Org. Lett. , vol.6 , pp. 2661-2664
    • Berkowitz, D.B.1    Maiti, G.2
  • 85
    • 20944445400 scopus 로고    scopus 로고
    • Double-cuvette ISES: In situ estimation of enantioselectivity and relative rate for catalyst screening
    • Dey, S., Karukurichi, K. R., Shen, W., Berkowitz, D. B. Double-cuvette ISES: in situ estimation of enantioselectivity and relative rate for catalyst screening. J. Am. Chem. Soc. 127, 8610-8611 (2005).
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 8610-8611
    • Dey, S.1    Karukurichi, K.R.2    Shen, W.3    Berkowitz, D.B.4
  • 86
    • 34848833887 scopus 로고    scopus 로고
    • Cassette in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides
    • Dey, S., Powell, D. R., Hu, C., Berkowitz, D. B. "Cassette" in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides. Angew. Chem. Int. Ed. 46, 7010-7014 (2007).
    • (2007) Angew. Chem. Int. Ed. , vol.46 , pp. 7010-7014
    • Dey, S.1    Powell, D.R.2    Hu, C.3    Berkowitz, D.B.4
  • 87
    • 80052599036 scopus 로고    scopus 로고
    • Combinatorial catalysis employing a visible enzymatic beacon in real time: Synthetically versatile (pseudo)halometalation/carbocyclizations
    • Friest, J. A., Broussy, S., Chung, W. J., Berkowitz, D. B. Combinatorial catalysis employing a visible enzymatic beacon in real time: synthetically versatile (pseudo)halometalation/carbocyclizations. Angew. Chem. Int. Ed. 50, 8895-8899 (2011).
    • (2011) Angew. Chem. Int. Ed. , vol.50 , pp. 8895-8899
    • Friest, J.A.1    Broussy, S.2    Chung, W.J.3    Berkowitz, D.B.4
  • 88
    • 84857208522 scopus 로고    scopus 로고
    • Halocarbocyclization entry into the oxabicyclo[4.3.1]decyl exomethylene-?-lactone cores of linearifolin and zaluzanin A: Exploiting combinatorial catalysis
    • Ginotra, S. K., Friest, J. A., Berkowitz, D. B. Halocarbocyclization entry into the oxabicyclo[4.3.1]decyl exomethylene-?-lactone cores of linearifolin and zaluzanin A: exploiting combinatorial catalysis. Org. Lett. 14, 968-971 (2012).
    • (2012) Org. Lett. , vol.14 , pp. 968-971
    • Ginotra, S.K.1    Friest, J.A.2    Berkowitz, D.B.3
  • 89
    • 4644233894 scopus 로고    scopus 로고
    • Screening of chiral catalysts and catalyst mixtures by mass spectrometric monitoring of catalytic intermediates
    • Markert, C., Pfaltz, A. Screening of chiral catalysts and catalyst mixtures by mass spectrometric monitoring of catalytic intermediates. Angew. Chem. Int. Ed. 43, 2498-2500 (2004).
    • (2004) Angew. Chem. Int. Ed. , vol.43 , pp. 2498-2500
    • Markert, C.1    Pfaltz, A.2
  • 90
    • 0033517001 scopus 로고    scopus 로고
    • Rapid screening of olefin polymerization catalyst libraries by electrospray ionization tandem mass spectrometry
    • Hinderling, C., Chen, P. Rapid screening of olefin polymerization catalyst libraries by electrospray ionization tandem mass spectrometry. Angew. Chem. Int. Ed. 38, 2253-2256 (1999).
    • (1999) Angew. Chem. Int. Ed. , vol.38 , pp. 2253-2256
    • Hinderling, C.1    Chen, P.2
  • 91
    • 41449099289 scopus 로고    scopus 로고
    • Combinatorial ligand development based on mass spectrometric screening and a double mass-labeling strategy
    • Markert, C., Rösel, P., Pfaltz, A. Combinatorial ligand development based on mass spectrometric screening and a double mass-labeling strategy. J. Am. Chem. Soc. 130, 3234-3235 (2008).
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 3234-3235
    • Markert, C.1    Rösel, P.2    Pfaltz, A.3
  • 92
    • 53549099942 scopus 로고    scopus 로고
    • Mass spectrometric screening of chiral catalysts by monitoring the back reaction of quasienantiomeric products: Palladium-catalyzed allylic substitution
    • Müller, C. A., Pfaltz, A. Mass spectrometric screening of chiral catalysts by monitoring the back reaction of quasienantiomeric products: palladium-catalyzed allylic substitution. Angew. Chem. Int. Ed. 47, 3363-3366 (2008).
    • (2008) Angew. Chem. Int. Ed. , vol.47 , pp. 3363-3366
    • Müller, C.A.1    Pfaltz, A.2
  • 93
    • 53549121968 scopus 로고    scopus 로고
    • Mass spectrometric screening of enantioselective Diels-Alder reactions
    • Teichert, A., Pfaltz, A. Mass spectrometric screening of enantioselective Diels-Alder reactions. Angew. Chem. Int. Ed. 47, 3360-3362 (2008).
    • (2008) Angew. Chem. Int. Ed. , vol.47 , pp. 3360-3362
    • Teichert, A.1    Pfaltz, A.2
  • 94
    • 73949140284 scopus 로고    scopus 로고
    • Enantioselective Michael addition to alpha, beta-unsaturated aldehydes: Combinatorial catalyst preparation and screening, reaction optimization, and mechanistic studies
    • Fleischer, I., Pfaltz, A. Enantioselective Michael addition to alpha, beta-unsaturated aldehydes: combinatorial catalyst preparation and screening, reaction optimization, and mechanistic studies. Chem. Eur. J. 16, 95-99 (2010).
    • (2010) Chem. Eur. J. , vol.16 , pp. 95-99
    • Fleischer, I.1    Pfaltz, A.2
  • 95
    • 84887970028 scopus 로고    scopus 로고
    • Organocatalytic asymmetric conjugate addition of aldehydes to nitroolefins: Identification of catalytic intermediates and the stereoselectivity-determining step by ESI-MS
    • Bächle, F., Duschmalé, J., Ebner, C., Pfaltz, A., Wennemers, H. Organocatalytic asymmetric conjugate addition of aldehydes to nitroolefins: identification of catalytic intermediates and the stereoselectivity-determining step by ESI-MS. Angew. Chem. Int. Ed. 52, 12619-12623 (2013).
    • (2013) Angew. Chem. Int. Ed. , vol.52 , pp. 12619-12623
    • Bächle, F.1    Duschmalé, J.2    Ebner, C.3    Pfaltz, A.4    Wennemers, H.5
  • 96
    • 0035915118 scopus 로고    scopus 로고
    • Testing racemic chiral catalysts for kinetic resolution potential
    • Dominguez, B., Hodnett, N. S., Lloyd-Jones, G. C. Testing racemic chiral catalysts for kinetic resolution potential. Angew. Chem. Int. Ed. 40, 4289-4291 (2001).
    • (2001) Angew. Chem. Int. Ed. , vol.40 , pp. 4289-4291
    • Dominguez, B.1    Hodnett, N.S.2    Lloyd-Jones, G.C.3
  • 97
    • 79953856934 scopus 로고    scopus 로고
    • Determining the enantioselectivity of chiral catalysts by mass spectrometric screening of their racemic forms
    • Ebner, C., Müller, C. A., Markert, C., Pfaltz, A. Determining the enantioselectivity of chiral catalysts by mass spectrometric screening of their racemic forms. J. Am. Chem. Soc. 133, 4710-4713 (2011).
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 4710-4713
    • Ebner, C.1    Müller, C.A.2    Markert, C.3    Pfaltz, A.4
  • 98
    • 77951671574 scopus 로고    scopus 로고
    • Catalyst selection based on intermediate stability measured by mass spectrometry
    • Wassenaar, J. et al. Catalyst selection based on intermediate stability measured by mass spectrometry. Nature Chem. 2, 417-421 (2010).
    • (2010) Nature Chem , vol.2 , pp. 417-421
    • Wassenaar, J.1
  • 99
    • 0000468730 scopus 로고    scopus 로고
    • Binding energy and catalysis: The implications for transition-state analogs and catalytic antibodies
    • Mader, M. M., Bartlett, P. A. Binding energy and catalysis: the implications for transition-state analogs and catalytic antibodies. Chem. Rev. 97, 1281-1302 (1997).
    • (1997) Chem. Rev. , vol.97 , pp. 1281-1302
    • Mader, M.M.1    Bartlett, P.A.2
  • 100
    • 0036025402 scopus 로고    scopus 로고
    • Enzyme-like catalysis by molecularly imprinted polymers
    • Wulff, G. Enzyme-like catalysis by molecularly imprinted polymers. Chem. Rev. 102, 1-28 (2002).
    • (2002) Chem. Rev. , vol.102 , pp. 1-28
    • Wulff, G.1
  • 101
    • 0242500379 scopus 로고    scopus 로고
    • Selection and amplification of a catalyst from a dynamic combinatorial library
    • Brisig, B., Sanders, J. K. M., Otto, S. Selection and amplification of a catalyst from a dynamic combinatorial library. Angew. Chem. Int. Ed. 42, 1270-1273 (2003).
    • (2003) Angew. Chem. Int. Ed. , vol.42 , pp. 1270-1273
    • Brisig, B.1    Sanders, J.K.M.2    Otto, S.3
  • 102
    • 24044533497 scopus 로고    scopus 로고
    • A catalyst for an acetal hydrolysis reaction from a dynamic combinatorial library
    • Vial, L., Sanders, J. K. M., Otto, S. A catalyst for an acetal hydrolysis reaction from a dynamic combinatorial library. New J. Chem. 29, 1001-1003 (2005).
    • (2005) New J. Chem. , vol.29 , pp. 1001-1003
    • Vial, L.1    Sanders, J.K.M.2    Otto, S.3
  • 103
    • 46149100860 scopus 로고    scopus 로고
    • Exploiting neighboring-group interactions for the self-selection of a catalytic unit
    • Gasparini, G., Prins, L. J., Scrimin, P. Exploiting neighboring-group interactions for the self-selection of a catalytic unit. Angew. Chem. Int. Ed. 47, 2475-2479 (2008).
    • (2008) Angew. Chem. Int. Ed. , vol.47 , pp. 2475-2479
    • Gasparini, G.1    Prins, L.J.2    Scrimin, P.3
  • 104
    • 77951915539 scopus 로고    scopus 로고
    • Evolution of metal complex-catalysts by dynamic templating with transition state analogs
    • Matsumoto, M., Estes, D., Nicholas, K. M. Evolution of metal complex-catalysts by dynamic templating with transition state analogs. Eur. J. Inorg. Chem. 2010, 1847-1852 (2010).
    • (2010) Eur. J. Inorg. Chem. , vol.2010 , pp. 1847-1852
    • Matsumoto, M.1    Estes, D.2    Nicholas, K.M.3
  • 105
    • 84873672400 scopus 로고    scopus 로고
    • Selection of chiral zinc catalysts for the kinetic resolution of esters via dynamic templating
    • Kannappan, R., Nicholas, K. M. Selection of chiral zinc catalysts for the kinetic resolution of esters via dynamic templating. ACS Comb. Sci. 15, 90-100 (2013).
    • (2013) ACS Comb. Sci. , vol.15 , pp. 90-100
    • Kannappan, R.1    Nicholas, K.M.2
  • 106
    • 84890947807 scopus 로고    scopus 로고
    • Scientist-led high-throughput experimentation (HTE) and its utility in academia and industry
    • Schmink, J. R., Bellomo, A., Berritt, S. Scientist-led high-throughput experimentation (HTE) and its utility in academia and industry. Aldrichim. Acta 46, 71-80 (2013).
    • (2013) Aldrichim. Acta , vol.46 , pp. 71-80
    • Schmink, J.R.1    Bellomo, A.2    Berritt, S.3
  • 107
    • 78650301260 scopus 로고    scopus 로고
    • Direct boronic acid synthesis from aryl chlorides: A simplified route to diverse boronate ester derivatives
    • Molander, G. A., Trice, S. L. J., Dreher, S. D. Palladium-catalyzed, direct boronic acid synthesis from aryl chlorides: a simplified route to diverse boronate ester derivatives. J. Am. Chem. Soc. 132, 17701-17703 (2010).
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 17701-17703
    • Molander, G.A.1    Trice, S.L.J.2    Palladium-Catalyzed, D.D.S.3
  • 108
    • 84901857595 scopus 로고    scopus 로고
    • Application of a robustness screen for the evaluation of synthetic organic methodology
    • Collins, K. D., Ru?hling, A., Glorius, F. Application of a robustness screen for the evaluation of synthetic organic methodology. Nature Protoc. 9, 1348-1353 (2014).
    • (2014) Nature Protoc , vol.9 , pp. 1348-1353
    • Collins, K.D.1    Ruhling, A.2    Glorius, F.3
  • 109
    • 84879338152 scopus 로고    scopus 로고
    • A robustness screen for the rapid assessment of chemical reactions
    • Collins, K. D., Glorius, F. A robustness screen for the rapid assessment of chemical reactions. Nature Chem. 5, 597-601 (2013).
    • (2013) Nature Chem , vol.5 , pp. 597-601
    • Collins, K.D.1    Glorius, F.2
  • 110
    • 84880922186 scopus 로고    scopus 로고
    • Employing a robustness screen: Rapid assessment of rhodium(III)-catalysed C-H activation reactions
    • Collins, K. D., Glorius, F. Employing a robustness screen: rapid assessment of rhodium(III)-catalysed C-H activation reactions. Tetrahedron 69, 7817-7825 (2013).
    • (2013) Tetrahedron , vol.69 , pp. 7817-7825
    • Collins, K.D.1    Glorius, F.2
  • 111
    • 84888809801 scopus 로고    scopus 로고
    • Cobalt precursors for high-throughput discovery of base metal asymmetric alkene hydrogenation catalysts
    • Friedfeld, M. R. et al. Cobalt precursors for high-throughput discovery of base metal asymmetric alkene hydrogenation catalysts. Science 342, 1076-1080 (2013).
    • (2013) Science , vol.342 , pp. 1076-1080
    • Friedfeld, M.R.1
  • 112
    • 84899936504 scopus 로고    scopus 로고
    • Late-stage functionalization of biologically active heterocycles through photoredox catalysis
    • DiRocco, D. A. et al. Late-stage functionalization of biologically active heterocycles through photoredox catalysis. Angew. Chem. Int. Ed. 53, 4802-4806 (2014).
    • (2014) Angew. Chem. Int. Ed. , vol.53 , pp. 4802-4806
    • Dirocco, D.A.1
  • 113
    • 84896462182 scopus 로고    scopus 로고
    • Three-component asymmetric catalytic Ugi reaction-concinnity from diversity by substrate-mediated catalyst assembly
    • Zhao, W., Huang, L., Guan, Y., Wulff, W. D. Three-component asymmetric catalytic Ugi reaction-concinnity from diversity by substrate-mediated catalyst assembly. Angew. Chem. Int. Ed. 53, 3436-3441 (2014).
    • (2014) Angew. Chem. Int. Ed. , vol.53 , pp. 3436-3441
    • Zhao, W.1    Huang, L.2    Guan, Y.3    Wulff, W.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.