-
1
-
-
0028757621
-
Multicomponent Reactions in Organic Chemistry
-
(a) Ugi, I.; Dömling, A.; Hörl, W. Multicomponent Reactions in Organic Chemistry. Endeavour 1994, 18, 115-122.
-
(1994)
Endeavour
, vol.18
, pp. 115-122
-
-
Ugi, I.1
Dömling, A.2
Hörl, W.3
-
2
-
-
0000512227
-
Multiple-Component Condensation Strategies for Combinatorial Library Synthesis
-
b) Armstrong, R. M.; Combs, A. P.; Tempest, P. A.; Brown, S. D.; Keating, T. A. Multiple-Component Condensation Strategies for Combinatorial Library Synthesis. Acc. Chem. Res. 1996, 29, 123-131.
-
(1996)
Acc. Chem. Res
, vol.29
, pp. 123-131
-
-
Armstrong, R.M.1
Combs, A.P.2
Tempest, P.A.3
Brown, S.D.4
Keating, T.A.5
-
3
-
-
0034665244
-
Maximizing Synthetic Efficiency: Multi-component Transformations Lead the Way
-
Bienaymé, H.; Hulme, C.; Oddon, G.; Schmitt, P. Maximizing Synthetic Efficiency: Multi-component Transformations Lead the Way. Chem. - Eur. J. 2000, 6, 3321-3329.
-
(2000)
Chem. - Eur. J
, vol.6
, pp. 3321-3329
-
-
Bienaymé, H.1
Hulme, C.2
Oddon, G.3
Schmitt, P.4
-
4
-
-
0037238724
-
Multi-component Reactions: Emerging Chemistry in Drug Discovery. From Xylocaine to Crixivan
-
Hulme, C.; Gore, V. Multi-component Reactions: Emerging Chemistry in Drug Discovery. From Xylocaine to Crixivan. Curr. Med. Chem. 2003, 10, 51-80.
-
(2003)
Curr. Med. Chem
, vol.10
, pp. 51-80
-
-
Hulme, C.1
Gore, V.2
-
5
-
-
31544434530
-
-
Dömling, A. Recent Developments in Isocyanide Multicomponent Reactions in Applied Chemistry. Chem. Rev. 2006, 106, 17-89.
-
(a) Dömling, A. Recent Developments in Isocyanide Multicomponent Reactions in Applied Chemistry. Chem. Rev. 2006, 106, 17-89.
-
-
-
-
6
-
-
2542509173
-
Multicomponent Reactions with Isocyanides
-
b) Dömling, A.; Ugi, I. Multicomponent Reactions with Isocyanides. Angew. Chem., Int. Ed. 2000, 39, 3169-3210.
-
(2000)
Angew. Chem., Int. Ed
, vol.39
, pp. 3169-3210
-
-
Dömling, A.1
Ugi, I.2
-
7
-
-
0038590245
-
The Discovery of New Multicomponent Reactions
-
c) Doemling., A. The Discovery of New Multicomponent Reactions. Curr. Opin. Chem. Biol. 2000, 4, 318-323.
-
(2000)
Curr. Opin. Chem. Biol
, vol.4
, pp. 318-323
-
-
Doemling, A.1
-
8
-
-
17144366282
-
Asymmetric Multicomponent Reactions: The New Frontier
-
Ramon, D. J.; Yus, M. Asymmetric Multicomponent Reactions: The New Frontier. Angew. Chem., Int. Ed. 2005, 44, 1602-1634.
-
(2005)
Angew. Chem., Int. Ed
, vol.44
, pp. 1602-1634
-
-
Ramon, D.J.1
Yus, M.2
-
9
-
-
3042799070
-
A Planning Strategy for Diversity-Oriented Synthesis
-
Burke, M. D.; Schreiber, S. L. A Planning Strategy for Diversity-Oriented Synthesis. Angew. Chem., Int. Ed. 2004, 43, 46-58.
-
(2004)
Angew. Chem., Int. Ed
, vol.43
, pp. 46-58
-
-
Burke, M.D.1
Schreiber, S.L.2
-
10
-
-
26844537872
-
The Passerini Reaction
-
Banfi, L.; Riva, R. The Passerini Reaction. Org. React. 2005, 65, 1-140.
-
(2005)
Org. React
, vol.65
, pp. 1-140
-
-
Banfi, L.1
Riva, R.2
-
11
-
-
0001521573
-
Versuche mit Isonitrilen
-
Ugi, I.; Meyr, R.; Fetzer, U.; Steinbruckner, C. Versuche mit Isonitrilen. Angew. Chem. 1959, 71, 386-388.
-
(1959)
Angew. Chem
, vol.71
, pp. 386-388
-
-
Ugi, I.1
Meyr, R.2
Fetzer, U.3
Steinbruckner, C.4
-
12
-
-
65249098705
-
-
Lemmen, P.; Fontain, E.; Bauer, J. Ivar K. Ugi (1930-2005): Multi-component Reactions, Computer and Phorphorous Chemistry. Angew. Chem., Int. Ed. 2006, 45, 193.
-
Lemmen, P.; Fontain, E.; Bauer, J. Ivar K. Ugi (1930-2005): Multi-component Reactions, Computer and Phorphorous Chemistry. Angew. Chem., Int. Ed. 2006, 45, 193.
-
-
-
-
13
-
-
0037007745
-
Metal-Promoted Variants of the Passerini Reaction Leading to Functionalized Heterocycles
-
Xia, Q.; Ganem, B. Metal-Promoted Variants of the Passerini Reaction Leading to Functionalized Heterocycles. Org. Lett. 2002, 4, 1631-1634.
-
(2002)
Org. Lett
, vol.4
, pp. 1631-1634
-
-
Xia, Q.1
Ganem, B.2
-
14
-
-
0029921014
-
-
A related mechanism has been proposed for the cyclization of a-ketoimidoylchlorides to 2-acyl-5-ethoxyoxazoles: Huang, W.-S.; Zhang, Y.-X.; Yuan, C.-Y. Base Induced Intramolecular Cyclization of α-Ketoimidoyl Chloride - An Efficient Preparation of 2-Acyl-5-ethoxyoxazoles. Synth. Commun. 1996, 26, 1149-1154.
-
A related mechanism has been proposed for the cyclization of a-ketoimidoylchlorides to 2-acyl-5-ethoxyoxazoles: Huang, W.-S.; Zhang, Y.-X.; Yuan, C.-Y. Base Induced Intramolecular Cyclization of α-Ketoimidoyl Chloride - An Efficient Preparation of 2-Acyl-5-ethoxyoxazoles. Synth. Commun. 1996, 26, 1149-1154.
-
-
-
-
15
-
-
65249183610
-
-
For related findings with alkyl-substituted isocyanoacetamides, see
-
For related findings with alkyl-substituted isocyanoacetamides, see:
-
-
-
-
16
-
-
0001419996
-
A Novel Multicomponent Synthesis of Polysubstituted 5-Aminooxazole and Its New Scaffold-Generating Reaction to Pyrrolo[3,4-b]pyridine
-
a) Janvier, P.; Sun, X.; Bienyamé, H.; Zhu, J. A Novel Multicomponent Synthesis of Polysubstituted 5-Aminooxazole and Its New Scaffold-Generating Reaction to Pyrrolo[3,4-b]pyridine. Org. Lett. 2001, 3, 877-880.
-
(2001)
Org. Lett
, vol.3
, pp. 877-880
-
-
Janvier, P.1
Sun, X.2
Bienyamé, H.3
Zhu, J.4
-
17
-
-
0037139571
-
Ammonium Chloride-Promoted Four-Component Synthesis of Pyrrolo[3,4-b]pyridin-5- one
-
b) Janvier, P.; Sun, X.; Bienyamé, H.; Zhu, J. Ammonium Chloride-Promoted Four-Component Synthesis of Pyrrolo[3,4-b]pyridin-5- one. J. Am. Chem. Soc. 2002, 124, 2560-2567.
-
(2002)
J. Am. Chem. Soc
, vol.124
, pp. 2560-2567
-
-
Janvier, P.1
Sun, X.2
Bienyamé, H.3
Zhu, J.4
-
18
-
-
0042855735
-
A General Synthesis of 2-Substituted-5-aminooxazoles: Building Blocks for Multifunctional Heterocycles
-
Xia, Q.; Ganem, B. A General Synthesis of 2-Substituted-5-aminooxazoles: Building Blocks for Multifunctional Heterocycles. Tetrahedron Lett. 2003, 44, 6825-6827.
-
(2003)
Tetrahedron Lett
, vol.44
, pp. 6825-6827
-
-
Xia, Q.1
Ganem, B.2
-
19
-
-
0042660845
-
New Four-Component Condensations Leading to 2,4,5-Trisubstituted Oxazoles
-
Wang, Q.; Ganem, B. New Four-Component Condensations Leading to 2,4,5-Trisubstituted Oxazoles. Tetrahedron Lett. 2003, 44, 6829-6832.
-
(2003)
Tetrahedron Lett
, vol.44
, pp. 6829-6832
-
-
Wang, Q.1
Ganem, B.2
-
20
-
-
84995181383
-
The α-Addition of Immonium Ions and Anions to Isonitriles Accompanied by Secondary Reactions
-
Ugi, I. The α-Addition of Immonium Ions and Anions to Isonitriles Accompanied by Secondary Reactions. Angew. Chem., Int. Ed. 1962, 4, 8-21.
-
(1962)
Angew. Chem., Int. Ed
, vol.4
, pp. 8-21
-
-
Ugi, I.1
-
21
-
-
30544450007
-
A New Approach to 4- and 5-Component Ugi Condensations Starting from Nitriles
-
Simoneau, C. A.; George, B. A.; Ganem, B. A New Approach to 4- and 5-Component Ugi Condensations Starting from Nitriles. Tetrahedron Lett. 2006, 47, 1205-1207.
-
(2006)
Tetrahedron Lett
, vol.47
, pp. 1205-1207
-
-
Simoneau, C.A.1
George, B.A.2
Ganem, B.3
-
22
-
-
27444431741
-
Multiple Component Fischer Indole Reactions
-
Simoneau, C. A.; Ganem, B. Multiple Component Fischer Indole Reactions. Tetrahedron 2005, 61, 11374-11379.
-
(2005)
Tetrahedron
, vol.61
, pp. 11374-11379
-
-
Simoneau, C.A.1
Ganem, B.2
-
23
-
-
84932093750
-
Convenient Preparation of 2,3-Dialkylindoles
-
Dave, V. Convenient Preparation of 2,3-Dialkylindoles. Org. Prep. Proced. Int. 1976, 8, 41-44.
-
(1976)
Org. Prep. Proced. Int
, vol.8
, pp. 41-44
-
-
Dave, V.1
-
24
-
-
33947346424
-
-
Gilman, H.; van Ess, P. R. The Preparation of Ketones by the Carbonation of Organolithium Compounds. J. Am. Chem. Soc. 1933, 55, 1258-1261.
-
(a) Gilman, H.; van Ess, P. R. The Preparation of Ketones by the Carbonation of Organolithium Compounds. J. Am. Chem. Soc. 1933, 55, 1258-1261.
-
-
-
-
25
-
-
0002233116
-
Preparation of Ketones from the Reaction of Organolithium Reagents with Carboxylic Acids
-
Review
-
b) Review: Jorgenson, M. J. Preparation of Ketones from the Reaction of Organolithium Reagents with Carboxylic Acids. Org. React. 1970, 18, 1-97.
-
(1970)
Org. React
, vol.18
, pp. 1-97
-
-
Jorgenson, M.J.1
-
26
-
-
0033544422
-
A Palladium-Catalyzed Method for the Preparation of Indoles via the Fischer Indole Synthesis
-
Wagaw, S.; Yang, B. H.; Buchwald, S. L. A Palladium-Catalyzed Method for the Preparation of Indoles via the Fischer Indole Synthesis. J. Am. Chem. Soc. 1999, 121, 10251-10263.
-
(1999)
J. Am. Chem. Soc
, vol.121
, pp. 10251-10263
-
-
Wagaw, S.1
Yang, B.H.2
Buchwald, S.L.3
-
27
-
-
0006636396
-
A New Glucosinolate Synthesis
-
(a) Keller, T. H.; Yelland, L. J.; Benn, M. H. A New Glucosinolate Synthesis. Can. J. Chem. 1984, 62, 437-440.
-
(1984)
Can. J. Chem
, vol.62
, pp. 437-440
-
-
Keller, T.H.1
Yelland, L.J.2
Benn, M.H.3
-
28
-
-
65249118552
-
-
Buchanan, J. B. Preparation of Thiolhydroxamate Esters from Nitroalkanes. U.S. Patent 3,787,470, 1974; Chem. Abstr. 1974, 80, 82059.
-
b) Buchanan, J. B. Preparation of Thiolhydroxamate Esters from Nitroalkanes. U.S. Patent 3,787,470, 1974; Chem. Abstr. 1974, 80, 82059.
-
-
-
-
29
-
-
65249094535
-
-
Copenhaver, J. W. Alpha-oximino Sulfides and their Preparation. U.S. Patent 2,786,865,1957; Chem Abstr. 1957, 51, 77105.
-
c) Copenhaver, J. W. Alpha-oximino Sulfides and their Preparation. U.S. Patent 2,786,865,1957; Chem Abstr. 1957, 51, 77105.
-
-
-
-
30
-
-
33846821774
-
One-pot Synthesis of Polysubstituted Indoles from Aliphatic Nitro Compounds under Mild Conditions
-
Simoneau, C. A.; Strohl, A. M.; Ganem, B. One-pot Synthesis of Polysubstituted Indoles from Aliphatic Nitro Compounds under Mild Conditions. Tetrahedron Lett. 2007, 48, 1809-1811.
-
(2007)
Tetrahedron Lett
, vol.48
, pp. 1809-1811
-
-
Simoneau, C.A.1
Strohl, A.M.2
Ganem, B.3
-
32
-
-
6444223724
-
Three-Component Condensation Leading to β-Aminoacid Diamides; Convergent Assembly of β -Peptide Analogues
-
Oaksmith, J. M.; Peters, U.; Ganem, B. Three-Component Condensation Leading to β-Aminoacid Diamides; Convergent Assembly of β -Peptide Analogues. J. Am. Chem. Soc. 2004, 125, 13606-13607.
-
(2004)
J. Am. Chem. Soc
, vol.125
, pp. 13606-13607
-
-
Oaksmith, J.M.1
Peters, U.2
Ganem, B.3
-
33
-
-
65249191130
-
-
Oaksmith, J. M. Ph.D. Thesis, Cornell University, 2006.
-
Oaksmith, J. M. Ph.D. Thesis, Cornell University, 2006.
-
-
-
-
34
-
-
0035815127
-
Nitrile Reduction in the Presence of Boc-Protected Amino Groups by Catalytic Hydrogenation over Palladium-Activated Raney-Nickel
-
Klenke, B.; Gilbert, I. H. Nitrile Reduction in the Presence of Boc-Protected Amino Groups by Catalytic Hydrogenation over Palladium-Activated Raney-Nickel. J. Org. Chem. 2001, 66, 2480-2483.
-
(2001)
J. Org. Chem
, vol.66
, pp. 2480-2483
-
-
Klenke, B.1
Gilbert, I.H.2
-
35
-
-
34447527272
-
Tandem Multicomponent/Click Reactions: Synthesis of Functionalized Oxazoles and Tetrazoles from Acyl Cyanides
-
Clémengon, I. F.; Ganem, B. Tandem Multicomponent/Click Reactions: Synthesis of Functionalized Oxazoles and Tetrazoles from Acyl Cyanides. Tetrahedron 2007, 63, 8665-8669.
-
(2007)
Tetrahedron
, vol.63
, pp. 8665-8669
-
-
Clémengon, I.F.1
Ganem, B.2
-
36
-
-
31944436067
-
Biological Alkylating Agents
-
Nogrady, T.; Doyle, T. W.; Morris, L. Diazo, Bromo, and Mesyloxy Ketones as Biological Alkylating Agents. J. Med. Chem. 1965, 8, 656-659.
-
(1965)
J. Med. Chem
, vol.8
, pp. 656-659
-
-
Nogrady, T.1
Doyle, T.W.2
Morris3
Diazo, L.4
Bromo5
Ketones as, M.6
-
37
-
-
85077892472
-
A Convenient Conversion of 2-Acyloxy-3- chlorocarboxamides to 3-Acyloxy-2-azetidinones in Heterogeneous Media
-
Sebti, S.; Foucaud, A. A Convenient Conversion of 2-Acyloxy-3- chlorocarboxamides to 3-Acyloxy-2-azetidinones in Heterogeneous Media. Synthesis 1983, 546-549.
-
(1983)
Synthesis
, pp. 546-549
-
-
Sebti, S.1
Foucaud, A.2
-
38
-
-
34249276673
-
Bioactive 2-Oxazolines: A New Approach via One-Pot, Four Component Reaction
-
Fan, L.; Lobkovsky, E.; Ganem, B. Bioactive 2-Oxazolines: A New Approach via One-Pot, Four Component Reaction. Org. Lett. 2007, 9, 2015-2017.
-
(2007)
Org. Lett
, vol.9
, pp. 2015-2017
-
-
Fan, L.1
Lobkovsky, E.2
Ganem, B.3
-
39
-
-
20244384148
-
-
Tsuda, M.; Yamakawa, M.; Oka, S.; Tanaka, Y.; Hoshino, Y.; Mikami, Y.; Sato, A.; Fujiwara, H.; Ohizumi, Y.; Kobayashi, J. Brasilibactin A, A Cytotoxic Compound from Actinomycete Nocardia. J. Nat. Prod. 2005, 68, 462-464.
-
Tsuda, M.; Yamakawa, M.; Oka, S.; Tanaka, Y.; Hoshino, Y.; Mikami, Y.; Sato, A.; Fujiwara, H.; Ohizumi, Y.; Kobayashi, J. Brasilibactin A, A Cytotoxic Compound from Actinomycete Nocardia. J. Nat. Prod. 2005, 68, 462-464.
-
-
-
-
40
-
-
0030727962
-
BE-32030 A, B, C, D, and E, New Antitumor Substances Produced by Nocardia sp
-
Tsukamoto, M.; Murooka, K.; Nakajima, S.; Abe, S.; Suzuki, H.; Hirano, K.; Kondo, H.; Kojiri, K.; Suda, H. BE-32030 A, B, C, D, and E, New Antitumor Substances Produced by Nocardia sp. A32030. J. Antibiot. 1997, 50, 815-21.
-
(1997)
J. Antibiot
, vol.A32030
-
-
Tsukamoto, M.1
Murooka, K.2
Nakajima, S.3
Abe, S.4
Suzuki, H.5
Hirano, K.6
Kondo, H.7
Kojiri, K.8
Suda, H.9
-
41
-
-
9144251572
-
-
Moody, D. B.; Young, D. C.; Cheng, T.-Y.; Rosat, J.-P.; Roura-mir, C.; O'Connor, P. B.; Zajonc, D. M.; Walz, A.; Miller, M. J.; Levery, S. B.; Wilson, I. A.; Costello, C. E.; Brenner, M. B. T Cell Activation by Lipopeptide Antigens. Science 2004, 303, 527-531.
-
Moody, D. B.; Young, D. C.; Cheng, T.-Y.; Rosat, J.-P.; Roura-mir, C.; O'Connor, P. B.; Zajonc, D. M.; Walz, A.; Miller, M. J.; Levery, S. B.; Wilson, I. A.; Costello, C. E.; Brenner, M. B. T Cell Activation by Lipopeptide Antigens. Science 2004, 303, 527-531.
-
-
-
-
42
-
-
50049086611
-
Multicomponent Reaction Design: A One-Pot Route to Substituted Di-O-acylglyceric Acid Diamides from α-Diazoketones
-
Fan, L.; Adams, A. M.; Ganem, B. Multicomponent Reaction Design: A One-Pot Route to Substituted Di-O-acylglyceric Acid Diamides from α-Diazoketones. Tetrahedron Lett. 2008, 49, 5983-5985.
-
(2008)
Tetrahedron Lett
, vol.49
, pp. 5983-5985
-
-
Fan, L.1
Adams, A.M.2
Ganem, B.3
-
43
-
-
33745787895
-
Design of Multi-component Reactions: From Libraries of Compounds to Libraries of Reactions
-
(a) Mironov, M. Design of Multi-component Reactions: From Libraries of Compounds to Libraries of Reactions. QSAR Comb. Sci. 2006, 25, 423-431.
-
(2006)
QSAR Comb. Sci
, vol.25
, pp. 423-431
-
-
Mironov, M.1
-
44
-
-
65249178663
-
Algorithm-based Methods for the Discovery of Novel Multicomponent Reactions
-
b) Weber, L. Algorithm-based Methods for the Discovery of Novel Multicomponent Reactions. Multicompon. React. 2005, 300-310.
-
(2005)
Multicompon. React
, pp. 300-310
-
-
Weber, L.1
-
45
-
-
0141757224
-
Multicomponent Coupling Reactions for Organic Synthesis: Chemoselective Reactions with Amide-Aldehyde Mixtures
-
c) Jacobi von Wangelin, A.; Neumann, H.; Gordes, D.; Klaus, S.; Strübing, D.; Beller, M. Multicomponent Coupling Reactions for Organic Synthesis: Chemoselective Reactions with Amide-Aldehyde Mixtures. Chem-Eur. J. 2003, 9, 4286-4294.
-
(2003)
Chem-Eur. J
, vol.9
, pp. 4286-4294
-
-
Jacobi von Wangelin, A.1
Neumann, H.2
Gordes, D.3
Klaus, S.4
Strübing, D.5
Beller, M.6
-
46
-
-
0033019939
-
Discovery of New Multi Component Reactions with Combinatorial Methods
-
d) Weber, L.; Illgen, K.; Almstetter, M. Discovery of New Multi Component Reactions with Combinatorial Methods. Synlett 1999, 3, 366-374.
-
(1999)
Synlett
, vol.3
, pp. 366-374
-
-
Weber, L.1
Illgen, K.2
Almstetter, M.3
-
47
-
-
0012063087
-
An Approach to Systematization and Design of Organic Reactions
-
Zefirov, N. S. An Approach to Systematization and Design of Organic Reactions. Acc. Chem. Res. 1987, 20, 237-243.
-
(1987)
Acc. Chem. Res
, vol.20
, pp. 237-243
-
-
Zefirov, N.S.1
-
48
-
-
65249162560
-
Computer Assisted Bilateral Generation of Reaction Networks from Educts and Products
-
Fontain, E.; Bauer, J.; Ugi, I. Computer Assisted Bilateral Generation of Reaction Networks from Educts and Products. Chem. Lett. 1987, 37-40.
-
(1987)
Chem. Lett
, pp. 37-40
-
-
Fontain, E.1
Bauer, J.2
Ugi, I.3
|