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Seminal reports: (a) Tuerk, C.; Gold, L. Science 1990, 249, 505.
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Seminal reports: (a) Tuerk, C.; Gold, L. Science 1990, 249, 505.
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4
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Recent reviews of evolved DNA/RNA aptamers: (a) Shamah, S. M.; Healy, J. M.; Cload, S. T. Acc. Chem. Res. 2008, 41, 130.
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Recent reviews of evolved DNA/RNA aptamers: (a) Shamah, S. M.; Healy, J. M.; Cload, S. T. Acc. Chem. Res. 2008, 41, 130.
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7
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35848937985
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In vitro selections of DNA-linked small molecules: (a) Wrenn, S. J.; Weisinger, R. M.; Halpin, D. R.; Harbury, P. B. J. Am. Chem. Soc. 2007, 129, 13137.
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In vitro selections of DNA-linked small molecules: (a) Wrenn, S. J.; Weisinger, R. M.; Halpin, D. R.; Harbury, P. B. J. Am. Chem. Soc. 2007, 129, 13137.
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(b) Melkko, S.; Zhang, Y.; Dumelin, C. E.; Scheuermann, J.; Neri, D. Angew. Chem., Int. Ed. 2007, 46, 4671.
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Zhang, Y.2
Dumelin, C.E.3
Scheuermann, J.4
Neri, D.5
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9
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0141988969
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Mock selections: (c) Doyon, J. B.; Snyder, T. M.; Liu, D. R. J. Am. Chem. Soc. 2003, 125, 12372.
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Mock selections: (c) Doyon, J. B.; Snyder, T. M.; Liu, D. R. J. Am. Chem. Soc. 2003, 125, 12372.
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10
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4644350506
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(d) Gartner, Z. J.; Tse, B. N.; Grubina, R.; Doyon, J. B.; Snyder, T. M.; Liu, D. R. Science 2004, 305, 1601.
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(a) Kanan, M. W.; Rozenman, M. M.; Sakurai, K.; Snyder, T. M.; Liu, D. R. Nature 2004, 431, 545.
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(c) Rozenman, M. M.; Kanan, M. W.; Liu, D. R. J. Am. Chem. Soc. 2007, 129, 14933.
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Tarasow, T. M.; Tarasow, S. L.; Eaton, B. E. Nature 1997, 389, 54.
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0033102314
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Other tags may be used
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(b) Seelig, B.; Jaschke, A. Chem. Biol. 1999, 6, 167. Other tags may be used.
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Chem. Biol
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(d) Pradeepkumar, P. I.; Hobartner, C.; Baum, D. A.; Silverman, S. K. Angew Chem., Int. Ed. 2008, 47, 1753.
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(e) Johnston, W. K.; Unrau, P. J.; Lawrence, M. S.; Glasner, M. E.; Bartel, D. P. Science 2001, 292, 1319.
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(b) Sheppard, T. L.; Ordoukhanian, P.; Joyce, G. F. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 7802.
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For an alternative approach, see: c
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For an alternative approach, see: (c) Hobartner, C.; Pradeepkumar, P. I.; Silverman, S. K. Chem. Commun. 2007, 2255.
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(a) Rozenman, M. M.; McNaughton, B. R.; Liu, D. R. Curr. Opin. Chem. Biol. 2007, 11, 259.
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26
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67649973329
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Note that in contrast with a conventional selection in which unfit library members are discarded and sequences encoding surviving members are replicated in a subsequent step, RDPCR achieves the selective replication of only those sequences encoding desired library members
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Note that in contrast with a conventional selection in which unfit library members are discarded and sequences encoding surviving members are replicated in a subsequent step, RDPCR achieves the selective replication of only those sequences encoding desired library members.
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28
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67650001355
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Computation carried out using the Oligonucleotide Modeling Platform OMP, DNA Software, Inc
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Computation carried out using the Oligonucleotide Modeling Platform (OMP, DNA Software, Inc.).
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29
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For examples of phosphodiester bond formation-dependent PCR, see: (a) Bartel, D. P, Szostak, J. W. Science 1993, 261, 1411
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For examples of phosphodiester bond formation-dependent PCR, see: (a) Bartel, D. P.; Szostak, J. W. Science 1993, 261, 1411.
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For a general review, see: Kubista, M.; Andrade, J. M.; Bengtsson, M.; Forootan, A.; Jonák, J.; Lind, K.; Sindelka, R.; Sjöback, R.; Sjögreen, B.; Strömbom, L.; Ståhlberg, A.; Zoric, N. Mol. Asp. Med. 2006, 27, 95.
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Heck, R. F. Org. React. 1982, 27, 345. See also ref 5a.
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35
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67649905054
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As little as 10 fmol of 9d and 9b could be carried through the process with similar results, suggesting that selections can be performed on a very small scale.
-
As little as 10 fmol of 9d and 9b could be carried through the process with similar results, suggesting that selections can be performed on a very small scale.
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36
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52649141086
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For approaches to protease substrate profiling by derivitization of free α-amines, see: a
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For approaches to protease substrate profiling by derivitization of free α-amines, see: (a) Mahrus, S.; Trinidad, J. C.; Barkan, D. T.; Sali, A.; Burlingame, A. L.; Wells, J. A. Cell 2008, 134, 866.
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DNA-templated amide bond formation with DMT-MM: (a) Li, X. Y.; Gartner, Z. J.; Tse, B. N.; Liu, D. R. J. Am. Chem. Soc. 2004, 126, 5090.
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DNA-templated amide bond formation with DMT-MM: (a) Li, X. Y.; Gartner, Z. J.; Tse, B. N.; Liu, D. R. J. Am. Chem. Soc. 2004, 126, 5090.
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41
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With EDC/sNHS: (b) Gartner, Z. J.; Kanan, M. W.; Liu, D. R. Angew. Chem., Int. Ed. 2002, 41, 1796.
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For a review of DTS, see: (c) Li, X. Y.; Liu, D. R. Angew. Chem., Int. Ed. 2004, 43, 4848.
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