IR-thermographic screening of thermoneutral or endothermic transformations: The ring-closing olefin metathesis reaction

Angewandte Chemie - International Edition

Volumn 39, Issue 7, 2000, Pages 1236-1239

  Reetz, Manfred T ^a   Becker, Michael H ^a   Liebl, Monika ^a   Fürstner, Alois ^a  

^a MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

Author keywords

Combinatorial chemistry; Homogeneous catalysis; Ring closing metathesis; Thermography

Indexed keywords

ALKENE;

ARTICLE; CHEMICAL REACTION; ENTHALPY; INFRARED RADIATION; THERMODYNAMICS; THERMOGRAPHY; VAPORIZATION;

EID: 0034599407     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(20000403)39:7<1236::AID-ANIE1236>3.0.CO;2-J     Document Type: Article

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39. For the substrate/catalyst activity screening the substrates were placed in the wells of a 96-well polypropylene microtiter plate (100 μL substrate per well). The temperature was calibrated in the range of 25-35°C. The reaction was initiated by the simultaneous addition of 100 μL of the four different precatalyst solutions (1-4) in toluene (0.01 M corresponding to 0.26 mol% precatalyst) at 30 °C to each substrate using a multiple pipette (the addition of the precatalyst solutions was completed within 90 s). As before, the temperature changes were detected periodically, shaking being interrupted. The detection time was 5 s, resulting in 250 recordings which were averaged.