Structural features of membrane-bound glucocerebrosidase and α-synuclein probed by neutron reflectometry and fluorescence spectroscopy

Journal of Biological Chemistry

Volumn 290, Issue 2, 2015, Pages 744-754

  Yap, Thai Leong ^a   Jiang, Zhiping ^a   Heinrich, Frank ^c,d   Gruschus, James M ^a   Pfefferkorn, Candace M ^a   Barros, Marilia ^c   Curtis, Joseph E ^d   Sidransky, Ellen ^b   Lee, Jennifer C ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c CARNEGIE MELLON UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIRCULAR DICHROISM SPECTROSCOPY; DICHROISM; DISEASES; ENZYMES; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; LIPID BILAYERS; MEMBRANES; NEUTRON REFLECTION; NEUTRON SCATTERING; PROTEINS; REFLECTION; REFLECTOMETERS; SURFACE PLASMON RESONANCE;

MEMBRANE-WATER INTERFACE; NEUTRON REFLECTOMETRY; NEUTRON SCATTERING LENGTH DENSITY; PHYSICAL INTERACTIONS; STRUCTURAL CHARACTERIZATION; STRUCTURAL INSIGHTS; SURFACE PLASMON RESONANCE SPECTROSCOPY; TETHERED LIPID BILAYERS;

ENZYME INHIBITION;

ALPHA SYNUCLEIN; GLUCOSYLCERAMIDASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; LIPID BILAYER; PROTEIN BINDING; TRYPTOPHAN;

ARTICLE; BILAYER MEMBRANE; CATALYSIS; CIRCULAR DICHROISM; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; FLUORESCENCE SPECTROSCOPY; GAUCHER DISEASE; LIPID MEMBRANE; LIPID VESICLE; MEMBRANE BINDING; NEUTRON REFLECTOMETRY; NEUTRON SCATTERING; PARKINSON DISEASE; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REFLECTOMETRY; SURFACE PLASMON RESONANCE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; GENETICS; HUMAN; LIPID BILAYER; METABOLISM; MUTATION; NEUTRON DIFFRACTION; PATHOLOGY; SPECTROFLUOROMETRY; ULTRASTRUCTURE;

ALPHA-SYNUCLEIN; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; HUMANS; LIPID BILAYERS; MUTATION; NEUTRON DIFFRACTION; PARKINSON DISEASE; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; SURFACE PLASMON RESONANCE; TRYPTOPHAN;

EID: 84920913800     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.610584     Document Type: Article

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